Mantle Cell Lymphoma Clinical Trials

A listing of 50 Mantle Cell Lymphoma clinical trials actively recruiting volunteers for paid trials and research studies in various therapeutic areas.

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There are currently 50 active clinical trials seeking participants for Mantle Cell Lymphoma research studies. The states with the highest number of trials for Mantle Cell Lymphoma participants are Illinois, New York, California and Washington.

Featured Trial

Paid Clinical Studies Nationwide

Recruiting

Nationwide clinical trials offered in your area. Some trials offering up to several thousand dollars in compensation for participation.

Conditions:

Healthy

Healthy Volunteer Study

Learn More

* Compensation for time may be available

Featured Trial

Chronic Cough Study

Recruiting

Are you tired of living with chronic cough? The ASPIRE Study is now looking to enroll people from all backgrounds to help research potential new treatment options for chronic cough. You are under no obligation to take part and health insurance is not required. Find out more today! We’d love to hear from you.

Conditions:

Chronic Cough

Refractory or Unexplained Chronic Cough

Cough

Asthma

Allergic Asthma

Learn More

Featured Trial

Studying an Investigational Virus Vaccine

Recruiting

The main objectives of this study are to assess the safety and effectiveness of an investigational vaccine aimed at preventing norovirus, commonly known as the stomach flu. Participants will be randomly assigned to receive either the investigational vaccine or a placebo. Should you express interest, you will be contacted directly by the research site, which will provide further details and answer any questions you may have about study requirements, risks/benefits, and any compensation.

Conditions:

Healthy

Interested in vaccine studies

All Conditions

Preventative Trials

Learn More

Featured Trial

Type 2 Diabetes Clinical Trial

Recruiting

Can changing your breakfast improve your type 2 diabetes? If you have an HbA1C of 7.0% or higher, you are invited to participate in an online study at the University of Michigan.

Conditions:

Type 2 Diabetes

Diabetes Mellitus Type 2 in Obese

Diabetes Type Two

Type 2 Diabetes Mellitus

Diabete Type 2

Learn More

A Study to Investigate the Efficacy and Safety of Sonrotoclax Plus Zanubrutinib Compared With Placebo Plus Zanubrutinib in Adults With Relapsed/Refractory Mantle Cell Lymphoma

NCT06742996

Recruiting

The goal of this study is to compare how well sonrotoclax plus zanubrutinib works versus zanubrutinib plus placebo in treating adults with relapsed/refractory (R/R) mantle cell lymphoma (MCL). This study will also look at the safety of sonrotoclax plus zanubrutinib versus zanubrutinib plus placebo.

Gender:

ALL

Ages:

18 years and above

Trial Updated:

04/17/2025

Locations: University of Alabama At Birmingham Hospital, Birmingham, Alabama +144 locations

University of Alabama At Birmingham Hospital, Birmingham, Alabama

Mayo Clinic Phoenix, Phoenix, Arizona

Yale University, Yale Cancer Center, New Haven, Connecticut

Memorial Cancer Institute, Memorial Healthcare System, Pembroke Pines, Florida

Cleveland Clinic Florida, Weston, Florida

Rush University Medical Center, Chicago, Illinois

Fort Wayne Medical Oncology and Hematology, Fort Wayne, Indiana

Mission Cancer and Blood, Waukee, Iowa

University of Maryland Greenebaum Comprehensive Cancer Center, Baltimore, Maryland

Dana Farber Cancer Institute Longwood Medical Center, Boston, Massachusetts

University of Michigan, Ann Arbor, Michigan

The Cancer and Hematology Centers, Grand Rapids, Michigan

Mayo Clinic Rochester, Rochester, Minnesota

Hattiesburg Hematology and Oncology Clinic, Hattiesburg, Mississippi

Washington University School of Medicine, Saint Louis, Missouri

The Valley Hospital, Inc, Paramus, New Jersey

Atrium Health Levine Cancer Institute (Lci), Charlotte, North Carolina

Duke University, Durham, North Carolina

University Hospitals, Cleveland, Ohio

Cleveland Clinic Foundation, Cleveland, Ohio

Ohio State University Comprehensive Cancer Center, Columbus, Ohio

Ohio Health Research Institute, Columbus, Ohio

Penn State Milton S Hershey Medical Center, Hershey, Pennsylvania

McGlinn Cancer Institute, West Reading, Pennsylvania

Tennessee Oncology, Nashville, Tennessee

Md Anderson Cancer Center, Houston, Texas

Texas Oncology Austin Midtown, Round Rock, Texas

University of Virginia, Charlottesville, Virginia

Virgina Cancer Specialists, Gainesville, Virginia

Vcu Massey Cancer Center, Richmond, Virginia

Northwest Cancer Specialist, Pc(Us Oncology Research), Vancouver, Washington

Hospital Aleman, Caba, Not set

FUNDALEU, Caba, Not set

Hospital Italiano de Buenos Aires, Ciudad Autonoma Buenos Aires, Not set

Hospital Universitario de Cordoba, Cordoba, Not set

Concord Repatriation General Hospital, Concord, New South Wales

Genesiscare North Shore, St Leonards, New South Wales

Westmead Hospital, Westmead, New South Wales

Sunshine Coast Hospital and Health Service, Birtinya, Queensland

Box Hill Hospital, Box Hill, Victoria

Monash Health, Clayton, Victoria

Rockingham Hospital, Cooloongup, Western Australia

Linear Clinical Research, Nedlands, Western Australia

One Clinical Research, Nedlands, Western Australia

Perth Blood Institute, West Perth, Western Australia

Ordensklinikum Linz Gmbh Elisabethinen, Linz, Not set

Universitatsklinik Fur Innere Medizin Iii Universitatsklinikum Der Pmu Landeskrankenhaus Salzburg, Salzburg, Not set

Uk St Poelten, St Polten, Not set

Medical University Vienna Oncology, Wien, Not set

Fundacao Pio Xii Hospital de Amor de Barretos, Barretos, Not set

Hospital Felicio Rocho, Belo Horizonte, Not set

Universidade de Campinas Centro de Hematologia E Hemoterapia, Campinas, Not set

Hospital Erasto Gaertner, Curitiba, Not set

Instituto Joinvilense de Hematologia E Oncologia, Joinville, Not set

Fundacao Universidade de Caxias Do Sul Instituto de Pesquisas Em Saude, Petropolis, Not set

Hospital de Clinicas de Porto Alegre, Porto AlegreRS, Not set

Hospital Do Cancer de Pernambuco, Recife, Not set

Hcfmusp Servico de Hematologia, Hemoterapia E Terapia Celular, Sao Paulo, Not set

Hospital Santa Rita de Cassia Afecc, Vitoria, Not set

Beijing Cancer Hospital, Beijing, Beijing

Beijing Hospital, Beijing, Beijing

The First Affiliated Hospital of Chongqing Medical University, Chongqing, Chongqing

Fujian Medical University Union Hospital, Fuzhou, Fujian

Sun Yat Sen University Cancer Center, Guangzhou, Guangdong

Nanfang Hospital of Southern Medical University, Guangzhou, Guangdong

Harbin Medical University Cancer Hospital, Harbin, Heilongjiang

The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan

Union Hospital of Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei

Tongji Hospital of Tongji Medical College Huazhong University of Science and Technology, Wuhan, Hubei

Jiangsu Province Hospital, Nanjing, Jiangsu

The Affiliated Hospital of Xuzhou Medical University, Xuzhou, Jiangsu

Jiangxi Province Cancer Hospital, Nanchang, Jiangxi

Liaoning Cancer Hospital and Institute, Shenyang, Liaoning

Shaanxi Provincial Peoples Hospital, Xian, Shaanxi

Linyi Cancer Hospital, Linyi, Shandong

The Affiliated Hospital of Qingdao University Branch West Coast, Qingdao, Shandong

Fudan University Shanghai Cancer Center, Shanghai, Shanghai

Sichuan Academy of Medical Sciences and Sichuan Provincial Peoples Hospital, Chengdu, Sichuan

The First Affiliated Hospital, Zhejiang University School of Medicinechengzhan, Hangzhou, Zhejiang

The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang

Chu Montpellier Hopital Saint Eloi, Montpellier, Not set

Centre Hospitalier Universitaire Nantes Hotel Dieu, Nantes, Not set

Chu Hopital Lyon Sud, PierreBenite, Not set

Chu Tours Hopital Bretonneau, Tours, Not set

Klinikum Chemnitz Ggmbh, Chemnitz, Not set

Klinikum Der Johann Wolfgang Goethe Universitat Medizinische Klinik I, Frankfurt am Main, Not set

