All Clinical Trials

A listing of 23128 clinical trials actively recruiting volunteers for paid trials and research studies in various therapeutic areas.

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Paid Clinical Studies Nationwide

Recruiting

Nationwide clinical trials offered in your area. Some trials offering up to several thousand dollars in compensation for participation.

Conditions:

Healthy

Healthy Volunteer Study

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Recruiting

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Conditions:

Overweight

Overweight and Obesity

Obesity

Weight Loss

Morbid Obesity

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Diabetes and Heart Disease Risk in Blacks

NCT00001853

Recruiting

It is unknown if obesity contributes to the development of heart disease in African American men and women. This study was created to determine whether there is a relationship between sex and body size and the incidence of heart disease in African American men and women. Researchers will attempt to associate obesity with the presence of heart disease risk factors. Risk factors that will be studied include; total body fat, body fat distribution, fat content of the blood (triglyceride concentration, low density lipoproteins \[LDL\], and high density lipoproteins \[HDL\]), how fast fat is removed from the blood, and how well insulin works in the body. Scientific studies have shown that obesity and increased levels of fat content in the blood are important risk factors for heart disease in Caucasian women. However, similar studies in African American women have failed to show the same correlation. In fact, it appears that African American women in all three body weight groupings, nonobese, overweight, and obese experience high death rates due to heart disease. In addition, prior research has shown that obese African American men tend to have elevated levels of fat in the blood while African American women have normal blood fat levels. Therefore, if high levels of triglycerides (fat found in the blood) are not seen in non-diabetic obese African American women, it cannot be considered a risk factor in this population. This suggests that studies conducted on Caucasian women may not provide insight into heart disease risk factors in African American women. The study will take 2000 healthy non-diabetic African American men and women (ages 18-70) and body mass index 3 subgroups; nonobese, overweight and obese. Diabetes undeniably increases the risk of heart disease. Therefore patients suffering from diabetes will not be included in the study. Candidates for the study will undergo a series of tests and examinations over 2 outpatient visits. Subjects will have body fat analyses, resting energy expenditure measurements, an EKG (electrocardiogram), and specific blood tests. Researchers believe this study will provide significant insight into the causes of obesity and heart disease in African Americans. Read Less

Gender:

ALL

Ages:

Between 18 years and 70 years

Trial Updated:

06/24/2025

Locations: National Institutes of Health Clinical Center, Bethesda, Maryland

Conditions: Diabetes, Obesity, Hypertension, Cardiovascular Diseases

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Clinical and Laboratory Study of Methylmalonic Acidemia

NCT00078078

Recruiting

Methylmalonic acidemia (MMA), one of the most common inborn errors of organic acid metabolism, is heterogeneous in etiology and clinical manifestations. Affected patients with cblA, cblB and mut classes of MMA are medically fragile and can suffer from complications such as metabolic stroke or infarction of the basal ganglia, pancreatitis, end stage renal failure, growth impairment, osteoporosis, and developmental delay. The frequency of these complications and their precipitants remain undefined. Furthermore, current treatment protocol outcomes have continued to demonstrate substantial morbidity and mortality in the patient population. Increasingly, solid organ transplantation (liver, and/or kidney) has been used to treat patients. Disordered transport and intracellular metabolism of vitamin B12 produces a distinct group of disorders that feature methylmalonic acidemia as well as (hyper)homocysteinemia. These conditions are named after the corresponding cellular complementation class - (cblC, cblD, cblF, cblJ and cblX) - and are also heterogenous, clinically and biochemically. The genetic disorders underlying cblE and cblG feature an isolated impairment of the activity of methionine synthase, a critical enzyme involved in the conversion of homocysteine to methionine and these disorders feature (hyper)homocysteinemia. Lastly, a group of patients can have increased methylmalonic acid and/or homocysteine in the blood or urine caused by variant(s) in recently identified (ACSF3) and unknown genes. In this protocol, we will clinically evaluate patients with methylmalonic acidemia and cobalamin metabolic defects. Routine inpatient admissions will last up to 4-5 days and involve urine collection, blood drawing, ophthalmological examination, radiological procedures, MRI/MRS, skin biopsies in some, and developmental testing. In a subset of patients who have or will receive renal, hepato- or hepato-renal transplants or have an unusual variant or clinical course and have MMA, a lumbar puncture to examine CSF metabolites will be performed. In this small group of patients, CSF metabolite monitoring may be used to adjust therapy. The study objectives will be to further delineate the spectrum of phenotypes and characterize the natural history of these enzymopathies, query for genotype/enzymatic/phenotype correlations, search for new genetic causes of methylmalonic acidemia and/or homocysteinemia, identify new disease biomarkers and define clinical outcome parameters for future clinical trials. The population will consist of participants previously evaluated at NIH, physician referrals, and families directed to the study from clinicaltrials.gov as well as the Organic Acidemia Association, Homocystinuria Network America and other national and international support groups. Most participants will be evaluated only at the NIH Clinical Center. However, if the NIH team decides that a patient under the age of 2 years is a candidate subject for this research protocol, that patient may enroll at the Children's National Medical Center (CNMC) site, pending approval by Dr Chapman, the Principal Investigator of the CNMC location Individuals may also enroll in the tissue collection only part of the study at the UPMC Children's Hospital of Pittsburgh or share medical history and clinical data via telemedicine visits remotely. Outcome measures will largely be descriptive and encompass correlations between clinical, biochemical and molecular parameters. Read Less

