The state of Massachusetts currently has 515 active clinical trials seeking participants for Cancer research studies. These trials are conducted in various cities, including Boston, Worcester, Springfield and Burlington.
Drug Screening Using Novel IMD in Renal Cell Carcinoma
NCT05700461
Recruiting
This research is being done to study the safety and feasibility of implanting and retrieving a microdevice that releases microdoses of 19 specific drugs or drug combinations as a possible tool to evaluate the effectiveness of several cancer drugs against metastatic renal cell carcinoma (RCC). The name of the intervention(s) involved in this study are: * Implantable Microdevice (IMD) * Surgery (excision of tumor) * Drugs used in this study will only include drugs already used as standard of car... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
06/20/2023
Locations: Dana-Farber Cancer Institute, Boston, Massachusetts
Conditions: Renal Cell Carcinoma, Metastatic Renal Cell Carcinoma, Kidney Cancer
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GCC19CART for Patients With Metastatic Colorectal Cancer
NCT05319314
Recruiting
Study ICT-GCC19CART-US-001 (CARAPIA-1) is a Phase 1 study evaluating the safety, tolerability, clinical activity, pharmacokinetics and pharmacodynamics of GCC19CART in subjects with relapsed or refractory metastatic colorectal cancer.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
06/02/2023
Locations: Dana-Farber Cancer Institute, Boston, Massachusetts
Conditions: Colorectal Cancer
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A Dose Escalation With Expansion Study of EMB-01 in Participants With Advanced/Metastatic Solid Tumors
NCT03797391
Recruiting
First-in-human, Phase I/II, Multicenter, Open-Label Study of EMB-01 in Patients with Advanced/Metastatic Solid Tumors
Gender:
ALL
Ages:
18 years and above
Trial Updated:
05/30/2023
Locations: Dana-Farber Cancer Institute, Boston, Massachusetts
Conditions: Neoplasms, Neoplasm Metastasis, Non-Small-Cell Lung Cancer
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Evaluation of PET Probe [68Ga]CBP8 in the Detection of Radiation Induced Tissue Injury
NCT04485286
Recruiting
The goal of this study is to investigate the efficacy of \[68Ga\]CBP8 to detect collagen deposition in radiation induced tissue injury.
Gender:
ALL
Ages:
Between 18 years and 80 years
Trial Updated:
04/30/2023
Locations: Massachusetts General Hospital, Boston, Massachusetts
Conditions: Lung Cancer, Radiation Fibrosis, Radiation Induced Lung Injury, Pancreas Cancer
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Patient-Centered Surgical Prehabilitation
NCT05715684
Recruiting
The purpose of this research is to validate the prehabilitation program which is defined as a set of interventions meant to prepare the body physically and nutritionally for the cystectomy procedure.
Gender:
ALL
Ages:
Between 18 years and 85 years
Trial Updated:
03/20/2023
Locations: Brigham and Women's Hospital, Boston, Massachusetts +1 locations
Conditions: Bladder Cancer, Cystectomy
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Collection and Distribution of Biospecimens for Novel Research Uses
NCT03848962
Recruiting
iSpecimen aims to create a clinical partner network of hospitals, laboratories, academic institutions, and other healthcare organizations ("institutions") capable of providing researchers and educators ("researchers") with annotated biospecimens for use in biomarker discovery and validation; diagnostic test and instrumentation development and validation; therapeutics development; other medical research including the impact that various specimen collection and handling methods and conditions have... Read More
Gender:
ALL
Ages:
Between 1 month and 89 years
Trial Updated:
11/08/2022
Locations: iSpecimen, Lexington, Massachusetts
Conditions: Cancer, Healthy, Gastrointestinal Complication, Autoimmune Diseases, Infectious Disease, Women's Health: High-Risk Pregnancy, Dermatologic Disease, Blood Disease
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The Genomic Medicine at VA Study
NCT04331535
Recruiting
This trial will determine the clinical effectiveness of polygenic risk score testing among patients at high genetic risk for at least one of six diseases (coronary artery disease, atrial fibrillation, type 2 diabetes mellitus, colorectal cancer, breast cancer, or prostate cancer), measured by time-to-diagnosis of prevalent or incident disease over 24 months.
Gender:
ALL
Ages:
Between 50 years and 70 years
Trial Updated:
09/29/2022
Locations: VA Boston Healthcare System, Boston, Massachusetts
Conditions: Coronary Artery Disease, Atrial Fibrillation, Type 2 Diabetes, Colorectal Cancer, Breast Cancer, Prostate Cancer
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Durvalumab (MEDI4736) and Tremelimumab and Radiation Therapy in Hepatocellular Carcinoma and Biliary Tract Cancer
NCT03482102
Recruiting
This research study is studying a combination of drugs as a possible treatment for Hepatocellular Carcinoma or Biliary Tract Cancer. The interventions involved in this study are: * Durvalumab * Tremelimumab * Radiation Therapy
Gender:
ALL
Ages:
18 years and above
Trial Updated:
09/07/2022
Locations: Massachusetts General Hospital, Boston, Massachusetts +1 locations
Conditions: Hepatocellular Carcinoma, Biliary Tract Cancer
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Nivolumab and Ipilimumab and Radiation Therapy in MSS and MSI High Colorectal and Pancreatic Cancer
NCT03104439
Recruiting
This research study is studying a combination of drugs with radiation therapy as a possible treatment for Microsatellite Stable Colorectal Cancer, Pancreatic Cancer, or MSI High Colorectal Cancer. The interventions involved in this study are: * Nivolumab * Ipilimumab * Radiation Therapy
Gender:
ALL
Ages:
18 years and above
Trial Updated:
09/07/2022
Locations: Massachusetts general Hospital, Boston, Massachusetts
Conditions: Microsatellite Stable Colorectal Cancer, Pancreatic Cancer, MSI High Colorectal Cancer
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Folfox+Irinotecan+Chemort In Esophageal Cancer
NCT04656041
Recruiting
In this research study, is studying how Liposomal Irinotecan in combination with the standard of care interventions FOLFOX, carboplatin paclitaxel, and radiation therapy affect gastroesophageal junction or esophagogastric cancer This research study involves the following study intervention: - Liposomal irinotecan
Gender:
ALL
Ages:
18 years and above
Trial Updated:
09/07/2022
Locations: Massachusetts General Hospital, Boston, Massachusetts +2 locations
Conditions: Gastroesophageal Junction Adenocarcinoma, Esophagogastric Cancer
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Gedatolisib Plus Fulvestrant With or Without Palbociclib vs Standard-of-Care for the Treatment of Patients With Advanced or Metastatic HR+/HER2- Breast Cancer
NCT05486143
Recruiting
This is a Phase 3, open-label, randomized, clinical trial evaluating the efficacy and safety of gedatolisib plus fulvestrant with or without palbociclib for the treatment of patients with locally advanced or metastatic HR+/HER2- breast cancer following progression on or after CDK4/6 and aromatase inhibitor therapy. Condition or disease: Breast Cancer Intervention/treatment: Drug: Gedatolisib Drug: Palbociclib Drug: Fulvestrant Drug: Alpelisib Phase 3
Gender:
All
Ages:
18 years and above
Trial Updated:
08/02/2022
Locations: Dana Farber Cancer Institute, Boston, Massachusetts
Conditions: Breast Cancer
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