Universitatsklinikum Halle, Halle Saale, Not set

Universitatsklinikum Hamburg Eppendorf, Hamburg, Not set

Dept of Medicine Iii, University Hospitallmu, Munchen, Not set

Stauferklinikum Schwabisch Gmund Kliniken Ostalb, Mutlangen, Not set

Policlinico Sorsola Malpighi, Aou Di Bologna, Bologna, Not set

Ospedale Vito Fazzi, Asl Lecce, Leece, Not set

Istituto Romagnolo Per Lo Studio Dei Tumori Dino Amadori Irst, Meldola, Not set

Azienda Sanitaria Universitaria Giuliano Isontina, Trieste, Not set

Azienda Ospedaliera Universitaria Integrata Di Verona, Verona, Not set

Aichi Cancer Center Hospital Clinical Oncology, Nagoya, Aichi

Toyohashi Municipal Hospital, Toyohashi, Aichi

Chiba Cancer Center, Chibashi, Chiba

Matsuyama Red Cross Hospital, Matsuyamashi, Ehime

Ogaki Municipal Hospital, Ogaki, Gifu

Hiroshima Red Cross Hospital and Atomic Bomb Survivors Hospital, Hiroshimashi, Hiroshima

Kobe City Medical Center General Hospital, KobeShi, Hyogo

Kagoshima University Hospital, Kagoshimashi, Kagoshima

Kanagawa Cancer Center, Yokohamashi, Kanagawa

Tohoku University Hospital, Sendaishi, Miyagi

Kurashiki Central Hospital, Kurashikishi, Okayama

Osaka Red Cross Hospital, Osakashi, Osaka

Dokkyo Medical University Saitama Medical Center, Koshigaya, Saitama

National Hospital Organization Okayama Medical Center, Okayama, Not set

Osaka Metropolitan University Hospital, Osaka, Not set

Institute of Science Tokyo Hospital, Tokyo, Not set

Yokohama Municipal Citizens Hospital, YokohamaShi, Not set

Pusan National University Hospital, SeoGu, Busan Gwang'yeogsi

Seoul National University Bundang Hospital, BundangGu SeongnamSi, Gyeonggi-do

Samsung Medical Center, GangnamGu, Seoul Teugbyeolsi

The Catholic University of Korea, Seoul St Marys Hospital, SeochoGu, Seoul Teugbyeolsi

Severance Hospital Yonsei University Health System, SeodaemunGu, Seoul Teugbyeolsi

Seoul National University Hospital, Seoul, Seoul Teugbyeolsi

Asan Medical Center, SongpaGu, Seoul Teugbyeolsi

The Catholic University of Korea, Yeouido St Marys Hospital, YeongdeungpoGu, Seoul Teugbyeolsi

North Shore Hospital, Auckland, Not set

Christchurch Hospital, Christchurch, Not set

Dunedin Hospital, Dunedin, Not set

Tauranga Hospital, Tauranga, Not set

Aidport Sp Z O O, Dopiewo, Not set

Pratia McM Krakow, Krakow, Not set

Uniwersytecki Szpital Kliniczny Nr W Lublinie, Lublin, Not set

Wielospecjalistyczne Centrum Onkologii I Traumatologii Im M Kopernika W Lodzi, OD, Not set

Lower Silesian Center of Oncology, Pulmonology and Hematology, Wrocaw, Not set

Auxilio Mutuo Cancer Center, San Juan, Not set

Ico H Duran I Reynals, Barcelona, Not set

Hospital Clinic de Barcelona, Barcelona, Not set

Hospital Universitario Fundacion Jimenez Diaz, Madrid, Not set

H Puerta de Hierro Majadahonda, Majadahonda, Not set

Etlik City Hospital, Ankara, Not set

Antalya Memorial Hospital, Dokuma, Not set

Tr Trakya University Health Research and Application Center (Hospital), Edirne, Not set

Kocaeli Universitesi Tip Fakultesi, Kocaeli, Not set

Birmingham Heartlands Hospital, Birmingham, Not set

The Royal Bournemouth and Christchurch Hospitals Nhs Foundation, Bournemouth, Not set

Beatson West of Scotland Cancer Centre, Glasgow, Not set

Churchill Hospital Oxford University Hospital Nhs Trust, Headington, Not set

University College Hospital, London, Not set

Derriford Hospital, Plymouth, Not set

Clatterbridge Cancer Centre, Wirral, Not set

Conditions: Mantle Cell Lymphoma, B Cell Lymphoma

Learn More ›

A Study of Zilovertamab Vedotin (MK-2140) as Monotherapy and in Combination in Participants With Aggressive and Indolent B-cell Malignancies (MK-2140-006)

NCT05458297

Recruiting

The purpose of this study is to assess the safety and tolerability of zilovertamab vedotin as monotherapy and in combination in participants with select B-cell lymphomas including mantle cell lymphoma (MCL), Richter's transformation lymphoma (RTL), follicular lymphoma (FL), and chronic lymphocytic leukemia (CLL). This study will also evaluate zilovertamab vedotin as monotherapy and in combination with respect to objective response rate. * Cohort A: Participants with relapsed or refractory MCL r... Read More

Gender:

ALL

Ages:

18 years and above

Trial Updated:

04/16/2025

Locations: Alaska Oncology and Hematology ( Site 0037), Anchorage, Alaska +107 locations

Alaska Oncology and Hematology ( Site 0037), Anchorage, Alaska

Banner MD Anderson Cancer Center ( Site 0040), Gilbert, Arizona

Banner MD Anderson Cancer Center - University Medical Center Phoenix-Medical Oncology ( Site 0036), Phoenix, Arizona

University of Colorado Anschutz Medical Campus-The Center for Cancer and Blood Disorders ( Site 0008, Aurora, Colorado

Cancer Care Specialists of Illinois ( Site 0031), Decatur, Illinois

University of Kansas Medical Center-Division of Hematologic Malignancies and Cellular Therapeutics (, Fairway, Kansas

Norton Women's and Children's Hospital-Norton Cancer Institute - St. Matthews ( Site 0007), Saint Matthews, Kentucky

Greenebaum Comprehensive Cancer Center-Hematology & Multiple Myeloma ( Site 0010), Baltimore, Maryland

Tufts Medical Center ( Site 0024), Boston, Massachusetts

Massachusetts General Hospital ( Site 0018), Boston, Massachusetts

Dana-Farber Cancer Institute-Lymphoma ( Site 0026), Boston, Massachusetts

University of Michigan ( Site 0009), Ann Arbor, Michigan

Henry Ford Hospital ( Site 0035), Detroit, Michigan

Icahn School of Medicine at Mount Sinai ( Site 0023), New York, New York

Sanford Fargo Medical Center-Roger Maris Cancer Center ( Site 0014), Fargo, North Dakota

The James Cancer Hospital and Solove Research Institute at The Ohio State University Comprehensive C, Columbus, Ohio

Avera Cancer Institute- Research ( Site 0011), Sioux Falls, South Dakota

Medical Oncology Associates, PS ( Site 0005), Spokane, Washington

University of Wisconsin Hospitals and Clinics-Carbone Cancer Center ( Site 0030), Madison, Wisconsin

MEDICAL COLLEGE OF WISCONSIN ( Site 0021), Milwaukee, Wisconsin

Liga Norte Riograndense Contra o Câncer-Centro de Pesquisa Clínica ( Site 1807), Natal, Rio Grande Do Norte

Instituto Nacional de Câncer - INCA-Divisão de Pesquisa Clínica e Desenvolvimento Tecnológico HC1 (, Rio de Janeiro, Not set

ICESP - INSTITUTO DO CÂNCER DO ESTADO DE SÃO PAULO ( Site 1808), Sao Paulo, Not set

Hospital Paulistano-Americas Oncologia ( Site 1805), Sao Paulo, Not set

BC Cancer Vancouver-Clinical Trials Unit ( Site 0201), Vancouver, British Columbia

The Moncton Hospital-Oncology ( Site 0211), Moncton, New Brunswick

QEII Health Sciences Centre - Victoria General Site ( Site 0213), Halifax, Nova Scotia

Lawson Health Research Institute - London Health Sciences Ce-London Regional Cancer Program ( Site 0, London, Ontario

Princess Margaret Cancer Centre-Division of Medical Oncology and Hematology ( Site 0200), Toronto, Ontario

Jewish General Hospital ( Site 0202), Montreal, Quebec

Allan Blair Cancer Centre-Care Services ( Site 0208), Regina, Saskatchewan

IC La Serena Research ( Site 1909), La Serena., Coquimbo

Centro de Estudios Clínicos SAGA-CECSAGA ( Site 1907), Santiago, Region M. De Santiago