Gender:

ALL

Ages:

Between 1 month and 115 years

Trial Updated:

06/24/2025

Locations: Children's National Medical Center, Washington, District of Columbia +2 locations

Conditions: Organic Acidemia, Methylmalonic Acidemia, Inborn Errors of Metabolism

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Registry of Older Patients With Cancer

NCT01137825

Recruiting

RATIONALE: Gathering information about older patients with cancer may help the study of cancer in the future. PURPOSE: This research study is gathering information from older patients with cancer into a registry.

Gender:

ALL

Ages:

65 years and above

Trial Updated:

06/24/2025

Locations: Seby B. Jones Cancer Center, Boone, North Carolina +6 locations

Conditions: Chronic Myeloproliferative Disorders, Cognitive/Functional Effects, Leukemia, Lymphoma, Lymphoproliferative Disorder, Multiple Myeloma and Plasma Cell Neoplasm, Myelodysplastic Syndromes, Myelodysplastic/Myeloproliferative Neoplasms, Unspecified Adult Solid Tumor, Protocol Specific

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Patient-Centered Assessment of Symptoms and Outcomes

NCT03952624

Recruiting

Background: The cause of fatigue is not well understood. It can be felt differently by different people. Some people think there are different types of fatigue, with different causes. Researchers think a therapy to treat one type of fatigue in one condition should be able to treat that type of fatigue in other conditions. Objective: To understand the types of fatigue. Eligibility: Adults 18 and older who have felt fatigue for more than a month, and non-fatigued adults Design: Participants... Read More

Gender:

ALL

Ages:

18 years and above

Trial Updated:

06/24/2025

Locations: National Institutes of Health Clinical Center, Bethesda, Maryland

Conditions: Fatigue, Cancer, CFS, ME/CFS, Myalgic Encephalomyelitis/Chronic Fatigue Syndrome, Lupus, Systemic Lupus Erthematosus, Sjogrens

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To Assess the Efficacy, Safety, and Tolerability of INCB000928 in Participants With Fibrodysplasia Ossificans Progressiva

NCT05090891

Recruiting

This Phase 2, Randomized, Double-Blind, Placebo-Controlled Study is intended to evaluate the Efficacy, Safety, and Tolerability and PK of INCB000928 administered to participants with a clinical diagnosis of fibrodysplasia ossificans progressiva (FOP).

Gender:

ALL

Ages:

Between 2 years and 99 years

Trial Updated:

06/24/2025

Locations: University of California San Francisco Medical Center, San Francisco, California +28 locations

University of California San Francisco Medical Center, San Francisco, California

Mayo Clinic Rochester, Rochester, Minnesota

Children'S Hospital of Philadelphia, Philadelphia, Pennsylvania

Penn Medicine - Perelman Center For Advanced Medicine, Philadelphia, Pennsylvania

Hospital Italiano de Buenos Aires, Ciudad Autonoma Buenos Aires, Not set

Royal North Shore Hospital, St Leonards, New South Wales

Murdoch Children'S Research Institute, Parkville, Victoria

Albert Einstein Israelite Hospital, San Paolo, Not set

University Health Network Toronto General Hospital, Toronto, Ontario

Centro de Estudios Reumatologicos, Santiago, Not set

Beijing Childrens Hospital Capital Medical University, Beijing, Not set

Tongji Hospital of Tongji University, Shanghai, Not set

Shanghai Childrens Medical Center, Shanghai, Not set

Childrens Hospital of Fudan University, Shanghai, Not set

Ap-Hp Hopital Lariboisiere, Paris, Not set

Hopital Necker-Enfants Malades, Paris, Not set

Uniklinik Koln, Koln, Not set

Ospedale Pediatrico G. Gaslini, Genova, Not set

Policlinico Universitario Agostino Gemelli Universita Cattolica Del Sacro Cuore, Rome, Not set

