The state of Massachusetts currently has 525 active clinical trials seeking participants for Cancer research studies. These trials are conducted in various cities, including Boston, Worcester, Springfield and Burlington.
A Novel Imaging Protocol in Use to Identify Lymph Nodes and Organs of Interest
Recruiting
This research study is a pilot clinical trial, which hypothesizes that the combination of electromagnetic tracking in conjunction with laparoscope imaging and ultrasound probe imaging will aid in reducing the complexity of both laparoscopic lymphadenectomy and/or organ removal in patients with a confirmed diagnosis of cancer in urologic regions of interest (Bladder, Prostate, Testicular, Kidney, Urethral, and Penis), by resulting in better visualization and more accurate localization of certain... Read More
Gender:
All
Ages:
18 years and above
Trial Updated:
10/23/2023
Locations: Brigham and Women's Hospital, Boston, Massachusetts
Conditions: Urologic Cancer, Urologic Neoplasms, Bladder Cancer, Prostate Cancer, Testicular Cancer, Kidney Cancer, Urethral Cancer, Penile Cancer
IlluminOss Photodynamic Bone Stabilization System for the Treatment of Impending and Actual Pelvis Fractures
Recruiting
The aim of this project is to assess the effectiveness of the IlluminOss pelvic implants in patients with pelvic metastatic disease presenting with pain, risk of pathologic fracture, non-displaced or minimally displaced pathologic fracture of the pelvis, and geriatric patients with pelvic fragility fractures. Results from this study will be used to confirm preliminary clinically and possibly statistically significant reductions in pain and improvements in function among these patients.
Gender:
All
Ages:
21 years and above
Trial Updated:
10/19/2023
Locations: Massachusetts General Hospital, Boston, Massachusetts
Conditions: Cancer Metastatic, Trauma, Pathologic Fracture
Alvimopan Versus Placebo in Patients Undergoing Radical Cystectomy on an Enhanced Recovery Protocol
Recruiting
To determine if Alvimopan during open or robotic radical cystectomy with urinary diversion results in quicker return of bowel function (GI-2 recovery = time to upper [first toleration of solid food] and lower [first bowel movement] gastrointestinal recovery) compared to placebo.
Gender:
All
Ages:
Between 18 years and 85 years
Trial Updated:
09/26/2023
Locations: Brigham and Women's Hospital, Boston, Massachusetts
Conditions: Bladder Cancer
Breast Cancer Survivor Educational Intervention
Recruiting
The goal of this study is to test a 6-week virtual education program among Black breast cancer survivors. The virtual program includes sessions on physical activity, goal setting, nutrition, sleep, stress, and social connections.
Gender:
Female
Ages:
22 years and above
Trial Updated:
09/22/2023
Locations: Massachusetts General Hospital Cancer Center, Boston, Massachusetts
Conditions: Breast Cancer, Breast Neoplasms, Breast Carcinoma, Breast Cancer Female
Lung Cancer Risk and Early Detection in Firefighters
Recruiting
This study will evaluate whether LDCT findings differ between firefighters and non-fighters, the relationship between occupational exposures and LDCT findings, and whether a proteomics assay can further risk-stratify screen-detected nodules among a study population of 850 current and retired firefighters and 1,120 matched controls.
Gender:
All
Ages:
Between 40 years and 80 years
Trial Updated:
09/21/2023
Locations: Massachusetts General Hospital, Boston, Massachusetts
Conditions: Lung Cancer, Lung Diseases
The Differential Impact of Proton Beam Irradiation Versus Conventional Radiation on Organs-at-risk in Stage II-III Breast Cancer Patients
Recruiting
The objective of the study is to serve as a correlative study for patients enrolled on the RadCOMP trial (NCT02603341), a randomized phase III study of stage II and III breast cancer patients treated with either conventional photon radiation or proton beam radiation
Gender:
All
Ages:
21 years and above
Trial Updated:
09/15/2023
Locations: Massachusetts General Hospital, Boston, Massachusetts
Conditions: Breast Cancer Stage II, Breast Cancer Stage III
Adapting the Tumor Board Model for Mental Illness and Cancer
Recruiting
This study examines the feasibility and acceptability of a virtual tumor board for cancer and mental illness for patients with serious mental illness and a new cancer diagnosis. The study also examines the impact on patient care, psychiatric symptoms, and clinician self-efficacy in managing this population.