Clínica Inmunocel ( Site 1910), Santiago, Region M. De Santiago

Clínica Alemana de Santiago ( Site 1903), Santiago, Region M. De Santiago

Beijing Cancer hospital ( Site 1200), Beijing, Beijing

Zhujiang Hospital ( Site 1207), Guangzhou, Guangdong

Southern Medical University Nanfang Hospital ( Site 1202), Guangzhou, Guangdong

Sun Yat-sen University Cancer Center ( Site 1201), Guangzhou, Guangdong

Henan Cancer Hospital-hematology department ( Site 1212), Zhengzhou, Henan

Union Hospital Tongji Medical College Huazhong University of Science and Technology ( Site 1210), Wuhan, Hubei

Tongji Hospital Tongji Medical,Science & Technology ( Site 1221), Wuhan, Hubei

The First Affiliated Hospital of Soochow University-hematology department ( Site 1218), Suzhou, Jiangsu

The Affiliated Hospital of Xuzhou Medical College ( Site 1223), Xuzhou, Jiangsu

The First Affiliated Hospital of Nanchang University ( Site 1204), Nanchang, Jiangxi

Jiangxi Provincial Cancer Hospital ( Site 1213), Nanchang, Jiangxi

Jilin Province Tumor Hospital-oncology department ( Site 1220), Chuangchun, Jilin

Fudan University Shanghai Cancer Center ( Site 1208), Shanghai, Shanghai

West China Hospital of Sichuan University-Head and Neck Oncology ( Site 1206), Cheng Du, Sichuan

The First Affiliated Hospital, Zhejiang University ( Site 1211), Hangzhou, Zhejiang

Zhejiang Cancer Hospital ( Site 1214), Hangzhou, Zhejiang

Fakultní nemocnice Brno Bohunice-Interni hematologicka a onkologicka klinika ( Site 0300), Brno, Brno-mesto

Fakultni nemocnice Ostrava-Klinika Hematoonkologie ( Site 0301), Ostrava, Moravskoslezsky Kraj

Vseobecna fakultni nemocnice v Praze-I. Interní klinika - klinika hematologie ( Site 0302), Praha 2, Not set

North Estonia Medical Centre Foundation ( Site 0401), Tallinn, Harjumaa

Universitaetsklinikum Ulm ( Site 0502), Ulm, Baden-Wurttemberg

Universitaetsklinikum Koeln ( Site 0506), Köln, Nordrhein-Westfalen

St. James's Hospital ( Site 0600), Dublin, Not set

Emek Medical Center-Hematology Unit ( Site 0705), Afula, Not set

Soroka Medical Center-Hematology Department ( Site 0707), Be'er Sheva, Not set

Rambam Health Care Campus-Hematology and Bone Marrow Transplantation ( Site 0706), Haifa, Not set

Carmel Hospital ( Site 0709), Haifa, Not set

Hadassah Medical Center ( Site 0701), Jerusalem, Not set

Galilee Medical Center ( Site 0710), Nahariya, Not set

Sheba Medical Center-Hemato Oncology ( Site 0700), Ramat Gan, Not set

IRCCS - AOU di Bologna-SSD: Diagnosi e terapie dei linfomi e delle sindromi linfoproliferative cron, Bologna, Emilia-Romagna

Humanitas-U.O di Oncologia medica ed Ematologia ( Site 0802), Rozzano, Milano

Azienda Ospedaliera Nazionale SS. Antonio e Biagio e Cesare -Azienda Ospedaliera Nazionale SS. Ant, Alessandria, Not set

Fondazione Policlinico Universitario Agostino Gemelli IRCCS -ISTITUTO DI EMATOLOGIA ( Site 0804), Roma, Not set

National Hospital Organization Nagoya Medical Center ( Site 1108), Nagoya, Aichi

Hokkaido University Hospital ( Site 1104), Sapporo, Hokkaido

Tokai University Hospital ( Site 1100), Isehara, Kanagawa

Tohoku University Hospital ( Site 1106), Sendai-shi, Miyagi

Kindai University Hospital ( Site 1102), Sayama, Osaka

National Cancer Center Hospital ( Site 1103), Chuo-ku, Tokyo

The Cancer Institute Hospital of JFCR ( Site 1101), Koto, Tokyo

Kyushu University Hospital ( Site 1105), Fukuoka, Not set

Okayama University Hospital ( Site 1107), Okayama, Not set

Seoul National University Hospital ( Site 1300), Seoul, Not set

Samsung Medical Center ( Site 1301), Seoul, Not set

Centro Medico Monte Carmelo ( Site 1702), Arequipa, Ariqipa

INSTITUTO NACIONAL DE ENFERMEDADES NEOPLASICAS ( Site 1700), Lima, Not set

Wojewodzkie Wielospecjalistyczne Centrum Onkologii i Traumat-Oddiał Hematologii Ogólnej ( Site 1008), Łódź, Lodzkie

Centrum Onkologii Ziemi Lubelskiej-Oddzial Hematologiczny ( Site 1006), Lublin, Lubelskie

Pratia MCM Krakow ( Site 1001), Krakow, Malopolskie

Narodowy Instytut Onkologii im. Marii Sklodowskiej-Curie - P-Klinika Nowotworów Układu Chłonnego ( S, Warszawa, Mazowieckie

Samodzielny Publiczny Zakład Opieki Zdrowotnej MSWiA w Olsztynie-Oddzial Kliniczny Hematologii ( Sit, Olsztyn, Warminsko-mazurskie

Champalimaud Foundation ( Site 2002), Lisbon, Lisboa

Unidade Local de Saude de Braga - Hospital de Braga ( Site 2001), Braga, Not set

Instituto Português de Oncologia do Porto Francisco Gentil, EPE ( Site 2000), Porto, Not set

National Cancer Centre Singapore ( Site 1500), Singapore, Central Singapore

Instituto Catalan de Oncologia - Hospital Duran i Reynals-Haematology Department ( Site 4003), L'Hospitalet Del Llobregat, Barcelona

Hospital Universitari Vall d'Hebron ( Site 4004), Barcelona, Cataluna

MD Anderson Cancer Center ( Site 4006), Madrid, Madrid, Comunidad De

Clinica Universidad de Navarra ( Site 4005), Pamplona, Navarra

Hospital Universitario de Salamanca - Complejo Asistencial Universitario de Salamanca-Hematology ( S, Salamanca, Not set

Skånes Universitetssjukhus Lund ( Site 5000), Lund, Skane Lan

Akademiska sjukhuset-Blod- och tumörsjukdomar ( Site 5002), Uppsala, Uppsala Lan

Sahlgrenska Universitetssjukhuset ( Site 5003), Gothenburg, Vastra Gotalands Lan

Mega Medipol-Hematology ( Site 6009), Stanbul, Istanbul

Ankara Universitesi Tip Fakultesi Hastanesi-hematology ( Site 6001), Ankara, Not set

Trakya University ( Site 6005), Edirne, Not set

Ege Universitesi Hastanesi ( Site 6002), İzmir, Not set

Ondokuz Mayıs Universitesi-Oncology department ( Site 6004), Samsun, Not set

The Royal Cornwall Hospital-Haematology ( Site 7006), Truro, Cornwall

University College London Hospital ( Site 7001), London, London, City Of

The Churchill Hospital ( Site 7002), Oxford, Oxfordshire

The Christie NHS Foundation Trust ( Site 7007), Manchester, Not set

Conditions: Chronic Lymphocytic Leukemia, Mantle Cell Lymphoma, Follicular Lymphoma, Richter Transformation Lymphoma

Learn More ›

Phase 2 Open Label Randomized Study of Pirtobrutinib and Brexucabtagene Autoleucel in R/R MCL

NCT06553872

Recruiting

This is a phase 2, open-label, randomized, multicenter clinical trial in patients with relapsed/refractory mantle cell lymphoma (R/R MCL) who meet the criteria for standard-of-care FDA label for CD19 CAR T-cell therapy with brexucabtagene autoleucel (brexu-cel).

