Ceftriaxone to PRevent pneumOnia and inflammatTion aftEr Cardiac arresT (PROTECT)
NCT04999592
Recruiting
Randomized-controlled trial and microbiome assessment to understand the risk-to-benefit ratio of prophylactic antibiotics (Ceftriaxone) vs placebo in patients with pneumonia and inflammation after cardiac arrest outside the hospital.
Gender:
All
Ages:
18 years and above
Locations: Maine Medical Center, Portland, Maine
Conditions: Out-Of-Hospital Cardiac Arrest, Pneumonia
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Neuroinflammatory Response and Headache Control in Patients After Subarachnoid Hemorrhage
NCT03604276
Recruiting
The purpose of this study is to determine the relationship between the Neuroinflammatory response and headache pain after subarachnoid hemorrhage.
Gender:
All
Ages:
18 years and above
Locations: Maine Medical Center, Portland, Maine
Conditions: Subarachnoid Hemorrhage, Aneurysmal, Headache, Subarachnoid Hemorrhage
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Acetaminophen and Ascorbate in Sepsis: Targeted Therapy to Enhance Recovery
NCT04291508
Recruiting
Prospective multi-center phase 2b randomized placebo-controlled double-blinded interventional platform trial of two different pharmacologic therapies (intravenous Vitamin C or intravenous Acetaminophen) for patients with sepsis-induced hypotension or respiratory failure.
Gender:
All
Ages:
18 years and above
Locations: Maine Medical Center, Portland, Maine +41 locations
Conditions: Acute Respiratory Distress Syndrome, Critical Illness, Respiratory Failure, Sepsis
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Study of Kidney Tumors in Younger Patients
NCT00898365
Recruiting
This research trial studies kidney tumors in younger patients. Collecting and storing samples of tumor tissue, blood, and urine from patients with cancer to study in the laboratory may help doctors learn more about changes that occur in deoxyribonucleic acid (DNA) and identify biomarkers related to cancer.
Gender:
All
Ages:
29 years and below
Locations: Eastern Maine Medical Center, Bangor, Maine +247 locations
Conditions: Adult Cystic Nephroma, Anaplastic Kidney Wilms Tumor, Angiolipoma, Cellular Congenital Mesoblastic Nephroma, Classic Congenital Mesoblastic Nephroma, Clear Cell Sarcoma of the Kidney, Congenital Mesoblastic Nephroma, Cystic Partially Differentiated Kidney Nephroblastoma, Diffuse Hyperplastic Perilobar Nephroblastomatosis, Extrarenal Rhabdoid Tumor, Kidney Medullary Carcinoma, Kidney Neoplasm, Kidney Oncocytoma, Kidney Wilms Tumor, Metanephric Adenofibroma, Metanephric Adenoma, Metanephric Stromal Tumor, Metanephric Tumor, Mixed Congenital Mesoblastic Nephroma, Ossifying Renal Tumor of Infancy, Papillary Renal Cell Carcinoma, Renal Cell Carcinoma, Renal Cell Carcinoma Associated With Xp11.2 Translocations/TFE3 Gene Fusions, Rhabdoid Tumor of the Kidney, Wilms Tumor
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Implementation of a Prehabilitation Program for Surgical Patients
NCT05377970
Recruiting
Frailty is a state of increased vulnerability to stressors with increased rates of poor outcomes. Surgery is one of these stressors, and previous research has therefore shown increased rates of morbidity and mortality in frail patients undergoing surgery. Prehabilitation programs can help mitigate the negative outcomes associated with frailty. The investigators hope to implement a newly developed prehabilitation pilot program in the Maine Medical Center Surgical Oncology Clinic to initially eval... Read More
Gender:
All
Ages:
18 years and above
Locations: Maine Medical Center, Portland, Maine
Conditions: Prehabilitation, Oncology, Surgical Oncology
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Study of Venetoclax in Combination With Carfilzomib and Dexamethasone in Participants With Relapsed or Refractory Multiple Myeloma (MM)
NCT02899052
Recruiting
A Phase 2, open-label, dose escalation study to evaluate the safety and efficacy of venetoclax in combination with carfilzomib-dexamethasone (Kd) in participants with relapsed or refractory MM and have received 1 to 3 prior lines of therapy. Part 4 of this study is currently enrolling.
