The state of Maryland currently has 39 active clinical trials seeking participants for Depression research studies. These trials are conducted in various cities, including Baltimore, Bethesda, Rockville and Annapolis.
Characterization and Treatment of Adolescent Depression
Recruiting
This research study seeks to find causes and treatments of depression in teenagers. The study goals are to increase our knowledge of treatments for depression and understand how the brain changes when teenagers have depression. The study will also compare teenagers with depression to those without mental health diagnoses. This outpatient study is recruiting participants ages 11-17 who are depressed. They must have a pediatrician or other medical provider, be medically healthy, and able to perfo... Read More
Gender:
All
Ages:
Between 11 years and 25 years
Trial Updated:
03/26/2024
Locations: National Institutes of Health Clinical Center, Bethesda, Maryland
Conditions: Depression
The Role of Hormones in Postpartum Mood Disorders
Recruiting
Determine whether postpartum depression is triggered by the abrupt withdrawal of estrogen and progesterone. The appearance of mood and behavioral symptoms during pregnancy and the postpartum period has been extensively reported. While there has been much speculation about possible biologically based etiologies for postpartum disorders (PPD), none has ever been confirmed. Preliminary results from two related studies (protocols 90-M-0088, 92-M-0174) provide evidence that women with menstrual cycl... Read More
Gender:
Female
Ages:
Between 18 years and 50 years
Trial Updated:
03/26/2024
Locations: National Institutes of Health Clinical Center, Bethesda, Maryland
Conditions: Postpartum Depression
Title: Safety and Feasibility of Individualized Low Amplitude Seizure Therapy (iLAST)
Recruiting
Background: Electroconvulsive therapy (ECT) is used to treat people with severe depression. During ECT, the brain is given electric pulses that cause a seizure. Although it is effective, it can cause side effects, including memory loss. Researchers want to study a new way to give ECT called iLAST. Objective: To see if iLAST is safe and feasible in treating depression. Eligibility: People ages 22 70 years old who have major depressive disorder and are eligible for ECT Design: Participants... Read More
Gender:
All
Ages:
Between 22 years and 70 years
Trial Updated:
03/25/2024
Locations: National Institutes of Health Clinical Center, Bethesda, Maryland
Conditions: Unipolar Depression
Exploring Mechanisms for Neuropsychiatric Symptoms of Parkinson Disease Using Transcranial Direct Current Stimulation
Recruiting
This study evaluates the effect of transcranial direct current stimulation (tDCS) on non-motor symptoms of Parkinson's disease, including depression and cognitive symptoms. Participants are randomized to receive active or sham tDCS for 30 minutes over 10 treatment sessions.
Gender:
All
Ages:
Between 18 years and 95 years
Trial Updated:
03/20/2024
Locations: Johns Hopkins Hospital / Johns Hopkins University, Baltimore, Maryland
Conditions: Idiopathic Parkinson's Disease, Parkinson Disease, Depression
Efficacy, Safety, and Tolerability of COMP360 in Participants With TRD
Recruiting
Efficacy, Safety, and Tolerability of a single administration of COMP360 in participants with treatment-resistant depression (TRD)
Gender:
All
Ages:
18 years and above
Trial Updated:
03/20/2024
Locations: Sheppard Pratt Health System, Baltimore, Maryland +2 locations
Conditions: Treatment Resistant Depression
BPL-003 Efficacy and Safety in Treatment Resistant Depression
Recruiting
This is a Phase 2 study randomized, quadruple masked, multi-center study designed to investigate the efficacy and safety of a single dose of BPL-003 combined with psychological support in patients with treatment resistant depression (TRD).