Gender:

ALL

Ages:

18 years and above

Trial Updated:

04/16/2025

Locations: Stanford Cancer Center, Stanford, California +2 locations

Conditions: Mantle Cell Lymphoma

Learn More ›

A Dose-Escalation and Expansion Study of BGB-16673 in Participants With B-Cell Malignancies

NCT05006716

Recruiting

Study consists of two main parts to explore BGB-16673 recommended dosing, a Phase 1 monotherapy dose finding comprised of monotherapy dose escalation and monotherapy safety expansion of selected doses, and a Phase 2 (expansion cohorts)

Gender:

ALL

Ages:

18 years and above

Trial Updated:

04/10/2025

Locations: University of Alabama At Birmingham Hospital, Birmingham, Alabama +118 locations

University of Alabama At Birmingham Hospital, Birmingham, Alabama

Western Regional Medical Center, Llc, Goodyear, Arizona

Mayo Clinic Phoenix, Phoenix, Arizona

Honor Health Research Institute, Scottsdale, Arizona

University of Arizona Cancer Center, Tucson, Arizona

University of California San Diego (Ucsd) Moores Cancer Center, La Jolla, California

Stanford Medicine, Palo Alto, California

UCLA Santa Monica Cancer Care, Santa Monica, California

Uchealth North, Fort Collins, Colorado

Mayo Clinic Jacksonville, Jacksonville, Florida

Mount Sinai Comprehensive Cancer Center, Miami Beach, Florida

Tampa General Hospital Cancer Institute, Tampa, Florida

Augusta University, Augusta, Georgia

Southeastern Regional Medical Center, Newnan, Georgia

Midwestern Regional Medical Center, Zion, Illinois

University of Iowa Hospitals and Clinics, Iowa City, Iowa

Norton Cancer Institute Pavilion, Louisville, Kentucky

Mary Bird Perkins Cancer Center, Baton Rouge, Louisiana

American Oncology Partners of Maryland Pa, Bethesda, Maryland

Dana Farber Cancer Institute, Boston, Massachusetts

Karmanos Cancer Institute, Detroit, Michigan

Mayo Clinic Rochester, Rochester, Minnesota

Nebraska Cancer Specialists, Omaha, Nebraska

Comprehensive Cancer Centers of Nevada, Las Vegas, Nevada

Summit Medical Group, Florham Park, New Jersey

Roswell Park Comprehensive Cancer Center, Buffalo, New York

Columbia University Medical Center, New York, New York

Weill Cornell Medical College Newyork Presbyterian Hospital, New York, New York

Memorial Sloan Kettering Cancer Center Mskcc, New York, New York

Tennesse Oncology Chattanooga, Chattanooga, Tennessee

Tennessee Oncology, Pllc Nashville, Nashville, Tennessee

Md Anderson Cancer Center, Houston, Texas

Virginia Commonwealth University Massey Cancer Center, Richmond, Virginia

Fred Hutchinson Cancer Research Center, Seattle, Washington

Concord Repatriation General Hospital, Concord, New South Wales

Calvary Mater Newcastle, Waratah, New South Wales

Princess Alexandra Hospital, Woolloongabba, Queensland

St Vincents Hospital Melbourne, Fitzroy, Victoria

Peninsula Private Hospital, Frankston, Victoria

Austin Health, Heidelberg, Victoria

Peter Maccallum Cancer Centre, Melbourne, Victoria

The Alfred Hospital, Melbourne, Victoria

Linear Clinical Research, Nedlands, Western Australia

Perth Blood Institute, West Perth, Western Australia

Hospital Sirio Libanes Brasilia, Brasilia, Not set

Instituto de Pesquisa Em Saude Da Universidade de Caxias Do Sul, Caxias do Sul, Not set

Hospital Erasto Gaertner, Curitiba, Not set

Centro Gaucho Integrado de Oncologia Hospital Mae de Deus, Porto Alegre, Not set

Hospital Ernesto Dornelles, Porto Alegre, Not set

Real E Benemerita Associacao Portuguesa de Sao Paulo, Sao Paulo, Not set

Hospital Alemao Oswaldo Cruz, Sao Paulo, Not set

Hospital Nove de Julho Dasa, Sao Paulo, Not set

Instituto Dor de Pesquisa E Ensino Sao Paulo, Sao Paulo, Not set

Sociedade Beneficente Israelita Brasileira Hospital Albert Einstein, Sao Paulo, Not set

Hospital Santa Rita de Cassia Afecc, Vitoria, Not set

Cross Cancer Institute, Edmonton, Alberta

British Columbia Cancer Agency the Vancouver Centre, Vancouver, British Columbia

Princess Margaret Cancer Centre, Toronto, Ontario

Arthur Je Child Comprehensive Cancer Centre, Calgary, Not set

Chu de Quebec Universite Laval, Hopital de Lenfant Jesus, Centre Integre de Cancerologie (Cic), Quebec, Not set

Centre de Lutte Contre Le Cancer Institut Bergonie, Bordeaux, Not set

Hopital Estaing, Clermontferrand, Not set

Chu Henri Mondor, Creteil, Not set

Hopital Claude Huriez Chu Lille, Lille, Not set

Centre Leon Berard, Lyon Cedex, Not set

Institut Paoli Calmettes, Marseille, Not set

Chu Montpellier Hopital Saint Eloi, Montpellier, Not set

Hopital de La Pitie Salpetriere, Paris, Not set

Centre Henri Becquerel, Rouen Cedex, Not set

Arensia Exploratory Medicine Llc, Tbilisi, Not set

Universitatsklinikum Carl Gustav Carus An Der Technischen Universitat Dresden, Dresden, Not set

Uniklinik Koln (Aor), Koln, Not set

Universitares Krebszentrum Leipzig, Leipzig, Not set

Universitaetsklinikum Schleswig Holstein Campus Luebeck, Luebeck, Not set

Klinikum Johannes Gutenberg Universitaet Mainz, Mainz, Not set

Klinikum Grosshadern Ludwig Maximilians Universitat Munchen, Munchen, Not set

Universitaetsklinikum Ulm, Ulm, Not set

Policlinico Sorsola Malpighi, Aou Di Bologna, Bologna, Not set

Ospedale San Raffaele, Milano, Not set

Istituto Europeo Di Oncologia, Milano, Not set

Niguarda Cancer Center Division of Hematology, Milano, Not set

Fondazione Policlinico Universitario Agostino Gemelli, Roma, Not set

Centroricerche Cliniche Di Verona Srl, Verona, Not set

Aichi Cancer Center Hospital Clinical Oncology, Nagoya, Aichi

Chiba Cancer Center, Chibashi, Chiba

National Cancer Center Hospital East, Kashiwa, Chiba

Cancer Institute Hospital of Jfcr, Kotoku, Tokyo

Yokohama Municipal Citizens Hospital, YokohamaShi, Not set

Inje University Busan Paik Hospital, BusanjinGu, Busan Gwang'yeogsi

Samsung Medical Center, GangnamGu, Seoul Teugbyeolsi

The Catholic University of Korea, Seoul St Marys Hospital, SeochoGu, Seoul Teugbyeolsi

Severance Hospital Yonsei University Health System, SeodaemunGu, Seoul Teugbyeolsi

Seoul National University Hospital, Seoul, Seoul Teugbyeolsi

Asan Medical Center, SongpaGu, Seoul Teugbyeolsi

Pusan National University Hospital, SeoGu, Not set

The Institute of Oncology, Arensia Exploratory Medicine, Chisinau, Not set

Hospital Universitario Vall Dhebron, Barcelona, Not set

Hospital de La Santa Creu I Sant Pau, Barcelona, Not set

Hospital General Universitario Gregorio Maranon, Madrid, Not set

Md Anderson Cancer Center Madrid Spain, Madrid, Not set

Hospital Universitario Fundacion Jimenez Diaz, Madrid, Not set

Hospital Universitario La Paz, Madrid, Not set

Hospital Universitario Puerta de Hierro Majadahonda, Majadahonda, Not set

Hospital Clinico Universitario de Valencia, Valencia, Not set

Sahlgrenska University Hospital Hematology, Goteborg, Not set

Karolinska Universitetssjukhuset Solna, Stockholm, Not set

Uppsala Akademiska Sjukhus, Uppsala, Not set

Ankara University, Abidinpaa, Not set

Dr Abdurrahman Yurtaslan Research and Training Hospital, Ankara, Not set

Dokuz Eylul University, Balcova, Not set

Erciyes University, Kayseri, Not set

Sakarya Training and Research Hospital, Sakarya, Not set

Ondokuz Mayis University, Samsun, Not set

Edinburgh Cancer Centre, Edinburgh, Not set

Churchill Hospital Oxford University Hospital Nhs Trust, Headington, Not set

St Jamess University Hospital, Leeds, Not set

Freeman Hospital, NewCastle Upon Tyne, Not set

Nottingham University Hospitals Nhs Trust, Nottingham, Not set

Derriford Hospital, Plymouth, Not set

Conditions: B-cell Malignancy, Marginal Zone Lymphoma, Follicular Lymphoma, Non-hodgkin Lymphoma, Waldenström Macroglobulinemia, Chronic Lymphocytic Leukemia, Small Lymphocytic Lymphoma, Mantle Cell Lymphoma, Diffuse Large B Cell Lymphoma

Learn More ›

SynKIR-310 for Relapsed/Refractory B-NHL

NCT06544265

Recruiting

This first-in-human (FIH) trial is designed to assess the safety, feasibility and preliminary efficacy of a single intravenous (IV) dose of SynKIR-310 administered to participants with relapsed/refractory B-NHL.

