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Prostate Adenocarcinoma Clinical Trials
A listing of 48 Prostate Adenocarcinoma clinical trials actively recruiting volunteers for paid trials and research studies in various therapeutic areas.
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There are currently 48 active clinical trials seeking participants for Prostate Adenocarcinoma research studies. The states with the highest number of trials for Prostate Adenocarcinoma participants are Illinois, California, Wisconsin and Pennsylvania.
Featured Trial
Paid Clinical Studies Nationwide
Recruiting
Nationwide clinical trials offered in your area. Some trials offering up to several thousand dollars in compensation for participation.
Featured Trial
Type 2 Diabetes Clinical Trial
Recruiting
Can changing your breakfast improve your type 2 diabetes? If you have an HbA1C of 7.0% or higher, you are invited to participate in an online study at the University of Michigan.
Conditions:
Type 2 Diabetes
Diabetes Mellitus Type 2 in Obese
Diabetes Type Two
Type 2 Diabetes Mellitus
Diabete Type 2
Featured Trial
Crohn's Disease Clinical Study
Recruiting
Help us study a potential new way to treat Crohn's disease. We are seeking adults living with Crohn's disease to join our latest clinical trial to help us learn more. Eligible participants will receive study-related treatment, assessments, and care at no cost. You will also receive reimbursement for travel while participating. Health insurance is not required to take part.
Conditions:
Crohn's Disease
Crohn Disease
Crohns Disease
Crohn's Disease (CD)
Crohn Colitis
Featured Offer
Lose Weight with GLP-1 Medications
Recruiting
Policy Lab has partnered with CareGLP to offer trusted access to GLP-1 medications, including generic alternatives to Ozempic® and Wegovy®.
GLP-1 medications are scientifically backed to help individuals achieve significant weight loss—on average, 15-20% of body weight within a year.
As a valued user, you’re eligible for $100 off your first program with code policy-lab-100.
GLP-1 medications are scientifically backed to help individuals achieve significant weight loss—on average, 15-20% of body weight within a year.
As a valued user, you’re eligible for $100 off your first program with code policy-lab-100.
Conditions:
Overweight
Overweight and Obesity
Obesity
Weight Loss
Morbid Obesity
Effects of Relugolix vs Leuprolide on Cardiac Function in Patients With Prostate Cancer
Recruiting
This phase II trial compares the effect of relugolix to leuprolide on cardiac function and performance in patients with prostate cancer. Androgen deprivation therapy (ADT) has been a key component for the treatment of advanced prostate cancer for decades. The term androgen deprivation therapy means lowering a man's testosterone. Long-term studies show that ADT may contribute to a detriment to cardiac health and predisposes men to developing cardiac diseases. Recent studies suggest that men takin... Read More
This phase II trial compares the effect of relugolix to leuprolide on cardiac function and performance in patients with prostate cancer. Androgen deprivation therapy (ADT) has been a key component for the treatment of advanced prostate cancer for decades. The term androgen deprivation therapy means lowering a man's testosterone. Long-term studies show that ADT may contribute to a detriment to cardiac health and predisposes men to developing cardiac diseases. Recent studies suggest that men taking relugolix for treatment of prostate cancer may have a lower risk of developing cardiovascular problems, but more studies are needed to understand this observation, and there are currently no studies reporting the direct impact of ADT (relugolix, versus the more-commonly used leuprolide) on cardiac function and outcomes.
Participants will receive definitive radiotherapy for unfavorable intermediate risk prostate cancer and 6-month ADT (either relugolix or leuprolide). In addition, participants will undergo the following:
1. Comprehensive cardiac and exercise testing before and after starting ADT
2. Completion of quality-of-life questionnaires at specific intervals during the study period
3. Provide blood samples at specific intervals during the study period to test for changes in steroid levels and certain biomarkers Read Less
Gender:
MALE
Ages:
18 years and above
Trial Updated:
09/16/2024
Locations: Ohio State University Comprehensive Cancer Center, Columbus, Ohio
Ohio State University Comprehensive Cancer Center, Columbus, Ohio
Conditions: Prostate Adenocarcinoma, Stage IIB Prostate Cancer AJCC v8, Stage IIC Prostate Cancer AJCC v8
Single-Port Transvesical Partial Prostatectomy Versus High Intensity Focused Ultrasound
Recruiting
This study aims to compare the novel single-port robotic partial prostatectomy to High-intensity focused ultrasound (HIFU) in patients with low to intermediate risk localized prostate cancer. These interventions have become acceptable focal therapies prevalent with beneficial oncologic outcomes and therefore need to be examined further.
This study aims to compare the novel single-port robotic partial prostatectomy to High-intensity focused ultrasound (HIFU) in patients with low to intermediate risk localized prostate cancer. These interventions have become acceptable focal therapies prevalent with beneficial oncologic outcomes and therefore need to be examined further. Read Less
Gender:
MALE
Ages:
19 years and above
Trial Updated:
06/21/2024
Locations: Glickman Urological & Kidney Institute, Cleveland Clinic Foundation, Case Comprehensive Cancer Center, Cleveland, Ohio
Glickman Urological & Kidney Institute, Cleveland Clinic Foundation, Case Comprehensive Cancer Center, Cleveland, Ohio
Conditions: Prostate Adenocarcinoma, Prostate Cancer
Focal Therapy With Stereotactic Body Radiation Therapy (SBRT) for Patients With a Single Prostate Tumor
Recruiting
Background:
The current standard treatment of prostate cancer is either surgery or radiation. Typically, this includes either the removal or radiation of the whole prostate gland. Many people now seek out focal therapy options to decrease the side effects of treatment. Until now, several forms of physical destruction with heat (thermal ablation), cold (cryotherapy), sound waves (HIFU), laser (FLA), and electrical energy (IRE). A new type of radiation (SBRT) may be an effective way to cure men o... Read More
Background:
The current standard treatment of prostate cancer is either surgery or radiation. Typically, this includes either the removal or radiation of the whole prostate gland. Many people now seek out focal therapy options to decrease the side effects of treatment. Until now, several forms of physical destruction with heat (thermal ablation), cold (cryotherapy), sound waves (HIFU), laser (FLA), and electrical energy (IRE). A new type of radiation (SBRT) may be an effective way to cure men of early-stage prostate cancer with fewer side effects than standard treatments.
Objective:
To see how people with untreated localized prostate cancer will respond to focal therapy with SBRT.
Eligibility:
People aged 18 years and older with untreated localized prostate cancer (prostate cancer which has not spread outside of the prostate gland).
Design:
* Participants will undergo screening including blood tests, an MRI, a PSMA PET/CT (18F-DCFPyL), and a biopsy.
* Small, non-radioactive, gold seeds about the size of a grain of rice will be placed in and/or around the tumor to help target the radiation treatment.
* Radiation (SBRT) will occur in 2 separate sessions about 1 week apart. No sedation is used, these sessions are painless. Each session will take about 1-2 hours. Participants can go home afterwards.
* Follow-up will continue for 2 years with repeat scans (MRI and PSMA PET/CT) and blood (PSA) tests.
* After two years, a biopsy will be done to understand the impact of this new treatment on prostate cancer. Read Less
Gender:
MALE
Ages:
Between 18 years and 120 years
Trial Updated:
05/22/2025
Locations: National Institutes of Health Clinical Center, Bethesda, Maryland
National Institutes of Health Clinical Center, Bethesda, Maryland
The Use of Ultrasound in Assessing Post-prostatectomy Erectile Dysfunction
Recruiting
Researchers are trying to determine whether there is additional utility to using vibroelastography, a noninvasive ultrasound technique to evaluate for the presence of tissue fibrosis, in conjunction with standard penile duplex Doppler ultrasound to assess erectile function (recovery) after prostate cancer surgery.
Researchers are trying to determine whether there is additional utility to using vibroelastography, a noninvasive ultrasound technique to evaluate for the presence of tissue fibrosis, in conjunction with standard penile duplex Doppler ultrasound to assess erectile function (recovery) after prostate cancer surgery. Read Less
Gender:
MALE
Ages:
40 years and above
Trial Updated:
05/19/2025
Locations: Mayo Clinic in Rochester, Rochester, Minnesota
Mayo Clinic in Rochester, Rochester, Minnesota
Conditions: Prostate Adenocarcinoma
rhPSMA-73 PET-MRI Imaging for the Detection of Prostate Cancer Among Men Who Are Otherwise Candidates for Active Surveillance
Recruiting
This clinical trial evaluates whether positron emission tomography-magnetic resonance imaging (PET-MRI) using the radioactive drug radiohybrid prostate-specific membrane antigen (rhPSMA)-7.3 may help in detecting higher grade or stage disease in men with low and favorable intermediate risk prostate cancer who are candidates for active surveillance. A PET scan is a test that uses a radioactive drug and a computer to create images of how organs and tissues in the body are functioning. The radioact... Read More
This clinical trial evaluates whether positron emission tomography-magnetic resonance imaging (PET-MRI) using the radioactive drug radiohybrid prostate-specific membrane antigen (rhPSMA)-7.3 may help in detecting higher grade or stage disease in men with low and favorable intermediate risk prostate cancer who are candidates for active surveillance. A PET scan is a test that uses a radioactive drug and a computer to create images of how organs and tissues in the body are functioning. The radioactive drug used in this study, rhPSMA-7.3, attaches to the abnormal cells in the body at a different rate than normal cells which allows the scanner to create a detailed picture of how the body is working. An MRI scan uses strong magnets and computers to create detailed images of the soft tissue in your body. A multiparametric (mp)MRI is a type of MRI scan that creates a more detailed picture of the prostate gland. Using rhPSMA-73 with PET-MRI and mpMRI may be more effective in detecting higher grade or stage disease in men with low and favorable intermediate risk prostate cancer. Read Less
Gender:
MALE
Ages:
18 years and above
Trial Updated:
05/19/2025
Locations: Northwestern University, Chicago, Illinois
Northwestern University, Chicago, Illinois
Conditions: Prostate Adenocarcinoma, Stage I Prostate Cancer AJCC v8, Stage IIA Prostate Cancer AJCC v8, Stage IIB Prostate Cancer AJCC v8
Neoadjuvant Atezolizumab-Based Combination Therapy in Men With Localized Prostate Cancer Prior to Radical Prostatectomy
Recruiting
This phase II trial studies how well atezolizumab works alone or in combination with etrumadenant or tocilizumab in treating men with localized prostate cancer before radical prostatectomy. Immunotherapy with monoclonal antibodies, such as atezolizumab, may help the body's immune system attack the cancer, and may interfere with the ability of tumor cells to grow and spread. Androgens can cause the growth of prostate cancer cells. IL-6 is expressed by prostate cancer and within the tumor microenv... Read More
This phase II trial studies how well atezolizumab works alone or in combination with etrumadenant or tocilizumab in treating men with localized prostate cancer before radical prostatectomy. Immunotherapy with monoclonal antibodies, such as atezolizumab, may help the body's immune system attack the cancer, and may interfere with the ability of tumor cells to grow and spread. Androgens can cause the growth of prostate cancer cells. IL-6 is expressed by prostate cancer and within the tumor microenvironment and shown to enhance prostate cancer and disease progression. Treatment with an anti-IL-6 antibody such as tocilizumab may inhibit cancer progression. Giving atezolizumab in combination with etrumadenant or tocilizumab may work better in treating prostate cancer. Read Less
Gender:
MALE
Ages:
18 years and above
Trial Updated:
05/12/2025
Locations: University of California, San Francisco, San Francisco, California +1 locations
University of California, San Francisco, San Francisco, California
Alvin J. Siteman Cancer Center at Washington University, Saint Louis, Missouri
Testing the Addition of the Drug Apalutamide to the Usual Hormone Therapy and Radiation Therapy After Surgery for Prostate Cancer, INNOVATE Trial
Recruiting
This phase III trial studies whether adding apalutamide to the usual treatment improves outcome in patients with lymph node positive prostate cancer after surgery. Radiation therapy uses high energy x-ray to kill tumor cells and shrink tumors. Androgens, or male sex hormones, can cause the growth of prostate cancer cells. Drugs, such as apalutamide, may help stop or reduce the growth of prostate cancer cell growth by blocking the attachment of androgen to its receptors on cancer cells, a mechani... Read More
This phase III trial studies whether adding apalutamide to the usual treatment improves outcome in patients with lymph node positive prostate cancer after surgery. Radiation therapy uses high energy x-ray to kill tumor cells and shrink tumors. Androgens, or male sex hormones, can cause the growth of prostate cancer cells. Drugs, such as apalutamide, may help stop or reduce the growth of prostate cancer cell growth by blocking the attachment of androgen to its receptors on cancer cells, a mechanism similar to stopping the entrance of a key into its lock. Adding apalutamide to the usual hormone therapy and radiation therapy after surgery may stabilize prostate cancer and prevent it from spreading and extend time without disease spreading compared to the usual approach. Read Less
Gender:
MALE
Ages:
18 years and above
Trial Updated:
05/06/2025
Locations: Cancer Center at Saint Joseph's, Phoenix, Arizona +334 locations
Cancer Center at Saint Joseph's, Phoenix, Arizona
University of Arkansas for Medical Sciences, Little Rock, Arkansas
Kaiser Permanente-Anaheim, Anaheim, California
Kaiser Permanente-Baldwin Park, Baldwin Park, California
Kaiser Permanente-Bellflower, Bellflower, California
Mercy Cancer Center - Carmichael, Carmichael, California
Mercy San Juan Medical Center, Carmichael, California
Mercy Cancer Center - Elk Grove, Elk Grove, California
Kaiser Permanente-Fontana, Fontana, California
Marin General Hospital, Greenbrae, California
Kaiser Permanente South Bay, Harbor City, California
Kaiser Permanente-Irvine, Irvine, California
Tibor Rubin VA Medical Center, Long Beach, California
Kaiser Permanente Los Angeles Medical Center, Los Angeles, California
Los Angeles General Medical Center, Los Angeles, California
USC / Norris Comprehensive Cancer Center, Los Angeles, California
Kaiser Permanente West Los Angeles, Los Angeles, California
UCLA / Jonsson Comprehensive Cancer Center, Los Angeles, California
Kaiser Permanente-Ontario, Ontario, California
Kaiser Permanente - Panorama City, Panorama City, California
Kaiser Permanente-Riverside, Riverside, California
Mercy Cancer Center - Rocklin, Rocklin, California
Mercy Cancer Center - Sacramento, Sacramento, California
University of California Davis Comprehensive Cancer Center, Sacramento, California
Kaiser Permanente-San Diego Zion, San Diego, California