Seoul National University Hospital, Seoul, Not set

Instituto Nacional de Rehabilitacion Luis Guillermo Ibarra, Tlalpan, Not set

Amsterdam Umc - Vu Medisch Centrum (Vumc), Amsterdam, Not set

Starship Childrens Hospital, Auckland, Not set

Centro Hospitalar Universitario de Lisboa Norte, Hospital Santa Maria, Lisbon, Not set

Groote Schuur Hospital Radiation Oncology, Cape Town, Not set

Hospital Universitario Ramon Y Cajal, Madrid, Not set

Ege University Faculty of Medicine, Izmir, Not set

Royal Manchester Childrens Hospital - Department of Paediatric Endocrinology, Manchester, Not set

Royal National Orthopaedic Hospital, Stanmore, Not set

Conditions: Fibrodysplasia Ossificans Progressiva (FOP)

Learn More ›

State-dependent Interoception, Value-based Decision-making, and Introspection

NCT05666726

Recruiting

Background: Negative emotional states can affect a person s behavior as they make decisions. For example, hunger may make people more impatient; they may then make riskier choices. Other negative emotional states that can change behavior include stress, pain, and sadness. By learning more about how emotions affect thinking and behavior in healthy people, researchers hope to better understand how to identify and treat people with mental disorders. Objective: To learn how negative emotions affe... Read More

Gender:

ALL

Ages:

Between 18 years and 55 years

Trial Updated:

06/24/2025

Locations: National Institutes of Health Clinical Center, Bethesda, Maryland

Conditions: Stress, Pain, Emotions, Craving, Frustration

Learn More ›

A Trial to Learn if Odronextamab Combined With Lenalidomide is Safe and Works Better Than Rituximab Combined With Lenalidomide in Adult Participants With Follicular Lymphoma and Marginal Zone Lymphoma

NCT06149286

Recruiting

This study is researching an experimental drug called odronextamab (referred to as study drug), in combination with lenalidomide. The study is focused on participants who have one of two types of cancer: follicular lymphoma (FL) or marginal zone lymphoma (MZL) that has come back after treatment (called "relapsed"), or did not respond to treatment (called "refractory"). FL and MZL are subtypes of Non-Hodgkin 's lymphoma (NHL). This study will be made up of two parts (Part 1 not randomized, Part... Read More

Gender:

ALL

Ages:

18 years and above

Trial Updated:

06/24/2025

Locations: David Geffen School of Medicine at UCLA, Los Angeles, California +143 locations

David Geffen School of Medicine at UCLA, Los Angeles, California

Boca Raton Clinical Research (BRCR) Global, Plantation, Florida

Indiana University and Comprehensive Cancer Center, Indianapolis, Indiana

Hattiesburg Clinic, Hattiesburg, Mississippi

Stony Brook University Hospital, Stony Brook, New York

Clinical Research Alliance Inc, Westbury, New York

Prohealth Care Inc, Waukesha, Wisconsin

Liverpool Hospital, Liverpool, New South Wales

Calvary Mater Newcastle, Waratah, New South Wales

Pindara Private Hospital, Benowa, Queensland

Epworth Freemasons, East Melbourne, Victoria

Ordensklinikum Linz, Linz, Osterreich

Kepler University Hospital, Linz, Upper Austria

Medical University Vienna, Vienna, Not set

Klinikum Wels Grieskirchen, Wels, Not set

Universitair Ziekenhuis (UZ) Gent/ Ghent University Hospital, Gent, Oost-Vlaanderen

Az Delta, Roeselare, West Vlaanderen

Ziekenhuis Netwerk Antwerpen Stuivenberg, Antwerp, Not set

Institut Jules Bordet, Brussels, Not set

Centre Hospitalier Universitaire at Universite Catholique de Louvain Namur, Yvoir, Not set