Gender:

ALL

Ages:

18 years and above

Trial Updated:

04/09/2025

Locations: Colorado Blood Cancer Institute, part of Sarah Cannon Cancer Institute, Denver, Colorado +2 locations

Conditions: B Cell Lymphoma, NHL, Adult, Mantle Cell Lymphoma, Relapsed Non-Hodgkin Lymphoma, Refractory Non-Hodgkin Lymphoma, Aggressive B-Cell Non-Hodgkin Lymphoma, Indolent B-Cell Non-Hodgkin Lymphoma, Follicular Lymphoma, Marginal Zone Lymphoma, DLBCL - Diffuse Large B Cell Lymphoma, HGBL with MYC and BCL2 And/or BCL6 Rearrangements, High-grade B-cell Lymphoma, Diffuse Large B Cell Lymphoma, Large B-cell Lymphoma, T-Cell/Histiocyte Rich Lymphoma, Non-hodgkin Lymphoma,B Cell, Primary Mediastinal Large B-cell Lymphoma (PMBCL), Epstein-Barr Virus Positive DLBCL, Nos, Follicular Lymphoma Grade 3B, DLBCL (Diffuse Large B-Cell Lymphoma) Associated with Chronic Inflammation, High Grade B-Cell Lymphoma, Not Otherwise Specified, Follicular Lymphoma Grade 3, Marginal Zone Splenic Lymphoma, DLBCL

Learn More ›

Vorinostat for Graft vs Host Disease Prevention in Children, Adolescents and Young Adults Undergoing Allogeneic Blood and Marrow Transplantation

NCT03842696

Recruiting

The purpose of this study is to determine the recommended phase 2 dose of the drug Vorinostat in children, adolescents and young adults following allogeneic blood or marrow transplant (BMT) and determine whether the addition of Vorinostat to the standard graft versus host disease (GVHD) prophylaxis will reduce the incidence of GVHD.

Gender:

ALL

Ages:

Between 3 years and 39 years

Trial Updated:

04/01/2025

Locations: University of Colorado, Aurora, Colorado +6 locations

Conditions: Hematologic Diseases, Chronic Myelogenous Leukemia - Chronic Phase, Chronic Myelogenous Leukemia, Accelerated Phase, Chronic Myelogenous Leukemia, Blastic Phase, Myelodysplastic Syndromes, Mantle Cell Lymphoma, Follicular Lymphoma, Diffuse Large B Cell Lymphoma, Non Hodgkin Lymphoma, Graft Vs Host Disease, Graft-versus-host-disease, Acute Leukemia in Remission

Learn More ›

A Long-term Extension Study of PCI-32765 (Ibrutinib)

NCT01804686

Recruiting

The purpose of this study is to collect long-term safety and efficacy data for participants treated with ibrutinib and to provide ongoing access to ibrutinib for participants who are currently enrolled in ibrutinib studies that have been completed according to the parent protocol, are actively receiving treatment with ibrutinib, and who continue to benefit from ibrutinib treatment.

Gender:

ALL

Ages:

18 years and above

Trial Updated:

03/28/2025

Locations: City of Hope Cancer Center, Duarte, California +173 locations

City of Hope Cancer Center, Duarte, California

University of California San Diego Medical Center, La Jolla, California

University of California Los Angeles, Los Angeles, California

St. Joseph Hospital Center for Cancer Prevention and Treatment, Orange, California

Stanford University Medical Center, Stanford, California

Stanford University, Stanford, California

Norwalk Medical Group, Norwalk, Connecticut

Northwest Georgia Oncology Centers PC, Marietta, Georgia

Northwestern University Hospital, Chicago, Illinois

Indiana University, Goshen, Indiana

Kansas University Medical Center, Westwood, Kansas

Louisville Oncology Suburban - Norton Cancer Institute, Louisville, Kentucky

Dana Farber Cancer Center, Boston, Massachusetts

University of Michigan Comprehensive Cancer Center, Ann Arbor, Michigan

Battle Creek Health Systm, Battle Creek, Michigan

Karmanos Cancer Institute - Wayne State University, Detroit, Michigan

Washington University, Saint Louis, Missouri

Dartmouth Hitchcock Medical Center, Lebanon, New Hampshire

Hackensack University Medical Center, Hackensack, New Jersey

Weill Medical College of Cornell University, New York, New York

Memorial Sloan-Kettering Cancer Center, New York, New York

Southeastern Medical Oncology Center, Goldsboro, North Carolina

The Ohio State University- James Cancer Hospital, Columbus, Ohio

Willamette Valley Cancer Center, Eugene, Oregon

Kaiser Permanente, Portland, Oregon

University of Pennsylvania Medical Center, Philadelphia, Pennsylvania

Avera Medical Group, Sioux Falls, South Dakota

MD Anderson Cancer Center - University of Texas, Houston, Texas

University of Virginia, Charlottesville, Virginia

University of Washington, Seattle, Washington

West Virginia University, Morgantown, West Virginia

University of Wisconsin Carbone Cancer Center - Wisconsin Institute for Medical Research, Madison, Wisconsin

CEMIC Saavedra, Ciudad Autonoma Buenos Aires, Not set

Fundaleu, Ciudad de Buenos Aires, Not set

Royal Adelaide Hospital, Adelaide, Not set

John Fawkner Cancer Trial Centre, Coburg, Not set

Concord Hospital, Concord, Not set

Austin Health, Heidelberg, Not set

Peter MacCallum Cancer Institute, Melbourne, Not set

Royal Perth Hospital, Perth, Not set

Alfred Hospital, Prahran, Not set

Adventist Health Care Limited trading as San Clinical Trials Unit, Wahroonga, Not set

UZA, Antwerp, Not set

A.Z. Sint Jan, Brugge, Not set

UCL - Saint Luc, Brussels, Not set

UZ Gent - departement oncologie, Gent, Not set

UZ Leuven Gasthuisberg, Leuven, Not set

UCL Mont-Godinne, Yvoir, Not set

Ministerio da Saude Instituto Nacional do Cancer, Rio De Janeiro, Not set

Santa Casa da Misericórdia da Bahia - Hospital Santa Isabel, Salvador, Not set

Instituto de Ensino e Pesquisa São Lucas, Sao Paulo, Not set

Jewish General Hospital, Montreal, Quebec

Peking University People s Hospital, Beijing, Not set

Peking University Third Hospital, Beijing, Not set

Peking University First Hospital, Beijing, Not set

West China Hospital Sichuan University, Chengdu, Not set

Fujian Medical University, Fuzhou, Not set

Sun Yat-sen University Cancer Hospital, Guangzhou, Not set

Zhejiang University First Hospital, Hangzhou, Not set

Ruijin Hospital, Shanghai, Not set

Tangdu hospital the Fourth Military Medical, Shanxi, Not set

The First Affliated Hospital of Soochow University, Suzhou, Not set

The Institute of Hematological disease, Tianjin, Not set

Wuhan Union Hospital, Wuhan, Not set

Fundacion Santa Fe, Bogota, Not set

Fundacion Oftalmologica de Santander - FOSCAL, Floridablanca, Not set

Fakultni nemocnice Brno, Interni hematologicka a onkologicka klinika, Brno, Not set

Fakultni nemocnice Kralovske Vinohrady - Interni hematologicka klinika, Praha 10, Not set

Vseobecna fakultni nemocnice v Praze - I. interni klinika - klinika hematologie, Praha 2, Not set

Hopital Henri Mondor, Creteil, Not set

Hôpital E. Muller, Mulhouse, Not set

Hopital Necker Enfants Malades, Paris cedex 15, Not set

HOPITAL SAINT LOUIS - Hematology / Oncology, Paris, Not set

Hopital Haut Leveque Service Maladie Du Sang, Pessac, Not set

CH LYON SUD - Hematology, Pierre Benite, Not set

CHU de Tours, Tours, Not set

Vivantes Klinikum Spandau-Klinik f. Innere Medizin Hämatologie/Onkologie/Gastroenterologie - Germany, Berlin, Not set

Universitätsklinikum Carl Gustav Carus; Med. Klinik und Poliklinik I - Hämatologische Ambulanz, Haus, Dresden, Not set

Universitätsklinikum Essen; Klinik f. Hämatologie- Germany, Essen, Not set

Justus-Liebig-Universitaet - Medizinische Klinik IV, Haematologie, Gießen, Not set