UCSF Medical Center-Mount Zion, San Francisco, California
UCSF Medical Center-Parnassus, San Francisco, California
UCSF Medical Center-Mission Bay, San Francisco, California
Kaiser Permanente-San Marcos, San Marcos, California
Ridley-Tree Cancer Center, Santa Barbara, California
Kaiser Permanente-Woodland Hills, Woodland Hills, California
Woodland Memorial Hospital, Woodland, California
Beebe South Coastal Health Campus, Millville, Delaware
Helen F Graham Cancer Center, Newark, Delaware
Medical Oncology Hematology Consultants PA, Newark, Delaware
Christiana Care Health System-Christiana Hospital, Newark, Delaware
Beebe Health Campus, Rehoboth Beach, Delaware
George Washington University Medical Center, Washington, District of Columbia
UM Sylvester Comprehensive Cancer Center at Aventura, Aventura, Florida
UM Sylvester Comprehensive Cancer Center at Coral Gables, Coral Gables, Florida
UM Sylvester Comprehensive Cancer Center at Deerfield Beach, Deerfield Beach, Florida
University of Miami Miller School of Medicine-Sylvester Cancer Center, Miami, Florida
UM Sylvester Comprehensive Cancer Center at Kendall, Miami, Florida
UM Sylvester Comprehensive Cancer Center at Plantation, Plantation, Florida
Tampa General Hospital, Tampa, Florida
Grady Health System, Atlanta, Georgia
Emory Proton Therapy Center, Atlanta, Georgia
Emory University Hospital Midtown, Atlanta, Georgia
Emory University Hospital/Winship Cancer Institute, Atlanta, Georgia
Emory Saint Joseph's Hospital, Atlanta, Georgia
Emory Decatur Hospital, Decatur, Georgia
Emory Johns Creek Hospital, Johns Creek, Georgia
Alton Memorial Hospital, Alton, Illinois
Rush - Copley Medical Center, Aurora, Illinois
Advocate Outpatient Center - Aurora, Aurora, Illinois
Advocate Good Shepherd Hospital, Barrington, Illinois
Illinois CancerCare-Bloomington, Bloomington, Illinois
Illinois CancerCare-Canton, Canton, Illinois
Illinois CancerCare-Carthage, Carthage, Illinois
Northwestern University, Chicago, Illinois
Rush University Medical Center, Chicago, Illinois
University of Illinois, Chicago, Illinois
University of Chicago Comprehensive Cancer Center, Chicago, Illinois
Advocate Illinois Masonic Medical Center, Chicago, Illinois
AMG Crystal Lake - Oncology, Crystal Lake, Illinois
Carle at The Riverfront, Danville, Illinois
Decatur Memorial Hospital, Decatur, Illinois
Northwestern Medicine Cancer Center Kishwaukee, DeKalb, Illinois
Illinois CancerCare-Dixon, Dixon, Illinois
Advocate Good Samaritan Hospital, Downers Grove, Illinois
Carle Physician Group-Effingham, Effingham, Illinois
Crossroads Cancer Center, Effingham, Illinois
Advocate Sherman Hospital, Elgin, Illinois
Elmhurst Memorial Hospital, Elmhurst, Illinois
Illinois CancerCare-Eureka, Eureka, Illinois
NorthShore University HealthSystem-Evanston Hospital, Evanston, Illinois
Illinois CancerCare-Galesburg, Galesburg, Illinois
Western Illinois Cancer Treatment Center, Galesburg, Illinois
Northwestern Medicine Cancer Center Delnor, Geneva, Illinois
NorthShore University HealthSystem-Glenbrook Hospital, Glenview, Illinois
Ingalls Memorial Hospital, Harvey, Illinois
Advocate South Suburban Hospital, Hazel Crest, Illinois
NorthShore University HealthSystem-Highland Park Hospital, Highland Park, Illinois
Illinois CancerCare-Kewanee Clinic, Kewanee, Illinois
AMG Libertyville - Oncology, Libertyville, Illinois
Condell Memorial Hospital, Libertyville, Illinois
Illinois CancerCare-Macomb, Macomb, Illinois
Carle Physician Group-Mattoon/Charleston, Mattoon, Illinois
Loyola University Medical Center, Maywood, Illinois
Edward Hospital/Cancer Center, Naperville, Illinois
UC Comprehensive Cancer Center at Silver Cross, New Lenox, Illinois
HSHS Saint Elizabeth's Hospital, O'Fallon, Illinois
Advocate Christ Medical Center, Oak Lawn, Illinois
Northwestern Medicine Orland Park, Orland Park, Illinois
University of Chicago Medicine-Orland Park, Orland Park, Illinois
Illinois CancerCare-Ottawa Clinic, Ottawa, Illinois
Advocate High Tech Medical Park, Palos Heights, Illinois
Advocate Lutheran General Hospital, Park Ridge, Illinois
Illinois CancerCare-Pekin, Pekin, Illinois
OSF Saint Francis Radiation Oncology at Pekin, Pekin, Illinois
Illinois CancerCare-Peoria, Peoria, Illinois
OSF Saint Francis Radiation Oncology at Peoria Cancer Center, Peoria, Illinois
Methodist Medical Center of Illinois, Peoria, Illinois
OSF Saint Francis Medical Center, Peoria, Illinois
Illinois CancerCare-Peru, Peru, Illinois
Valley Radiation Oncology, Peru, Illinois
Illinois CancerCare-Princeton, Princeton, Illinois
Memorial Hospital East, Shiloh, Illinois
Southern Illinois University School of Medicine, Springfield, Illinois
Springfield Clinic, Springfield, Illinois
Springfield Memorial Hospital, Springfield, Illinois
Carle Cancer Center, Urbana, Illinois
Northwestern Medicine Cancer Center Warrenville, Warrenville, Illinois
Illinois CancerCare - Washington, Washington, Illinois
Reid Health, Richmond, Indiana
McFarland Clinic - Ames, Ames, Iowa
UI Health Care Mission Cancer and Blood - Ankeny Clinic, Ankeny, Iowa
Saint Anthony Regional Hospital, Carroll, Iowa
Saint Luke's Hospital, Cedar Rapids, Iowa
Mercy Hospital, Cedar Rapids, Iowa
Oncology Associates at Mercy Medical Center, Cedar Rapids, Iowa
Iowa Methodist Medical Center, Des Moines, Iowa
UI Health Care Mission Cancer and Blood - Des Moines Clinic, Des Moines, Iowa
Broadlawns Medical Center, Des Moines, Iowa
Mercy Medical Center - Des Moines, Des Moines, Iowa
Iowa Lutheran Hospital, Des Moines, Iowa
Methodist West Hospital, West Des Moines, Iowa
University of Kansas Cancer Center, Kansas City, Kansas
The University of Kansas Cancer Center - Olathe, Olathe, Kansas
University of Kansas Cancer Center-Overland Park, Overland Park, Kansas
Salina Regional Health Center, Salina, Kansas
University of Kansas Health System Saint Francis Campus, Topeka, Kansas
University of Kansas Hospital-Westwood Cancer Center, Westwood, Kansas
LSU Health Baton Rouge-North Clinic, Baton Rouge, Louisiana
Our Lady of the Lake Physician Group, Baton Rouge, Louisiana
Mary Bird Perkins Cancer Center, Baton Rouge, Louisiana
Mary Bird Perkins Cancer Center - Metairie, Metairie, Louisiana
East Jefferson General Hospital, Metairie, Louisiana
LSU Healthcare Network / Metairie Multi-Specialty Clinic, Metairie, Louisiana
Tulane University School of Medicine, New Orleans, Louisiana
Ochsner Medical Center Jefferson, New Orleans, Louisiana
Lafayette Family Cancer Center-EMMC, Brewer, Maine
Massachusetts General Hospital Cancer Center, Boston, Massachusetts
Brigham and Women's Hospital, Boston, Massachusetts
Dana-Farber Cancer Institute, Boston, Massachusetts
Trinity Health Saint Joseph Mercy Hospital Ann Arbor, Ann Arbor, Michigan
Trinity Health Medical Center - Brighton, Brighton, Michigan
Trinity Health Medical Center - Canton, Canton, Michigan
Chelsea Hospital, Chelsea, Michigan
Henry Ford Hospital, Detroit, Michigan
McLaren Cancer Institute-Flint, Flint, Michigan
Singh and Arora Hematology Oncology PC, Flint, Michigan
Karmanos Cancer Institute at McLaren Greater Lansing, Lansing, Michigan
Mid-Michigan Physicians-Lansing, Lansing, Michigan
University of Michigan Health - Sparrow Lansing, Lansing, Michigan
Trinity Health Saint Mary Mercy Livonia Hospital, Livonia, Michigan
McLaren Cancer Institute-Macomb, Mount Clemens, Michigan
McLaren Cancer Institute-Owosso, Owosso, Michigan
Minnesota Oncology - Burnsville, Burnsville, Minnesota
Mercy Hospital, Coon Rapids, Minnesota
Fairview Southdale Hospital, Edina, Minnesota
Unity Hospital, Fridley, Minnesota
Fairview Clinics and Surgery Center Maple Grove, Maple Grove, Minnesota
Minnesota Oncology Hematology PA-Maplewood, Maplewood, Minnesota
Saint John's Hospital - Healtheast, Maplewood, Minnesota
Abbott-Northwestern Hospital, Minneapolis, Minnesota
Hennepin County Medical Center, Minneapolis, Minnesota
Monticello Cancer Center, Monticello, Minnesota
North Memorial Medical Health Center, Robbinsdale, Minnesota
Coborn Cancer Center at Saint Cloud Hospital, Saint Cloud, Minnesota
Park Nicollet Clinic - Saint Louis Park, Saint Louis Park, Minnesota
Regions Hospital, Saint Paul, Minnesota
United Hospital, Saint Paul, Minnesota
Saint Francis Regional Medical Center, Shakopee, Minnesota
Lakeview Hospital, Stillwater, Minnesota
Ridgeview Medical Center, Waconia, Minnesota
Rice Memorial Hospital, Willmar, Minnesota
Minnesota Oncology Hematology PA-Woodbury, Woodbury, Minnesota
Saint Louis Cancer and Breast Institute-Ballwin, Ballwin, Missouri
Saint Francis Medical Center, Cape Girardeau, Missouri
Siteman Cancer Center at West County Hospital, Creve Coeur, Missouri
University of Kansas Cancer Center - North, Kansas City, Missouri
University of Kansas Cancer Center - Lee's Summit, Lee's Summit, Missouri
University of Kansas Cancer Center at North Kansas City Hospital, North Kansas City, Missouri
Washington University School of Medicine, Saint Louis, Missouri
Siteman Cancer Center-South County, Saint Louis, Missouri
Siteman Cancer Center at Christian Hospital, Saint Louis, Missouri
Mercy Hospital Saint Louis, Saint Louis, Missouri
Siteman Cancer Center at Saint Peters Hospital, Saint Peters, Missouri
Billings Clinic Cancer Center, Billings, Montana
Benefis Sletten Cancer Institute, Great Falls, Montana
Cancer Partners of Nebraska, Lincoln, Nebraska
Comprehensive Cancer Centers of Nevada - Henderson, Henderson, Nevada
OptumCare Cancer Care at Seven Hills, Henderson, Nevada
OptumCare Cancer Care at Charleston, Las Vegas, Nevada
Radiation Oncology Centers of Nevada Central, Las Vegas, Nevada
GenesisCare USA - Las Vegas, Las Vegas, Nevada
Radiation Oncology Centers of Nevada Southeast, Las Vegas, Nevada
Comprehensive Cancer Centers of Nevada - Northwest, Las Vegas, Nevada
OptumCare Cancer Care at MountainView, Las Vegas, Nevada
Comprehensive Cancer Centers of Nevada - Town Center, Las Vegas, Nevada
Comprehensive Cancer Centers of Nevada-Summerlin, Las Vegas, Nevada
Summerlin Hospital Medical Center, Las Vegas, Nevada
Comprehensive Cancer Centers of Nevada, Las Vegas, Nevada
GenesisCare USA - Fort Apache, Las Vegas, Nevada
OptumCare Cancer Care at Fort Apache, Las Vegas, Nevada
Comprehensive Cancer Centers of Nevada - Central Valley, Las Vegas, Nevada
Renown Regional Medical Center, Reno, Nevada
New Hampshire Oncology Hematology PA-Concord, Concord, New Hampshire
Solinsky Center for Cancer Care, Manchester, New Hampshire
Memorial Sloan Kettering Basking Ridge, Basking Ridge, New Jersey
Cooper Hospital University Medical Center, Camden, New Jersey
Saint Barnabas Medical Center, Livingston, New Jersey
Memorial Sloan Kettering Monmouth, Middletown, New Jersey
Memorial Sloan Kettering Bergen, Montvale, New Jersey
Rutgers Cancer Institute of New Jersey, New Brunswick, New Jersey
Rutgers New Jersey Medical School, Newark, New Jersey
Robert Wood Johnson University Hospital Somerset, Somerville, New Jersey
MD Anderson Cancer Center at Cooper-Voorhees, Voorhees, New Jersey
Sands Cancer Center, Canandaigua, New York
Memorial Sloan Kettering Commack, Commack, New York
Northwell Health Physicians Partners Radiation Medicine at Queens, Forest Hills, New York
Memorial Sloan Kettering Westchester, Harrison, New York
Northwell Health/Center for Advanced Medicine, Lake Success, New York
Garnet Health Medical Center, Middletown, New York
Memorial Sloan Kettering Cancer Center, New York, New York
Queens Cancer Center, Rego Park, New York
Wilmot Cancer Institute Radiation Oncology at Greece, Rochester, New York
Highland Hospital, Rochester, New York
University of Rochester, Rochester, New York
Memorial Sloan Kettering Nassau, Uniondale, New York
Wilmot Cancer Institute at Webster, Webster, New York
Duke Cancer Center Cary, Cary, North Carolina
Duke University Medical Center, Durham, North Carolina
Duke Cancer Center Raleigh, Raleigh, North Carolina
Wake Forest University Health Sciences, Winston-Salem, North Carolina
Cleveland Clinic Akron General, Akron, Ohio
Miami Valley Hospital South, Centerville, Ohio
University of Cincinnati Cancer Center-UC Medical Center, Cincinnati, Ohio
Cleveland Clinic Cancer Center/Fairview Hospital, Cleveland, Ohio
Cleveland Clinic Foundation, Cleveland, Ohio
Ohio State University Comprehensive Cancer Center, Columbus, Ohio
Miami Valley Hospital, Dayton, Ohio
Premier Blood and Cancer Center, Dayton, Ohio
Miami Valley Hospital North, Dayton, Ohio
Armes Family Cancer Center, Findlay, Ohio
Atrium Medical Center-Middletown Regional Hospital, Franklin, Ohio
Cleveland Clinic Cancer Center Mansfield, Mansfield, Ohio
Hillcrest Hospital Cancer Center, Mayfield Heights, Ohio
North Coast Cancer Care, Sandusky, Ohio
Cleveland Clinic Cancer Center Strongsville, Strongsville, Ohio
Upper Valley Medical Center, Troy, Ohio
University of Cincinnati Cancer Center-West Chester, West Chester, Ohio
Cleveland Clinic Wooster Family Health and Surgery Center, Wooster, Ohio
University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma
Legacy Mount Hood Medical Center, Gresham, Oregon
Legacy Good Samaritan Hospital and Medical Center, Portland, Oregon
UPMC Altoona, Altoona, Pennsylvania
UPMC-Heritage Valley Health System Beaver, Beaver, Pennsylvania
Crozer-Keystone Regional Cancer Center at Broomall, Broomall, Pennsylvania
Carlisle Regional Cancer Center, Carlisle, Pennsylvania
Christiana Care Health System-Concord Health Center, Chadds Ford, Pennsylvania
Delaware County Memorial Hospital, Drexel Hill, Pennsylvania
UPMC Hillman Cancer Center Erie, Erie, Pennsylvania
UPMC Cancer Center at UPMC Horizon, Farrell, Pennsylvania
Crozer Regional Cancer Center at Brinton Lake, Glen Mills, Pennsylvania
UPMC Cancer Centers - Arnold Palmer Pavilion, Greensburg, Pennsylvania
UPMC Pinnacle Cancer Center/Community Osteopathic Campus, Harrisburg, Pennsylvania
Penn State Milton S Hershey Medical Center, Hershey, Pennsylvania
IRMC Cancer Center, Indiana, Pennsylvania
UPMC-Johnstown/John P. Murtha Regional Cancer Center, Johnstown, Pennsylvania
UPMC Cancer Center at UPMC McKeesport, McKeesport, Pennsylvania
UPMC Hillman Cancer Center at Rocco And Nancy Ortenzio Cancer Pavilion, Mechanicsburg, Pennsylvania
UPMC Cancer Center - Monroeville, Monroeville, Pennsylvania
UPMC Hillman Cancer Center in Coraopolis, Moon, Pennsylvania
UPMC-Magee Womens Hospital, Pittsburgh, Pennsylvania
UPMC-Saint Margaret, Pittsburgh, Pennsylvania
UPMC-Shadyside Hospital, Pittsburgh, Pennsylvania
UPMC-Passavant Hospital, Pittsburgh, Pennsylvania
UPMC-Saint Clair Hospital Cancer Center, Pittsburgh, Pennsylvania
UPMC Cancer Center at UPMC Northwest, Seneca, Pennsylvania
UPMC Uniontown Hospital Radiation Oncology, Uniontown, Pennsylvania
Crozer-Chester Medical Center, Upland, Pennsylvania
UPMC Washington Hospital Radiation Oncology, Washington, Pennsylvania
Chester County Hospital, West Chester, Pennsylvania
Reading Hospital, West Reading, Pennsylvania
UPMC Memorial, York, Pennsylvania
Avera Cancer Institute - Mitchell, Mitchell, South Dakota
Avera Cancer Institute, Sioux Falls, South Dakota
UT Southwestern/Simmons Cancer Center-Dallas, Dallas, Texas
Tarrant County Hospital District/JPS Health Network, Fort Worth, Texas
UT Southwestern/Simmons Cancer Center-Fort Worth, Fort Worth, Texas
UT Southwestern Clinical Center at Richardson/Plano, Richardson, Texas
Audie L Murphy VA Hospital, San Antonio, Texas
VCU Massey Cancer Center at Hanover Medical Park, Mechanicsville, Virginia
Bon Secours Saint Francis Medical Center, Midlothian, Virginia
Bon Secours Cancer Institute at Reynolds Crossing, Richmond, Virginia
VCU Massey Cancer Center at Stony Point, Richmond, Virginia
Virginia Commonwealth University/Massey Cancer Center, Richmond, Virginia
Legacy Salmon Creek Hospital, Vancouver, Washington
West Virginia University Charleston Division, Charleston, West Virginia
Langlade Hospital and Cancer Center, Antigo, Wisconsin
ThedaCare Regional Cancer Center, Appleton, Wisconsin
Aurora Cancer Care-Southern Lakes VLCC, Burlington, Wisconsin
