The city of Minneapolis, Minnesota, currently has 16 active clinical trials seeking participants for Parkinson's Disease research studies.
Udall Project 1 Aim 4
Recruiting
By defining the strength and direction of connectivity patterns at rest and during movement across the basal ganglia-thalamocortical (BGTC) network we will characterize the role of individual circuits in motor performance and cognitive function, paving the way for future development of optimization algorithms for DBS that take advantage of this understanding.
Gender:
ALL
Ages:
21 years and above
Trial Updated:
04/15/2025
Locations: University Of Minnesota, Minneapolis, Minnesota
Conditions: Parkinsons Disease, Deep Brain Stimulation
Aim 3 Particle Swarm Optimization PIGD
Recruiting
In Parkinson's disease (PD) patients undergoing standard-of-care Deep Brain Stimulation (DBS) therapy, to compare the effect on Parkinson's symptoms of two different neurostimulator settings designed to differ from each other as much as possible with respect to how much they activate two different neuroanatomical structures: the axonal pathway from Globus Pallidus (GP) to Pedunculopontine Nucleus (PPN), and the axonal pathway from PPN to GP.
Gender:
ALL
Ages:
Between 18 years and 85 years
Trial Updated:
04/15/2025
Locations: University of Minnesota, Minneapolis, Minnesota
Conditions: Parkinson's Disease and Parkinsonism
Vestibular and Cortical Contributions to Transitions in Freezing of Gait in Parkinson's Disease
Recruiting
Currently, there is a lack of comprehensive knowledge about the role of vestibulospinal drive and cortical activity during self-initiated movement transitions in older adults and people with PD (both with and without FOG). This set of experiments has two primary purposes: to (1) understand the pathological neurophysiology underlying freezing of gait (FOG) during movement transitions and FOG-inducing movements and (2) identify neurological biomarkers associated with FOG and FOG-inducing movements... Read More
Gender:
ALL
Ages:
Between 21 years and 80 years
Trial Updated:
03/28/2025
Locations: University of Minnesota, Movement Disorders Lab, Minneapolis, Minnesota
Conditions: Parkinson Disease
Udall Project 2 Aim 2A&C
Recruiting
This protocol will leverage the novel (on-label, FDA-approved) local field potential measuring capability of the Medtronic Percept™ PC DBS system to study the effects of globus pallidus internus and globus pallidus externus (GPi, GPe) DBS on: the wash-out and wash-in dynamics of motor behavior and local field potentials (LFPs) and correlations between fluctuations in gait and LFPs during activities of daily living (recorded over 4 weeks). These experiments will elucidate the relationships betwee... Read More
Gender:
ALL
Ages:
All
Trial Updated:
03/21/2025
Locations: University of Minnesota, Minneapolis, Minnesota
Conditions: Parkinson Disease
Sleep-specific DBS Therapy in Parkinson's Disease
Recruiting
Sleep-wake disturbances are a major factor associated with reduced quality of life of individuals with Parkinson's disease (PD), a progressive neurological disorder affecting millions of people in the U.S and worldwide. The brain mechanisms underlying these sleep disorders, and the effects of therapeutic interventions such as deep brain stimulation on sleep-related neuronal activity and sleep behavior, are not well understood. Results from this study will provide a better understanding of the br... Read More
Gender:
ALL
Ages:
21 years and above
Trial Updated:
02/13/2025
Locations: University Of Minnesota, Minneapolis, Minnesota
Conditions: Deep Brain Stimulation, Parkinson's Disease and Parkinsonism, Dystonia
Circuit-Based Deep Brain Stimulation for Parkinson's Disease P1A2&3 Catalyst
Recruiting
This study will help us better understand how the brain works in people with Parkinson's disease (PD). PD is a brain disease that gets worse over time, and affects over 10 million people world-wide. A common treatment for PD is Deep Brain Stimulation (DBS). To improve DBS therapy for PD, we need a deeper understanding of how the different parts of the brain work together in PD, and how this relates to movement and thinking problems that people with PD experience. We may be able to use the resul... Read More
Gender:
FEMALE
Ages:
21 years and above
Trial Updated:
01/22/2025
Locations: University Of Minnesota, Minneapolis, Minnesota
Conditions: Parkinson Disease
Characterizing the Pathophysiological Role of the Pallido-thalamocortical Motor Pathway in Parkinson's Disease.