Universitätsklinikum Heidelberg Med. Klinik IV, Heidelberg, Not set

Universitätsklinikum des Saarlandes, Homburg/Saar, Not set

Gemeinschaftspraxis Dres. Uhle/Müller/Kröning/Jentsch-Ullrich - Germany, Magdeburg, Not set

OnkoNet Marburg GmbH, Marburg, Not set

Universitätsklinikum für Innere Med. III_Hämatologie, Onkologie...- Germany, Ulm, Not set

Laiko General Hospital - 1st department of Internal Medicine, Athens, Not set

G Papanikolaou Hospital of Thessaloniki, Thessalonikis, Not set

Semmelweis Egyetem, I. Belgyogyaszati Klinika, Budapest N/a, Not set

Szegedi Tudomanyegyetem II. Belgyogyaszati Klinika, Szeged, Not set

St James's Hospital, Dublin, Not set

Haemek Medical Center, Afula, Not set

Hillel Yaffe Medical Center - Oncology, Hadera, Not set

Rambam Health Care Campus, Haifa, Not set

Rabin Medical Center Beilinson Campus, Petah Tikva, Not set

Sheba Medical Center, Ramat-Gan, Not set

Tel Aviv Sourasky Medical Center, Tel Aviv, Not set

ASST Grande Ospedale Metropolitano Niguarda, Milano, Not set

DIPARTIMENTO DI BIOTECNOLOGIE CELLULARI ED EMATOLOGIA - UNIVERSITà ''LA SAPIENZA'', Roma, Not set

A.O.Citta della Salute e della Scienza di Torino, Torino, Not set

Tokyo Metropolitan Cancer and Infectious Diseases Center Komagome Hospital, Bunkyo ku, Not set

Hiroshima University Hospital, Hiroshima shi, Not set

Hokkaido University Hospital, Sapporo-shi, Not set

National Cancer Center, Goyang-Si, Not set

The Catholic University of Korea Seoul St Mary s Hospital, Seoul, Not set

Oaxaca Site Management Organization S.C., Oaxaca, Not set

VU medisch centrum - Afd.Interne - INT, Amsterdam, Not set

Szpital Specjalistyczny w Brzozowie Podkarpacki Osrodek Onkologiczny im Ks B Markiewicza, Brzozow, Not set

Samodzielny Publiczny Zaklad Opieki Zdrowotnej Zespol Szpitali Miejskich, Chorzow, Not set

Uniwersyteckie Centrum Kliniczne, Gdansk, Not set

Pratia MCM Krakow, Krakow, Not set

Oddzial Hematologii, Opole, Not set

Wojewodzki Szpital Specjalistyczny im. Janusza Korczaka, Slupsk, Not set

Katedra I Klinika Hematologii Nowotworow Krwi I Transplantacji Szpiku, Wroclaw, Not set

Instituto Portugues de Oncologia, Lisboa, Not set

Hospital De Santa Maria, Lisbon, Not set

Instituto Portugues de Oncologia, Porto, Not set

Auxilio Mutuo Cancer Center, San Juan, Not set

Arkhangelsk Regional Clinical Hospital, Arkhangelsk, Not set

Chelyabinsk Regiona Onc. Center, Chelyabinsk, Not set

Emergency Hospital of Dzerzhinsk, Dzerzhinsk, Not set

Cancer Research Center, Moscow N/a, Not set

S.P. Botkin Moscow City Clinical Hospital, Moscow, Not set

Regional Clinical Hospital n.a.Semashko, Nizhni Novgorod, Not set

Medical Scientific Radiology - Center, Obninsk, Not set

Perm Medical Sanitary Unit#1, Perm, Not set

Republican Hospital named by V.A.Baranova, Petrozavodsk, Not set

Rostov Research Institute of Oncology, Rostov-Na-Donu, Not set

Ryazan Regional Clinical Hospital, Ryazan, Not set

Leningrad region clinical hospital, Saint, Not set

Samara Region Clinical Hospital, Samara, Not set

Federal Center of Heart, Blood and Endocrinology, Sankt-Peterburg, Not set

Oncological dispensary #2, Sochi, Not set

City Clinical Oncology Dispensary, St. Petersburg, Not set

Clinical Research Institute of Hematology and Transfusiology, St.-Petersburg, Not set

Oncology Dispensary of Komi Republic, Syktyvkar, Not set

Hospital Vall d'Hebron, Barcelona N/a, Not set

Inst. Cat. Doncologia-H Duran I Reynals, L'hospitalet De Llobregat, Not set

Hosp. Univ. de La Princesa, Madrid, Not set

Hosp. Gral. Univ. Gregorio Maranon, Madrid, Not set

Hosp. Univ. Infanta Leonor, Madrid, Not set

Fundacion Jimenez Diaz, Madrid, Not set

Clinica Universitaria de Navarra, Pamplona N/a, Not set

Hospital Clinico Universitario Salamanca, Salamanca, Not set

Sahlgrenska University hospital, Hematology Dept, Göteborg, Not set

Skanes universitetssjukhus, Lund, Not set

Karolinska Universitetssjukhuset Solna, Centrum för Hematologi, Stockholm, Stockholm, Not set

Changhua Cristian Hospital, Changhua County, Not set

Ankara University, Ankara, Not set

American Hospital, Istanbul, Not set

Istanbul University, Istanbul, Not set

Dokuz Eylul Universitesi Tip Fakultesi, Izmir, Not set

Erciyes University, Kayseri, Not set

Communal Nonprofit Enterprise 'Cherkasy Regional Oncology Dispensary Of Cherkasy Regional Council', Cherkasy, Not set

Dnepropetrovsk City Clinical Hospital #4, Regional Hematology Center, Dnepropetrovsk, Not set

SI Grigoriev Institute for Medical Radiology National Academy of Medical Science of Ukraine, Kharkiv, Not set

Khmelnitskiy Regional Hospital, Hematology Department, Khmelnitskiy, Not set

State Institution Scientific Center for Radiation Medicine Academy of Medical Sciences of Ukraine, Kiev, Not set

Institute of Blood Pathology and Transfusion Medicine of AMS of Ukraine, Lviv, Not set

Vinnytsya Regional Clinical Hospital named after M.I.Pirogov, Vinnitsa, Not set

University Hospitals Birmingham NHS Trust,, Birmingham, Not set

Royal Bournemouth Hospital, Bournemouth, Not set

Colchester Hospital University NHS, Colchester, Not set

Beatson West Of Scotland Cancer Centre, Glasgow, Not set

St James's Institute of Oncology, Leeds, Not set

Leicester Royal Infirmary - Haematology, Leicester, Not set

St Bartholomew's Hospital - Dept of Haematology, London, Not set

University College London Hospitals NHSFT, London, Not set

Kings College Hospital, London, Not set

Christie Hospital, Manchester, Not set

Nottingham University Hospitals NHS Trust, Nottingham, Not set

Derriford Hospital, Plymouth, Not set

Royal Hallamshire Hospital, Sheffield, Not set

Southampton General Hospital, Southampton, Not set

Royal Marsden Hospital (Sutton), Sutton, Not set

Conditions: Chronic Lymphocytic Leukemia, Small Lymphocytic Lymphoma, Mantle Cell Lymphoma, Follicular Lymphoma, Diffuse Large B-cell Lymphoma, Waldenstrom Macroglobulinemia, Chronic Graft Versus Host Disease

Learn More ›

Testing Continuous Versus Intermittent Treatment With the Study Drug Zanubrutinib for Older Patients With Previously Untreated Mantle Cell Lymphoma

NCT05976763

Recruiting

This phase III trial tests whether continuous or intermittent zanubrutinib after achieving a complete remission (CR) with rituximab works in older adult patients with mantle cell lymphoma (MCL) who have not received treatment in the past (previously untreated). Rituximab is a monoclonal antibody that may interfere with the ability of cancer cells to grow and spread. Zanubrutinib may stop the growth of cancer cells by blocking some of the enzymes needed for cell growth. When zanubrutinib is used... Read More

Gender:

ALL

Ages:

60 years and above

Trial Updated:

03/28/2025

Locations: Tower Cancer Research Foundation, Beverly Hills, California +208 locations