Marshfield Medical Center-EC Cancer Center, Eau Claire, Wisconsin
Aurora Health Care Germantown Health Center, Germantown, Wisconsin
Aurora Cancer Care-Grafton, Grafton, Wisconsin
Bellin Memorial Hospital, Green Bay, Wisconsin
Aurora BayCare Medical Center, Green Bay, Wisconsin
Aurora Cancer Care-Kenosha South, Kenosha, Wisconsin
Aurora Bay Area Medical Group-Marinette, Marinette, Wisconsin
Marshfield Medical Center-Marshfield, Marshfield, Wisconsin
Froedtert Menomonee Falls Hospital, Menomonee Falls, Wisconsin
Aurora Cancer Care-Milwaukee, Milwaukee, Wisconsin
Aurora Saint Luke's Medical Center, Milwaukee, Wisconsin
Medical College of Wisconsin, Milwaukee, Wisconsin
Aurora Sinai Medical Center, Milwaukee, Wisconsin
Marshfield Medical Center - Minocqua, Minocqua, Wisconsin
Cancer Center of Western Wisconsin, New Richmond, Wisconsin
Drexel Town Square Health Center, Oak Creek, Wisconsin
Vince Lombardi Cancer Clinic - Oshkosh, Oshkosh, Wisconsin
Aurora Cancer Care-Racine, Racine, Wisconsin
Aspirus Cancer Care - James Beck Cancer Center, Rhinelander, Wisconsin
Marshfield Medical Center-Rice Lake, Rice Lake, Wisconsin
Vince Lombardi Cancer Clinic-Sheboygan, Sheboygan, Wisconsin
Aspirus Cancer Care - Stevens Point, Stevens Point, Wisconsin
Marshfield Medical Center-River Region at Stevens Point, Stevens Point, Wisconsin
Aurora Medical Center in Summit, Summit, Wisconsin
Aspirus Regional Cancer Center, Wausau, Wisconsin
Aurora Cancer Care-Milwaukee West, Wauwatosa, Wisconsin
Aurora West Allis Medical Center, West Allis, Wisconsin
Froedtert West Bend Hospital/Kraemer Cancer Center, West Bend, Wisconsin
Diagnostic and Treatment Center, Weston, Wisconsin
Marshfield Medical Center - Weston, Weston, Wisconsin
Aspirus Cancer Care - Wisconsin Rapids, Wisconsin Rapids, Wisconsin
Conditions: Prostate Adenocarcinoma, Stage I Prostate Cancer AJCC v8, Stage II Prostate Cancer AJCC v8, Stage III Prostate Cancer AJCC v8, Stage IVA Prostate Cancer AJCC v8
Testing Shorter Duration Radiation Therapy Versus the Usual Radiation Therapy in Patients With High Risk Prostate Cancer
Recruiting
This phase III trial compares stereotactic body radiation therapy (SBRT), (five treatments over two weeks using a higher dose per treatment) to usual radiation therapy (20 to 45 treatments over 4 to 9 weeks) for the treatment of high-risk prostate cancer. SBRT uses special equipment to position a patient and deliver radiation to tumors with high precision. This method may kill tumor cells with fewer doses over a shorter period of time. This trial is evaluating if shorter duration radiation preve... Read More
This phase III trial compares stereotactic body radiation therapy (SBRT), (five treatments over two weeks using a higher dose per treatment) to usual radiation therapy (20 to 45 treatments over 4 to 9 weeks) for the treatment of high-risk prostate cancer. SBRT uses special equipment to position a patient and deliver radiation to tumors with high precision. This method may kill tumor cells with fewer doses over a shorter period of time. This trial is evaluating if shorter duration radiation prevents cancer from coming back as well as the usual radiation treatment. Read Less
Gender:
MALE
Ages:
18 years and above
Trial Updated:
05/06/2025
Locations: University of Alabama at Birmingham Cancer Center, Birmingham, Alabama +290 locations
University of Alabama at Birmingham Cancer Center, Birmingham, Alabama
Lewis and Faye Manderson Cancer Center, Tuscaloosa, Alabama
University of Arkansas for Medical Sciences, Little Rock, Arkansas
Kaiser Permanente-Deer Valley Medical Center, Antioch, California
Tower Cancer Research Foundation, Beverly Hills, California
Kaiser Permanente Dublin, Dublin, California
Kaiser Permanente-Fremont, Fremont, California
Fresno Cancer Center, Fresno, California
Kaiser Permanente-Fresno, Fresno, California
UCI Health - Chao Family Comprehensive Cancer Center and Ambulatory Care, Irvine, California
Cedars Sinai Medical Center, Los Angeles, California
Kaiser Permanente-Modesto, Modesto, California
Kaiser Permanente Oakland-Broadway, Oakland, California
Kaiser Permanente-Oakland, Oakland, California
UC Irvine Health/Chao Family Comprehensive Cancer Center, Orange, California
Kaiser Permanente-Rancho Cordova Cancer Center, Rancho Cordova, California
Kaiser Permanente- Marshall Medical Offices, Redwood City, California
Kaiser Permanente-Richmond, Richmond, California
Rohnert Park Cancer Center, Rohnert Park, California
Kaiser Permanente-Roseville, Roseville, California
The Permanente Medical Group-Roseville Radiation Oncology, Roseville, California
Kaiser Permanente Downtown Commons, Sacramento, California
Kaiser Permanente-South Sacramento, Sacramento, California
South Sacramento Cancer Center, Sacramento, California
Kaiser Permanente-San Francisco, San Francisco, California
Kaiser Permanente-Santa Teresa-San Jose, San Jose, California
Kaiser Permanente San Leandro, San Leandro, California
Kaiser San Rafael-Gallinas, San Rafael, California
Kaiser Permanente Medical Center - Santa Clara, Santa Clara, California
Kaiser Permanente-Santa Rosa, Santa Rosa, California
Kaiser Permanente Cancer Treatment Center, South San Francisco, California
Kaiser Permanente-South San Francisco, South San Francisco, California
Kaiser Permanente-Stockton, Stockton, California
Torrance Memorial Physician Network - Cancer Care, Torrance, California
Kaiser Permanente Medical Center-Vacaville, Vacaville, California
Kaiser Permanente-Vallejo, Vallejo, California
Kaiser Permanente-Walnut Creek, Walnut Creek, California
Helen F Graham Cancer Center, Newark, Delaware
Medical Oncology Hematology Consultants PA, Newark, Delaware
Christiana Care Health System-Wilmington Hospital, Wilmington, Delaware
George Washington University Medical Center, Washington, District of Columbia
Jupiter Medical Center, Jupiter, Florida
Grady Health System, Atlanta, Georgia
Emory Proton Therapy Center, Atlanta, Georgia
Emory University Hospital Midtown, Atlanta, Georgia
Emory University Hospital/Winship Cancer Institute, Atlanta, Georgia
Emory Saint Joseph's Hospital, Atlanta, Georgia
Emory Decatur Hospital, Decatur, Georgia
Hawaii Cancer Care - Westridge, 'Aiea, Hawaii
Pali Momi Medical Center, 'Aiea, Hawaii
The Queen's Medical Center - West Oahu, 'Ewa Beach, Hawaii
Hawaii Cancer Care Inc - Waterfront Plaza, Honolulu, Hawaii
Queen's Cancer Cenrer - POB I, Honolulu, Hawaii
Queen's Medical Center, Honolulu, Hawaii
Straub Clinic and Hospital, Honolulu, Hawaii
University of Hawaii Cancer Center, Honolulu, Hawaii
Queen's Cancer Center - Kuakini, Honolulu, Hawaii
The Cancer Center of Hawaii-Liliha, Honolulu, Hawaii
Kapiolani Medical Center for Women and Children, Honolulu, Hawaii
Castle Medical Center, Kailua, Hawaii
Wilcox Memorial Hospital and Kauai Medical Clinic, Lihue, Hawaii
Alton Memorial Hospital, Alton, Illinois
Advocate Outpatient Center - Aurora, Aurora, Illinois
Advocate Good Shepherd Hospital, Barrington, Illinois
Illinois CancerCare-Bloomington, Bloomington, Illinois
Illinois CancerCare-Carthage, Carthage, Illinois
Northwestern University, Chicago, Illinois
University of Illinois, Chicago, Illinois
Advocate Illinois Masonic Medical Center, Chicago, Illinois
AMG Crystal Lake - Oncology, Crystal Lake, Illinois
Carle at The Riverfront, Danville, Illinois
Decatur Memorial Hospital, Decatur, Illinois
Northwestern Medicine Cancer Center Kishwaukee, DeKalb, Illinois
Advocate Good Samaritan Hospital, Downers Grove, Illinois
Carle Physician Group-Effingham, Effingham, Illinois
Crossroads Cancer Center, Effingham, Illinois
Advocate Sherman Hospital, Elgin, Illinois
Illinois CancerCare-Galesburg, Galesburg, Illinois
Northwestern Medicine Cancer Center Delnor, Geneva, Illinois
Advocate South Suburban Hospital, Hazel Crest, Illinois
Illinois CancerCare-Kewanee Clinic, Kewanee, Illinois
AMG Libertyville - Oncology, Libertyville, Illinois
Condell Memorial Hospital, Libertyville, Illinois
Illinois CancerCare-Macomb, Macomb, Illinois
Carle Physician Group-Mattoon/Charleston, Mattoon, Illinois
Cancer Care Center of O'Fallon, O'Fallon, Illinois
HSHS Saint Elizabeth's Hospital, O'Fallon, Illinois
Advocate Christ Medical Center, Oak Lawn, Illinois
Illinois CancerCare-Ottawa Clinic, Ottawa, Illinois
Advocate High Tech Medical Park, Palos Heights, Illinois
Advocate Lutheran General Hospital, Park Ridge, Illinois
Illinois CancerCare-Pekin, Pekin, Illinois
OSF Saint Francis Medical Center, Peoria, Illinois
Illinois CancerCare-Peru, Peru, Illinois
Illinois CancerCare-Princeton, Princeton, Illinois
Memorial Hospital East, Shiloh, Illinois
Southern Illinois University School of Medicine, Springfield, Illinois
Springfield Memorial Hospital, Springfield, Illinois
Carle Cancer Center, Urbana, Illinois
Northwestern Medicine Cancer Center Warrenville, Warrenville, Illinois
Goshen Center for Cancer Care, Goshen, Indiana
McFarland Clinic - Ames, Ames, Iowa
Ascension Via Christi Hospitals Wichita, Wichita, Kansas
Mary Bird Perkins Cancer Center, Baton Rouge, Louisiana
MaineHealth Coastal Cancer Treatment Center, Bath, Maine
MaineHealth Maine Medical Center - Portland, Portland, Maine
MaineHealth Cancer Care Center of York County, Sanford, Maine
MaineHealth Maine Medical Center- Scarborough, Scarborough, Maine
Maryland Proton Treatment Center, Baltimore, Maryland
University of Maryland/Greenebaum Cancer Center, Baltimore, Maryland
UM Baltimore Washington Medical Center/Tate Cancer Center, Glen Burnie, Maryland
UM Capital Region Medical Center, Largo, Maryland
Brigham and Women's Hospital, Boston, Massachusetts
Dana-Farber Cancer Institute, Boston, Massachusetts
Dana-Farber/Brigham and Women's Cancer Center at Milford Regional, Milford, Massachusetts
Dana-Farber/Brigham and Women's Cancer Center at South Shore, South Weymouth, Massachusetts
Trinity Health Saint Joseph Mercy Hospital Ann Arbor, Ann Arbor, Michigan
Trinity Health Medical Center - Brighton, Brighton, Michigan
Trinity Health Medical Center - Canton, Canton, Michigan
Chelsea Hospital, Chelsea, Michigan
Corewell Health Dearborn Hospital, Dearborn, Michigan
Genesys Hurley Cancer Institute, Flint, Michigan
Hurley Medical Center, Flint, Michigan
Corewell Health Grand Rapids Hospitals - Butterworth Hospital, Grand Rapids, Michigan
University of Michigan Health - Sparrow Lansing, Lansing, Michigan
Trinity Health Saint Mary Mercy Livonia Hospital, Livonia, Michigan
Corewell Health Lakeland Hospitals - Niles Hospital, Niles, Michigan
Corewell Health William Beaumont University Hospital, Royal Oak, Michigan
MyMichigan Medical Center Saginaw, Saginaw, Michigan
Corewell Health Lakeland Hospitals - Marie Yeager Cancer Center, Saint Joseph, Michigan
Corewell Health Lakeland Hospitals - Saint Joseph Hospital, Saint Joseph, Michigan
Munson Medical Center, Traverse City, Michigan
Corewell Health Beaumont Troy Hospital, Troy, Michigan
University of Michigan Health - West, Wyoming, Michigan
Sanford Joe Lueken Cancer Center, Bemidji, Minnesota
Saint Luke's Hospital of Duluth, Duluth, Minnesota
Fairview Southdale Hospital, Edina, Minnesota
Regions Hospital, Saint Paul, Minnesota
Lakeview Hospital, Stillwater, Minnesota
Saint Francis Medical Center, Cape Girardeau, Missouri
Siteman Cancer Center at West County Hospital, Creve Coeur, Missouri
Washington University School of Medicine, Saint Louis, Missouri
Siteman Cancer Center-South County, Saint Louis, Missouri
Missouri Baptist Medical Center, Saint Louis, Missouri
Siteman Cancer Center at Christian Hospital, Saint Louis, Missouri
Mercy Hospital Saint Louis, Saint Louis, Missouri
Siteman Cancer Center at Saint Peters Hospital, Saint Peters, Missouri
Mercy Hospital Springfield, Springfield, Missouri
Billings Clinic Cancer Center, Billings, Montana
Benefis Sletten Cancer Institute, Great Falls, Montana
Hi-Line Sletten Cancer Center, Havre, Montana
Dartmouth Hitchcock Medical Center/Dartmouth Cancer Center, Lebanon, New Hampshire
Jersey City Medical Center, Jersey City, New Jersey
Saint Barnabas Medical Center, Livingston, New Jersey
Monmouth Medical Center, Long Branch, New Jersey
Rutgers Cancer Institute of New Jersey, New Brunswick, New Jersey
Rutgers New Jersey Medical School, Newark, New Jersey
Newark Beth Israel Medical Center, Newark, New Jersey
Capital Health Medical Center-Hopewell, Pennington, New Jersey
Community Medical Center, Toms River, New Jersey
University of New Mexico Cancer Center, Albuquerque, New Mexico
Northwell Health Imbert Cancer Center, Bay Shore, New York
Sands Cancer Center, Canandaigua, New York
Noyes Memorial Hospital/Myers Cancer Center, Dansville, New York
Northwell Health Physicians Partners Radiation Medicine at Queens, Forest Hills, New York
Northwell Health Cancer Institute at Huntington, Greenlawn, New York
Northwell Health/Center for Advanced Medicine, Lake Success, New York
Northern Westchester Hospital, Mount Kisco, New York
Manhattan Eye Ear and Throat Hospital, New York, New York
Lenox Hill Hospital, New York, New York
Highland Hospital, Rochester, New York
University of Rochester, Rochester, New York
Phelps Memorial Hospital Center, Sleepy Hollow, New York
Stony Brook University Medical Center, Stony Brook, New York
Westchester Medical Center, Valhalla, New York
Wilmot Cancer Institute at Webster, Webster, New York
Sanford Roger Maris Cancer Center, Fargo, North Dakota
Altru Cancer Center, Grand Forks, North Dakota
Cleveland Clinic Akron General, Akron, Ohio
UH Seidman Cancer Center at UH Avon Health Center, Avon, Ohio
UHHS-Chagrin Highlands Medical Center, Beachwood, Ohio
Aultman Health Foundation, Canton, Ohio
Case Western Reserve University, Cleveland, Ohio
MetroHealth Medical Center, Cleveland, Ohio
Ohio State University Comprehensive Cancer Center, Columbus, Ohio
Riverside Methodist Hospital, Columbus, Ohio
Grant Medical Center, Columbus, Ohio
Doctors Hospital, Columbus, Ohio
Delaware Health Center-Grady Cancer Center, Delaware, Ohio
Grady Memorial Hospital, Delaware, Ohio
Dublin Methodist Hospital, Dublin, Ohio
OhioHealth Mansfield Hospital, Mansfield, Ohio
OhioHealth Marion General Hospital, Marion, Ohio
UH Seidman Cancer Center at Lake Health Mentor Campus, Mentor, Ohio
University Hospitals Parma Medical Center, Parma, Ohio
University Hospitals Portage Medical Center, Ravenna, Ohio
University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma
Saint Charles Health System, Bend, Oregon
Clackamas Radiation Oncology Center, Clackamas, Oregon
Providence Portland Medical Center, Portland, Oregon
Providence Saint Vincent Medical Center, Portland, Oregon
Kaiser Permanente Northwest, Portland, Oregon
Carlisle Regional Cancer Center, Carlisle, Pennsylvania
Christiana Care Health System-Concord Health Center, Chadds Ford, Pennsylvania
Chambersburg Hospital, Chambersburg, Pennsylvania
Geisinger Medical Center, Danville, Pennsylvania
Ephrata Cancer Center, Ephrata, Pennsylvania
UPMC Hillman Cancer Center Erie, Erie, Pennsylvania
UPMC Cancer Center at UPMC Horizon, Farrell, Pennsylvania
Adams Cancer Center, Gettysburg, Pennsylvania
UPMC Pinnacle Cancer Center/Community Osteopathic Campus, Harrisburg, Pennsylvania
Penn State Milton S Hershey Medical Center, Hershey, Pennsylvania
Sechler Family Cancer Center, Lebanon, Pennsylvania
Geisinger Medical Oncology-Lewisburg, Lewisburg, Pennsylvania
UPMC Hillman Cancer Center at Rocco And Nancy Ortenzio Cancer Pavilion, Mechanicsburg, Pennsylvania
UPMC-Magee Womens Hospital, Pittsburgh, Pennsylvania
University of Pittsburgh Cancer Institute (UPCI), Pittsburgh, Pennsylvania
UPMC-Shadyside Hospital, Pittsburgh, Pennsylvania
UPMC-Saint Clair Hospital Cancer Center, Pittsburgh, Pennsylvania
Geisinger Cancer Services-Pottsville, Pottsville, Pennsylvania
Reading Hospital, West Reading, Pennsylvania
Geisinger Wyoming Valley/Henry Cancer Center, Wilkes-Barre, Pennsylvania
WellSpan Health-York Cancer Center, York, Pennsylvania
WellSpan Health-York Hospital, York, Pennsylvania
