The state of Minnesota currently has 11 active clinical trials seeking participants for COVID19 research studies. These trials are conducted in various cities, including Minneapolis, Rochester, Saint Paul and Duluth.
Diaphragmatic Breathing Exercises for Post-COVID-19 Diaphragmatic Dysfunction (DD)
Recruiting
Diaphragm is the principal muscle of inspiration. Diaphragmatic dysfunction is seen in many conditions including following intubation, lung disease, prolonged ventilation, neuromuscular disease, phrenic nerve injury. The possible mechanisms of diaphragmatic dysfunction in patients with COVID19 are critical illness myopathy, ventilator-induced diaphragm dysfunction, iatrogenic phrenic nerve injury particularly secondary to line placement, post-infectious inflammatory neuropathy of the phrenic ner... Read More
Gender:
All
Ages:
18 years and above
Trial Updated:
03/22/2024
Locations: University of Minnesota, Minneapolis, Minnesota
Conditions: Post-Acute Sequelae of COVID-19
Strategies and Treatments for Respiratory Infections &; Viral Emergencies (STRIVE): Shionogi Protease Inhibitor
Recruiting
Treatments are needed to improve outcomes among patients hospitalized for COVID-19, including direct-acting antiviral (DAA) agents to mitigate the pathology driven by ongoing viral replication. This trial will evaluate S-217622, an anti-SARS-CoV2 3C-like protease inhibitor (PI) developed by Shionogi &; Co. Ltd. The study design is a randomized, placebo-controlled, multi-center international clinical trial that will evaluate the clinical efficacy of S-217622 when given in addition to standard of... Read More
Gender:
All
Ages:
18 years and above
Trial Updated:
03/13/2024
Locations: Hennepin Healthcare Research Institute (Site 027-001), Minneapolis, Minnesota +3 locations
Conditions: COVID-19
Strategies and Treatments for Respiratory Infections &Amp; Viral Emergencies (STRIVE): Immune Modulation Strategy Trial
Recruiting
COVID-19 can trigger a dysregulated immune response, and previous studies have shown that immune modulation can improve outcomes in hospitalized patients. This trial is designed to determine whether intensification of immune modulation early in the course of the disease (while patients are on low flow oxygen) with abatacept (active arm) combined with standard of care (SOC) improves recovery as compared with placebo + SOC (placebo arm). For both groups, intensification of immunomodulation will be... Read More
Gender:
All
Ages:
18 years and above
Trial Updated:
03/08/2024
Locations: M Health Fairview University of Minnesota Medical Center (112-001), Minneapolis, Minnesota +1 locations
Conditions: COVID-19
A Study of Healthy Microbiome, Healthy Mind
Recruiting
Researchers are doing this study to find out if a high fermented food diet is tolerable, and if it will help improve quality of life after surviving a critical illness, including severe COVID-19, by promoting gut health recovery and decreasing gut inflammation.