University Hospital Hradec Kralove, Hradec Kralove, East Bohemia

University Hospital Kralovske Vinohrady, Prague, Not set

Vseobecna Fakultni Nemocnice V Praze, Praha, Not set

Institut Paoli-Calmettes, Marseille, Bouches Du Rhone

Centre Hospitalier Universitaire de Rennes, Rennes, Bretagne

Centre Hospitalier Regional Universitaire de Tours, Tours, Centre Val De Loire

Polyclinique Bordeaux Nord Aquitaine, Bordeaux Cedex, Gironde

Centre Francois Magendie, Pessac, Gironde

Hopital Victor Dupouy Argenteuil, Argenteuil, Ile De France

Avicenne Hospital, Bobigny, Ile De France

Hopital Saint Vincent de Paul, Lille, Nord

Centre Henri Becquerel, Rouen, Normandie

Nantes University Hospital, Nantes, Pays De La Loire

Centre Hospitalier Metropole Savoie, Chambery, Savoie

Gustave Roussy, Villejuif, Val De Marne / Ile De France

Centre Hospitalier d'Avignon, Avignon, Not set

Centre Hospitalier Universitaire (CHU) Montpellier, Montpellier, Not set

Hopital Saint Louis, Paris, Not set

Assistance Publique-Hopitaux de Paris (AP-HP), Paris, Not set

Stauferklinikum, Mutlangen, Baden-Wuerttemberg

Robert-Bosch-Krankenhaus, Stuttgart, Baden-Wurttemberg

Clinic Frankfurt (Oder), Frankfurt, Hesse

Stadtisches Krankenhaus Kiel, Kiel, Not set

Assuta Ashdod Medical Center, Ashdod, Not set

Hadassah Medical Center, Jerusalem, Not set

Galilee Medical Center, Nahariya, Not set

Rabin Medical Center, Petah Tikva, Not set

Chaim Sheba Medical Center, Ramat-Gan, Not set

Assuta Medical Centers, Tel Aviv, Not set

Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori, Meldola, Forli Cesena

S Gerardo Hospital, Monza, Monza E Brianza

Centro Di Riferimento Oncologico (CRO), Aviano, National Cancer Institute, Aviano, Province Of Pordenone

Candiolo Cancer Institute, FPO, IRCCS, Candiolo, Torino

University of Bologna Dipartimento di Medicina Specialistica Diagnostica e Sperimentale, Bologna, Not set

Azienda Ospedaliera Spedali Civili di Brescia, Brescia, Not set

Ospedale Policlinico San Martino IRCCS, Genova, Not set

Istituto Europeo di Oncologia, Milano, Not set

ASST Grande Ospedale Metropolitano Niguarda - Main Address, Milan, Not set

A.O.U. di Modena, Modena, Not set

Federico II University, Napoli, Not set

AOU Maggiore della Carita, Novara, Not set

Fondazione IRCCS Policlinico San Matteo, Pavia, Not set

Azienda Ospedaliera di Perugia, Perugia, Not set

Ospedale Santa Maria delle Croci, Ravenna, Not set

Santa Maria della Misericordia, Udine, Not set

St. Vincents Hospital - The Catholic University of Korea, Suwon-si, Gyeonggi-do

Jeonbuk National University Hospital, Jeonju, Jeollabuk

Gachon University Gil Medical Center, Incheon, Namdong-Gu

Inje University Busan Paik Hospital, Busan, Not set

Pusan National University Hospital, Busan, Not set

Yeyungnam University Medical Center, Daegu, Not set

Yonsei University Health System, Seoul, Not set

Asan Medical Center, Seoul, Not set

Samsung Medical Center, Seoul, Not set

Yeouido St. Marys Hospital, Seoul, Not set

Seoul St Marys Hospital, Seoul, Not set

Seoul National University Hospital, Seoul, Not set

Ulsan University Hospital, Ulsan, Not set

Hospital Sultanah Aminah Jhor Bahru, Johor Bahru, Johor

University of Malaya Medical Centre, Kuala Lumpur, Negeri / Wilayah Persekutuan

Hospital Queen Elizabeth, Kota Kinabalu, Sabah

Hospital Ampang, Ampang, Selangor

Subang Jaya Medical Center, Subang Jaya, Selangor

Uniwersytecki Szpital Kliniczny, Wroclaw, Dolnoslaskie

Specjalistyczny Szpital im A. Sokolowskiego w Walbrzychu, Walbrzych, Lower Silesian

Pratia MCM Krakow, Krakow, Malopolska

Uniwersyteckie Centrum Kliniczne, Gdansk, Pomorskie

Pratia Poznan Medical Center, Poznan, Wielkopolska

Aidport, Skorzewo, Wielkopolska

Szpital Uniwersytecki Nr2 Bydgoszcz, Bydgoszcz, Not set

Pratia Onkologia Katowice, Katowice, Not set

Wojewodzkie Wielospecjalistyczne Centrum Onkologii i Traumatologii im. Mikolaja Kopernika w Lodzi (Copernicus Memorial Hospital), Lodz, Not set

Uniwersytecki Szpital Kliniczny Nr 4 w Lublinie, Centrum Innowacyjnych Terapii, Lublin, Not set

