The city of Boston, Massachusetts, currently has 29 active clinical trials seeking participants for Depression research studies.
Sensor-based Characterization of Depression
Recruiting
This is a longitudinal study where individual with Major Depressive Disorder (MDD) will be monitored for 12 weeks. The study aims to develop an objective, sensor-based, algorithm able to detect the presence of depression as well as predict treatment response. Measurement-based treatment is considered optimal and the development of a valid passive, objective, behavioral and biological assessment of depressive symptoms that does not rely on clinician interviews will improve monitoring and ultimate... Read More
Gender:
All
Ages:
Between 18 years and 75 years
Trial Updated:
11/02/2023
Locations: Depression Clinical Research Program, Boston, Massachusetts +1 locations
Conditions: Unipolar Depression
Xenon Inhalation Therapy for Major Depressive Disorder and Bipolar Disorder
Recruiting
The investigators will test the hypothesis that inhaled xenon will produce a rapid improvement in depressive symptoms in patients suffering from treatment-resistant depression. Specifically, the investigators will conduct a parallel randomized, double-blind crossover study that will compare the effects of xenon-oxygen (35:65 ratio by volume) added to treatment as usual (X-TAU group) to the effects of nitrogen-oxygen (35:65 ratio by volume) added to treatment as usual (N-TAU group). A total of 20... Read More
Gender:
All
Ages:
Between 18 years and 65 years
Trial Updated:
10/18/2023
Locations: Dauten Family Center for Bipolar Treatment Innovation, Boston, Massachusetts
Conditions: Major Depressive Disorder, Bipolar Depression
Study on Allopregnanolone and Depression in Perimenopausal Women
Recruiting
This study aims to identify how the progesterone metabolite allopregnanolone affects behavior and neurobiology that may underlie perimenopausal depression.
Gender:
Female
Ages:
Between 40 years and 60 years
Trial Updated:
11/08/2022
Locations: Brigham and Women's Hospital, Boston, Massachusetts
Conditions: Depression
PEERS Plus mHealth Enhanced Peer Support
Recruiting
The goal of this intervention study is to design and learn whether peer support that is delivered through video chats and texting can decrease depression among older adults. Participants will be assigned to a peer support program where they will receive 8 video chats with a peer mentor who provide social support and supportive texts over 8 weeks.
Gender:
All
Ages:
50 years and above
Trial Updated:
11/03/2022
Locations: Massachusetts General Hospital, Boston, Massachusetts
Conditions: Depression in Old Age
Neuroimaging Sleep and Mood in Depression
Recruiting
This study will investigate how sleep and mood are related in patients with depression and in healthy controls. It will use MRI-based measures of brain function to determine how neural systems are modulated by sleep and sleep deprivation, and its links to mood in depression.
Gender:
All
Ages:
Between 18 years and 80 years
Trial Updated:
08/26/2022
Locations: Boston University, Boston, Massachusetts
Conditions: Major Depression