Recruiting
When a patient gets DBS surgery, the neurosurgeon makes a hole in the skull through which they can put the DBS lead down in deep parts of the brain that help control movement. For this study, research participants will also have an ECoG strip put through the same hole (no extra holes are being made for research purposes). The ECoG strip is a little less than half an inch wide, and a little more than 2.5 inches long. It is very, very thin; it is a thin plastic film with flat metal sensors that ca... Read More
Gender:
ALL
Ages:
Between 21 years and 75 years
Trial Updated:
01/14/2025
Locations: University of Minnesota, Minneapolis, Minnesota
Conditions: Parkinson Disease
Effects of Pallidal Deep Brain Stimulation Location on Motor Impairment in Parkinson's Disease
Recruiting
This protocol will characterize the effects of deep brain stimulation (DBS) location (both adverse and beneficial) on motor signs in people with Parkinson's disease (PD). This information can be used to inform future DBS protocols to tailor stimulation to the specific needs of a patient. If targeted dorsal GP stimulation is shown to significantly improve motor features that are typically resistant to dopamine replacement therapy, these experiments will likely have major impact on clinical practi... Read More
Gender:
ALL
Ages:
Between 21 years and 89 years
Trial Updated:
12/11/2024
Locations: University Of Minnesota, Minneapolis, Minnesota
Conditions: Parkinson's Disease
Kinematic and Neural Dynamics of Postural Instability in Parkinson's Disease
Recruiting
Balance problems and falls are among the most common complaints in Veterans with Parkinson's Disease (PD), but there are no effective treatments and the ability to measure balance and falls remains quite poor. This study uses wearable sensors to measure balance and uses deep brain stimulation electrodes to measure electric signals from the brain in Veterans with PD. The investigators hope to use this data to better understand the brain pathways underlying balance problems in PD so that new treat... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
11/15/2024
Locations: Minneapolis VA Health Care System, Minneapolis, MN, Minneapolis, Minnesota
Conditions: Parkinson's Disease
Study in Parkinson Disease of Exercise
Recruiting
This study is a Phase 3 multi-site, randomized, evaluator-masked, study of endurance treadmill exercise on changes in the Movement Disorder Society-Unified Parkinson Disease Rating Scale (MDS-UPDRS) Part III score at 12 months among persons with early stage Parkinson disease. 370 participants will be randomly assigned to 2 groups: 1)60-65% HRmax or 2)80-85% HRmax 4 times per week. The primary objective is to test whether the progression of the signs of Parkinson's disease is attenuated at 12 mon... Read More
Gender:
ALL
Ages:
Between 40 years and 80 years
Trial Updated:
11/12/2024
Locations: University of Minnesota, Minneapolis, Minnesota
Conditions: Parkinson Disease
North American Prodromal Synucleinopathy Consortium Stage 2
Recruiting
This study will enroll participants with idiopathic REM sleep behavior disorder (RBD) and healthy controls for the purpose of preparing for a clinical trial of neuroprotective treatments against synucleinopathies.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
11/04/2024
Locations: University of Minnesota, Minneapolis, Minnesota
Conditions: REM Sleep Behavior Disorder, Parkinson Disease, Lewy Body Dementia, Dementia With Lewy Bodies, Multiple System Atrophy, REM Sleep Parasomnias
Neuroplasticity in Parkinson's Disease
Recruiting
The purpose of this project is to increase our understanding of the early state and temporal evolution of neuroplastic changes in the cortex and subthalamic nucleus (STN) of people with PD, and the relationship of these changes to the emergence and expression of PD motor and non-motor signs. Neurophysiological biomarkers derived from this work may be important for the early detection and prediction of progression of disease. They can also provide the means to assess the efficacy of interventions... Read More
Gender:
ALL
Ages:
Between 21 years and 75 years
Trial Updated:
10/29/2024
Locations: University of Minnesota, Minneapolis, Minnesota
Conditions: Parkinson, Parkinson Disease