Narodowy Instytut Onkologii - Clinical Study Location -, Warsaw, Not set

University Hospital of Santiago de Compostela, Santiago de Compostela, A Coruna

Hospital Universitario Central de Asturias, Oviedo, Asturias

Son Espases University Hospital, Palma, Balearic Islands

Hospital Universitario Marques de Valdecilla, Santander, Cantabria

Hospital Universitario Quironsalud Madrid, Pozuelo de Alarcon, Madrid

University Hospital Vall d'Hebron, Barcelona, Not set

Hospital Clinic de Barcelona, Barcelona, Not set

Hospital de la Santa Creu i Sant Pau, Barcelona, Not set

Hospital Virgen De Las Nieves De Granada, Granada, Not set

Hospital Universitario Ramon y Cajal, Madrid, Not set

Fundacion Jimenez Diaz University Hospital, Madrid, Not set

Hospital Universitario12 de Octubre, Madrid, Not set

Hospital Universitario HM Sanchinarro, Servicio de Hematologia, Madrid, Not set

Hospital Universitario de Salamanca, Salamanca, Not set

University Hospital Virgen del Rocio, Seville, Not set

Instituto Valenciano de Oncologia, Valencia, Not set

University Hospital Doctor Peset, Valencia, Not set

Chang Gung Medical Foundation Chia Yi Branch, Puzi City, Chiayi County

Changhua Christian Hospital, Changhua city, Not set

Show Chwan Memorial Hospital, Changhua City, Not set

Chang Gung Memorial Hospital Kaohsiung, Kaohsiung City, Not set

Kaohsiung Medical University Hospital, Kaohsiung, Not set

Taipei Medical University - Shuang Ho Hospital, New Taipei City, Not set

National Cheng Kung University Hospital, Tainan City, Not set

National Taiwan University Hospital, Taipei City, Not set

Tri-Service General Hospital, Taipei City, Not set

Taipei Veterans General Hospital, Taipei, Not set

Taipei Municipal Wan Fang Hospital, Taipei, Not set

Chang Gung Memorial Hospital, Taoyuan City, Not set

Chulalongkorn University, Bangkok, Krung Thep Maha Nakhon [Bangko]

Sriraj Hospital, Bangkok, Not set

Chiang Mai University, Chiang Mai, Not set

Dr. Abdurrahman Yurtaslan Oncology Training and Research Hospital, Yenimahalle, Ankara

Gazi University, Ankara, Central Anatolia

VM Medical Park Mersin Hospital, Mezitli, Mersin

Tekirdag Namik Kemal University Hospital, Tekirdag, Suleymanpasa

Istanbul University, Istanbul Medical Faculty, Istanbul, Not set

Ege University, Izmir, Not set

Dokuz Eylul University, Izmir, Not set

Sakarya University Medical Faculty, Sakarya, Not set

Ondokuz Mayis Universitesi Tip Fakultesi Hastanesi, Samsun, Not set

Zonguldak Bulent Ecevit Univesity, Zonguldak, Not set

Royal Cornwall Hospital NHS Trust, Truro, Cornwall

Derriford Hospital and the Royal Eye Infirmary, Plymouth, Devon

University Hospitals Dorset, Bournemouth, Dorset

Barking, Havering and Redbridge University Hospitals NHS Trust, Romford, Essex

Salisbury Foundation Trust, Salisbury, Hampshire

The Hillingdon Hospital, Uxbridge, Middlesex

James Paget University Hospitals Nhs Foundation Trust, Great Yarmouth, Not set

South Warwickshire NHS Foundation Trust, Warwick, Not set

Conditions: Relapsed/Refractory Follicular Lymphoma, Marginal Zone Lymphoma (MZL)

Learn More ›

A Study of Tirzepatide in Adolescents With Obesity and Weight-Related Comorbidities (SURMOUNT-ADOLESCENTS-2)

NCT06439277

Recruiting

The goal of the study is to assess how tirzepatide impacts bodyweight and cardiovascular risk factors when used in conjunction with healthy nutrition and physical activity in adolescents with obesity and multiple weight related comorbidities. The study will last approximately 76 weeks and may include up to 23 visits.

Gender:

ALL

Ages:

Between 12 years and 17 years

Trial Updated:

06/24/2025

Locations: Children's Hospital Los Angeles, Los Angeles, California +71 locations

Children's Hospital Los Angeles, Los Angeles, California

Sutter Valley Medical Foundation (SVMF) Pediatric Endocrinology, Sacramento, California

Nemours Children's Health - Delaware, Wilmington, Delaware

CenExel iResearch, LLC, Decatur, Georgia

Ann & Robert H. Lurie Children's Hospital of Chicago, Chicago, Illinois

Indiana University Health University Hospital, Indianapolis, Indiana

UBMD Pediatrics, Buffalo, New York

SUNY Upstate Medical University, Syracuse, New York

Driscoll Children's Hospital, Corpus Christi, Texas

Consano Clinical Research, LLC, Shavano Park, Texas

Texas Valley Clinical Research, Weslaco, Texas

Alliance for Multispecialty Research, LLC, Layton, Utah

DIM Clínica Privada, Ramos Mejía, Buenos Aires

Investigaciones Medicas Imoba Srl, Buenos Aires, Ciudad Autónoma De Buenos Aires

Centro Medico Dra. Laura Maffei- Investigacion Clinica Aplicada, Ciudad Autonoma de Buenos Aires, Ciudad Autónoma De Buenos Aires