Gender:
All
Ages:
18 years and above
Trial Updated:
08/01/2023
Locations: Mass General/North Shore Center for Outpatient Care, Danvers, Massachusetts
Conditions: Cancer, Severe Major Depression, Schizophrenia, Bipolar Disorder, Lung Cancer, Breast Cancer, Head and Neck Cancer, Gastrointestinal Cancer, Genitourinary Cancer
Groningen International Study on Sentinel Nodes in Vulvar Cancer-III
Recruiting
Vulvar cancer patients with SN-metastasis > 2mm will receive chemoradiation instead of an inguinofemoral lymphadenectomy.
Gender:
Female
Ages:
18 years and above
Trial Updated:
07/27/2023
Locations: Baystate Medical Center, Springfield, Massachusetts
Conditions: Vulvar Cancer, Sentinel Lymph Node, Lymph Node Metastases
Project 1: Self-Triage by 2D Full-field Digital Mammography or Synthetic Images
Recruiting
One method of breast cancer screening involves radiologists reading digital tomosynthesis (DBT) images. DBT consists of a 3D stack of x-ray "slices" through the breast. The exam is accompanied by a 2D image like a standard mammogram, a single x-ray of the breast. In a screening setting, most cases are normal. Sometimes it is obvious that a case is normal from a quick look at the 2D image. It would speed up the process of screening if readers could dismiss a clearly normal case on the basis of th... Read More
Gender:
All
Ages:
18 years and above
Trial Updated:
07/21/2023
Locations: Visual Attention Lab / Brigham and Women's Hospital, Boston, Massachusetts
Conditions: Breast Cancer Screening
Drug Screening Using Novel IMD in Renal Cell Carcinoma
Recruiting
This research is being done to study the safety and feasibility of implanting and retrieving a microdevice that releases microdoses of 19 specific drugs or drug combinations as a possible tool to evaluate the effectiveness of several cancer drugs against metastatic renal cell carcinoma (RCC). The name of the intervention(s) involved in this study are: Implantable Microdevice (IMD) Surgery (excision of tumor) Drugs used in this study will only include drugs already used as standard of care for... Read More
Gender:
All
Ages:
18 years and above
Trial Updated:
06/20/2023
Locations: Dana-Farber Cancer Institute, Boston, Massachusetts
Conditions: Renal Cell Carcinoma, Metastatic Renal Cell Carcinoma, Kidney Cancer
GCC19CART for Patients With Metastatic Colorectal Cancer
Recruiting
Study ICT-GCC19CART-US-001 (CARAPIA-1) is a Phase 1 study evaluating the safety, tolerability, clinical activity, pharmacokinetics and pharmacodynamics of GCC19CART in subjects with relapsed or refractory metastatic colorectal cancer.
Gender:
All
Ages:
18 years and above
Trial Updated:
06/02/2023
Locations: Dana-Farber Cancer Institute, Boston, Massachusetts
Conditions: Colorectal Cancer
A Dose Escalation With Expansion Study of EMB-01 in Participants With Advanced/Metastatic Solid Tumors
Recruiting
First-in-human, Phase I/II, Multicenter, Open-Label Study of EMB-01 in Patients with Advanced/Metastatic Solid Tumors
Gender:
All
Ages:
18 years and above
Trial Updated:
05/30/2023
Locations: Dana-Farber Cancer Institute, Boston, Massachusetts
Conditions: Neoplasms, Neoplasm Metastasis, Non-Small-Cell Lung Cancer