Gender:
All
Ages:
18 years and above
Trial Updated:
02/26/2024
Locations: Mayo Clinic Minnesota, Rochester, Minnesota
Conditions: Critical Illness, COVID-19, PICS, Cognitive Impairment, Mental Health Impairment, Weakness, Muscle, Dysbiosis
ACTIV-6: COVID-19 Study of Repurposed Medications - Arm G (Metformin)
Recruiting
The purpose of this study is to evaluate the effectiveness of repurposed medications (study drug(s) in reducing symptoms of non-hospitalized participants with mild to moderate COVID-19. Participants will receive either study drug or placebo. Participants will self-report any new or worsening symptoms or medical events experienced while taking study drug or placebo. This study is intended to be all remote with no in person visits, unless the study team feels it is in the best interest of a partic... Read More
Gender:
All
Ages:
30 years and above
Trial Updated:
02/12/2024
Locations: Essentia Health, Duluth, Minnesota +1 locations
Conditions: Covid19
Long COVID Ultrasound Trial
Recruiting
The research objective is to assess the safety and potential efficacy of spleen ultrasound stimulation as an intervention for Long COVID in a pilot study. Specific Aims include: Measure Long COVID disease activity before, during and after an 8-week course of spleen-directed daily ultrasound stimulation. Measure molecular correlates of Long COVID disease activity before, during and after an 8-week course of spleen-directed daily ultrasound stimulation. Track adverse events throughout the study... Read More
Gender:
All
Ages:
Between 18 years and 65 years
Trial Updated:
01/04/2024
Locations: University of Minnesota - Phillips-Wangensteen Building, Minneapolis, Minnesota
Conditions: Long Covid
A Study of Post COVID-19 Mechanisms for Chronic Lung Sequelae
Recruiting
The purpose of this study is to understand why some people experience long term effects, such as shortness of breath and fatigue, after a severe COVID-19 infection
Gender:
All
Ages:
18 years and above
Trial Updated:
12/04/2023
Locations: Mayo Clinic Minnesota, Rochester, Minnesota
Conditions: COVID-19
Pharmacokinetics, Pharmacodynamics, and Safety Profile of Understudied Drugs Administered to Children Per Standard of Care (POPS)
Recruiting
The study investigators are interested in learning more about how drugs, that are given to children by their health care provider, act in the bodies of children and young adults in hopes to find the most safe and effective dose for children. The primary objective of this study is to evaluate the PK of understudied drugs currently being administered to children per SOC as prescribed by their treating provider.
Gender:
All
Ages:
Between 0 years and 20 years
Trial Updated:
09/21/2023
Locations: University of Minnesota, Minneapolis, Minnesota
Conditions: Coronavirus Infection (COVID-19), Pulmonary Arterial Hypertension, Urinary Tract Infections in Children, Hypertension, Pain, Hyperphosphatemia, Primary Hyperaldosteronism, Edema, Hypokalemia, Heart Failure, Menorrhagia, Insomnia, Pneumonia, Skin Infection, Arrythmia, Asthma in Children, Bronchopulmonary Dysplasia, Adrenal Insufficiency, Fibrinolysis; Hemorrhage, Hemophilia, Attention Deficit Hyperactivity Disorder, Multisystem Inflammatory Syndrome in Children (MIS-C), Kawasaki Disease, Coagulation Disorder, Down Syndrome
Phase III DAS181 Lower Tract PIV Infection in Immunocompromised Subjects (Substudy: DAS181 for COVID-19): RCT Study
Recruiting
This study will seek to enroll immunocompromised patients with Lower Tract parainfluenza infection. It also contains a sub-study to enroll patients with severe COVID-19.
Gender:
All
Ages:
All
Trial Updated:
07/19/2023
Locations: Mayo Clinic Rochester, Rochester, Minnesota
Conditions: Lower Respiratory Tract Infection, Parainfluenza, Immunocompromised, COVID-19
ARrest RESpiraTory Failure From PNEUMONIA
Recruiting
This research study seeks to establish the effectiveness of a combination of an inhaled corticosteroid and a beta agonist compared to placebo for the prevention of acute respiratory failure (ARF) in hospitalized patients with pneumonia and hypoxemia.
Gender:
All
Ages:
18 years and above
Trial Updated:
06/26/2023
Locations: Mayo Clinic - Rochester, Rochester, Minnesota
Conditions: Pneumonia, Hypoxemia, Acute Respiratory Failure, COVID-19 Pneumonia
Vagal Nerve Stimulation for Post COVID Fatigue
Recruiting
The purpose of this study is to evaluate the impact of vagal nerve stimulation on patients with post COVID syndrome who have fatigue and headache.
Gender:
All
Ages:
18 years and above
Trial Updated:
02/13/2023
Locations: Mayo Clinic in Rochester, Rochester, Minnesota
Conditions: Post COVID Syndrome, Fatigue, Headache