Centro de Investigaciones Médicas Tucuman, SAN M. DE Tucuman, Tucumán

Fundación Respirar, Buenos Aires, Not set

Centro de Investigaciones Metabólicas (CINME), Ciudad Autónoma de Buenos Aires, Not set

Hunter Medical Research Institute, Newcastle, New South Wales

University of Sydney - Charles Perkins Centre, Sydney, New South Wales

The Children's Hospital at Westmead, Westmead, New South Wales

Cornerstone Dermatology, Coorparoo, Queensland

Nightingale Research, Adelaide, South Australia

Perth Children's Hospital, Perth, Western Australia

Alberta Children's Hospital, Calgary, Alberta

Kids Clinic, Ajax, Ontario

Winterberry Research Inc., Hamilton, Ontario

Premier Clinical Trial Network, Hamilton, Ontario

Bluewater Clinical Research Group Inc., Sarnia, Ontario

Assistance Publique Hôpitaux de Marseille - Hôpital de la Timone, Marseille, Bouches-du-Rhône

CHU de Toulouse - Hôpital des Enfants, Toulouse, Haute-Garonne

Centre Hospitalier Universitaire d'Angers, Angers, Maine-et-Loire

Hôpital Jeanne de Flandre, Lille, Nord-Pas-de-Calais

Hospices Civils de Lyon - Hopital Louis Pradel, Bron, Rhône

Hôpital Armand Trousseau, Paris, Not set

Assistance Publique - Hopitaux de Paris (AP-HP) - Hopital Robert Debre - Centre Hospitalo Universitaire (C -T, Paris, Not set

Universitaetsklinikum Ulm, Ulm, Baden-Württemberg

Universitaetsklinikum Koeln, Köln, Nordrhein-Westfalen

Universitätsklinikum Leipzig, Leipzig, Sachsen

Soroka Medical Center, Be'er Sheva, HaDarom

Yitzhak Shamir Medical Center, Beer Yaacov, HaMerkaz

Meir Medical Center, Kfar Saba, HaMerkaz

Schneider Children's Medical Center, Petah-Tikva, HaMerkaz

Sheba Medical Center, Ramat Gan, HaMerkaz

Emek Medical Center, Afula, HaTsafon

Rambam Health Care Campus, Haifa, HaTsafon

Shaare Zedek Medical Center, Jerusalem, Yerushalayim

Carmel Hospital, Haifa, Ḥeifā

Centro de Investigacion Medica de Occidente, S.C., Guadalajara, Jalisco

Christus - Latam Hub Center of Excellence and Innovation S.C., Monterrey, Nuevo León

Clínica García Flores SC, Monterrey, Nuevo León

Centro de Atención e Investigación Clínica, Aguascalientes, Not set

Consultorio Médico de Endocrinología y Pediatría, Puebla, Not set

University Pediatric Hospital, San Juan, Not set

Hospital Universitario Reina Sofia, Cordoba, Andalucía

Hospital Universitari Vall d'Hebron, Barcelona, Barcelona [Barcelona]

Hospital Infantil Universitario Niño Jesús, Madrid, Madrid, Comunidad De

H.R.U Málaga - Hospital General, Málaga, Not set

Hospital Universitari i Politecnic La Fe, València, Not set

China Medical University Hospital, Taichung, Not set

National Cheng Kung University Hospital, Tainan, Not set

National Taiwan University Hospital, Taipei, Not set

Chang Gung Medical Foundation-Linkou Branch, Taoyuan, Not set

Addenbrooke's Hospital, Cambridge, Cambridgeshire

Leicester Royal Infirmary, Leicester, England

Royal Victoria Infirmary, Newcastle upon Tyne, England

Southampton General Hospital, Southampton, Hampshire

Paediatric and Adolescent OutpatientsElizabeth Garrett Anderson WingUniversity College Hospital, London, London, City Of

Royal Hospital for Children, Glagow, Scotland

Leeds General Infirmary, Leeds, Not set

Alder Hey Children's Hospital, Liverpool, Not set

Sheffield Children's Hospital, Sheffield, Not set

Conditions: Obesity, Weight Gain

Learn More ›

A Study to Test Long-term Treatment With Brigimadlin in People With Solid Tumours Who Took Part in a Previous Study With This Medicine

