There are currently 207 clinical trials in Worcester, Massachusetts looking for participants to engage in research studies. Trials are conducted at various facilities, including University of Massachusetts Medical School, UMass Memorial Medical Center, University of Massachusetts Memorial Medical Center and UMass Memorial Medical Center - University Campus. Whether you're a healthy volunteer looking to participate in paid medical research or seeking trials related to a specific condition, the city provides a diverse range of opportunities near you.
Outcomes and Data Collection for Fecal Microbiota Transplantation for the Treatment of Recurrent Clostridium Difficile
NCT03562741
Recruiting
The purpose of this study is to see if stool transplant performed by colonoscopy is effective at treating recurrent Clostridium difficile (C. diff) infection of the colon. During the procedure a stool sample is taken from a healthy donor (usually family member or close friend) and transplanted directly into the colon of the patient with C. diff infection. The goal of this experimental procedure (called fecal microbiota transplantation) is to replenish the good bacteria in the colon that can help... Read More
Gender:
ALL
Ages:
16 years and above
Trial Updated:
04/30/2024
Locations: UMass Memorial Medical Center, Worcester, Massachusetts
Conditions: Clostridium Difficile Infection Recurrence, Clostridium Difficile Infection
Register for Updates
Asthma Link Effectiveness Trial: Cluster Randomized Controlled Trial
NCT06388460
Recruiting
The goal of this cluster RCT is to determine the effectiveness of Asthma Link, a school supervised asthma therapy program, compared with an educational asthma workbook, in improving asthma symptoms for children with poorly controlled asthma aged 5-14.
Gender:
ALL
Ages:
Between 5 years and 14 years
Trial Updated:
04/23/2024
Locations: University of Massachusetts Chan Medical School, Worcester, Massachusetts
Conditions: Childhood Asthma
Register for Updates
Performance of SGM-101 for the Delineation of Primary and Recurrent Tumor and Metastases in Patients Undergoing Surgery for Colorectal Cancer
NCT03659448
Recruiting
The performance of SGM-101, an intraoperative imaging agent, will be compared to that of standard "white light" visualization during surgical resections of colorectal cancer.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
04/23/2024
Locations: University of Massachusetts, Worcester, Massachusetts
Conditions: Colorectal Neoplasms
Register for Updates
Ultrasound Guided Femoral Nerve Block
NCT02381717
Recruiting
The goal of the study is to evaluate whether pain control achieved by Ultrasound Guided Femoral Nerve Blockade (USFNB) is equal in efficacy to standard pain management practice of parenteral injection of opioid pain medication in patients presenting to the emergency department (ED) with hip fracture.
Gender:
ALL
Ages:
Between 18 years and 101 years
Trial Updated:
04/02/2024
Locations: St. Vincent's Hospital, Worcester, Massachusetts
Conditions: Hip Fracture
Register for Updates
Cold Agglutinin Disease Real World Evidence Registry
NCT05791708
Recruiting
This is a multinational, multi-center, observational, prospective, longitudinal disease registry designed to collect data on participants with cold agglutinin disease (CAD) or cold agglutinin syndrome (CAS). Among them, a minimum of 30 patients with CAD treated with sutimlimab are expected to take part in the sutimlimab cohort study. Patients with CAD who have been enrolled in previous sutimlimab clinical trials (e.g., BIVV009-01/LTS16214 \[NCT02502903,CAD patients\], BIVV009-03/EFC16215 \[NCT03... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
03/27/2024
Locations: Reliant Medical Group Site Number : 1205, Worcester, Massachusetts
Conditions: Cold Agglutinin Disease (CAD), Cold Agglutinin Syndrome (CAS)
Register for Updates
Prospective Collection of PillCam SB3 Videos and Raw Data Files for Future Developments (SODA)
NCT03771508
Recruiting
Observational, Multicenter, Post-market, Minimal risk, Prospective data collection of PillCam SB3 videos (including PillCam reports) and raw data files and optional collection of Eneteroscopy reports
Gender:
ALL
Ages:
All
Trial Updated:
03/20/2024
Locations: UMass Memorial Health Care, Worcester, Massachusetts
Conditions: Small Intestine Disease, Small Intestine Cancer, Small Intestinal Ulcer Bleeding, Small Intestine Obstruction, Small Intestine Adenocarcinoma, Small Intestine Polyp
Register for Updates