Gender:
All
Ages:
Between 18 years and 75 years
Trial Updated:
03/19/2024
Locations: Sunstone Medical PC (Sunstone Therapies / Aquilino Cancer Center), Rockville, Maryland
Conditions: Treatment Resistant Depression
Neuropharmacologic Imaging and Biomarker Assessments of Response to Acute and Repeated-Dosed Ketamine Infusions in Major Depressive Disorder
Recruiting
Background: Most medications that treat depression take weeks or months to work. Researchers want to develop fast-acting treatments. One dose of ketamine has a rapid antidepressant effect. For most people, this lasts a week or less. Repeated doses of ketamine may help maintain this effect. Objective: Main Study: To study the effects of ketamine in treating depression. Ketamine Metabolites Substudy: To study how ketamine effects brain chemistry. To study how ketamine effects the brain. This... Read More
Gender:
All
Ages:
Between 18 years and 65 years
Trial Updated:
03/14/2024
Locations: National Institutes of Health Clinical Center, Bethesda, Maryland
Conditions: Healthy Volunteer, Major Depressive Disorder, Depression
Evaluation of Patients With Mood and Anxiety Disorders and Healthy Volunteers
Recruiting
The purpose of this protocol is to allow for the careful screening of patients and healthy volunteers for participation in research protocols in the Experimental Therapeutics and Pathophysiology Lab (ETPB) at the National Institute of Mental Health (NIMH) and for the collection of natural history data. In addition the protocol will allow clinicians to gain more experience in the use of a variety of polysomnographic and high-density EEG recordings. Subjects in this protocol will undergo an evalua... Read More
Gender:
All
Ages:
Between 3 years and 99 years
Trial Updated:
03/14/2024
Locations: National Institutes of Health Clinical Center, Bethesda, Maryland
Conditions: Depression, Mood Disorders, Anxiety Disorders, Healthy Volunteers, Bipolar Disorder
Neurobiology of Suicide
Recruiting
Background: There are no good treatments for people considering suicide. Researchers want to study suicide with questions, blood tests, brain imaging, and sleep studies. They hope to better understand suicide, so they can help suicidal people. Objective: To understand what happens in the brain when someone has thought about or attempted suicide. Eligibility: Group 1: Adults ages 18 70 who have thought about or attempted suicide recently Group 2: Adults ages 18 70 who have thought about or... Read More
Gender:
All
Ages:
Between 18 years and 70 years
Trial Updated:
03/12/2024
Locations: National Institutes of Health Clinical Center, Bethesda, Maryland
Conditions: Healthy Volunteers, Depression
A Prospective, Multi-center, Randomized Controlled Blinded Trial Demonstrating the Safety and Effectiveness of VNS Therapy® System as Adjunctive Therapy Versus a No Stimulation Control in Subjects With Treatment-Resistant Depression
Recruiting
Objectives of this study are to determine whether active VNS Therapy treatment is superior to a no stimulation control in producing a reduction in baseline depressive symptom severity, based on multiple depression scale assessment tools at 12 months from randomization.
Gender:
All
Ages:
18 years and above
Trial Updated:
03/11/2024
Locations: Sheppard Pratt Health System, Inc., Baltimore, Maryland +1 locations
Conditions: Treatment Resistant Depression
PET Imaging of Cyclooxygenase in Participants With Major Depressive Disorder (MDD)
Recruiting
Background: Researchers developed [11C]MC1, a radioligand for cyclooxygenase-2 (COX-2). COX-2 is an enzyme induced in the brain during inflammation. Researchers want to see the levels of COX-1 (measured as distribution volume VT) are elevated in the brain of two groups of mood disorders patients undergoing MDE relative to the control group. Objective: To determine whether COX-1 and COX-2 are detectable in the brains of individuals with MDD experiencing a major depressive episode (MDE). Eligi... Read More
Gender:
All
Ages:
Between 18 years and 70 years
Trial Updated:
03/06/2024
Locations: National Institutes of Health Clinical Center, Bethesda, Maryland
Conditions: Depression
A Study to Assess Change in Disease Activity and Adverse Events (AEs) With Cariprazine in the Treatment of Depressive Episodes in Pediatric Participants Participants (10 to 17 Years of Age) With Bipolar I Disorder.
Recruiting
Bipolar disorder is a severe chronic mood disorder that affects up to 4% of the adult population and 1.8% of the pediatric population in the United States. The treatment of the depressive episodes of bipolar disorder in the pediatric population has not been as widely studied as the treatment of depressive episodes in bipolar disorder in adults, therefore pharmacotherapeutic options are limited. Given the change in disease state and safety demonstrated in adults with depressive episodes associate... Read More
Gender:
All
Ages:
Between 10 years and 17 years
Trial Updated:
03/04/2024
Locations: The Kennedy Krieger Institute /ID# 226509, Baltimore, Maryland
Conditions: Depression, Bipolar I Disorder