NCT06619509

Recruiting

This study is open to adults who participated in a previous clinical study with brigimadlin. The goal of this study is to find out how well people with solid tumours tolerate long-term treatment with brigimadlin. Brigimadlin is a so-called MDM2 inhibitor that is being developed to treat cancer. Participants are grouped in cohorts depending on their treatment in the previous study: * Cohort 1a got brigimadlin and continues treatment with brigimadlin * Cohort 1b got brigimadlin for 4 or less tr... Read More

Gender:

ALL

Ages:

18 years and above

Trial Updated:

06/24/2025

Locations: Precision NextGen Oncology, Beverly Hills, California +52 locations

Precision NextGen Oncology, Beverly Hills, California

Sarcoma Oncology Center, Santa Monica, California

Yale Cancer Center, New Haven, Connecticut

Mayo Clinic Cancer Center, Jacksonville, Florida

Northwestern University, Chicago, Illinois

Washington University School of Medicine, Saint Louis, Missouri

Nebraska Cancer Specialists-Omaha-69066, Omaha, Nebraska

Northwell Health, Lake Success, New York

West Cancer Center & Research Institute, Germantown, Tennessee

Henry-Joyce Cancer Clinic, Nashville, Tennessee

The University of Texas MD Anderson Cancer Center, Houston, Texas

Utah Cancer Specialists Cancer Center, Salt Lake City, Utah

Fred Hutchinson Cancer Research Center, Seattle, Washington

University of Wisconsin, Madison, Wisconsin

Sanatorio Finochietto, Caba, Not set

Prince of Wales Hospital-Randwick-66496, Randwick, New South Wales

Princess Alexandra Hospital, Woolloongabba, Queensland

Brussels - UNIV Saint-Luc, Bruxelles, Not set

UZ Leuven, Leuven, Not set

H.S.J. Beneficência Portuguesa - São Paulo, Sao Paulo, Not set

Arthur J. E. Child Comprehensive Cancer Centre, Calgary, Alberta

Princess Margaret Cancer Centre, Toronto, Ontario

Sun Yat-Sen University Cancer Center, Guangzhou, Not set

Wuhan Union Hospital, Wuhan, Not set

University Hospital Olomouc, Olomouc, Not set

Copenhagen University Hospital, Rigshospitalet, København Ø, Not set

CTR Leon Berard, Lyon, Not set

CTR Eugène Marquis, Rennes, Not set

Helios Klinikum Berlin-Buch, Berlin, Not set

Universitätsklinikum Frankfurt, Frankfurt, Not set

Universitätsklinikum Tübingen, Tübingen, Not set

Clinexpert Gyongyos, Gyongyos, Not set

Sourasky Medical Center, Tel-Aviv, Not set

Fondazione IRCCS Istituto Nazionale dei Tumori, Milano, Not set

Istituto Nazionale IRCCS Tumori Fondazione Pascale, Napoli, Not set

Istituto Oncologico Veneto IRCCS, Padova, Not set

National Hospital Organization Kyushu Cancer Center, Fukuoka, Fukuoka, Not set

Kyushu University Hospital, Fukuoka, Fukuoka, Not set

Kanagawa Cancer Center, Kanagawa, Yokohama, Not set

Tohoku University Hospital, Miyagi, Sendai, Not set

Okayama University Hospital, Okayama, Okayama, Not set

Osaka International Cancer Institute, Osaka, Osaka, Not set

National Cancer Center Hospital, Tokyo, Chuo-ku, Not set

Oslo Universitetssykehus HF, Radiumhospitalet, Oslo, Not set

Oncology Center-Maria Sklodowska-Curie Institute, Warsaw, Not set

Hospital Miguel Servet, Aragon, Not set

Fundación Jiménez Díaz, Madrid, Not set

Hospital Universitario HM Sanchinarro, Madrid, Not set

Karolinska Comprehensive Cancer Center, Stockholm, Not set

University Hospital Bern/Inselspital Bern, Bern, Not set

Taipei Veterans General Hospital, Taipei, Not set

Addenbrooke's Hospital, Cambridge, Not set

The Royal Marsden Hospital, Chelsea, London, Not set

Conditions: Solid Tumours

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Testing the Addition of the Immunotherapy Drug, Pembrolizumab, to Radiation Therapy Compared to the Usual Chemotherapy Treatment During Radiation Therapy for Bladder Cancer, PARRC Trial

NCT06770582

Recruiting

This phase II trial compares the use of pembrolizumab and radiation therapy to chemotherapy with cisplatin, gemcitabine, 5-fluorouracil or mitomycin-C and radiation therapy for the treatment of non-muscle invasive bladder cancer. Immunotherapy with monoclonal antibodies, such as pembrolizumab, may help the body's immune system attack the cancer, and may interfere with the ability of tumor cells to grow and spread. Chemotherapy drugs, such as cisplatin, gemcitabine, 5-fluorouracil or mitomycin-C,... Read More