Adapt2Quit - An Adaptive Motivational System for Socio-Economically Disadvantaged Smokers
NCT04720625
Recruiting
The goal of this research is to test the Adapt2Quit computer program that uses participant input (message rating on how much the text motivational message might influence one to quit smoking) to select and text motivational messages that are more likely to help a user stop smoking. This Adapt2Quit system will be compared with a quitline facilitation-only control (text messages will be sent to facilitate quitline use). The primary research hypothesis is that the Adapt2Quit recommender-selected me... Read More
Gender:
ALL
Ages:
Between 18 years and 99 years
Trial Updated:
02/20/2024
Locations: University of Massachusetts Medical School, Worcester, Massachusetts
Conditions: Tobacco Smoking
Register for Updates
A Study of HMPL-306 in Advanced Hematological Malignancies With mIDH
NCT04764474
Recruiting
An open label single-arm clinical trial to evaluate the safety, tolerability, PK, PD, and preliminary efficacy of HMPL-306 in subjects with advanced relapsed, refractory, or resistant hematological malignancies that harbor IDH mutations.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
02/13/2024
Locations: University of Massachusetts Medical School, Worcester, Massachusetts
Conditions: Isocitrate Dehydrogenase Gene Mutation
Register for Updates
Comparative Effectiveness of CET vs. SST in SMI (Serious Mental Illness)
NCT04321759
Recruiting
To compare two evidence-based treatments, Cognitive Enhancement Therapy (CET) and Social Skills Training (SST) that have been shown in meta-analyses and in our own research to be effective to improve community functioning. The investigators will test the impact of CET and SST on community functioning, with special attention to their relative effectiveness for patients differing in baseline cognitive skills and age. The research uses a cluster design in which different mental health service cente... Read More
Gender:
ALL
Ages:
Between 18 years and 65 years
Trial Updated:
11/13/2023
Locations: UMass Medical School, Worcester, Massachusetts
Conditions: Schizophrenia and Related Disorders
Register for Updates
A Study to Evaluate the Safety, Tolerability, and Exploratory Efficacy of IMS001 in Subjects With Multiple Sclerosis
NCT04956744
Recruiting
This is a Phase 1 study of IMS001, given as a single dose to subjects with Multiple Sclerosis who experience inadequate response and/or intolerability to disease modifying treatments. IMS001 is a human embryonic cell derived (hESC) mesenchymal stem cell (MSC). MSCs have the potential to modulate disease course.
Gender:
ALL
Ages:
Between 18 years and 65 years
Trial Updated:
09/26/2023
Locations: UMass Memorial Medical Center, Worcester, Massachusetts
Conditions: Multiple Sclerosis
Register for Updates
A Study to Evaluate Administration of SBT101 Gene Therapy in Adult Patients With Adrenomyeloneuropathy (AMN)
NCT05394064
Recruiting
This is a Phase 1/2 randomized, blinded, dose-escalation study to evaluate the safety and efficacy of intrathecal (IT) administration of SBT101, a recombinant adeno-associated virus serotype 9 (AAV9) containing a functional copy of the human adenosine triphosphate (ATP)-binding cassette transporter subfamily D member 1 (ABCD1; hABCD1) gene, in adult patients with adrenomyeloneuropathy (AMN) aged 18-65 years. Patients will receive a single dose of SBT101 via IT route (or an imitation procedure)... Read More
Gender:
MALE
Ages:
Between 18 years and 65 years
Trial Updated:
09/11/2023
Locations: University of Massachusetts Chan Medical School, Worcester, Massachusetts
Conditions: AMN, AMN Gene Mutation, X-ALD
Register for Updates
Trauma-informed Approach to Timely Detection and Management of Early Postpartum Hypertension
NCT05884190
Recruiting
The investigators primary project goal is to improve clinical outcomes, including mental health outcomes, among postpartum at-risk women experiencing health disparities by increasing awareness, detection, and timely care of postpartum hypertension, mental health and cardiovascular complications. The investigators will accomplish this by comparing the effectiveness of two multi-component multi-level healthcare delivery models focused on early detection and control of postpartum hypertension and t... Read More
Gender:
FEMALE
Ages:
18 years and above
Trial Updated:
08/31/2023
Locations: University of Massachusetts Memorial Health, Worcester, Massachusetts
Conditions: Postpartum Hypertension
Register for Updates