There are currently 13 active clinical trials seeking participants for Acute Respiratory Distress Syndrome research studies. The states with the highest number of trials for Acute Respiratory Distress Syndrome participants are California, Massachusetts, New York and Ohio.
Cardiovascular Magnetic Resonance Prognosticators in Pediatric Oncology Patients With Sepsis
NCT05930418
Recruiting
The overall purpose of this protocol is to identify subacute sepsis-associated cardiac disease in pediatric patients with cancer by CMR and evaluate the CMR findings during their follow-up. This will help inform heart failure management decision making. Evidence of dysfunction or elevated T2 values may inform adjustment of afterload reduction and beta blocker administration, and elevated ECV findings will suggest the need for increased surveillance for diastolic dysfunction. Primary Objectives:... Read More
Gender:
ALL
Ages:
Between 9 years and 25 years
Trial Updated:
02/10/2025
Locations: St. Jude Children's Research Hospital, Memphis, Tennessee
Conditions: Acute Respiratory Distress Syndrome, Sepsis, Cardiovascular Shock
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Rhu-pGSN for Acute Respiratory Distress Syndrome (ARDS)
NCT05947955
Recruiting
BTI-203 is a randomized, double-blind, placebo-controlled, multicenter, Phase 2 proof-of-concept (POC) study to evaluate the efficacy and safety of rhu-pGSN plus standard of care (SOC) in subjects with moderate-to-severe ARDS (P/F ratio ≤150) due to pneumonia or other infections. Potential subjects hospitalized with pneumonia or other infections are to be screened within 24 hours of diagnosis of ARDS.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
01/10/2025
Locations: University of California Irvine Medical Center, Irvine, California +16 locations
Conditions: Acute Respiratory Distress Syndrome, Infections
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ARDS in Children and ECMO Initiation Strategies Impact on Neurodevelopment (ASCEND)
NCT05388708
Recruiting
ASCEND researchers are partnering with families of children who receive extracorporeal membrane oxygenation (ECMO) after a sudden failure of breathing named pediatric acute respiratory distress syndrome (PARDS). ECMO is a life support technology that uses an artificial lung outside of the body to do the lung's work. ASCEND has two objectives. The first objective is to learn more about children's abilities and quality of life among ECMO-supported children in the year after they leave the pediatr... Read More
Gender:
ALL
Ages:
Between 14 days and 20 years
Trial Updated:
12/11/2024
Locations: Children's of Alabama, Birmingham, Alabama +98 locations
Conditions: Acute Respiratory Distress Syndrome, Extracorporeal Membrane Oxygenation
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Extracellular Vesicle Treatment for Acute Respiratory Distress Syndrome (ARDS) (EXTINGUISH ARDS)
NCT05354141
Recruiting
To evaluate the safety and efficacy of intravenous (IV) administration of bone marrow mesenchymal stem cell derived extracellular vesicles (EVs), ExoFlo, versus placebo for the treatment of hospitalized patients with moderate-to-severe Acute Respiratory Distress Syndrome (ARDS).
Gender:
ALL
Ages:
Between 18 years and 75 years
Trial Updated:
11/21/2024
Locations: Direct Biologics Investigational Site, Birmingham, Alabama +37 locations
Conditions: Acute Respiratory Distress Syndrome, ARDS
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Dead Space and Inhaled Nitric Oxide in Pediatric Acute Respiratory Distress Syndrome
NCT06690801
Recruiting
The goal of this observational study is to determine whether a marker of dead space (the end-tidal to alveolar dead space fraction \[AVDSf\]) is more strongly associated with mortality risk than markers of oxygenation abnormality (oxygenation index) and to determine whether dead space (AVDSf) is an important marker of heterogeneity in the inhaled nitric oxide (iNO) treatment effect for children with acute respiratory distress syndrome (ARDS). The study aims are: 1. To validate AVDSf for risk s... Read More
Gender:
ALL
Ages:
Between 0 years and 21 years
Trial Updated:
11/13/2024
Locations: Children's Hospital Los Angeles, Los Angeles, California +9 locations
Conditions: Acute Respiratory Distress Syndrome
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Non-invasive Vagal Neurostimulation (nVNS) for Traumatic Brain Injury (TBI)-Induced Acute Respiratory Distress
NCT04935697
Recruiting
This is a prospective, randomized, two-arm, controlled 30-day investigational pilot trial using the gammaCore Sapphire S non-invasive vagus nerve stimulation (nVNS) device + standard of care (SOC) in newly-hospitalized patients with mild-to-moderate traumatic brain injury (TBI) to prevent the progression towards immunokine storms, systemic inflammatory response syndrome (SIRS), severe respiratory distress, and requirement for invasive mechanical ventilation, and death, when compared to SOC alone... Read More
Gender:
ALL
Ages:
Between 12 years and 80 years
Trial Updated:
07/01/2024
Locations: AHN Allegheny General Hospital, Pittsburgh, Pennsylvania
Conditions: Acute Respiratory Distress Syndrome, Acute Lung Injury, Acute Lung Injury/Acute Respiratory Distress Syndrome (ARDS), Traumatic Brain Injury