Gender:

ALL

Ages:

18 years and above

Trial Updated:

06/24/2025

Locations: AIS Cancer Center at San Joaquin Community Hospital, Bakersfield, California +38 locations

AIS Cancer Center at San Joaquin Community Hospital, Bakersfield, California

Shaw Cancer Center, Edwards, Colorado

Helen F Graham Cancer Center, Newark, Delaware

Medical Oncology Hematology Consultants PA, Newark, Delaware

University of Florida Health Science Center - Gainesville, Gainesville, Florida

Cancer Care Specialists of Illinois - Decatur, Decatur, Illinois

Decatur Memorial Hospital, Decatur, Illinois

Crossroads Cancer Center, Effingham, Illinois

Southern Illinois University School of Medicine, Springfield, Illinois

Springfield Clinic, Springfield, Illinois

Springfield Memorial Hospital, Springfield, Illinois

Louisiana Hematology Oncology Associates LLC, Baton Rouge, Louisiana

Mary Bird Perkins Cancer Center, Baton Rouge, Louisiana

Mary Bird Perkins Cancer Center - Gonzales, Gonzales, Louisiana

Mary Bird Perkins Cancer Center - Metairie, Metairie, Louisiana

Saint Francis Medical Center, Cape Girardeau, Missouri

Parkland Health Center - Farmington, Farmington, Missouri

Missouri Baptist Medical Center, Saint Louis, Missouri

Sainte Genevieve County Memorial Hospital, Sainte Genevieve, Missouri

Missouri Baptist Sullivan Hospital, Sullivan, Missouri

BJC Outpatient Center at Sunset Hills, Sunset Hills, Missouri

University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma

Christiana Care Health System-Concord Health Center, Chadds Ford, Pennsylvania

UPMC Cancer Center at UPMC Horizon, Farrell, Pennsylvania

UPMC Cancer Centers - Arnold Palmer Pavilion, Greensburg, Pennsylvania

UPMC Cancer Center - Monroeville, Monroeville, Pennsylvania

UPMC Hillman Cancer Center - Monroeville, Monroeville, Pennsylvania

UPMC Hillman Cancer Center - New Castle, New Castle, Pennsylvania

UPMC-Saint Margaret, Pittsburgh, Pennsylvania

University of Pittsburgh Cancer Institute (UPCI), Pittsburgh, Pennsylvania

UPMC-Shadyside Hospital, Pittsburgh, Pennsylvania

UPMC-Passavant Hospital, Pittsburgh, Pennsylvania

UPMC Cancer Center at UPMC Northwest, Seneca, Pennsylvania

UPMC Cancer Center-Washington, Washington, Pennsylvania

UPMC Washington Hospital Radiation Oncology, Washington, Pennsylvania

Bon Secours Memorial Regional Medical Center, Mechanicsville, Virginia

Bon Secours Saint Francis Medical Center, Midlothian, Virginia

Bon Secours Saint Mary's Hospital, Richmond, Virginia

Bon Secours Cancer Institute at Reynolds Crossing, Richmond, Virginia

Conditions: Non-Muscle Invasive Bladder Urothelial Carcinoma, Recurrent Non-Muscle Invasive Bladder Urothelial Carcinoma, Stage I Bladder Cancer AJCC v8

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Sample Collections From the Airways of Asthmatic Patients

NCT00001888

Recruiting

Fiberoptic bronchoscopy is a procedure which involves passing a pencil-thin tube into the lung in order to collect fluid and cells from the airways. Fiberoptic bronchoscopy can collect cells from the walls of airways by gently brushing them (bronchial brushing). In addition, squirting small amounts of sterile water in to the airway and gently suctioning it back into the bronchoscope (bronchoalveolar lavage) collects cells. In this study, researchers plan to perform these tests on patients with... Read More

Gender:

ALL

Ages:

Between 18 years and 75 years

Trial Updated:

06/24/2025

Locations: National Institutes of Health Clinical Center, Bethesda, Maryland

Conditions: Asthma

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Collection of Data and Samples From Healthy Donors for Use in Translational Research

NCT00090662

Recruiting

Increased numbers of white blood cells called eosinophils can cause disease. To investigate this disease, researchers need blood, urine, sputum, stool, cerebrospinal fluid, skin and/or bone marrow samples to compare to samples from patients with this problem. Some of the samples will be used for genetic testing or future research. This study will last for about 10 years and will include a maximum of 50 paid volunteers ages 18 to 65.

Gender:

ALL

Ages:

Between 18 years and 85 years

Trial Updated:

06/24/2025

Locations: National Institutes of Health Clinical Center, Bethesda, Maryland

Conditions: Healthy Volunteer

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