The city of Rochester, Minnesota, currently has 5 active clinical trials seeking participants for Depression research studies.
Treatment ResistAnt Depression Subcallosal CingulatE Network DBS (TRANSCEND)
Recruiting
The goal of this clinical trial is to evaluate the effectiveness and safety of bilateral stimulation of the subcallosal cingulate white matter (SCCwm) using Deep Brain Stimulation (DBS) as an adjunctive treatment of non-psychotic unipolar Major Depressive Disorder (MDD) in adults.
Gender:
ALL
Ages:
Between 22 years and 70 years
Trial Updated:
03/26/2025
Locations: Mayo Clinic, Rochester, Minnesota
Conditions: Treatment Resistant Depression
Transcranial Direct Current Stimulation (tDCS) as an Adjunctive Treatment for Treatment Resistant Depression (TRD)
Recruiting
The researchers are trying to test the feasibility and acceptability of using transcranial Direct Current Stimulation (tDCS) in hospitalized adult patients with Treatment Resistant Depression (TRD), assess for any preliminary effect on depressive and cognitive symptoms, and explore the utility of biomarkers to assess response to tDCS.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
03/22/2025
Locations: Mayo Clinic in Rochester, Rochester, Minnesota
Conditions: Treatment Resistant Depression
Effect of Vagal Nerve Stimulation on Gastric Motor Functions
Recruiting
The specific aim of this study is to compare simultaneous assessment of gastric emptying and gastric accommodation in response to the same caloric meal before and three months after activation of left cervical VNS. Our hypothesis is that cervical VNS increases gastric accommodation and accelerates gastric emptying.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
03/14/2025
Locations: Mayo Clinic in Rochester, Rochester, Minnesota
Conditions: Epilepsy, Depression
8 Week Multi-site Study of MYDAYIS® for Bipolar Depression
Recruiting
This protocol is a Phase 2 multi-site study which aims to evaluate the safety and effectiveness of MYDAYIS\® as adjunctive therapy for adults with bipolar depression. Results from this study WILL NOT be used to contribute to an approval of MYDAYIS \® for this indication.
Gender:
ALL
Ages:
Between 18 years and 55 years
Trial Updated:
03/12/2025
Locations: Mayo Clinic in Rochester, Rochester, Minnesota
Conditions: Bipolar Depression
Intravenous Ketamine for Treatment-Resistant Depression
Recruiting
The purpose of this study is to to evaluate the relationships between peak (% change from baseline) central GABA and Glu levels during a 40-min IV ketamine or normal saline infusion utilizing fMRS, and change in peripheral GABA and Glu levels from baseline to 24-hr postinfusion utilizing LCMS, with baseline to 24-hr post-infusion change in depression (MADRS) in 30 TRD adults.
Gender:
ALL
Ages:
Between 18 years and 65 years
Trial Updated:
03/06/2025
Locations: Mayo Clinic in Rochester, Rochester, Minnesota
Conditions: Depressive Disorder, Treatment-Resistant, Treatment Resistant Depression (TRD)