Estimating Brain Biomechanics Using MRI
Recruiting
Objective: In this study we will develop and apply imaging techniques to perform the first three-dimensional (3-D) measurements of brain biomechanics during mild head movement in healthy human subjects. Biomechanics is the application of mechanics, or the physical principles in action when force is applied to an object, to the anatomical structure and/or function of organisms. Such techniques will be invaluable for building computational models of brain biomechanics, understanding variability of... Read More
Gender:
All
Ages:
Between 18 years and 65 years
Trial Updated:
11/29/2023
Locations: National Institutes of Health Clinical Center, Bethesda, Maryland
Conditions: Healthy Volunteer, Traumatic Brain Injury, Brain Mapping, Craniocerebral Trauma, Magnetic Resonance Imaging
Analysis of Specimens From Individuals With Pulmonary Fibrosis
Recruiting
The etiology of pulmonary fibrosis is unknown. Analyses of blood, genomic DNA, and specimens procured by bronchoscopy, lung biopsy, lung transplantation, clinically-indicated extra-pulmonary biopsies, or post-mortem examination from individuals with this disorder may contribute to our understanding of the pathogenic mechanisms of pulmonary fibrosis. The purpose of this protocol is to procure and analyze blood, genomic DNA, and specimens by bronchoscopy, lung biopsy, lung transplantation, extra-p... Read More
Gender:
All
Ages:
Between 18 years and 115 years
Trial Updated:
11/28/2023
Locations: National Institutes of Health Clinical Center, Bethesda, Maryland
Conditions: Pulmonary Fibrosis, Healthy Volunteers, Hermansky-Pudlak Syndrome (HPS)
Influence of Brain Oscillation-Dependent TMS on Motor Function
Recruiting
Background: When people have a stroke, they often have difficulty moving their arms and hands. Transcranial magnetic stimulation (TMS) can improve how well people with and without stroke can move their arms and hands. But the effects of TMS are minor, and it doesn t work for everyone. Researchers want to study how to time brain stimulation so that the effects are more consistent. Objective: To understand how the brain responds to transcranial magnetic stimulation so that treatments for people... Read More
Gender:
All
Ages:
18 years and above
Trial Updated:
11/28/2023
Locations: National Institutes of Health Clinical Center, Bethesda, Maryland
Conditions: Healthy, Stroke, Normal Physiology, Aging
Prospective Evaluation of Next Generation CT Reconstruction (NextGenIR)
Recruiting
Background: - Computed Tomography (CT) is a scan that makes detailed pictures of the body. It uses radiation to do that. In 2011, about 85.3 million CT scans were done in the United States. But there is growing concern about the health effects of radiation. There are new and different ways to make CT pictures that use less radiation. Researchers want to learn whether these new methods create images that are similar to images from a traditional CT. Objective: - To learn if new CT imaging metho... Read More
Gender:
All
Ages:
Between 18 years and 99 years
Trial Updated:
11/25/2023
Locations: National Institutes of Health Clinical Center, Bethesda, Maryland
Conditions: Healthy Subjects
Microbial, Immune, and Metabolic Perturbations by Antibiotics (MIME Study)
Recruiting
More than 250 million courses of antibiotics are prescribed annually in the ambulatory care setting in the United States alone, including more than 40 million in children under 18 years of age. The perception that antibiotic use has minimal attendant adverse side effects contributes to the over-utilization of antibiotics in clinical circumstances when they are not strictly indicated. We have learned much about the human microbiome. The emerging view is of profound life-long bi-directional intera... Read More
Gender:
All
Ages:
Between 18 years and 49 years
Trial Updated:
11/25/2023
Locations: National Institutes of Health Clinical Center, Bethesda, Maryland
Conditions: Normal Physiology, Healthy
New Heart Imaging Techniques to Evaluate Possible Heart Disease
Recruiting
Background: - Imaging tests, such as magnetic resonance imaging (MRI), can provide information about heart and blood vessels. The tests let doctors can see the amount of blood vessel narrowing and vessel wall thickness. This information may help diagnose and treat heart disease and other conditions that lead to heart attacks. Better MRI methods are needed to improve heart disease diagnosis, especially by avoiding the use of radiation. Researchers are testing new techniques to improve the qualit... Read More
Gender:
All
Ages:
Between 18 years and 100 years
Trial Updated:
11/23/2023
Locations: National Institutes of Health Clinical Center, Bethesda, Maryland
Conditions: Healthy, Obesity, Diabetes, Healthy Volunteers, Atherosclerosis
