The city of Columbia, Missouri, currently has 4 active clinical trials seeking participants for Healthy research studies.
Short Term Sirolimus Treatment and MRI of the Brain
Recruiting
Alzheimer's disease is a devastating neurodegenerative disease characterized by accumulation of clumps (also called plaques) and bundles of fibers (also called tangles) in the brain, for which there is currently no cure. Sirolimus is an FDA-approved medication which may improve the blood flow to the brain. This study is designed to see if sirolimus treatment improves MRI blood flow to the brain in individuals with and without a genetic predisposition to Alzheimer's disease.
Gender:
All
Ages:
Between 45 years and 65 years
Trial Updated:
03/12/2024
Locations: University of Missouri-Columbia, Columbia, Missouri
Conditions: Genetic Predisposition to Disease, Healthy Volunteers
Impact of Intranasal Insulin on Sympathetic Activity and Cerebral Vasodilation
Recruiting
The purpose of this project is to examine the impact of increases in brain insulin on sympathetic nervous system activity, as well as peripheral and cerebral blood flow in humans.
Gender:
All
Ages:
Between 18 years and 45 years
Trial Updated:
02/21/2024
Locations: University of Missouri, Columbia, Missouri
Conditions: Healthy, Vasodilation, Insulin Resistance, Autonomic Dysfunction, Obesity
Sex Disparities in Hypoxic Vasodilation and Impact of Obesity
Recruiting
The purpose of this project is to examine key mechanisms contributing to sex-differences in hypoxic vasodilation and the impact of obesity, with particular emphasis on the sympathetic nervous system.
Gender:
All
Ages:
Between 18 years and 45 years
Trial Updated:
02/15/2024
Locations: University of Missouri, Columbia, Missouri
Conditions: Obesity, Vasodilation, Healthy
Sex Disparities in Hypoxic Sympatholysis and Impact of Obesity
Recruiting
Patients with sleep apnea are at increased risk of developing cardiovascular disease - with women at potentially greater risk than men. Contributing mechanisms are not well understood, but may be related to how women respond to low oxygen and, given over 70% of patients with sleep apnea are obese, the impact of obesity. This project seeks to increase our understanding of mechanisms that may contribute to sex differences in the cardiovascular response to low oxygen with the hope that this knowled... Read More
Gender:
All
Ages:
Between 18 years and 45 years
Trial Updated:
04/03/2023
Locations: University of Missouri-Columbia, Columbia, Missouri
Conditions: Obesity, Healthy, Vasoconstriction, Vasodilation