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Precision Ventilation vs Standard Care for Acute Respiratory Distress Syndrome
NCT06066502
Recruiting
The goal of this interventional study is to compare standard mechanical ventilation to a lung-stress oriented ventilation strategy in patients with Acute Respiratory Distress Syndrome (ARDS). Participants will be ventilated according to one of two different strategies. The main question the study hopes to answer is whether the personalized ventilation strategy helps improve survival.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
07/01/2024
Locations: Beth Israel Deaconess Medical Center, Boston, Massachusetts +1 locations
Conditions: Acute Respiratory Distress Syndrome, Respiratory Failure
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Vascular ARDS Recruitment After Inhaled Nitric Oxide
NCT05801224
Recruiting
Acute respiratory distress syndrome (ARDS) is when a person's lungs become inflamed, which can be caused by infection, trauma, surgery, blood transfusion, or burn. ARDS often leads to a situation where the person cannot breathe independently and needs machines' help. Once the lungs are inflamed, the small air sacs responsible for exchanging gases (i.e., ventilation) and the blood flow in the lungs (i.e., perfusion) can be affected. In the past, most research focused on studying ventilation physi... Read More
Gender:
All
Ages:
Between 18 years and 80 years
Trial Updated:
03/26/2024
Locations: Massachusetts General Hospital, Boston, Massachusetts
Conditions: Acute Respiratory Distress Syndrome, Ventilation Perfusion Mismatch
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The Effects of Music Therapy on Adult Patients Requiring Mechanical Ventilation in the ICU
NCT03642002
Recruiting
While most studies in the medical literature that indicate "music" as an intervention may recognize its impact and capacity to decrease pain perception, anxiety, and/or its role in the regulation of cardiac and respiratory function in ICU patients, no identifiable studies have implemented entrained live music therapy protocols into clinical trials. Music therapy treatment is a non-pharmacological intervention that is individually tailored to the patient's needs and focuses on the assessment and... Read More
Gender:
All
Ages:
18 years and above
Trial Updated:
03/22/2024
Locations: Mount Sinai West, New York, New York +1 locations
Conditions: Acute Respiratory Distress Syndrome, Acute Hypoxemic Respiratory Failure, Acute Hypercapnic Respiratory Failure
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Macrophage Programing in Acute Lung Injury: MiniBAL
NCT05767671
Recruiting
The goal of this observational clinical trial is to learn about the role white blood cells (macrophages) play in lung inflammation in people with Acute Respiratory Distress Syndrome (ARDS). The main questions it aims to answer are: How does the immune system respond to different kinds of lung injury and inflammation and how do those processes differ from each other? What roles do the cells that live in the lungs (macrophages) play in turning off inflammation? How does their role differ from oth... Read More
Gender:
All
Ages:
Between 18 years and 80 years
Trial Updated:
01/30/2024
Locations: Intermountain Health - St. Joseph's Hospital - National Jewish Health, Denver, Colorado
Conditions: Acute Respiratory Distress Syndrome, Ventilator Associated Pneumonia
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Phase 2a Multiple Ascending Dose Study in Hospitalized Patients With Pneumonia.
NCT05123755
Recruiting
A Phase 2a, randomized, double-blind, placebo-controlled, multiple ascending dose study in patients who are hospitalized with presumed pneumonia requiring supplemental oxygen therapy. The purpose of this study is to examine the safety, tolerability and efficacy of AV-001 Injection administration daily to the earlier of day 28 or EOT (day prior to hospital discharge). A total of 120 eligible patients (20 patients in each of cohort 1, 2 and 3 and 60 patients in cohort 4) will be recruited from up... Read More
Gender:
All
Ages:
18 years and above
Trial Updated:
09/27/2023
Locations: Hoag Memorial Hospital Presbyterian, Newport Beach, California +6 locations
Conditions: Acute Respiratory Distress Syndrome, COVID-19 Acute Respiratory Distress Syndrome, Viral or Bacterial Infections, Pneumonia, Pneumonia, Viral, Respiratory Infection
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Clinical Decision Support for Mechanical Ventilation of Patients With ARDS
NCT03984175
Recruiting
Perform a pilot study of quality improvement interventions for critical care physicians (intensivists) and respiratory therapists (RTs) to improve application of low tidal volume mechanical ventilation (LTVV) for patients with the acute respiratory distress syndrome (ARDS) using the computerized mechanical ventilation protocols currently available in the investigator's Cerner electronic health record (EHR).
Gender:
All
Ages:
18 years and above
Trial Updated:
08/01/2022
Locations: Intermountain Medical Center, Murray, Utah
Conditions: Acute Respiratory Distress Syndrome
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