Study of New Magnetic Resonance Imaging Methods of the Brain
Recruiting
The purpose of this investigation is to develop improved magnetic resonance imaging (MRI) techniques and hardware for studying brain function. MRI is a diagnostic tool that provides information about brain chemistry and physiology. This study will evaluate new MRI methods for monitoring blood flow to regions of the brain in response to simple tasks. The MRI machine used in this study is more powerful than those in most hospitals, permitting a higher visual resolution. Normal healthy volunteers... Read More
Gender:
All
Ages:
Between 18 years and 120 years
Trial Updated:
11/23/2023
Locations: National Institutes of Health Clinical Center, Bethesda, Maryland
Conditions: Healthy, Magnetic Resonance Imaging, Adult, Brain Mapping, fMRI, Healthy Volunteer
Collection of Tissue Specimens From Patients With Solid Tumors or Blood Disorders and Their HLA-Compatible Family Members
Recruiting
This study will collect biological samples for use in research experiments aimed at better understanding the clinical features of certain diseases. The specimens may be used to evaluate the effectiveness of known therapies, refine treatment approaches, identify potential new therapies, and explore opportunities for disease prevention. The following individuals 2 years of age or older may be eligible for this study: Patients with a cancerous solid tumor or a cancerous or non-cancerous blood dis... Read More
Gender:
All
Ages:
Between 2 years and 100 years
Trial Updated:
11/23/2023
Locations: National Institutes of Health Clinical Center, Bethesda, Maryland
Conditions: Neoplasms, Hematologic Neoplasms, Healthy Volunteers
Study of Human Non-Shivering Thermogenesis and Basal Metabolic Rate
Recruiting
Background: - Changes in how a person s body burns energy or calories can affect their weight over time. The lowest level of energy the body needs to function is called basal metabolic rate. In the cold, we burn extra energy, even before we start to shiver. This is called non-shivering thermogenesis and it occurs in different types of tissue such as muscle and fat. Researchers want to learn more about this type of energy burning and how it is regulated. They hope this will help treat obesity in... Read More
Gender:
Male
Ages:
Between 18 years and 35 years
Trial Updated:
11/23/2023
Locations: National Institutes of Health Clinical Center, Bethesda, Maryland
Conditions: Healthy Volunteers
Neuropharmacologic Imaging and Biomarker Assessments of Response to Acute and Repeated-Dosed Ketamine Infusions in Major Depressive Disorder
Recruiting
Background: Most medications that treat depression take weeks or months to work. Researchers want to develop fast-acting treatments. One dose of ketamine has a rapid antidepressant effect. For most people, this lasts a week or less. Repeated doses of ketamine may help maintain this effect. Objective: Main Study: To study the effects of ketamine in treating depression. Ketamine Metabolites Substudy: To study how ketamine effects brain chemistry. To study how ketamine effects the brain. This... Read More
Gender:
All
Ages:
Between 18 years and 65 years
Trial Updated:
11/23/2023
Locations: National Institutes of Health Clinical Center, Bethesda, Maryland
Conditions: Healthy Volunteer, Major Depressive Disorder, Depression
Cytapheresis of Volunteer Donors
Recruiting
Background: - National Institute on Aging researchers are looking at studies that require large numbers of white blood cells for lab use. Standard blood samples do not provide enough white blood cells for these studies. Researchers want to use cytapheresis to collect white blood cells from volunteer donors. This procedure can collect larger amounts of white blood cells and reduce the amount of fluid and other cells that are lost. Objectives: - To use cytapheresis to collect white blood cells... Read More
Gender:
All
Ages:
18 years and above
Trial Updated:
11/23/2023
Locations: National Institute of Aging, Clinical Research Unit, Baltimore, Maryland
Conditions: Healthy Volunteers
Adaptive Optics Retinal Imaging
Recruiting
Background: - By the time diseases of the retina are detected, serious damage has often already been done. Researchers want to find better ways of viewing the retina. One way called adaptive optics may help detect problems earlier. Objectives: - To study if adaptive optics can help find better ways to diagnose, treat, and manage retinal diseases. Eligibility: People over age 12 with an eye disease. Healthy volunteers over age 12 with 20/20 vision or better. Design: Participants will be sc... Read More
Gender:
All
Ages:
12 years and above
Trial Updated:
11/23/2023
Locations: National Institutes of Health Clinical Center, Bethesda, Maryland
Conditions: Eye Diseases, Healthy Volunteers