Tower Cancer Research Foundation, Beverly Hills, California

City of Hope Comprehensive Cancer Center, Duarte, California

City of Hope at Irvine Lennar, Irvine, California

Cedars Sinai Medical Center, Los Angeles, California

Smilow Cancer Hospital-Derby Care Center, Derby, Connecticut

Smilow Cancer Hospital Care Center-Fairfield, Fairfield, Connecticut

Smilow Cancer Hospital Care Center at Glastonbury, Glastonbury, Connecticut

Smilow Cancer Hospital Care Center at Greenwich, Greenwich, Connecticut

Smilow Cancer Hospital Care Center - Guilford, Guilford, Connecticut

Smilow Cancer Hospital Care Center at Saint Francis, Hartford, Connecticut

Yale University, New Haven, Connecticut

Yale-New Haven Hospital North Haven Medical Center, North Haven, Connecticut

Smilow Cancer Hospital Care Center at Long Ridge, Stamford, Connecticut

Smilow Cancer Hospital-Torrington Care Center, Torrington, Connecticut

Smilow Cancer Hospital Care Center-Trumbull, Trumbull, Connecticut

Smilow Cancer Hospital-Waterbury Care Center, Waterbury, Connecticut

Smilow Cancer Hospital Care Center - Waterford, Waterford, Connecticut

Helen F Graham Cancer Center, Newark, Delaware

Medical Oncology Hematology Consultants PA, Newark, Delaware

Grady Health System, Atlanta, Georgia

Emory University Hospital Midtown, Atlanta, Georgia

Emory University Hospital/Winship Cancer Institute, Atlanta, Georgia

Emory Saint Joseph's Hospital, Atlanta, Georgia

Augusta University Medical Center, Augusta, Georgia

Emory Johns Creek Hospital, Johns Creek, Georgia

Saint Alphonsus Cancer Care Center-Boise, Boise, Idaho

Saint Luke's Cancer Institute - Boise, Boise, Idaho

Saint Alphonsus Cancer Care Center-Caldwell, Caldwell, Idaho

Kootenai Health - Coeur d'Alene, Coeur d'Alene, Idaho

Saint Luke's Cancer Institute - Fruitland, Fruitland, Idaho

Saint Luke's Cancer Institute - Meridian, Meridian, Idaho

Saint Alphonsus Cancer Care Center-Nampa, Nampa, Idaho

Saint Luke's Cancer Institute - Nampa, Nampa, Idaho

Kootenai Clinic Cancer Services - Post Falls, Post Falls, Idaho

Kootenai Clinic Cancer Services - Sandpoint, Sandpoint, Idaho

Illinois CancerCare-Bloomington, Bloomington, Illinois

Illinois CancerCare-Canton, Canton, Illinois

Illinois CancerCare-Carthage, Carthage, Illinois

University of Illinois, Chicago, Illinois

Carle at The Riverfront, Danville, Illinois

Cancer Care Specialists of Illinois - Decatur, Decatur, Illinois

Decatur Memorial Hospital, Decatur, Illinois

Illinois CancerCare-Dixon, Dixon, Illinois

Carle Physician Group-Effingham, Effingham, Illinois

Crossroads Cancer Center, Effingham, Illinois

Illinois CancerCare-Eureka, Eureka, Illinois

Illinois CancerCare-Galesburg, Galesburg, Illinois

Illinois CancerCare-Kewanee Clinic, Kewanee, Illinois

Illinois CancerCare-Macomb, Macomb, Illinois

Carle Physician Group-Mattoon/Charleston, Mattoon, Illinois

Cancer Care Center of O'Fallon, O'Fallon, Illinois

Illinois CancerCare-Ottawa Clinic, Ottawa, Illinois

Illinois CancerCare-Pekin, Pekin, Illinois

Illinois CancerCare-Peoria, Peoria, Illinois

Illinois CancerCare-Peru, Peru, Illinois

Illinois CancerCare-Princeton, Princeton, Illinois

Memorial Hospital East, Shiloh, Illinois

Southern Illinois University School of Medicine, Springfield, Illinois

Springfield Clinic, Springfield, Illinois

Springfield Memorial Hospital, Springfield, Illinois

Carle Cancer Center, Urbana, Illinois

Illinois CancerCare - Washington, Washington, Illinois

Northwest Cancer Center - Main Campus, Crown Point, Indiana

Northwest Oncology LLC, Dyer, Indiana

Northwest Cancer Center - Hobart, Hobart, Indiana

Saint Mary Medical Center, Hobart, Indiana

Saint Catherine Hospital, Indianapolis, Indiana

The Community Hospital, Munster, Indiana

Women's Diagnostic Center - Munster, Munster, Indiana

Northwest Cancer Center - Valparaiso, Valparaiso, Indiana

Mary Greeley Medical Center, Ames, Iowa

McFarland Clinic - Ames, Ames, Iowa

UI Health Care Mission Cancer and Blood - Ankeny Clinic, Ankeny, Iowa

McFarland Clinic - Boone, Boone, Iowa

Saint Anthony Regional Hospital, Carroll, Iowa

Iowa Methodist Medical Center, Des Moines, Iowa

UI Health Care Mission Cancer and Blood - Des Moines Clinic, Des Moines, Iowa

Broadlawns Medical Center, Des Moines, Iowa

Mercy Medical Center - Des Moines, Des Moines, Iowa

McFarland Clinic - Trinity Cancer Center, Fort Dodge, Iowa

Trinity Regional Medical Center, Fort Dodge, Iowa

University of Iowa/Holden Comprehensive Cancer Center, Iowa City, Iowa

McFarland Clinic - Jefferson, Jefferson, Iowa

McFarland Clinic - Marshalltown, Marshalltown, Iowa

HaysMed, Hays, Kansas

University of Kansas Cancer Center, Kansas City, Kansas

Lawrence Memorial Hospital, Lawrence, Kansas

The University of Kansas Cancer Center - Olathe, Olathe, Kansas

University of Kansas Cancer Center-Overland Park, Overland Park, Kansas

Freeman Physician Group of Pittsburg, Pittsburg, Kansas

Salina Regional Health Center, Salina, Kansas

University of Kansas Health System Saint Francis Campus, Topeka, Kansas

University of Kansas Hospital-Westwood Cancer Center, Westwood, Kansas

Alliance for Clinical Trials in Oncology, Boston, Massachusetts

Trinity Health Saint Joseph Mercy Hospital Ann Arbor, Ann Arbor, Michigan

Trinity Health IHA Medical Group Hematology Oncology - Brighton, Brighton, Michigan

Trinity Health Medical Center - Brighton, Brighton, Michigan

Trinity Health IHA Medical Group Hematology Oncology - Canton, Canton, Michigan

Trinity Health Medical Center - Canton, Canton, Michigan

Chelsea Hospital, Chelsea, Michigan

Trinity Health IHA Medical Group Hematology Oncology - Chelsea Hospital, Chelsea, Michigan

Wayne State University/Karmanos Cancer Institute, Detroit, Michigan

Weisberg Cancer Treatment Center, Farmington Hills, Michigan

Corewell Health Farmington Hills Hospital, Farmington Hills, Michigan

Cancer Hematology Centers - Flint, Flint, Michigan

Genesee Hematology Oncology PC, Flint, Michigan

Genesys Hurley Cancer Institute, Flint, Michigan

Hurley Medical Center, Flint, Michigan

Trinity Health Saint Mary Mercy Livonia Hospital, Livonia, Michigan

Henry Ford Saint John Hospital - Macomb Medical, Macomb, Michigan

Corewell Health William Beaumont University Hospital, Royal Oak, Michigan

MyMichigan Medical Center Saginaw, Saginaw, Michigan

Oncology Hematology Associates of Saginaw Valley PC, Saginaw, Michigan

MyMichigan Medical Center Tawas, Tawas City, Michigan

Corewell Health Beaumont Troy Hospital, Troy, Michigan

Saint Mary's Oncology/Hematology Associates of West Branch, West Branch, Michigan

Huron Gastroenterology PC, Ypsilanti, Michigan

Trinity Health IHA Medical Group Hematology Oncology Ann Arbor Campus, Ypsilanti, Michigan

Sanford Joe Lueken Cancer Center, Bemidji, Minnesota

Essentia Health Saint Joseph's Medical Center, Brainerd, Minnesota

Mercy Hospital, Coon Rapids, Minnesota

Essentia Health - Deer River Clinic, Deer River, Minnesota

Essentia Health Cancer Center, Duluth, Minnesota

Essentia Health Hibbing Clinic, Hibbing, Minnesota

Saint John's Hospital - Healtheast, Maplewood, Minnesota

Abbott-Northwestern Hospital, Minneapolis, Minnesota

Park Nicollet Clinic - Saint Louis Park, Saint Louis Park, Minnesota

Regions Hospital, Saint Paul, Minnesota

United Hospital, Saint Paul, Minnesota

Essentia Health Sandstone, Sandstone, Minnesota

Essentia Health Virginia Clinic, Virginia, Minnesota

Saint Francis Medical Center, Cape Girardeau, Missouri

Saint Luke's Hospital, Chesterfield, Missouri

Siteman Cancer Center at West County Hospital, Creve Coeur, Missouri

University Health Truman Medical Center, Kansas City, Missouri

University of Kansas Cancer Center - North, Kansas City, Missouri

University of Kansas Cancer Center - Lee's Summit, Lee's Summit, Missouri

University of Kansas Cancer Center at North Kansas City Hospital, North Kansas City, Missouri

