The state of Minnesota currently has 27 active clinical trials seeking participants for Hypertension research studies. These trials are conducted in various cities, including Minneapolis, Rochester, Saint Paul and Duluth.
BradycArdia paCemaKer With AV Interval Modulation for Blood prEssure treAtmenT
Recruiting
A prospective, multinational, randomized, double-blind, clinical trial evaluating the safety and effectiveness of a novel atrioventricular interval modulation (AVIM) algorithm downloaded into a dual-chamber Medtronic Astra/Azure pacemaker.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
05/22/2025
Locations: Mayo Clinic, Rochester, Minnesota
Conditions: Hypertension, Hypertension, Systolic, Hypertension, Essential
A Study to Identify an Optimal Dose of QCZ484 in Mild to Moderate Hypertensive Patients
Recruiting
The purpose of this study is to evaluate the efficacy, safety and tolerability of QCZ484 or placebo, given subcutaneously, every 6 months, at different dose levels in patients with mild to moderate hypertension
Gender:
ALL
Ages:
Between 18 years and 75 years
Trial Updated:
05/20/2025
Locations: Synexus Clinical Research US Inc, Richfield, Minnesota
Conditions: Hypertension
SPYRAL AFFIRM Global Study of RDN With the Symplicity Spyral RDN System in Subjects With Uncontrolled HTN
Recruiting
The purpose of this single-arm interventional study is to evaluate the long-term safety, efficacy, and durability of the Symplicity Spyral system in subjects treated with renal denervation. Additionally, long-term follow-up data will also be collected from eligible subjects previously treated in the SPYRAL PIVOTAL-SPYRAL HTN-OFF MED and SPYRAL HTN-ON MED studies.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
05/19/2025
Locations: Metropolitan Heart and Vascular Institute (MHVI), Coon Rapids, Minnesota +1 locations
Conditions: Hypertension, Vascular Diseases, Cardiovascular Diseases, Chronic Kidney Diseases, Diabetes Mellitus
HTN App for HTN Control and Cardiovascular Health Among African-Americans
Recruiting
The purpose of this study is to test the hypertension (HTN) app-based intervention to see if it is more effective in improving uncontrolled HTN and HTN self-care among Africian-Americans from baseline to post-intervention (immediate, 3 months and 6 months post-intervention) as compared to the standard of care.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
05/19/2025
Locations: Mayo Clinic, Rochester, Minnesota
Conditions: Hypertension
Frespaciguat INSIGNIA-PH-COPD: A Study of the Efficacy and Safety of Frespaciguat (an Inhaled sGC Stimulator) in Adults With PH-COPD
Recruiting
Researchers are looking for ways to treat pulmonary hypertension (PH) caused by chronic obstructive pulmonary disease (COPD). The goal of the study is to learn if people who take frespaciguat can walk farther in 6 minutes at Week 24 compared to people who take placebo.
Gender:
ALL
Ages:
Between 40 years and 85 years
Trial Updated:
05/09/2025
Locations: Mayo Clinic in Rochester, Minnesota ( Site 0131), Rochester, Minnesota
Conditions: Pulmonary Hypertension, Chronic Obstructive Pulmonary Disease
Aqueous Humor Dynamic Components That Determine Intraocular Pressure Variance
Recruiting
Glaucoma is a major cause of blindness. The inability to predict a patient's IOP response to medications is a critical barrier for the clinician to consistently provide highly effective IOP-based treatments. Current trial-and-error approaches to glaucoma management are inefficient and have not addressed this barrier as there are no predictive factors for drug response. Our long-term goal is to improve outcomes by identifying biomarkers and environmental factors that profile a patient at risk for... Read More
Gender:
ALL
Ages:
30 years and above
Trial Updated:
05/01/2025
Locations: Mayo Clinic, Rochester, Minnesota
Conditions: Glaucoma, OHT - Ocular Hypertension
Melatonin Effects on Cardiovascular Disease Mechanisms in the Menopause Transition: A Randomized Clinical Trial
Recruiting
The purpose of this research is to study the effects of 12 weeks of melatonin supplementation compared to placebo in women who are in the menopause transition (perimenopause) and have high blood pressure.
Gender:
FEMALE
Ages:
Between 40 years and 55 years
Trial Updated:
04/21/2025
Locations: Mayo Clinic in Rochester, Rochester, Minnesota
Conditions: Perimenopause, Hypertension
A Study Evaluating the Efficacy and Safety of Ralinepag to Improve Treatment Outcomes in PAH Patients
Recruiting
Study ROR-PH-301, ADVANCE OUTCOMES, is designed to assess the efficacy and safety of ralinepag when added to pulmonary arterial hypertension (PAH) standard of care or PAH-specific background therapy in subjects with World Health Organization (WHO) Group 1 PAH.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
04/17/2025
Locations: Mayo Clinic, Rochester, Minnesota
Conditions: PAH, Pulmonary Hypertension, Pulmonary Arterial Hypertension, Hypertension, Connective Tissue Diseases, Familial Primary Pulmonary Hypertension, Vascular Diseases, Cardiovascular Diseases, Hypertension, Pulmonary, Lung Diseases, Respiratory Tract Disease
A Study of Pulmonary Hypertension Peripheral Limitations
Recruiting
The investigators are doing this research study to compare whole body aerobic training with isolated leg training (with weights) and its impact on effectiveness in symptoms and quality of life in patients with Pulmonary Arterial Hypertension (PAH).
Gender:
ALL
Ages:
18 years and above
Trial Updated:
03/31/2025
Locations: Mayo Clinic in Rochester, Rochester, Minnesota
Conditions: Pulmonary Arterial Hypertension, Healthy
Evaluating Raised Intracranial Pressure Using MR Elastography
Recruiting
Investigators will compare magnetic resonance (MR) elastography measurements to other forms of noninvasive methods of detecting raised intracranial pressure, including optical coherence tomography (OCT) imaging measurements of the retinal nerve fiber layer (RNFL) and indirect signs of raised intracranial pressure on magnetic resonance imaging (MRI).
Gender:
ALL
Ages:
18 years and above
Trial Updated:
03/26/2025
Locations: Mayo Clinic in Rochester, Rochester, Minnesota
Conditions: Idiopathic Intracranial Hypertension
Early Feasibility Study of "HyperQureTM RDN System", Laparoscopic Renal Denervation Therapy, in Patients With Resistant Hypertension
Recruiting
HQ-HTN-G01 is a prospective, multicenter, single arm, open label, early feasibility study to evaluate initial safety and device design concept of "HyperQureTM RDN System", laparoscopic renal denervation therapy, in patients with resistant hypertension on three(3) or more antihypertensive medications
Gender:
ALL
Ages:
Between 22 years and 80 years
Trial Updated:
03/25/2025
Locations: Mayo Clinic, Rochester, Minnesota
Conditions: Resistant Hypertension
Autonomic Regulation of Blood Pressure in Premature and Early Menopausal Women
Recruiting
This is a cross-sectional study in which the investigators will determine the impact of premature/early menopause on MSNA, BP and baroreflex sensitivity in younger (≤49 yr old) and older (≥50 yr old) women. Specifically, aim one will determine mechanisms driving autonomic dysregulation of BP in premature and early menopausal women and aim two will determine mechanisms driving autonomic dysregulation of BP in older menopausal women. The study design outlined below will permit testing of aim one a... Read More
Gender:
FEMALE
Ages:
Between 35 years and 70 years
Trial Updated:
03/21/2025
Locations: University of Minnesota, Minneapolis, Minnesota
Conditions: Hypertension, Menopause, Premature, Menopause, Blood Pressure