The state of Iowa currently has 5 active clinical trials seeking participants for Parkinson's Disease research studies. These trials are conducted in various cities, including Iowa City, Des Moines, Sioux City and Cedar Rapids.
Efficacy, Safety, Tolerability, Pharmacodynamics, and Pharmacokinetics of BIA 28-6156 in GBA-PD
NCT05819359
Recruiting
The purpose of this randomized, double-blind, placebo-controlled study is to assess the efficacy of BIA 28-6156 over placebo in delaying clinical meaningful motor progression over 78 weeks in subjects with Parkinson's disease who have a pathogenic variant in the glucocerebrosidase 1 (GBA1) gene (GBA-PD).
Gender:
All
Ages:
Between 35 years and 80 years
Trial Updated:
03/28/2024
Locations: University of Iowa Hospitals and Clinics, Iowa City, Iowa
Conditions: Parkinson's Disease
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Visualization of the STN and GPi for DBS
NCT05774041
Recruiting
The purpose of the study is to determine if using SIS System for DBS planning results in less distance between the planned target location and the actual implanted lead location than DBS planning without SIS System.
Gender:
All
Ages:
18 years and above
Trial Updated:
03/01/2024
Locations: University of Iowa, Iowa City, Iowa
Conditions: Deep Brain Stimulation, Parkinson Disease
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Study in Parkinson Disease of Exercise
NCT04284436
Recruiting
This study is a Phase 3 multi-site, randomized, evaluator-masked, study of endurance treadmill exercise on changes in the Movement Disorder Society-Unified Parkinson Disease Rating Scale (MDS-UPDRS) Part III score at 12 months among persons with early stage Parkinson disease. 370 participants will be randomly assigned to 2 groups: 1)60-65% HRmax or 2)80-85% HRmax 4 times per week. The primary objective is to test whether the progression of the signs of Parkinson's disease is attenuated at 12 mon... Read More
Gender:
All
Ages:
Between 40 years and 80 years
Trial Updated:
02/20/2024
Locations: Iowa State University, Ames, Iowa
Conditions: Parkinson Disease
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Subthalamic Nucleus Deep Brain Stimulation in Speech Study
NCT05493670
Recruiting
Parkinson's disease (PD) patients treated with deep brain stimulation (DBS) of the subthalamic nucleus (STN) have unpredictable and varied speech outcomes after this treatment. Our research will prospectively document speech performance before, during and 6- and 12-months after STN-DBS in 80 surgically treated patients and compared with 40 non-surgical controls with Parkinson's disease. This study will provide unique insights into the role of STN in speech production, document speech outcome in... Read More
Gender:
All
Ages:
Between 21 years and 84 years
Trial Updated:
12/21/2023
Locations: University of Iowa Hospitals and Clinics, Iowa City, Iowa
Conditions: Parkinson Disease, Dysarthria
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Cerebellar Stimulation and Cognitive Control
NCT03217110
Recruiting
The purpose of this study is to examine whether cerebellar stimulation can be used to improve cognitive deficits and mood in patients with schizophrenia, autism, bipolar disorder, Parkinson's disease, and major depression.
Gender:
All
Ages:
Between 18 years and 90 years
Trial Updated:
12/11/2023
Locations: University of Iowa, Iowa City, Iowa
Conditions: Schizophrenia, Autism Spectrum Disorder, Bipolar Disorder, Depression, Parkinson Disease
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