Efficacy and Safety of Tozorakimab in Symptomatic Chronic Obstructive Pulmonary Disease With a History of Exacerbations
NCT05166889
Recruiting
The purpose of this Phase III study is to evaluate the efficacy and safety of tozorakimab Dose 1 and Dose 2 administered subcutaneously (SC) in adult participants with symptomatic COPD and history of ≥ 2 moderate or ≥ 1 severe exacerbation of COPD in the previous 12 months. Participants should be receiving optimised treatment with maintenance inhaled therapy (ICS/LABA/LAMA triple therapy, or dual therapy if triple is not considered appropriate) in stable doses throughout at least 3 months prior... Read More
Gender:
All
Ages:
Between 40 years and 130 years
Trial Updated:
11/08/2023
Locations: Research Site, Rochester, Minnesota
Conditions: Chronic Obstructive Pulmonary Disease (COPD)
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myAirvo 3 (High Flow Nasal Therapy; HFNT) for COPD Patients in the Home
NCT05204888
Recruiting
Parallel-group, prospective, randomized, controlled phase III trial of home High flow Nasal Therapy (HFNT) via myAirvo 3 plus usual COPD medical care vs. usual COPD medical care, for at least 1 year and up to two years in 642 GOLD Grade D, Stages II-IV patients with moderate to very severe COPD at risk for moderate and severe exacerbations with a prior history of severe exacerbation requiring hospitalization within the past 6 weeks.
Gender:
All
Ages:
30 years and above
Trial Updated:
08/15/2023
Locations: University of Minnesota, Minneapolis, Minnesota +1 locations
Conditions: COPD
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Collection of Blood From Healthy Patients, Patients With Benign Disease and Patients With Cancer
NCT05181826
Recruiting
To acquire blood samples from subjects for various purposes, including: i) determining the sensitivity and specificity of select DNA methylation markers for the detection of various types of cancer, ii) identifying benign conditions that may induce false positive or false negative results, and iii) defining the effects of potential interfering substances, such as chemotherapy drugs.
Gender:
All
Ages:
18 years and above
Trial Updated:
07/10/2023
Locations: Allina Health, Virginia Piper Cancer Institute, Coon Rapids, Minnesota +2 locations
Conditions: Cancer, Liver Cirrhosis, Chronic Hepatitis, Hepatitis B, Hepatitis C, Diabetes, COPD
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Increasing Adherence to Pulmonary Rehabilitation After COPD Related Hospitalizations (Study 2)
NCT04521608
Recruiting
This study is being done to test the comparative effectiveness of participating in a Pulmonary Rehabilitation Program at home using new technology and health coaching following dismissal from the hospital compared to the referral to a center based pulmonary rehabilitation that may include the choice of center based or telehealth.
Gender:
All
Ages:
40 years and above
Trial Updated:
06/29/2023
Locations: Mayo Clinic in Rochester, Rochester, Minnesota
Conditions: COPD Exacerbation
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A Home-based Module to Promote Mindful Breathing Awareness for COPD Patients
NCT04517500
Recruiting
The purpose of this study is to develop a mindful breathing module to an already effective and developed home based rehabilitation program for guiding COPD patients in a mindful breathing practice and further palliate breathlessness and anxiety.
Gender:
All
Ages:
40 years and above
Trial Updated:
05/22/2023
Locations: Minnesota HealthSolutions Corporporation, Minneapolis, Minnesota +1 locations
Conditions: COPD
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