Gibbs Cancer Center-Gaffney, Gaffney, South Carolina
Gibbs Cancer Center-Pelham, Greer, South Carolina
Spartanburg Medical Center, Spartanburg, South Carolina
SMC Center for Hematology Oncology Union, Union, South Carolina
Sanford USD Medical Center - Sioux Falls, Sioux Falls, South Dakota
MD Anderson in The Woodlands, Conroe, Texas
Brooke Army Medical Center, Fort Sam Houston, Texas
M D Anderson Cancer Center, Houston, Texas
MD Anderson West Houston, Houston, Texas
MD Anderson League City, League City, Texas
MD Anderson in Sugar Land, Sugar Land, Texas
Farmington Health Center, Farmington, Utah
University of Utah Sugarhouse Health Center, Salt Lake City, Utah
Huntsman Cancer Institute/University of Utah, Salt Lake City, Utah
Central Vermont Medical Center/National Life Cancer Treatment, Berlin, Vermont
University of Vermont Medical Center, Burlington, Vermont
University of Vermont and State Agricultural College, Burlington, Vermont
Dartmouth Cancer Center - North, Saint Johnsbury, Vermont
Augusta Health Center for Cancer and Blood Disorders, Fishersville, Virginia
Bon Secours Memorial Regional Medical Center, Mechanicsville, Virginia
Bon Secours Saint Francis Medical Center, Midlothian, Virginia
Bon Secours Saint Mary's Hospital, Richmond, Virginia
Bon Secours Cancer Institute at Reynolds Crossing, Richmond, Virginia
VCU Massey Cancer Center at Stony Point, Richmond, Virginia
Virginia Commonwealth University/Massey Cancer Center, Richmond, Virginia
Fred Hutchinson Cancer Center, Seattle, Washington
FHCC at Northwest Hospital, Seattle, Washington
University of Washington Medical Center - Montlake, Seattle, Washington
Edwards Comprehensive Cancer Center, Huntington, West Virginia
Langlade Hospital and Cancer Center, Antigo, Wisconsin
Aurora Cancer Care-Southern Lakes VLCC, Burlington, Wisconsin
Aurora Health Care Germantown Health Center, Germantown, Wisconsin
Aurora Cancer Care-Grafton, Grafton, Wisconsin
Saint Vincent Hospital Cancer Center Green Bay, Green Bay, Wisconsin
Aurora BayCare Medical Center, Green Bay, Wisconsin
Aurora Cancer Care-Kenosha South, Kenosha, Wisconsin
Aurora Bay Area Medical Group-Marinette, Marinette, Wisconsin
Froedtert Menomonee Falls Hospital, Menomonee Falls, Wisconsin
Aurora Cancer Care-Milwaukee, Milwaukee, Wisconsin
Aurora Saint Luke's Medical Center, Milwaukee, Wisconsin
Medical College of Wisconsin, Milwaukee, Wisconsin
Aurora Sinai Medical Center, Milwaukee, Wisconsin
Zablocki Veterans Administration Medical Center, Milwaukee, Wisconsin
Cancer Center of Western Wisconsin, New Richmond, Wisconsin
Drexel Town Square Health Center, Oak Creek, Wisconsin
Vince Lombardi Cancer Clinic - Oshkosh, Oshkosh, Wisconsin
Aurora Cancer Care-Racine, Racine, Wisconsin
Aspirus Cancer Care - James Beck Cancer Center, Rhinelander, Wisconsin
Saint Vincent Hospital Cancer Center at Sheboygan, Sheboygan, Wisconsin
Sheboygan Physicians Group, Sheboygan, Wisconsin
Vince Lombardi Cancer Clinic-Sheboygan, Sheboygan, Wisconsin
Aspirus Cancer Care - Stevens Point, Stevens Point, Wisconsin
Saint Vincent Hospital Cancer Center at Sturgeon Bay, Sturgeon Bay, Wisconsin
Aurora Medical Center in Summit, Summit, Wisconsin
Vince Lombardi Cancer Clinic-Two Rivers, Two Rivers, Wisconsin
Aspirus Regional Cancer Center, Wausau, Wisconsin
Aurora Cancer Care-Milwaukee West, Wauwatosa, Wisconsin
Aurora West Allis Medical Center, West Allis, Wisconsin
Froedtert West Bend Hospital/Kraemer Cancer Center, West Bend, Wisconsin
Aspirus Cancer Care - Wisconsin Rapids, Wisconsin Rapids, Wisconsin
Ottawa Hospital and Cancer Center-General Campus, Ottawa, Ontario
Odette Cancer Centre- Sunnybrook Health Sciences Centre, Toronto, Ontario
University Health Network-Princess Margaret Hospital, Toronto, Ontario
CHUM - Centre Hospitalier de l'Universite de Montreal, Montreal, Quebec
CHU de Quebec-L'Hotel-Dieu de Quebec (HDQ), Quebec City, Quebec
Pamela Youde Nethersole Eastern Hospital, Chai Wan, Not set
Kantonsspital Aarau, Aarau, Not set
Conditions: Stage III Prostate Cancer AJCC v8, Stage IVA Prostate Cancer AJCC v8, Prostate Adenocarcinoma
Two Studies for Patients With High Risk Prostate Cancer Testing Less Intense Treatment for Patients With a Low Gene Risk Score and Testing a More Intense Treatment for Patients With a High Gene Risk Score, The PREDICT-RT Trial
Recruiting
This phase III trial compares less intense hormone therapy and radiation therapy to usual hormone therapy and radiation therapy in treating patients with high risk prostate cancer and low gene risk score. This trial also compares more intense hormone therapy and radiation therapy to usual hormone therapy and radiation therapy in patients with high risk prostate cancer and high gene risk score. Apalutamide may help fight prostate cancer by blocking the use of androgen by the tumor cells. Radiatio... Read More
This phase III trial compares less intense hormone therapy and radiation therapy to usual hormone therapy and radiation therapy in treating patients with high risk prostate cancer and low gene risk score. This trial also compares more intense hormone therapy and radiation therapy to usual hormone therapy and radiation therapy in patients with high risk prostate cancer and high gene risk score. Apalutamide may help fight prostate cancer by blocking the use of androgen by the tumor cells. Radiation therapy uses high energy rays to kill tumor cells and shrink tumors. Giving a shorter hormone therapy treatment may work the same at controlling prostate cancer compared to the usual 24 month hormone therapy treatment in patients with low gene risk score. Adding apalutamide to the usual treatment may increase the length of time without prostate cancer spreading as compared to the usual treatment in patients with high gene risk score. Read Less
Gender:
MALE
Ages:
18 years and above
Trial Updated:
05/06/2025
Locations: Fairbanks Memorial Hospital, Fairbanks, Alaska +590 locations
Fairbanks Memorial Hospital, Fairbanks, Alaska
Arizona Center for Cancer Care - Gilbert, Gilbert, Arizona
Arizona Center for Cancer Care-Peoria, Peoria, Arizona
Arizona Center for Cancer Care - Phoenix, Phoenix, Arizona
Arizona Center for Cancer Care - Scottsdale, Scottsdale, Arizona
University of Arizona Cancer Center-North Campus, Tucson, Arizona
University of Arkansas for Medical Sciences, Little Rock, Arkansas
Sutter Cancer Centers Radiation Oncology Services-Auburn, Auburn, California
AIS Cancer Center at San Joaquin Community Hospital, Bakersfield, California
Alta Bates Summit Medical Center-Herrick Campus, Berkeley, California
Sutter Cancer Centers Radiation Oncology Services-Cameron Park, Cameron Park, California
Enloe Medical Center, Chico, California
City of Hope Comprehensive Cancer Center, Duarte, California
Kaiser Permanente Dublin, Dublin, California
UC San Diego Health System - Encinitas, Encinitas, California
Kaiser Permanente-Fremont, Fremont, California
Palo Alto Medical Foundation-Fremont, Fremont, California
Washington Hospital, Fremont, California
Kaiser Permanente-Fresno, Fresno, California
Marin General Hospital, Greenbrae, California
UCI Health - Chao Family Comprehensive Cancer Center and Ambulatory Care, Irvine, California
City of Hope at Irvine Lennar, Irvine, California
UC San Diego Moores Cancer Center, La Jolla, California
City of Hope Antelope Valley, Lancaster, California
Los Angeles General Medical Center, Los Angeles, California
USC / Norris Comprehensive Cancer Center, Los Angeles, California
Cedars Sinai Medical Center, Los Angeles, California
Fremont - Rideout Cancer Center, Marysville, California
Memorial Medical Center, Modesto, California
Kaiser Permanente-Modesto, Modesto, California
Providence Queen of The Valley, Napa, California
Kaiser Permanente-Oakland, Oakland, California
Saint Joseph Hospital - Orange, Orange, California
UC Irvine Health/Chao Family Comprehensive Cancer Center, Orange, California
Palo Alto Medical Foundation Health Care, Palo Alto, California
Stanford Cancer Institute Palo Alto, Palo Alto, California
Kaiser Permanente-Roseville, Roseville, California
Sutter Cancer Centers Radiation Oncology Services-Roseville, Roseville, California
Kaiser Permanente Downtown Commons, Sacramento, California
Sutter Medical Center Sacramento, Sacramento, California
University of California Davis Comprehensive Cancer Center, Sacramento, California
Kaiser Permanente-South Sacramento, Sacramento, California
California Protons Cancer Therapy Center, San Diego, California
Sharp Memorial Hospital, San Diego, California
Kaiser Permanente-San Francisco, San Francisco, California
UCSF Medical Center-Mission Bay, San Francisco, California
Kaiser Permanente-Santa Teresa-San Jose, San Jose, California
Stanford Cancer Center South Bay, San Jose, California
Kaiser Permanente San Leandro, San Leandro, California
UCSF Cancer Center - San Mateo, San Mateo, California
Ridley-Tree Cancer Center, Santa Barbara, California
Kaiser Permanente Medical Center - Santa Clara, Santa Clara, California
Kaiser Permanente-Santa Rosa, Santa Rosa, California
City of Hope South Pasadena, South Pasadena, California
Kaiser Permanente-South San Francisco, South San Francisco, California
Palo Alto Medical Foundation-Sunnyvale, Sunnyvale, California
Cedars-Sinai Cancer - Tarzana, Tarzana, California
City of Hope South Bay, Torrance, California
Torrance Memorial Physician Network - Cancer Care, Torrance, California
Torrance Memorial Medical Center, Torrance, California
Gene Upshaw Memorial Tahoe Forest Cancer Center, Truckee, California
City of Hope Upland, Upland, California
Kaiser Permanente-Vallejo, Vallejo, California
Kaiser Permanente-Walnut Creek, Walnut Creek, California
John Muir Medical Center-Walnut Creek, Walnut Creek, California
UCHealth University of Colorado Hospital, Aurora, Colorado
Rocky Mountain Cancer Centers-Boulder, Boulder, Colorado
UCHealth Memorial Hospital Central, Colorado Springs, Colorado
Memorial Hospital North, Colorado Springs, Colorado
Shaw Cancer Center, Edwards, Colorado
Poudre Valley Hospital, Fort Collins, Colorado
Cancer Care and Hematology-Fort Collins, Fort Collins, Colorado
Banner North Colorado Medical Center, Greeley, Colorado
UCHealth Greeley Hospital, Greeley, Colorado
UCHealth Highlands Ranch Hospital, Highlands Ranch, Colorado
Medical Center of the Rockies, Loveland, Colorado
Banner McKee Medical Center, Loveland, Colorado
Hartford HealthCare - Saint Vincent's Medical Center, Bridgeport, Connecticut
Smilow Cancer Hospital-Derby Care Center, Derby, Connecticut
Smilow Cancer Hospital Care Center-Fairfield, Fairfield, Connecticut
Smilow Cancer Hospital Care Center at Greenwich, Greenwich, Connecticut
Smilow Cancer Hospital Care Center - Guilford, Guilford, Connecticut
Hartford Hospital, Hartford, Connecticut
Smilow Cancer Hospital Care Center at Saint Francis, Hartford, Connecticut
Midstate Medical Center, Meriden, Connecticut
The Hospital of Central Connecticut, New Britain, Connecticut
Yale University, New Haven, Connecticut
Yale-New Haven Hospital North Haven Medical Center, North Haven, Connecticut
Smilow Cancer Hospital-Orange Care Center, Orange, Connecticut
Smilow Cancer Hospital Care Center at Long Ridge, Stamford, Connecticut
Stamford Hospital/Bennett Cancer Center, Stamford, Connecticut
Smilow Cancer Hospital Care Center-Trumbull, Trumbull, Connecticut
Smilow Cancer Hospital Care Center - Waterford, Waterford, Connecticut
Bayhealth Hospital Kent Campus, Dover, Delaware
Helen F Graham Cancer Center, Newark, Delaware
Medical Oncology Hematology Consultants PA, Newark, Delaware
Mount Sinai Comprehensive Cancer Center at Aventura, Aventura, Florida
Veterans Administration Hospital, Bay Pines, Florida
Boca Raton Regional Hospital, Boca Raton, Florida
University of Florida Health Science Center - Gainesville, Gainesville, Florida
Mayo Clinic in Florida, Jacksonville, Florida
GenesisCare USA - Lakewood Ranch, Lakewood Ranch, Florida
Mount Sinai Medical Center, Miami Beach, Florida
Miami Cancer Institute, Miami, Florida
GenesisCare USA - Plantation, Plantation, Florida
Tampa General Hospital, Tampa, Florida
Grady Health System, Atlanta, Georgia
Emory Proton Therapy Center, Atlanta, Georgia
Emory University Hospital Midtown, Atlanta, Georgia
Emory University Hospital/Winship Cancer Institute, Atlanta, Georgia
Emory Saint Joseph's Hospital, Atlanta, Georgia
Emory Decatur Hospital, Decatur, Georgia
Emory Johns Creek Hospital, Johns Creek, Georgia
Lewis Cancer and Research Pavilion at Saint Joseph's/Candler, Savannah, Georgia
Hawaii Cancer Care - Westridge, 'Aiea, Hawaii
Pali Momi Medical Center, 'Aiea, Hawaii
The Queen's Medical Center - West Oahu, 'Ewa Beach, Hawaii
Hawaii Cancer Care Inc - Waterfront Plaza, Honolulu, Hawaii
Queen's Cancer Cenrer - POB I, Honolulu, Hawaii
Queen's Medical Center, Honolulu, Hawaii
Straub Clinic and Hospital, Honolulu, Hawaii
University of Hawaii Cancer Center, Honolulu, Hawaii
Queen's Cancer Center - Kuakini, Honolulu, Hawaii
The Cancer Center of Hawaii-Liliha, Honolulu, Hawaii
Alton Memorial Hospital, Alton, Illinois
Rush - Copley Medical Center, Aurora, Illinois
Advocate Good Shepherd Hospital, Barrington, Illinois
Illinois CancerCare-Bloomington, Bloomington, Illinois
Illinois CancerCare-Canton, Canton, Illinois
Illinois CancerCare-Carthage, Carthage, Illinois
Northwestern University, Chicago, Illinois
Rush University Medical Center, Chicago, Illinois
University of Illinois, Chicago, Illinois
University of Chicago Comprehensive Cancer Center, Chicago, Illinois
Advocate Illinois Masonic Medical Center, Chicago, Illinois
AMG Crystal Lake - Oncology, Crystal Lake, Illinois
Carle at The Riverfront, Danville, Illinois
Decatur Memorial Hospital, Decatur, Illinois
Northwestern Medicine Cancer Center Kishwaukee, DeKalb, Illinois
Advocate Good Samaritan Hospital, Downers Grove, Illinois
Crossroads Cancer Center, Effingham, Illinois
Advocate Sherman Hospital, Elgin, Illinois
Elmhurst Memorial Hospital, Elmhurst, Illinois
Illinois CancerCare-Eureka, Eureka, Illinois
Illinois CancerCare-Galesburg, Galesburg, Illinois
Northwestern Medicine Cancer Center Delnor, Geneva, Illinois
Northwestern Medicine Glenview Outpatient Center, Glenview, Illinois
Northwestern Medicine Grayslake Outpatient Center, Grayslake, Illinois
Ingalls Memorial Hospital, Harvey, Illinois
Advocate South Suburban Hospital, Hazel Crest, Illinois
Edward Hines Jr VA Hospital, Hines, Illinois
Illinois CancerCare-Kewanee Clinic, Kewanee, Illinois
Northwestern Medicine Lake Forest Hospital, Lake Forest, Illinois
AMG Libertyville - Oncology, Libertyville, Illinois
Condell Memorial Hospital, Libertyville, Illinois
Illinois CancerCare-Macomb, Macomb, Illinois
Carle Physician Group-Mattoon/Charleston, Mattoon, Illinois
Loyola University Medical Center, Maywood, Illinois
Edward Hospital/Cancer Center, Naperville, Illinois
UC Comprehensive Cancer Center at Silver Cross, New Lenox, Illinois
HSHS Saint Elizabeth's Hospital, O'Fallon, Illinois
Northwestern Medicine Oak Brook, Oak Brook, Illinois
Advocate Christ Medical Center, Oak Lawn, Illinois
Northwestern Medicine Orland Park, Orland Park, Illinois
University of Chicago Medicine-Orland Park, Orland Park, Illinois
Illinois CancerCare-Ottawa Clinic, Ottawa, Illinois
Advocate High Tech Medical Park, Palos Heights, Illinois
Advocate Lutheran General Hospital, Park Ridge, Illinois
Illinois CancerCare-Pekin, Pekin, Illinois
Illinois CancerCare-Peoria, Peoria, Illinois
Methodist Medical Center of Illinois, Peoria, Illinois
OSF Saint Francis Medical Center, Peoria, Illinois
Illinois CancerCare-Peru, Peru, Illinois
Edward Hospital/Cancer Center?Plainfield, Plainfield, Illinois
Illinois CancerCare-Princeton, Princeton, Illinois
UW Health Carbone Cancer Center Rockford, Rockford, Illinois
Memorial Hospital East, Shiloh, Illinois
Springfield Memorial Hospital, Springfield, Illinois
Carle Cancer Center, Urbana, Illinois