Gender:
All
Ages:
18 years and above
Locations: Central Maine Medical Center /ID# 218856, Lewiston, Maine +31 locations
Conditions: Multiple Myeloma
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Light Treatment Effectiveness (LITE) Study
NCT03726489
Recruiting
To compare the effectiveness, safety (tolerability), and duration of treatment response at 12 weeks of home versus office-based narrowband ultraviolet B phototherapy for the treatment of psoriasis
Gender:
All
Ages:
12 years and above
Locations: MaineHealth/Maine Medical Center, Portland, Maine +37 locations
Conditions: Psoriasis, Psoriatic Plaque
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Atenolol for the Prevention of Osteoporosis (APO)
NCT04905277
Recruiting
Evaluate whether treatment with a widely used beta blocker, atenolol, will prevent bone loss at the lower back and hip in postmenopausal women.
Gender:
Female
Ages:
Between 50 years and 75 years
Locations: MaineHealth, Scarborough, Maine +2 locations
Conditions: Healthy
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Firehawk Rapamycin Target Eluting Coronary Stent North American Trial
NCT04562532
Recruiting
The aim of the TARGET-IV NA trial is to demonstrate the clinical non-inferiority of the Firehawk® rapamycin eluting stent system in comparison to currently approved 2nd generation DES for the treatment of subjects with ischemic heart disease (NSTEMI, recent STEMI (>24 hours from initial presentation and in whom enzyme levels have peaked), unstable angina, and stable coronary disease), with atherosclerotic target lesion(s) in coronary arteries with visually estimated reference vessel diameters ≥2... Read More
Gender:
All
Ages:
18 years and above
Locations: Eastern Maine Medical Center-Northern Light Cardiology, Bangor, Maine +56 locations
Conditions: Coronary Artery Disease
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Carotid Revascularization and Medical Management for Asymptomatic Carotid Stenosis Trial - Hemodynamics (CREST-H)
NCT03121209
Recruiting
We aim to determine whether cognitive impairment attributable to cerebral hemodynamic impairment in patients with high-grade asymptomatic carotid artery stenosis is reversible with restoration of flow. To accomplish this aim CREST-H will add on to the NINDS-sponsored CREST-2 trial (parallel, outcome-blinded Phase 3 clinical trials for patients with asymptomatic high-grade carotid artery stenosis which will compare carotid endarterectomy plus intensive medical management (IMM) versus IMM alone (n... Read More
Gender:
All
Ages:
Between 35 years and 86 years
Locations: Maine Medical Center, Portland, Maine +54 locations
Conditions: Internal Carotid Artery Stenosis, Cognitive Impairment
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MOms in REcovery (MORE) Study: Defining Optimal Care
NCT04251208
Recruiting
Northern New England has among the highest rates of opioid dependence in the U.S, with prevalence highest and growing among those of between the ages of 18-35 years. This region also has among the highest rates of opioid-related deaths in the U.S., with a disproportionate high rate among pregnant women with opioid use disorder. In northern New England (Maine, New Hampshire, & Vermont), 5-8% of newborns have mothers with an opioid use disorder (OUD), greatly increasing the risk of poor outcomes,... Read More
Gender:
Female
Ages:
Between 16 years and 50 years
Locations: Maine General Hospital, Augusta, Maine +9 locations
Conditions: Opioid-Related Disorders, NAS, Substance Use Disorders
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Nerve Block for Pain Control After Fracture Surgery
NCT05391464
Recruiting
Surgical treatment for patients with a fracture of the ankle or distal radius is commonly offered on an outpatient basis. Patients are routinely discharged from hospital within 4 hours of their procedure. The surgery is commonly performed under peripheral nerve block with sedation, or under general anesthesia with postoperative peripheral nerve block, (if required for analgesic purposes). It is unclear which of these two strategies offers patients superior pain relief in the first few days follo... Read More
Gender:
All
Ages:
18 years and above
Locations: MaineGeneral Medical Center, Augusta, Maine
Conditions: Ankle Fractures, Distal Radius Fracture
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