Northwestern Medicine Cancer Center Warrenville, Warrenville, Illinois
Illinois CancerCare - Washington, Washington, Illinois
IU Health West Hospital, Avon, Indiana
IU Health North Hospital, Carmel, Indiana
UChicago Medicine Northwest Indiana, Crown Point, Indiana
Indiana University/Melvin and Bren Simon Cancer Center, Indianapolis, Indiana
IU Health Methodist Hospital, Indianapolis, Indiana
UI Health Care Mission Cancer and Blood - Ankeny Clinic, Ankeny, Iowa
Saint Luke's Hospital, Cedar Rapids, Iowa
Mercy Hospital, Cedar Rapids, Iowa
Oncology Associates at Mercy Medical Center, Cedar Rapids, Iowa
Iowa Methodist Medical Center, Des Moines, Iowa
UI Health Care Mission Cancer and Blood - Des Moines Clinic, Des Moines, Iowa
Broadlawns Medical Center, Des Moines, Iowa
University of Kansas Cancer Center, Kansas City, Kansas
The University of Kansas Cancer Center - Olathe, Olathe, Kansas
University of Kansas Cancer Center-Overland Park, Overland Park, Kansas
Salina Regional Health Center, Salina, Kansas
University of Kansas Health System Saint Francis Campus, Topeka, Kansas
University of Kansas Hospital-Westwood Cancer Center, Westwood, Kansas
Ascension Via Christi Hospitals Wichita, Wichita, Kansas
Saint Joseph Hospital East, Lexington, Kentucky
The James Graham Brown Cancer Center at University of Louisville, Louisville, Kentucky
UofL Health Medical Center Northeast, Louisville, Kentucky
Mary Bird Perkins Cancer Center, Baton Rouge, Louisiana
Mary Bird Perkins Cancer Center - Metairie, Metairie, Louisiana
East Jefferson General Hospital, Metairie, Louisiana
LSU Healthcare Network / Metairie Multi-Specialty Clinic, Metairie, Louisiana
Tulane University School of Medicine, New Orleans, Louisiana
MaineHealth Coastal Cancer Treatment Center, Bath, Maine
MaineHealth Maine Medical Center - Portland, Portland, Maine
Penobscot Bay Medical Center, Rockport, Maine
MaineHealth Cancer Care Center of York County, Sanford, Maine
MaineHealth Maine Medical Center- Scarborough, Scarborough, Maine
MaineHealth Cancer Care and IV Therapy - South Portland, South Portland, Maine
Luminis Health Anne Arundel Medical Center, Annapolis, Maryland
Maryland Proton Treatment Center, Baltimore, Maryland
University of Maryland/Greenebaum Cancer Center, Baltimore, Maryland
Veterans Administration Medical Center-Baltimore, Baltimore, Maryland
Johns Hopkins University/Sidney Kimmel Cancer Center, Baltimore, Maryland
UM Upper Chesapeake Medical Center, Bel Air, Maryland
Suburban Hospital, Bethesda, Maryland
University of Maryland Shore Medical Center at Easton, Easton, Maryland
UM Baltimore Washington Medical Center/Tate Cancer Center, Glen Burnie, Maryland
UM Capital Region Medical Center, Largo, Maryland
Massachusetts General Hospital Cancer Center, Boston, Massachusetts
Brigham and Women's Hospital, Boston, Massachusetts
Boston Medical Center, Boston, Massachusetts
Dana-Farber Cancer Institute, Boston, Massachusetts
Cape Cod Hospital, Hyannis, Massachusetts
Dana-Farber/Brigham and Women's Cancer Center at Milford Regional, Milford, Massachusetts
Dana-Farber/Brigham and Women's Cancer Center at South Shore, South Weymouth, Massachusetts
Trinity Health Saint Joseph Mercy Hospital Ann Arbor, Ann Arbor, Michigan
University of Michigan Comprehensive Cancer Center, Ann Arbor, Michigan
McLaren Cancer Institute-Bay City, Bay City, Michigan
Trinity Health IHA Medical Group Hematology Oncology - Brighton, Brighton, Michigan
Trinity Health Medical Center - Brighton, Brighton, Michigan
University of Michigan - Brighton Center for Specialty Care, Brighton, Michigan
Henry Ford Cancer Institute-Downriver, Brownstown, Michigan
Trinity Health IHA Medical Group Hematology Oncology - Canton, Canton, Michigan
Trinity Health Medical Center - Canton, Canton, Michigan
Chelsea Hospital, Chelsea, Michigan
Trinity Health IHA Medical Group Hematology Oncology - Chelsea Hospital, Chelsea, Michigan
McLaren Cancer Institute-Clarkston, Clarkston, Michigan
Michigan Healthcare Professionals Clarkston, Clarkston, Michigan
Henry Ford Macomb Hospital-Clinton Township, Clinton Township, Michigan
Corewell Health Dearborn Hospital, Dearborn, Michigan
Henry Ford Medical Center-Fairlane, Dearborn, Michigan
Wayne State University/Karmanos Cancer Institute, Detroit, Michigan
Henry Ford Hospital, Detroit, Michigan
Michigan Healthcare Professionals Farmington, Farmington Hills, Michigan
Weisberg Cancer Treatment Center, Farmington Hills, Michigan
Genesys Hurley Cancer Institute, Flint, Michigan
McLaren Cancer Institute-Flint, Flint, Michigan
Corewell Health Grand Rapids Hospitals - Butterworth Hospital, Grand Rapids, Michigan
Trinity Health Grand Rapids Hospital, Grand Rapids, Michigan
Bronson Methodist Hospital, Kalamazoo, Michigan
West Michigan Cancer Center, Kalamazoo, Michigan
Karmanos Cancer Institute at McLaren Greater Lansing, Lansing, Michigan
University of Michigan Health - Sparrow Lansing, Lansing, Michigan
McLaren Cancer Institute-Lapeer Region, Lapeer, Michigan
Trinity Health Saint Mary Mercy Livonia Hospital, Livonia, Michigan
Michigan Healthcare Professionals Macomb, Macomb, Michigan
Michigan Healthcare Professionals Madison Heights, Madison Heights, Michigan
McLaren Cancer Institute-Macomb, Mount Clemens, Michigan
McLaren Cancer Institute-Central Michigan, Mount Pleasant, Michigan
Corewell Health Lakeland Hospitals - Niles Hospital, Niles, Michigan
Henry Ford Medical Center-Columbus, Novi, Michigan
McLaren-Port Huron, Port Huron, Michigan
Corewell Health William Beaumont University Hospital, Royal Oak, Michigan
MyMichigan Medical Center Saginaw, Saginaw, Michigan
Corewell Health Lakeland Hospitals - Marie Yeager Cancer Center, Saint Joseph, Michigan
Corewell Health Lakeland Hospitals - Saint Joseph Hospital, Saint Joseph, Michigan
Henry Ford Macomb Health Center - Shelby Township, Shelby, Michigan
Munson Medical Center, Traverse City, Michigan
Corewell Health Beaumont Troy Hospital, Troy, Michigan
Michigan Healthcare Professionals Troy, Troy, Michigan
Henry Ford West Bloomfield Hospital, West Bloomfield, Michigan
University of Michigan Health - West, Wyoming, Michigan
Trinity Health IHA Medical Group Hematology Oncology Ann Arbor Campus, Ypsilanti, Michigan
Mayo Clinic Health System in Albert Lea, Albert Lea, Minnesota
Mercy Hospital, Coon Rapids, Minnesota
Miller-Dwan Hospital, Duluth, Minnesota
Unity Hospital, Fridley, Minnesota
Saint John's Hospital - Healtheast, Maplewood, Minnesota
Abbott-Northwestern Hospital, Minneapolis, Minnesota
Hennepin County Medical Center, Minneapolis, Minnesota
Monticello Cancer Center, Monticello, Minnesota
Mayo Clinic in Rochester, Rochester, Minnesota
Park Nicollet Clinic - Saint Louis Park, Saint Louis Park, Minnesota
Regions Hospital, Saint Paul, Minnesota
University of Mississippi Medical Center, Jackson, Mississippi
Saint Francis Medical Center, Cape Girardeau, Missouri
MU Health - University Hospital/Ellis Fischel Cancer Center, Columbia, Missouri
Siteman Cancer Center at West County Hospital, Creve Coeur, Missouri
Parkland Health Center - Farmington, Farmington, Missouri
Freeman Health System, Joplin, Missouri
University of Kansas Cancer Center - North, Kansas City, Missouri
University of Kansas Cancer Center - Lee's Summit, Lee's Summit, Missouri
University of Kansas Cancer Center at North Kansas City Hospital, North Kansas City, Missouri
Phelps Health Delbert Day Cancer Institute, Rolla, Missouri
Washington University School of Medicine, Saint Louis, Missouri
Siteman Cancer Center-South County, Saint Louis, Missouri
Missouri Baptist Medical Center, Saint Louis, Missouri
Siteman Cancer Center at Christian Hospital, Saint Louis, Missouri
Mercy Hospital Saint Louis, Saint Louis, Missouri
Siteman Cancer Center at Saint Peters Hospital, Saint Peters, Missouri
Sainte Genevieve County Memorial Hospital, Sainte Genevieve, Missouri
Mercy Hospital Springfield, Springfield, Missouri
Missouri Baptist Sullivan Hospital, Sullivan, Missouri
BJC Outpatient Center at Sunset Hills, Sunset Hills, Missouri
Billings Clinic Cancer Center, Billings, Montana
Benefis Sletten Cancer Institute, Great Falls, Montana
Nebraska Medicine-Bellevue, Bellevue, Nebraska
Nebraska Medicine-Village Pointe, Omaha, Nebraska
University of Nebraska Medical Center, Omaha, Nebraska
New Hampshire Oncology Hematology PA-Concord, Concord, New Hampshire
Exeter Hospital, Exeter, New Hampshire
Dartmouth Hitchcock Medical Center/Dartmouth Cancer Center, Lebanon, New Hampshire
Solinsky Center for Cancer Care, Manchester, New Hampshire
Clara Maass Medical Center, Belleville, New Jersey
Cooper Hospital University Medical Center, Camden, New Jersey
AtlantiCare Surgery Center, Egg Harbor Township, New Jersey
Trinitas Hospital and Comprehensive Cancer Center - Williamson Street Campus, Elizabeth, New Jersey
The Cancer Institute of New Jersey Hamilton, Hamilton, New Jersey
Jersey City Medical Center, Jersey City, New Jersey
Saint Barnabas Medical Center, Livingston, New Jersey
Rutgers Cancer Institute of New Jersey, New Brunswick, New Jersey
Rutgers New Jersey Medical School, Newark, New Jersey
Newark Beth Israel Medical Center, Newark, New Jersey
The Valley Hospital - Luckow Pavilion, Paramus, New Jersey
Valley Health System Ridgewood Campus, Ridgewood, New Jersey
Sidney Kimmel Cancer Center Washington Township, Sewell, New Jersey
Robert Wood Johnson University Hospital Somerset, Somerville, New Jersey
Community Medical Center, Toms River, New Jersey
MD Anderson Cancer Center at Cooper-Voorhees, Voorhees, New Jersey
Lovelace Medical Center-Saint Joseph Square, Albuquerque, New Mexico
University of New Mexico Cancer Center, Albuquerque, New Mexico
Lovelace Radiation Oncology, Albuquerque, New Mexico
Presbyterian Kaseman Hospital, Albuquerque, New Mexico
Presbyterian Rust Medical Center/Jorgensen Cancer Center, Rio Rancho, New Mexico
Northwell Health Imbert Cancer Center, Bay Shore, New York
Montefiore Medical Center-Einstein Campus, Bronx, New York
Montefiore Medical Center - Moses Campus, Bronx, New York
New York-Presbyterian/Brooklyn Methodist Hospital, Brooklyn, New York
Roswell Park Cancer Institute, Buffalo, New York
Sands Cancer Center, Canandaigua, New York
Mary Imogene Bassett Hospital, Cooperstown, New York
Noyes Memorial Hospital/Myers Cancer Center, Dansville, New York
The New York Hospital Medical Center of Queens, Flushing, New York
Northwell Health Physicians Partners Radiation Medicine at Queens, Forest Hills, New York
Glens Falls Hospital, Glens Falls, New York
Northwell Health Cancer Institute at Huntington, Greenlawn, New York
Northwell Health/Center for Advanced Medicine, Lake Success, New York
Laura and Isaac Perlmutter Cancer Center at NYU Langone, New York, New York
NYP/Columbia University Medical Center/Herbert Irving Comprehensive Cancer Center, New York, New York
Manhattan Eye Ear and Throat Hospital, New York, New York
NYP/Weill Cornell Medical Center, New York, New York
Lenox Hill Hospital, New York, New York
Queens Cancer Center, Rego Park, New York
Highland Hospital, Rochester, New York
University of Rochester, Rochester, New York
Phelps Memorial Hospital Center, Sleepy Hollow, New York
Staten Island University Hospital, Staten Island, New York
Stony Brook University Medical Center, Stony Brook, New York
State University of New York Upstate Medical University, Syracuse, New York
Westchester Medical Center, Valhalla, New York
Wilmot Cancer Institute at Webster, Webster, New York
Duke Cancer Center Cary, Cary, North Carolina
Carolinas Medical Center/Levine Cancer Institute, Charlotte, North Carolina
Novant Health Presbyterian Medical Center, Charlotte, North Carolina
Atrium Health Pineville/LCI-Pineville, Charlotte, North Carolina
Atrium Health University City/LCI-University, Charlotte, North Carolina
Levine Cancer Institute-Ballantyne, Charlotte, North Carolina
Atrium Health Cabarrus/LCI-Concord, Concord, North Carolina
Durham VA Medical Center, Durham, North Carolina
Duke University Medical Center, Durham, North Carolina
Novant Health Cancer Institute - Huntersville, Huntersville, North Carolina
Novant Health Presbyterian Medical Center Huntersville, Huntersville, North Carolina
Matthews Radiation Oncology Center, Matthews, North Carolina
Novant Health Cancer Institute - Matthews, Matthews, North Carolina
Atrium Health Union/LCI-Union, Monroe, North Carolina
Novant Health Cancer Institute - Mooresville, Mooresville, North Carolina
UNC Rex Healthcare, Raleigh, North Carolina
Duke Cancer Center Raleigh, Raleigh, North Carolina
UNC Rex Cancer Center of Wakefield, Raleigh, North Carolina
Novant Cancer Institute Radiation Oncology - Supply, Supply, North Carolina
Novant Health Cancer Institute Radiation Oncology - Wilmington, Wilmington, North Carolina
Novant Health New Hanover Regional Medical Center, Wilmington, North Carolina
Novant Health Forsyth Medical Center, Winston-Salem, North Carolina
Wake Forest University Health Sciences, Winston-Salem, North Carolina
Altru Cancer Center, Grand Forks, North Dakota
Summa Health System - Akron Campus, Akron, Ohio
Cleveland Clinic Akron General, Akron, Ohio
Summa Health System - Barberton Campus, Barberton, Ohio
Aultman Health Foundation, Canton, Ohio
Adena Regional Medical Center, Chillicothe, Ohio
The Christ Hospital, Cincinnati, Ohio
Ohio State University Comprehensive Cancer Center, Columbus, Ohio
Riverside Methodist Hospital, Columbus, Ohio
Grant Medical Center, Columbus, Ohio
Doctors Hospital, Columbus, Ohio
Delaware Health Center-Grady Cancer Center, Delaware, Ohio
Dublin Methodist Hospital, Dublin, Ohio
OhioHealth Mansfield Hospital, Mansfield, Ohio
OhioHealth Marion General Hospital, Marion, Ohio
Summa Health Medina Medical Center, Medina, Ohio
ProMedica Flower Hospital, Sylvania, Ohio
Cancer Centers of Southwest Oklahoma Research, Lawton, Oklahoma
University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma
Saint Charles Health System, Bend, Oregon
Legacy Mount Hood Medical Center, Gresham, Oregon
Providence Willamette Falls Medical Center, Oregon City, Oregon
Legacy Good Samaritan Hospital and Medical Center, Portland, Oregon
Providence Portland Medical Center, Portland, Oregon
Providence Saint Vincent Medical Center, Portland, Oregon
Legacy Meridian Park Hospital, Tualatin, Oregon
Saint Luke's Cancer Center - Allentown, Allentown, Pennsylvania
UPMC Altoona, Altoona, Pennsylvania
UPMC-Heritage Valley Health System Beaver, Beaver, Pennsylvania
Saint Luke's University Hospital-Bethlehem Campus, Bethlehem, Pennsylvania
Crozer-Keystone Regional Cancer Center at Broomall, Broomall, Pennsylvania
Carlisle Regional Cancer Center, Carlisle, Pennsylvania
Christiana Care Health System-Concord Health Center, Chadds Ford, Pennsylvania
Chambersburg Hospital, Chambersburg, Pennsylvania
Geisinger Medical Center, Danville, Pennsylvania
Delaware County Memorial Hospital, Drexel Hill, Pennsylvania
Saint Luke's Hospital-Anderson Campus, Easton, Pennsylvania
Ephrata Cancer Center, Ephrata, Pennsylvania
UPMC Hillman Cancer Center Erie, Erie, Pennsylvania
Saint Vincent Hospital, Erie, Pennsylvania
UPMC Cancer Center at UPMC Horizon, Farrell, Pennsylvania
Adams Cancer Center, Gettysburg, Pennsylvania
Crozer Regional Cancer Center at Brinton Lake, Glen Mills, Pennsylvania
UPMC Cancer Centers - Arnold Palmer Pavilion, Greensburg, Pennsylvania
UPMC Pinnacle Cancer Center/Community Osteopathic Campus, Harrisburg, Pennsylvania
Penn State Milton S Hershey Medical Center, Hershey, Pennsylvania
IRMC Cancer Center, Indiana, Pennsylvania
Jefferson Hospital, Jefferson Hills, Pennsylvania
UPMC-Johnstown/John P. Murtha Regional Cancer Center, Johnstown, Pennsylvania
Sechler Family Cancer Center, Lebanon, Pennsylvania
Geisinger Medical Oncology-Lewisburg, Lewisburg, Pennsylvania
UPMC Cancer Center at UPMC McKeesport, McKeesport, Pennsylvania
Yolanda G Barco Oncology Institute, Meadville, Pennsylvania
UPMC Hillman Cancer Center at Rocco And Nancy Ortenzio Cancer Pavilion, Mechanicsburg, Pennsylvania
Forbes Hospital, Monroeville, Pennsylvania
UPMC Cancer Center - Monroeville, Monroeville, Pennsylvania
UPMC Hillman Cancer Center in Coraopolis, Moon, Pennsylvania
Thomas Jefferson University Hospital, Philadelphia, Pennsylvania
Temple University Hospital, Philadelphia, Pennsylvania
Allegheny General Hospital, Pittsburgh, Pennsylvania
UPMC-Magee Womens Hospital, Pittsburgh, Pennsylvania
UPMC-Saint Margaret, Pittsburgh, Pennsylvania
West Penn Hospital, Pittsburgh, Pennsylvania
University of Pittsburgh Cancer Institute (UPCI), Pittsburgh, Pennsylvania
UPMC-Shadyside Hospital, Pittsburgh, Pennsylvania
UPMC-Passavant Hospital, Pittsburgh, Pennsylvania
UPMC-Saint Clair Hospital Cancer Center, Pittsburgh, Pennsylvania
Geisinger Cancer Services-Pottsville, Pottsville, Pennsylvania
Saint Luke's Hospital - Upper Bucks Campus, Quakertown, Pennsylvania
Saint Luke's Hospital-Quakertown Campus, Quakertown, Pennsylvania
UPMC Cancer Center at UPMC Northwest, Seneca, Pennsylvania
Saint Luke's Hospital - Monroe Campus, Stroudsburg, Pennsylvania
UPMC Cancer Center-Uniontown, Uniontown, Pennsylvania
UPMC Uniontown Hospital Radiation Oncology, Uniontown, Pennsylvania
UPMC Cancer Center-Washington, Washington, Pennsylvania
UPMC Washington Hospital Radiation Oncology, Washington, Pennsylvania
Chester County Hospital, West Chester, Pennsylvania
Reading Hospital, West Reading, Pennsylvania
Wexford Health and Wellness Pavilion, Wexford, Pennsylvania
Geisinger Wyoming Valley/Henry Cancer Center, Wilkes-Barre, Pennsylvania
Divine Providence Hospital, Williamsport, Pennsylvania
Asplundh Cancer Pavilion, Willow Grove, Pennsylvania
WellSpan Health-York Cancer Center, York, Pennsylvania
UPMC Memorial, York, Pennsylvania
Rhode Island Hospital, Providence, Rhode Island
Smilow Cancer Hospital Care Center - Westerly, Westerly, Rhode Island
Saint Joseph's/Candler - Bluffton Campus, Bluffton, South Carolina
Medical University of South Carolina, Charleston, South Carolina
MUSC Health Florence Medical Center, Florence, South Carolina
Saint Francis Hospital, Greenville, South Carolina
Saint Francis Cancer Center, Greenville, South Carolina
Self Regional Healthcare, Greenwood, South Carolina
Gibbs Cancer Center-Pelham, Greer, South Carolina
The Radiation Oncology Center-Hilton Head/Bluffton, Hilton Head Island, South Carolina
Carolina Regional Cancer Center, Myrtle Beach, South Carolina
Beaufort Memorial/New River Cancer Center, Okatie, South Carolina
Spartanburg Medical Center, Spartanburg, South Carolina
Thompson Cancer Survival Center, Knoxville, Tennessee
Thompson Oncology Group-Maryville, Maryville, Tennessee
Thompson Oncology Group-Oak Ridge, Oak Ridge, Tennessee
Houston Methodist San Jacinto Hospital, Baytown, Texas
MD Anderson in The Woodlands, Conroe, Texas
Houston Methodist Hospital, Houston, Texas
M D Anderson Cancer Center, Houston, Texas
Methodist Willowbrook Hospital, Houston, Texas
MD Anderson West Houston, Houston, Texas
Houston Methodist West Hospital, Houston, Texas
MD Anderson League City, League City, Texas
Texas Oncology-McKinney, McKinney, Texas
Houston Methodist Saint John Hospital, Nassau Bay, Texas
University of Texas Health Science Center at San Antonio, San Antonio, Texas
MD Anderson in Sugar Land, Sugar Land, Texas
Houston Methodist Sugar Land Hospital, Sugar Land, Texas
Houston Methodist The Woodlands Hospital, The Woodlands, Texas
American Fork Hospital / Huntsman Intermountain Cancer Center, American Fork, Utah
Farmington Health Center, Farmington, Utah
Logan Regional Hospital, Logan, Utah
Intermountain Medical Center, Murray, Utah
McKay-Dee Hospital Center, Ogden, Utah
Utah Valley Regional Medical Center, Provo, Utah
Riverton Hospital, Riverton, Utah
Saint George Regional Medical Center, Saint George, Utah
University of Utah Sugarhouse Health Center, Salt Lake City, Utah
Utah Cancer Specialists-Salt Lake City, Salt Lake City, Utah
Huntsman Cancer Institute/University of Utah, Salt Lake City, Utah
LDS Hospital, Salt Lake City, Utah
Central Vermont Medical Center/National Life Cancer Treatment, Berlin, Vermont
University of Vermont Medical Center, Burlington, Vermont
Dartmouth Cancer Center - North, Saint Johnsbury, Vermont
Inova Alexandria Hospital, Alexandria, Virginia
Inova Schar Cancer Institute, Fairfax, Virginia
Inova Fair Oaks Hospital, Fairfax, Virginia
Bon Secours Saint Francis Medical Center, Midlothian, Virginia
Bon Secours Cancer Institute at Reynolds Crossing, Richmond, Virginia
Virginia Commonwealth University/Massey Cancer Center, Richmond, Virginia
Oncology and Hematology Associates of Southwest Virginia, Roanoke, Virginia
Virginia Mason Medical Center, Seattle, Washington
Legacy Cancer Institute Medical Oncology and Day Treatment, Vancouver, Washington
Legacy Salmon Creek Hospital, Vancouver, Washington
Providence Saint Mary Regional Cancer Center, Walla Walla, Washington
Wheeling Hospital/Schiffler Cancer Center, Wheeling, West Virginia
Langlade Hospital and Cancer Center, Antigo, Wisconsin
ThedaCare Regional Cancer Center, Appleton, Wisconsin
Ascension Saint Elizabeth Hospital, Appleton, Wisconsin
Northwest Wisconsin Cancer Center, Ashland, Wisconsin
Ascension Southeast Wisconsin Hospital - Elmbrook Campus, Brookfield, Wisconsin
Aurora Cancer Care-Southern Lakes VLCC, Burlington, Wisconsin
Ascension Calumet Hospital, Chilton, Wisconsin
HSHS Sacred Heart Hospital, Eau Claire, Wisconsin
Marshfield Medical Center-EC Cancer Center, Eau Claire, Wisconsin
Ascension Saint Francis - Reiman Cancer Center, Franklin, Wisconsin
Aurora Health Care Germantown Health Center, Germantown, Wisconsin
Aurora Cancer Care-Grafton, Grafton, Wisconsin
Saint Vincent Hospital Cancer Center Green Bay, Green Bay, Wisconsin
Saint Vincent Hospital Cancer Center at Saint Mary's, Green Bay, Wisconsin
Aurora BayCare Medical Center, Green Bay, Wisconsin
University of Wisconsin Carbone Cancer Center - Johnson Creek, Johnson Creek, Wisconsin
Aurora Cancer Care-Kenosha South, Kenosha, Wisconsin
Mayo Clinic Health System-Franciscan Healthcare, La Crosse, Wisconsin
University of Wisconsin Carbone Cancer Center - Eastpark Medical Center, Madison, Wisconsin
University of Wisconsin Carbone Cancer Center - University Hospital, Madison, Wisconsin
Aurora Bay Area Medical Group-Marinette, Marinette, Wisconsin
Marshfield Medical Center-Marshfield, Marshfield, Wisconsin
Froedtert Menomonee Falls Hospital, Menomonee Falls, Wisconsin
Ascension Columbia Saint Mary's Hospital Ozaukee, Mequon, Wisconsin
Aurora Cancer Care-Milwaukee, Milwaukee, Wisconsin
Ascension Columbia Saint Mary's Hospital - Milwaukee, Milwaukee, Wisconsin
Aurora Saint Luke's Medical Center, Milwaukee, Wisconsin
Medical College of Wisconsin, Milwaukee, Wisconsin
Aurora Sinai Medical Center, Milwaukee, Wisconsin
Zablocki Veterans Administration Medical Center, Milwaukee, Wisconsin
Marshfield Medical Center - Minocqua, Minocqua, Wisconsin
Drexel Town Square Health Center, Oak Creek, Wisconsin
Ascension Mercy Hospital, Oshkosh, Wisconsin
Vince Lombardi Cancer Clinic - Oshkosh, Oshkosh, Wisconsin
Ascension All Saints Hospital, Racine, Wisconsin
Aurora Cancer Care-Racine, Racine, Wisconsin
Aspirus Cancer Care - James Beck Cancer Center, Rhinelander, Wisconsin
Marshfield Medical Center-Rice Lake, Rice Lake, Wisconsin
Saint Vincent Hospital Cancer Center at Sheboygan, Sheboygan, Wisconsin
Vince Lombardi Cancer Clinic-Sheboygan, Sheboygan, Wisconsin
Aspirus Cancer Care - Stevens Point, Stevens Point, Wisconsin
Marshfield Medical Center-River Region at Stevens Point, Stevens Point, Wisconsin
Saint Vincent Hospital Cancer Center at Sturgeon Bay, Sturgeon Bay, Wisconsin
Aurora Medical Center in Summit, Summit, Wisconsin
Vince Lombardi Cancer Clinic-Two Rivers, Two Rivers, Wisconsin
Aspirus Regional Cancer Center, Wausau, Wisconsin
Ascension Medical Group Southeast Wisconsin - Mayfair Road, Wauwatosa, Wisconsin
Aurora Cancer Care-Milwaukee West, Wauwatosa, Wisconsin
Aurora West Allis Medical Center, West Allis, Wisconsin
Froedtert West Bend Hospital/Kraemer Cancer Center, West Bend, Wisconsin
Marshfield Medical Center - Weston, Weston, Wisconsin
Aspirus Cancer Care - Wisconsin Rapids, Wisconsin Rapids, Wisconsin
Arthur J E Child Comprehensive Cancer Centre, Calgary, Alberta
Ottawa Hospital and Cancer Center-General Campus, Ottawa, Ontario
University Health Network-Princess Margaret Hospital, Toronto, Ontario
The Research Institute of the McGill University Health Centre (MUHC), Montreal, Quebec
CHU de Quebec-L'Hotel-Dieu de Quebec (HDQ), Quebec City, Quebec
Centre Hospitalier Universitaire de Sherbrooke-Fleurimont, Sherbrooke, Quebec
Allan Blair Cancer Centre, Regina, Saskatchewan
Saskatoon Cancer Centre, Saskatoon, Saskatchewan
Conditions: Prostate Adenocarcinoma, Stage III Prostate Cancer AJCC v8, Stage IVA Prostate Cancer AJCC v8
Two Studies for Patients With Unfavorable Intermediate Risk Prostate Cancer Testing Less Intense Treatment for Patients With a Low Gene Risk Score and Testing a More Intense Treatment for Patients With a Higher Gene Risk Score, The Guidance Trial
Recruiting
This phase III trial uses the Decipher risk score to guide therapy selection. Decipher score is based on the activity of 22 genes in prostate tumor and may predict how likely it is for recurrent prostate cancer to spread (metastasize) to other parts of the body. Decipher score in this study is used for patient selection and the two variations of treatment to be studied: intensification for higher Decipher score or de-intensification for low Decipher score. Patients with higher Decipher risk scor... Read More
This phase III trial uses the Decipher risk score to guide therapy selection. Decipher score is based on the activity of 22 genes in prostate tumor and may predict how likely it is for recurrent prostate cancer to spread (metastasize) to other parts of the body. Decipher score in this study is used for patient selection and the two variations of treatment to be studied: intensification for higher Decipher score or de-intensification for low Decipher score. Patients with higher Decipher risk score will be assigned to the part of the study that compares the use of 6 months of the usual treatment (hormone therapy and radiation treatment) to the use of darolutamide plus the usual treatment (intensification). The purpose of this section of the study is to determine whether the additional drug can reduce the chance of cancer coming back and spreading in patients with higher Decipher score. The addition of darolutamide to the usual treatment may better control the cancer and prevent it from spreading. Alternatively, patients with low Decipher risk score will be assigned to the part of the study that compares the use of radiation treatment alone (de-intensification) to the usual approach (6 months of hormone therapy plus radiation). The purpose of this part of the study is to determine if radiation treatment alone is as effective compared to the usual treatment without affecting the chance of tumor coming back in patients with low Decipher score prostate cancer. Radiation therapy uses high energy to kill tumor cells and reduce the tumor size. Hormone therapy drugs such as darolutamide suppress or block the production or action of male hormones that play role in prostate cancer development. Effect of radiation treatment alone in patients with low Decipher score prostate cancer could be the same as the usual approach in stabilizing prostate cancer and preventing it from spreading, while avoiding the side effects associated with hormonal therapy. Read Less
Gender:
MALE
Ages:
18 years and above
Trial Updated:
05/06/2025
Locations: University of Alabama at Birmingham Cancer Center, Birmingham, Alabama +558 locations
University of Alabama at Birmingham Cancer Center, Birmingham, Alabama
Banner MD Anderson Cancer Center, Gilbert, Arizona
Arizona Center for Cancer Care - Gilbert, Gilbert, Arizona
Arizona Center for Cancer Care-Peoria, Peoria, Arizona
Arizona Center for Cancer Care - Phoenix, Phoenix, Arizona
Arizona Center for Cancer Care - Scottsdale, Scottsdale, Arizona
Arizona Center for Cancer Care-Surprise, Surprise, Arizona
University of Arkansas for Medical Sciences, Little Rock, Arkansas
Sutter Cancer Centers Radiation Oncology Services-Auburn, Auburn, California
AIS Cancer Center at San Joaquin Community Hospital, Bakersfield, California
Tower Cancer Research Foundation, Beverly Hills, California
Sutter Cancer Centers Radiation Oncology Services-Cameron Park, Cameron Park, California
City of Hope Corona, Corona, California
City of Hope Comprehensive Cancer Center, Duarte, California
Kaiser Permanente Dublin, Dublin, California
UC San Diego Health System - Encinitas, Encinitas, California
Kaiser Permanente-Fremont, Fremont, California
Washington Hospital, Fremont, California
Kaiser Permanente-Fresno, Fresno, California
Marin General Hospital, Greenbrae, California
UCI Health - Chao Family Comprehensive Cancer Center and Ambulatory Care, Irvine, California
City of Hope at Irvine Lennar, Irvine, California
UC San Diego Moores Cancer Center, La Jolla, California
City of Hope Antelope Valley, Lancaster, California
Los Angeles General Medical Center, Los Angeles, California
USC / Norris Comprehensive Cancer Center, Los Angeles, California
Cedars Sinai Medical Center, Los Angeles, California
Fremont - Rideout Cancer Center, Marysville, California
Memorial Medical Center, Modesto, California
Kaiser Permanente-Modesto, Modesto, California
Providence Queen of The Valley, Napa, California
Kaiser Permanente-Oakland, Oakland, California
Saint Joseph Hospital - Orange, Orange, California
UC Irvine Health/Chao Family Comprehensive Cancer Center, Orange, California
Palo Alto Medical Foundation Health Care, Palo Alto, California
Kaiser Permanente-Roseville, Roseville, California
Sutter Cancer Centers Radiation Oncology Services-Roseville, Roseville, California
Kaiser Permanente Downtown Commons, Sacramento, California
Sutter Medical Center Sacramento, Sacramento, California
University of California Davis Comprehensive Cancer Center, Sacramento, California
Kaiser Permanente-South Sacramento, Sacramento, California
California Protons Cancer Therapy Center, San Diego, California
Sharp Memorial Hospital, San Diego, California
Kaiser Permanente-San Francisco, San Francisco, California
UCSF Medical Center-Mission Bay, San Francisco, California
Kaiser Permanente-Santa Teresa-San Jose, San Jose, California
Kaiser Permanente San Leandro, San Leandro, California
Ridley-Tree Cancer Center, Santa Barbara, California
Kaiser Permanente Medical Center - Santa Clara, Santa Clara, California
Kaiser Permanente-Santa Rosa, Santa Rosa, California
City of Hope South Pasadena, South Pasadena, California
Kaiser Permanente-South San Francisco, South San Francisco, California
Palo Alto Medical Foundation-Sunnyvale, Sunnyvale, California
Cedars-Sinai Cancer - Tarzana, Tarzana, California
City of Hope South Bay, Torrance, California
Torrance Memorial Physician Network - Cancer Care, Torrance, California
Torrance Memorial Medical Center, Torrance, California
Gene Upshaw Memorial Tahoe Forest Cancer Center, Truckee, California
City of Hope Upland, Upland, California
Kaiser Permanente-Vallejo, Vallejo, California
Sutter Solano Medical Center/Cancer Center, Vallejo, California
Kaiser Permanente-Walnut Creek, Walnut Creek, California
UCHealth University of Colorado Hospital, Aurora, Colorado
Rocky Mountain Cancer Centers-Boulder, Boulder, Colorado
UCHealth Memorial Hospital Central, Colorado Springs, Colorado
Memorial Hospital North, Colorado Springs, Colorado
Shaw Cancer Center, Edwards, Colorado
Poudre Valley Hospital, Fort Collins, Colorado
Cancer Care and Hematology-Fort Collins, Fort Collins, Colorado
Banner North Colorado Medical Center, Greeley, Colorado
UCHealth Greeley Hospital, Greeley, Colorado
UCHealth Highlands Ranch Hospital, Highlands Ranch, Colorado
Medical Center of the Rockies, Loveland, Colorado
Banner McKee Medical Center, Loveland, Colorado
Hartford HealthCare - Saint Vincent's Medical Center, Bridgeport, Connecticut
Smilow Cancer Hospital Care Center at Greenwich, Greenwich, Connecticut
Smilow Cancer Hospital Care Center - Guilford, Guilford, Connecticut
Hartford Hospital, Hartford, Connecticut
Midstate Medical Center, Meriden, Connecticut
The Hospital of Central Connecticut, New Britain, Connecticut
Yale University, New Haven, Connecticut
Norwalk Hospital, Norwalk, Connecticut
Smilow Cancer Hospital Care Center-Trumbull, Trumbull, Connecticut
Smilow Cancer Hospital Care Center - Waterford, Waterford, Connecticut
Beebe South Coastal Health Campus, Millville, Delaware
Helen F Graham Cancer Center, Newark, Delaware
Medical Oncology Hematology Consultants PA, Newark, Delaware
Beebe Health Campus, Rehoboth Beach, Delaware
George Washington University Medical Center, Washington, District of Columbia
Veterans Administration Hospital, Bay Pines, Florida
Boca Raton Regional Hospital, Boca Raton, Florida
University of Florida Health Science Center - Gainesville, Gainesville, Florida
Jupiter Medical Center, Jupiter, Florida
GenesisCare USA - Plantation, Plantation, Florida
Cleveland Clinic-Weston, Weston, Florida
Grady Health System, Atlanta, Georgia
Emory Proton Therapy Center, Atlanta, Georgia
Emory University Hospital Midtown, Atlanta, Georgia
Piedmont Hospital, Atlanta, Georgia
Emory University Hospital/Winship Cancer Institute, Atlanta, Georgia
Emory Saint Joseph's Hospital, Atlanta, Georgia
Emory Decatur Hospital, Decatur, Georgia
Piedmont Fayette Hospital, Fayetteville, Georgia
Northeast Georgia Medical Center-Gainesville, Gainesville, Georgia
Emory Johns Creek Hospital, Johns Creek, Georgia
Lewis Cancer and Research Pavilion at Saint Joseph's/Candler, Savannah, Georgia
Hawaii Cancer Care - Westridge, 'Aiea, Hawaii
The Queen's Medical Center - West Oahu, 'Ewa Beach, Hawaii
Hawaii Cancer Care Inc - Waterfront Plaza, Honolulu, Hawaii
Queen's Cancer Cenrer - POB I, Honolulu, Hawaii
Queen's Medical Center, Honolulu, Hawaii
Queen's Cancer Center - Kuakini, Honolulu, Hawaii
Saint Luke's Cancer Institute - Boise, Boise, Idaho
Saint Luke's Cancer Institute - Fruitland, Fruitland, Idaho
Saint Luke's Cancer Institute - Meridian, Meridian, Idaho
Saint Luke's Cancer Institute - Nampa, Nampa, Idaho
Saint Luke's Cancer Institute - Twin Falls, Twin Falls, Idaho
Alton Memorial Hospital, Alton, Illinois
Rush - Copley Medical Center, Aurora, Illinois
Advocate Good Shepherd Hospital, Barrington, Illinois
Illinois CancerCare-Bloomington, Bloomington, Illinois
Illinois CancerCare-Canton, Canton, Illinois
Illinois CancerCare-Carthage, Carthage, Illinois
Northwestern University, Chicago, Illinois
Rush University Medical Center, Chicago, Illinois
University of Illinois, Chicago, Illinois
Advocate Illinois Masonic Medical Center, Chicago, Illinois
AMG Crystal Lake - Oncology, Crystal Lake, Illinois
Carle at The Riverfront, Danville, Illinois
Decatur Memorial Hospital, Decatur, Illinois
Northwestern Medicine Cancer Center Kishwaukee, DeKalb, Illinois
Advocate Good Samaritan Hospital, Downers Grove, Illinois
Crossroads Cancer Center, Effingham, Illinois
Advocate Sherman Hospital, Elgin, Illinois
Elmhurst Memorial Hospital, Elmhurst, Illinois
Illinois CancerCare-Eureka, Eureka, Illinois
Illinois CancerCare-Galesburg, Galesburg, Illinois
Northwestern Medicine Cancer Center Delnor, Geneva, Illinois
Northwestern Medicine Glenview Outpatient Center, Glenview, Illinois
Northwestern Medicine Grayslake Outpatient Center, Grayslake, Illinois
Advocate South Suburban Hospital, Hazel Crest, Illinois
Edward Hines Jr VA Hospital, Hines, Illinois
Illinois CancerCare-Kewanee Clinic, Kewanee, Illinois
Northwestern Medicine Lake Forest Hospital, Lake Forest, Illinois
AMG Libertyville - Oncology, Libertyville, Illinois
Condell Memorial Hospital, Libertyville, Illinois
Illinois CancerCare-Macomb, Macomb, Illinois
Carle Physician Group-Mattoon/Charleston, Mattoon, Illinois
Loyola University Medical Center, Maywood, Illinois
Edward Hospital/Cancer Center, Naperville, Illinois
HSHS Saint Elizabeth's Hospital, O'Fallon, Illinois
Advocate Christ Medical Center, Oak Lawn, Illinois
Northwestern Medicine Orland Park, Orland Park, Illinois
Illinois CancerCare-Ottawa Clinic, Ottawa, Illinois
Advocate High Tech Medical Park, Palos Heights, Illinois
Advocate Lutheran General Hospital, Park Ridge, Illinois
Illinois CancerCare-Pekin, Pekin, Illinois
Illinois CancerCare-Peoria, Peoria, Illinois
Methodist Medical Center of Illinois, Peoria, Illinois
OSF Saint Francis Medical Center, Peoria, Illinois
Illinois CancerCare-Peru, Peru, Illinois
Illinois CancerCare-Princeton, Princeton, Illinois
UW Health Carbone Cancer Center Rockford, Rockford, Illinois
Memorial Hospital East, Shiloh, Illinois
Springfield Memorial Hospital, Springfield, Illinois
Carle Cancer Center, Urbana, Illinois
Northwestern Medicine Cancer Center Warrenville, Warrenville, Illinois
Illinois CancerCare - Washington, Washington, Illinois
Saint Luke's Hospital, Cedar Rapids, Iowa
Mercy Hospital, Cedar Rapids, Iowa
Iowa Methodist Medical Center, Des Moines, Iowa
University of Kansas Cancer Center, Kansas City, Kansas
The University of Kansas Cancer Center - Olathe, Olathe, Kansas
University of Kansas Cancer Center-Overland Park, Overland Park, Kansas
University of Kansas Hospital-Indian Creek Campus, Overland Park, Kansas
Salina Regional Health Center, Salina, Kansas
Cotton O'Neil Cancer Center / Stormont Vail Health, Topeka, Kansas
University of Kansas Health System Saint Francis Campus, Topeka, Kansas
University of Kansas Hospital-Westwood Cancer Center, Westwood, Kansas
Ascension Via Christi Hospitals Wichita, Wichita, Kansas
Saint Joseph Radiation Oncology Resource Center, Lexington, Kentucky
Mary Bird Perkins Cancer Center - Metairie, Metairie, Louisiana
East Jefferson General Hospital, Metairie, Louisiana
LSU Healthcare Network / Metairie Multi-Specialty Clinic, Metairie, Louisiana
MaineHealth Maine Medical Center - Portland, Portland, Maine
Penobscot Bay Medical Center, Rockport, Maine
MaineHealth Maine Medical Center- Scarborough, Scarborough, Maine
MaineHealth Cancer Care and IV Therapy - South Portland, South Portland, Maine
Luminis Health Anne Arundel Medical Center, Annapolis, Maryland
Maryland Proton Treatment Center, Baltimore, Maryland
University of Maryland/Greenebaum Cancer Center, Baltimore, Maryland
UM Upper Chesapeake Medical Center, Bel Air, Maryland
University of Maryland Shore Medical Center at Easton, Easton, Maryland
UM Baltimore Washington Medical Center/Tate Cancer Center, Glen Burnie, Maryland
UM Capital Region Medical Center, Largo, Maryland
TidalHealth Richard A Henson Cancer Institute, Ocean Pines, Maryland
TidalHealth Peninsula Regional, Salisbury, Maryland
Beverly Hospital, Beverly, Massachusetts
Lahey Hospital and Medical Center, Burlington, Massachusetts
Addison Gilbert Hospital, Gloucester, Massachusetts
Lahey Medical Center-Peabody, Peabody, Massachusetts
Beth Israel Deaconess Medical Center/Winchester Center for Cancer Care, Winchester, Massachusetts
Veteran's Administration Medical Center - Ann Arbor, Ann Arbor, Michigan
Trinity Health Saint Joseph Mercy Hospital Ann Arbor, Ann Arbor, Michigan
University of Michigan Comprehensive Cancer Center, Ann Arbor, Michigan
McLaren Cancer Institute-Bay City, Bay City, Michigan
Trinity Health IHA Medical Group Hematology Oncology - Brighton, Brighton, Michigan
Trinity Health Medical Center - Brighton, Brighton, Michigan
Henry Ford Cancer Institute-Downriver, Brownstown, Michigan
Trinity Health IHA Medical Group Hematology Oncology - Canton, Canton, Michigan
Trinity Health Medical Center - Canton, Canton, Michigan
Chelsea Hospital, Chelsea, Michigan
Trinity Health IHA Medical Group Hematology Oncology - Chelsea Hospital, Chelsea, Michigan
McLaren Cancer Institute-Clarkston, Clarkston, Michigan
Michigan Healthcare Professionals Clarkston, Clarkston, Michigan
Henry Ford Macomb Hospital-Clinton Township, Clinton Township, Michigan
Wayne State University/Karmanos Cancer Institute, Detroit, Michigan
Henry Ford Hospital, Detroit, Michigan
Michigan Healthcare Professionals Farmington, Farmington Hills, Michigan
Weisberg Cancer Treatment Center, Farmington Hills, Michigan
Genesys Hurley Cancer Institute, Flint, Michigan
McLaren Cancer Institute-Flint, Flint, Michigan
Trinity Health Grand Rapids Hospital, Grand Rapids, Michigan
Bronson Methodist Hospital, Kalamazoo, Michigan
West Michigan Cancer Center, Kalamazoo, Michigan
Karmanos Cancer Institute at McLaren Greater Lansing, Lansing, Michigan
University of Michigan Health - Sparrow Lansing, Lansing, Michigan
McLaren Cancer Institute-Lapeer Region, Lapeer, Michigan
Trinity Health Saint Mary Mercy Livonia Hospital, Livonia, Michigan
Michigan Healthcare Professionals Macomb, Macomb, Michigan
Michigan Healthcare Professionals Madison Heights, Madison Heights, Michigan
McLaren Cancer Institute-Macomb, Mount Clemens, Michigan
McLaren Cancer Institute-Central Michigan, Mount Pleasant, Michigan
Corewell Health Lakeland Hospitals - Niles Hospital, Niles, Michigan
Henry Ford Medical Center-Columbus, Novi, Michigan
McLaren Cancer Institute-Northern Michigan, Petoskey, Michigan
Trinity Health Saint Joseph Mercy Oakland Hospital, Pontiac, Michigan
McLaren-Port Huron, Port Huron, Michigan
Corewell Health William Beaumont University Hospital, Royal Oak, Michigan
MyMichigan Medical Center Saginaw, Saginaw, Michigan
Corewell Health Lakeland Hospitals - Marie Yeager Cancer Center, Saint Joseph, Michigan
Corewell Health Lakeland Hospitals - Saint Joseph Hospital, Saint Joseph, Michigan
MyMichigan Medical Center Tawas, Tawas City, Michigan
Munson Medical Center, Traverse City, Michigan
Corewell Health Beaumont Troy Hospital, Troy, Michigan
Michigan Healthcare Professionals Troy, Troy, Michigan
Henry Ford West Bloomfield Hospital, West Bloomfield, Michigan
University of Michigan Health - West, Wyoming, Michigan
Trinity Health IHA Medical Group Hematology Oncology Ann Arbor Campus, Ypsilanti, Michigan
Miller-Dwan Hospital, Duluth, Minnesota
Saint Luke's Hospital of Duluth, Duluth, Minnesota
Hennepin County Medical Center, Minneapolis, Minnesota
Park Nicollet Clinic - Saint Louis Park, Saint Louis Park, Minnesota
Regions Hospital, Saint Paul, Minnesota
Saint Francis Medical Center, Cape Girardeau, Missouri
MU Health - University Hospital/Ellis Fischel Cancer Center, Columbia, Missouri
Siteman Cancer Center at West County Hospital, Creve Coeur, Missouri
Parkland Health Center - Farmington, Farmington, Missouri
University of Kansas Cancer Center - North, Kansas City, Missouri
University of Kansas Cancer Center - Lee's Summit, Lee's Summit, Missouri
University of Kansas Cancer Center at North Kansas City Hospital, North Kansas City, Missouri
Phelps Health Delbert Day Cancer Institute, Rolla, Missouri
SSM Health Saint Louis University Hospital, Saint Louis, Missouri
Washington University School of Medicine, Saint Louis, Missouri
Siteman Cancer Center-South County, Saint Louis, Missouri
Missouri Baptist Medical Center, Saint Louis, Missouri
Siteman Cancer Center at Christian Hospital, Saint Louis, Missouri
Siteman Cancer Center at Saint Peters Hospital, Saint Peters, Missouri
Sainte Genevieve County Memorial Hospital, Sainte Genevieve, Missouri
Mercy Hospital Springfield, Springfield, Missouri
Missouri Baptist Sullivan Hospital, Sullivan, Missouri
BJC Outpatient Center at Sunset Hills, Sunset Hills, Missouri
Billings Clinic Cancer Center, Billings, Montana
Saint James Community Hospital and Cancer Treatment Center, Butte, Montana
Benefis Sletten Cancer Institute, Great Falls, Montana
Nebraska Medicine-Bellevue, Bellevue, Nebraska
Nebraska Medicine-Village Pointe, Omaha, Nebraska
University of Nebraska Medical Center, Omaha, Nebraska
New Hampshire Oncology Hematology PA-Concord, Concord, New Hampshire
Dartmouth Hitchcock Medical Center/Dartmouth Cancer Center, Lebanon, New Hampshire
Solinsky Center for Cancer Care, Manchester, New Hampshire
Memorial Sloan Kettering Basking Ridge, Basking Ridge, New Jersey
Clara Maass Medical Center, Belleville, New Jersey
Cooper Hospital University Medical Center, Camden, New Jersey
AtlantiCare Surgery Center, Egg Harbor Township, New Jersey
Trinitas Hospital and Comprehensive Cancer Center - Williamson Street Campus, Elizabeth, New Jersey
The Cancer Institute of New Jersey Hamilton, Hamilton, New Jersey
Jersey City Medical Center, Jersey City, New Jersey
Saint Barnabas Medical Center, Livingston, New Jersey
Memorial Sloan Kettering Monmouth, Middletown, New Jersey
Memorial Sloan Kettering Bergen, Montvale, New Jersey
Cooper CyberKnife Center, Mount Laurel, New Jersey
Rutgers Cancer Institute of New Jersey, New Brunswick, New Jersey
Rutgers New Jersey Medical School, Newark, New Jersey
Newark Beth Israel Medical Center, Newark, New Jersey
The Valley Hospital - Luckow Pavilion, Paramus, New Jersey
Sidney Kimmel Cancer Center Washington Township, Sewell, New Jersey
Robert Wood Johnson University Hospital Somerset, Somerville, New Jersey
Community Medical Center, Toms River, New Jersey
MD Anderson Cancer Center at Cooper-Voorhees, Voorhees, New Jersey
Lovelace Medical Center-Saint Joseph Square, Albuquerque, New Mexico
University of New Mexico Cancer Center, Albuquerque, New Mexico
Lovelace Radiation Oncology, Albuquerque, New Mexico
Presbyterian Kaseman Hospital, Albuquerque, New Mexico
Presbyterian Rust Medical Center/Jorgensen Cancer Center, Rio Rancho, New Mexico
Northwell Health Imbert Cancer Center, Bay Shore, New York
Montefiore Medical Center-Einstein Campus, Bronx, New York
Montefiore Medical Center - Moses Campus, Bronx, New York
New York-Presbyterian/Brooklyn Methodist Hospital, Brooklyn, New York
Roswell Park Cancer Institute, Buffalo, New York
Memorial Sloan Kettering Commack, Commack, New York
Mary Imogene Bassett Hospital, Cooperstown, New York
Noyes Memorial Hospital/Myers Cancer Center, Dansville, New York
Arnot Ogden Medical Center/Falck Cancer Center, Elmira, New York
The New York Hospital Medical Center of Queens, Flushing, New York
Northwell Health Physicians Partners Radiation Medicine at Queens, Forest Hills, New York
Glens Falls Hospital, Glens Falls, New York
Northwell Health Cancer Institute at Huntington, Greenlawn, New York
Memorial Sloan Kettering Westchester, Harrison, New York
Northwell Health/Center for Advanced Medicine, Lake Success, New York
NYP/Columbia University Medical Center/Herbert Irving Comprehensive Cancer Center, New York, New York
Manhattan Eye Ear and Throat Hospital, New York, New York
Memorial Sloan Kettering Cancer Center, New York, New York
Lenox Hill Hospital, New York, New York
Queens Cancer Center, Rego Park, New York
Highland Hospital, Rochester, New York
University of Rochester, Rochester, New York
Phelps Memorial Hospital Center, Sleepy Hollow, New York
Staten Island University Hospital, Staten Island, New York
Stony Brook University Medical Center, Stony Brook, New York
State University of New York Upstate Medical University, Syracuse, New York
Memorial Sloan Kettering Nassau, Uniondale, New York
Westchester Medical Center, Valhalla, New York
Wilmot Cancer Institute at Webster, Webster, New York
Mission Hospital, Asheville, North Carolina
Duke Cancer Center Cary, Cary, North Carolina
UNC Lineberger Comprehensive Cancer Center, Chapel Hill, North Carolina
Durham VA Medical Center, Durham, North Carolina
Duke University Medical Center, Durham, North Carolina
UNC Rex Healthcare, Raleigh, North Carolina
Duke Cancer Center Raleigh, Raleigh, North Carolina
UNC Rex Cancer Center of Wakefield, Raleigh, North Carolina
Novant Cancer Institute Radiation Oncology - Supply, Supply, North Carolina
Novant Health Cancer Institute Radiation Oncology - Wilmington, Wilmington, North Carolina
Novant Health New Hanover Regional Medical Center, Wilmington, North Carolina
Sanford Bismarck Medical Center, Bismarck, North Dakota
Sanford Broadway Medical Center, Fargo, North Dakota
Sanford Roger Maris Cancer Center, Fargo, North Dakota
Altru Cancer Center, Grand Forks, North Dakota
Summa Health System - Akron Campus, Akron, Ohio
Cleveland Clinic Akron General, Akron, Ohio
UH Seidman Cancer Center at UH Avon Health Center, Avon, Ohio
Summa Health System - Barberton Campus, Barberton, Ohio
UHHS-Chagrin Highlands Medical Center, Beachwood, Ohio
Aultman Health Foundation, Canton, Ohio
Adena Regional Medical Center, Chillicothe, Ohio
University of Cincinnati Cancer Center-UC Medical Center, Cincinnati, Ohio
Case Western Reserve University, Cleveland, Ohio
MetroHealth Medical Center, Cleveland, Ohio
Cleveland Clinic Cancer Center/Fairview Hospital, Cleveland, Ohio
Cleveland Clinic Foundation, Cleveland, Ohio
Ohio State University Comprehensive Cancer Center, Columbus, Ohio
Riverside Methodist Hospital, Columbus, Ohio
Grant Medical Center, Columbus, Ohio
Doctors Hospital, Columbus, Ohio
Delaware Health Center-Grady Cancer Center, Delaware, Ohio
Dublin Methodist Hospital, Dublin, Ohio
OhioHealth Mansfield Hospital, Mansfield, Ohio
Cleveland Clinic Cancer Center Mansfield, Mansfield, Ohio
OhioHealth Marion General Hospital, Marion, Ohio
Hillcrest Hospital Cancer Center, Mayfield Heights, Ohio
Summa Health Medina Medical Center, Medina, Ohio
UH Seidman Cancer Center at Lake Health Mentor Campus, Mentor, Ohio
UH Seidman Cancer Center at Southwest General Hospital, Middleburg Heights, Ohio
University Hospitals Parma Medical Center, Parma, Ohio
University Hospitals Portage Medical Center, Ravenna, Ohio
North Coast Cancer Care, Sandusky, Ohio
UH Seidman Cancer Center at Firelands Regional Medical Center, Sandusky, Ohio
Cleveland Clinic Cancer Center Strongsville, Strongsville, Ohio
ProMedica Flower Hospital, Sylvania, Ohio
South Pointe Hospital, Warrensville Heights, Ohio
University of Cincinnati Cancer Center-West Chester, West Chester, Ohio
Cleveland Clinic Wooster Family Health and Surgery Center, Wooster, Ohio
University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma
Saint Charles Health System, Bend, Oregon
Legacy Mount Hood Medical Center, Gresham, Oregon
Legacy Good Samaritan Hospital and Medical Center, Portland, Oregon
Providence Portland Medical Center, Portland, Oregon
Oregon Health and Science University, Portland, Oregon
Legacy Meridian Park Hospital, Tualatin, Oregon
Saint Luke's Cancer Center - Allentown, Allentown, Pennsylvania
UPMC Altoona, Altoona, Pennsylvania
UPMC-Heritage Valley Health System Beaver, Beaver, Pennsylvania
Saint Luke's University Hospital-Bethlehem Campus, Bethlehem, Pennsylvania
Crozer-Keystone Regional Cancer Center at Broomall, Broomall, Pennsylvania
Carlisle Regional Cancer Center, Carlisle, Pennsylvania
Christiana Care Health System-Concord Health Center, Chadds Ford, Pennsylvania
Chambersburg Hospital, Chambersburg, Pennsylvania
Geisinger Medical Center, Danville, Pennsylvania
Delaware County Memorial Hospital, Drexel Hill, Pennsylvania
Northeast Radiation Oncology Center, Dunmore, Pennsylvania
Saint Luke's Hospital-Anderson Campus, Easton, Pennsylvania
Ephrata Cancer Center, Ephrata, Pennsylvania
UPMC Hillman Cancer Center Erie, Erie, Pennsylvania
Saint Vincent Hospital, Erie, Pennsylvania
UPMC Cancer Center at UPMC Horizon, Farrell, Pennsylvania
Adams Cancer Center, Gettysburg, Pennsylvania
Crozer Regional Cancer Center at Brinton Lake, Glen Mills, Pennsylvania
UPMC Cancer Centers - Arnold Palmer Pavilion, Greensburg, Pennsylvania
UPMC Pinnacle Cancer Center/Community Osteopathic Campus, Harrisburg, Pennsylvania
Penn State Milton S Hershey Medical Center, Hershey, Pennsylvania
IRMC Cancer Center, Indiana, Pennsylvania
Jefferson Hospital, Jefferson Hills, Pennsylvania
UPMC-Johnstown/John P. Murtha Regional Cancer Center, Johnstown, Pennsylvania
Sechler Family Cancer Center, Lebanon, Pennsylvania
Geisinger Medical Oncology-Lewisburg, Lewisburg, Pennsylvania
Yolanda G Barco Oncology Institute, Meadville, Pennsylvania
UPMC Hillman Cancer Center at Rocco And Nancy Ortenzio Cancer Pavilion, Mechanicsburg, Pennsylvania
Forbes Hospital, Monroeville, Pennsylvania
UPMC Cancer Center - Monroeville, Monroeville, Pennsylvania
UPMC Hillman Cancer Center - Monroeville, Monroeville, Pennsylvania
UPMC Hillman Cancer Center in Coraopolis, Moon, Pennsylvania
Allegheny Valley Hospital, Natrona Heights, Pennsylvania
Thomas Jefferson University Hospital, Philadelphia, Pennsylvania
Jefferson Torresdale Hospital, Philadelphia, Pennsylvania
Allegheny General Hospital, Pittsburgh, Pennsylvania
UPMC-Saint Margaret, Pittsburgh, Pennsylvania
West Penn Hospital, Pittsburgh, Pennsylvania
University of Pittsburgh Cancer Institute (UPCI), Pittsburgh, Pennsylvania
UPMC-Shadyside Hospital, Pittsburgh, Pennsylvania
UPMC-Passavant Hospital, Pittsburgh, Pennsylvania
UPMC-Saint Clair Hospital Cancer Center, Pittsburgh, Pennsylvania
Geisinger Cancer Services-Pottsville, Pottsville, Pennsylvania
Saint Luke's Hospital - Upper Bucks Campus, Quakertown, Pennsylvania
Saint Luke's Hospital-Quakertown Campus, Quakertown, Pennsylvania
UPMC Cancer Center at UPMC Northwest, Seneca, Pennsylvania
Saint Luke's Hospital - Monroe Campus, Stroudsburg, Pennsylvania
Chester County Hospital, West Chester, Pennsylvania
Reading Hospital, West Reading, Pennsylvania
Wexford Health and Wellness Pavilion, Wexford, Pennsylvania
Geisinger Wyoming Valley/Henry Cancer Center, Wilkes-Barre, Pennsylvania
Divine Providence Hospital, Williamsport, Pennsylvania
Asplundh Cancer Pavilion, Willow Grove, Pennsylvania
WellSpan Health-York Cancer Center, York, Pennsylvania
UPMC Memorial, York, Pennsylvania
Saint Joseph's/Candler - Bluffton Campus, Bluffton, South Carolina
Medical University of South Carolina, Charleston, South Carolina
MUSC Health Florence Medical Center, Florence, South Carolina
Saint Francis Hospital, Greenville, South Carolina
Saint Francis Cancer Center, Greenville, South Carolina
Self Regional Healthcare, Greenwood, South Carolina
Gibbs Cancer Center-Pelham, Greer, South Carolina
The Radiation Oncology Center-Hilton Head/Bluffton, Hilton Head Island, South Carolina
Carolina Regional Cancer Center, Myrtle Beach, South Carolina
Beaufort Memorial/New River Cancer Center, Okatie, South Carolina
Spartanburg Medical Center, Spartanburg, South Carolina
Sanford Cancer Center Oncology Clinic, Sioux Falls, South Dakota
Sanford USD Medical Center - Sioux Falls, Sioux Falls, South Dakota
The Children's Hospital at TriStar Centennial, Nashville, Tennessee
Vanderbilt University/Ingram Cancer Center, Nashville, Tennessee
MD Anderson in The Woodlands, Conroe, Texas
UT Southwestern Simmons Cancer Center - RedBird, Dallas, Texas
UT Southwestern/Simmons Cancer Center-Dallas, Dallas, Texas
Brooke Army Medical Center, Fort Sam Houston, Texas
UT Southwestern/Simmons Cancer Center-Fort Worth, Fort Worth, Texas
M D Anderson Cancer Center, Houston, Texas
MD Anderson West Houston, Houston, Texas
MD Anderson League City, League City, Texas
UT Southwestern Clinical Center at Richardson/Plano, Richardson, Texas
University of Texas Health Science Center at San Antonio, San Antonio, Texas
MD Anderson in Sugar Land, Sugar Land, Texas
American Fork Hospital / Huntsman Intermountain Cancer Center, American Fork, Utah
Sandra L Maxwell Cancer Center, Cedar City, Utah
Farmington Health Center, Farmington, Utah
Logan Regional Hospital, Logan, Utah
Intermountain Medical Center, Murray, Utah
McKay-Dee Hospital Center, Ogden, Utah
Utah Valley Regional Medical Center, Provo, Utah
Riverton Hospital, Riverton, Utah
Saint George Regional Medical Center, Saint George, Utah
University of Utah Sugarhouse Health Center, Salt Lake City, Utah
Huntsman Cancer Institute/University of Utah, Salt Lake City, Utah
LDS Hospital, Salt Lake City, Utah
Central Vermont Medical Center/National Life Cancer Treatment, Berlin, Vermont
University of Vermont Medical Center, Burlington, Vermont
Dartmouth Cancer Center - North, Saint Johnsbury, Vermont
University of Virginia Cancer Center, Charlottesville, Virginia
Inova Schar Cancer Institute, Fairfax, Virginia
Inova Fair Oaks Hospital, Fairfax, Virginia
Bon Secours Saint Francis Medical Center, Midlothian, Virginia
Bon Secours Cancer Institute at Reynolds Crossing, Richmond, Virginia
Virginia Commonwealth University/Massey Cancer Center, Richmond, Virginia
Virginia Mason Medical Center, Seattle, Washington
Legacy Cancer Institute Medical Oncology and Day Treatment, Vancouver, Washington
Legacy Salmon Creek Hospital, Vancouver, Washington
Providence Saint Mary Regional Cancer Center, Walla Walla, Washington
Langlade Hospital and Cancer Center, Antigo, Wisconsin
ThedaCare Regional Cancer Center, Appleton, Wisconsin
Ascension Saint Elizabeth Hospital, Appleton, Wisconsin
Northwest Wisconsin Cancer Center, Ashland, Wisconsin
Ascension Southeast Wisconsin Hospital - Elmbrook Campus, Brookfield, Wisconsin
Aurora Cancer Care-Southern Lakes VLCC, Burlington, Wisconsin
Ascension Calumet Hospital, Chilton, Wisconsin
Marshfield Medical Center-EC Cancer Center, Eau Claire, Wisconsin
Ascension Saint Francis - Reiman Cancer Center, Franklin, Wisconsin
Aurora Health Care Germantown Health Center, Germantown, Wisconsin
Aurora Cancer Care-Grafton, Grafton, Wisconsin
Bellin Memorial Hospital, Green Bay, Wisconsin
Saint Vincent Hospital Cancer Center Green Bay, Green Bay, Wisconsin
Saint Vincent Hospital Cancer Center at Saint Mary's, Green Bay, Wisconsin
Aurora BayCare Medical Center, Green Bay, Wisconsin
University of Wisconsin Carbone Cancer Center - Johnson Creek, Johnson Creek, Wisconsin
Aurora Cancer Care-Kenosha South, Kenosha, Wisconsin
University of Wisconsin Carbone Cancer Center - Eastpark Medical Center, Madison, Wisconsin
University of Wisconsin Carbone Cancer Center - University Hospital, Madison, Wisconsin
Aurora Bay Area Medical Group-Marinette, Marinette, Wisconsin
Marshfield Medical Center-Marshfield, Marshfield, Wisconsin
Froedtert Menomonee Falls Hospital, Menomonee Falls, Wisconsin
Ascension Columbia Saint Mary's Hospital Ozaukee, Mequon, Wisconsin
Aurora Cancer Care-Milwaukee, Milwaukee, Wisconsin
Ascension Columbia Saint Mary's Hospital - Milwaukee, Milwaukee, Wisconsin
Aurora Saint Luke's Medical Center, Milwaukee, Wisconsin
Medical College of Wisconsin, Milwaukee, Wisconsin
Aurora Sinai Medical Center, Milwaukee, Wisconsin
Zablocki Veterans Administration Medical Center, Milwaukee, Wisconsin
Marshfield Medical Center - Minocqua, Minocqua, Wisconsin
ProHealth D N Greenwald Center, Mukwonago, Wisconsin
Drexel Town Square Health Center, Oak Creek, Wisconsin
ProHealth Oconomowoc Memorial Hospital, Oconomowoc, Wisconsin
Ascension Mercy Hospital, Oshkosh, Wisconsin
Vince Lombardi Cancer Clinic - Oshkosh, Oshkosh, Wisconsin
Ascension All Saints Hospital, Racine, Wisconsin
Aurora Cancer Care-Racine, Racine, Wisconsin
Aspirus Cancer Care - James Beck Cancer Center, Rhinelander, Wisconsin
Marshfield Medical Center-Rice Lake, Rice Lake, Wisconsin
Saint Vincent Hospital Cancer Center at Sheboygan, Sheboygan, Wisconsin
Vince Lombardi Cancer Clinic-Sheboygan, Sheboygan, Wisconsin
Aspirus Cancer Care - Stevens Point, Stevens Point, Wisconsin
Marshfield Medical Center-River Region at Stevens Point, Stevens Point, Wisconsin
Saint Vincent Hospital Cancer Center at Sturgeon Bay, Sturgeon Bay, Wisconsin
Aurora Medical Center in Summit, Summit, Wisconsin
Vince Lombardi Cancer Clinic-Two Rivers, Two Rivers, Wisconsin
UW Cancer Center at ProHealth Care, Waukesha, Wisconsin
Aspirus Regional Cancer Center, Wausau, Wisconsin
Ascension Medical Group Southeast Wisconsin - Mayfair Road, Wauwatosa, Wisconsin
Aurora Cancer Care-Milwaukee West, Wauwatosa, Wisconsin
Aurora West Allis Medical Center, West Allis, Wisconsin
Froedtert West Bend Hospital/Kraemer Cancer Center, West Bend, Wisconsin
Marshfield Medical Center - Weston, Weston, Wisconsin
Aspirus Cancer Care - Wisconsin Rapids, Wisconsin Rapids, Wisconsin
Arthur J E Child Comprehensive Cancer Centre, Calgary, Alberta
Atlantic Health Sciences Corporation-Saint John Regional Hospital, Saint John, New Brunswick
Juravinski Cancer Centre at Hamilton Health Sciences, Hamilton, Ontario
University Health Network-Princess Margaret Hospital, Toronto, Ontario
The Research Institute of the McGill University Health Centre (MUHC), Montreal, Quebec
CHU de Quebec-L'Hotel-Dieu de Quebec (HDQ), Quebec City, Quebec
Centre Hospitalier Universitaire de Sherbrooke-Fleurimont, Sherbrooke, Quebec
Allan Blair Cancer Centre, Regina, Saskatchewan
Saskatoon Cancer Centre, Saskatoon, Saskatchewan
Conditions: Prostate Adenocarcinoma
Placebo-Controlled Trial of Urolithin A Supplementation in Men With Prostate Cancer Undergoing Radical Prostatectomy, URO-PRO Trial
Recruiting
This phase II randomized control trial assesses the effect of Urolithin A (Uro-A) supplementation compared to placebo in men with biopsy-confirmed prostate cancer undergoing radical prostatectomy (RP) progressive disease. A total of 90 men will be accrued and randomized 1:1 to receive a 1000 mg daily dose of Uro-A in two 250 mg capsules PO BID or two placebo capsules BID daily for 3 to 6 weeks prior to RP. The primary endpoint is to determine the effect of Uro-A on decreasing prostate tumor tiss... Read More
This phase II randomized control trial assesses the effect of Urolithin A (Uro-A) supplementation compared to placebo in men with biopsy-confirmed prostate cancer undergoing radical prostatectomy (RP) progressive disease. A total of 90 men will be accrued and randomized 1:1 to receive a 1000 mg daily dose of Uro-A in two 250 mg capsules PO BID or two placebo capsules BID daily for 3 to 6 weeks prior to RP. The primary endpoint is to determine the effect of Uro-A on decreasing prostate tumor tissue oxidative stress (measured by 8-OHdG) compared to placebo. Read Less
Gender:
MALE
Ages:
18 years and above
Trial Updated:
05/02/2025
Locations: Cedars Sinai Medical Center, Los Angeles, California +4 locations
Cedars Sinai Medical Center, Los Angeles, California
Northwestern University, Chicago, Illinois
University of Chicago Comprehensive Cancer Center, Chicago, Illinois
Duke University Medical Center, Durham, North Carolina
University of Wisconsin Carbone Cancer Center - University Hospital, Madison, Wisconsin
Conditions: Prostate Adenocarcinoma
Two-fraction HDR Monotherapy for Localized Prostate Cancer
Recruiting
This is a single center single arm prospective pilot study investigating the safety of high dose rate (HDR) brachytherapy as monotherapy delivered in 2 fractions 3 hours apart. HDR monotherapy has been established as safe and effective in this context, however previous studies have delivered 2 fractions on separate days, or at least 6 hours apart. Clinically, this regimen, if shown to be safe and effective in future studies, has the potential to reduce operative resources and logistical stresses... Read More
This is a single center single arm prospective pilot study investigating the safety of high dose rate (HDR) brachytherapy as monotherapy delivered in 2 fractions 3 hours apart. HDR monotherapy has been established as safe and effective in this context, however previous studies have delivered 2 fractions on separate days, or at least 6 hours apart. Clinically, this regimen, if shown to be safe and effective in future studies, has the potential to reduce operative resources and logistical stresses on brachytherapy departments. Read Less
Gender:
MALE
Ages:
18 years and above
Trial Updated:
04/28/2025
Locations: University of California, San Francisco, San Francisco, California
University of California, San Francisco, San Francisco, California
Conditions: Prostate Adenocarcinoma, Localized Prostate Carcinoma
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