Washington University School of Medicine, Saint Louis, Missouri

Mercy Hospital South, Saint Louis, Missouri

Siteman Cancer Center-South County, Saint Louis, Missouri

Siteman Cancer Center at Christian Hospital, Saint Louis, Missouri

Siteman Cancer Center at Saint Peters Hospital, Saint Peters, Missouri

Mercy Hospital Springfield, Springfield, Missouri

CoxHealth South Hospital, Springfield, Missouri

Community Hospital of Anaconda, Anaconda, Montana

Billings Clinic Cancer Center, Billings, Montana

Bozeman Health Deaconess Hospital, Bozeman, Montana

Benefis Sletten Cancer Institute, Great Falls, Montana

Logan Health Medical Center, Kalispell, Montana

Community Medical Center, Missoula, Montana

Nebraska Medicine-Bellevue, Bellevue, Nebraska

Nebraska Medicine-Village Pointe, Omaha, Nebraska

University of Nebraska Medical Center, Omaha, Nebraska

Roswell Park Cancer Institute, Buffalo, New York

Hematology Oncology Associates of CNY at Camillus, Camillus, New York

Hematology Oncology Associates of Central New York-East Syracuse, East Syracuse, New York

NYP/Weill Cornell Medical Center, New York, New York

University of Rochester, Rochester, New York

Wilmot Cancer Institute at Webster, Webster, New York

UNC Lineberger Comprehensive Cancer Center, Chapel Hill, North Carolina

Duke University Medical Center, Durham, North Carolina

Sanford Bismarck Medical Center, Bismarck, North Dakota

Essentia Health Cancer Center-South University Clinic, Fargo, North Dakota

Sanford Broadway Medical Center, Fargo, North Dakota

Sanford Roger Maris Cancer Center, Fargo, North Dakota

Ohio State University Comprehensive Cancer Center, Columbus, Ohio

Cancer Centers of Southwest Oklahoma Research, Lawton, Oklahoma

University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma

Oklahoma Cancer Specialists and Research Institute-Tulsa, Tulsa, Oklahoma

Providence Newberg Medical Center, Newberg, Oregon

Saint Alphonsus Cancer Care Center-Ontario, Ontario, Oregon

Providence Willamette Falls Medical Center, Oregon City, Oregon

Providence Portland Medical Center, Portland, Oregon

Providence Saint Vincent Medical Center, Portland, Oregon

Rhode Island Hospital, Providence, Rhode Island

Smilow Cancer Hospital Care Center - Westerly, Westerly, Rhode Island

Prisma Health Cancer Institute - Spartanburg, Boiling Springs, South Carolina

Medical University of South Carolina, Charleston, South Carolina

Prisma Health Cancer Institute - Easley, Easley, South Carolina

Prisma Health Cancer Institute - Butternut, Greenville, South Carolina

Prisma Health Cancer Institute - Faris, Greenville, South Carolina

Prisma Health Cancer Institute - Eastside, Greenville, South Carolina

Prisma Health Cancer Institute - Greer, Greer, South Carolina

Prisma Health Cancer Institute - Seneca, Seneca, South Carolina

Sanford Cancer Center Oncology Clinic, Sioux Falls, South Dakota

Sanford USD Medical Center - Sioux Falls, Sioux Falls, South Dakota

Huntsman Cancer Institute/University of Utah, Salt Lake City, Utah

VCU Massey Cancer Center at Stony Point, Richmond, Virginia

Virginia Commonwealth University/Massey Cancer Center, Richmond, Virginia

Swedish Cancer Institute-Edmonds, Edmonds, Washington

Swedish Cancer Institute-Issaquah, Issaquah, Washington

Swedish Medical Center-First Hill, Seattle, Washington

Duluth Clinic Ashland, Ashland, Wisconsin

Marshfield Medical Center-EC Cancer Center, Eau Claire, Wisconsin

University of Wisconsin Carbone Cancer Center - Johnson Creek, Johnson Creek, Wisconsin

Gundersen Lutheran Medical Center, La Crosse, Wisconsin

University of Wisconsin Carbone Cancer Center - Eastpark Medical Center, Madison, Wisconsin

University of Wisconsin Carbone Cancer Center - University Hospital, Madison, Wisconsin

Marshfield Medical Center-Marshfield, Marshfield, Wisconsin

Medical College of Wisconsin, Milwaukee, Wisconsin

Marshfield Medical Center - Minocqua, Minocqua, Wisconsin

ProHealth D N Greenwald Center, Mukwonago, Wisconsin

Froedtert and MCW Moorland Reserve Health Center, New Berlin, Wisconsin

ProHealth Oconomowoc Memorial Hospital, Oconomowoc, Wisconsin

Marshfield Medical Center-Rice Lake, Rice Lake, Wisconsin

Marshfield Medical Center-River Region at Stevens Point, Stevens Point, Wisconsin

UW Cancer Center at ProHealth Care, Waukesha, Wisconsin

Marshfield Medical Center - Weston, Weston, Wisconsin

Conditions: Mantle Cell Lymphoma

Learn More ›

Acalabrutinib and Obinutuzumab for the Treatment of Previously Untreated Follicular Lymphoma or Other Indolent Non-Hodgkin Lymphomas

NCT04883437

Recruiting

This phase II trial studies the effect of acalabrutinib and obinutuzumab in treating patients with follicular lymphoma or other indolent non-Hodgkin lymphoma for which the patient has not received treatment in the past (previously untreated). Acalabrutinib may stop the growth of cancer cells by blocking some of the enzymes needed for cell growth. Immunotherapy with obinutuzumab may induce changes in body's immune system and may interfere with the ability of cancer cells to grow and spread. Givin... Read More

Gender:

ALL

Ages:

18 years and above

Trial Updated:

03/24/2025

Locations: Emory University Hospital/Winship Cancer Institute, Atlanta, Georgia

Conditions: Grade 1 Follicular Lymphoma, Grade 2 Follicular Lymphoma, Grade 3a Follicular Lymphoma, Indolent Non-Hodgkin Lymphoma, Lymphoplasmacytic Lymphoma, Lymphoproliferative Disorder, Mantle Cell Lymphoma, Marginal Zone Lymphoma

Learn More ›

Cytokine-Treated Veto Cells in Treating Patients with Hematologic Malignancies Following Stem Cell Transplant

NCT03622788

Recruiting

This phase I/II trial studies how well cytokine-treated veto cells work in treating patients with hematologic malignancies following stem cell transplant. Giving chemotherapy and total-body irradiation before a stem cell transplant helps stop the growth of cells in the bone marrow, including normal blood-forming cells (stem cells) and cancer cells. When the healthy stem cells from a donor are infused into the patient, they may help the patient's bone marrow make stem cells, red blood cells, whit... Read More

Gender:

ALL

Ages:

Between 12 years and 75 years

Trial Updated:

03/21/2025

Locations: M D Anderson Cancer Center, Houston, Texas

Conditions: Acute Lymphoblastic Leukemia, Acute Myeloid Leukemia, Aplastic Anemia, Bone Marrow Failure, Chronic Lymphocytic Leukemia, Chronic Myelogenous Leukemia, BCR-ABL1 Positive, Follicular Lymphoma, Hodgkin Lymphoma, Mantle Cell Lymphoma, Myelodysplastic Syndrome, Myeloproliferative Neoplasm, Non-Hodgkin Lymphoma, Plasma Cell Myeloma

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Phase II Study of Pirtobrutinib, Rituximab (PR) in Previously Untreated Low and Intermediate Risk MCL (Mantle Cell Lymphoma) Patients

NCT06263491

Recruiting

To learn if the chemotherapy-free combination of pirtobrutinib (also called LOXO-305) and rituximab can help provide long term remission in low and intermediate risk MCL.

Gender:

ALL

Ages:

18 years and above

Trial Updated:

03/18/2025

Locations: MD Anderson Cancer Center, Houston, Texas

Conditions: Mantle Cell Lymphoma

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A Dose Escalation and Dose Expansion Study of Intratumoral ONM-501 Alone and in Combination With Cemiplimab in Patients With Advanced Solid Tumors and Lymphomas.

NCT06022029

Recruiting

A phase 1, multicenter, open label, non-randomized dose escalation and dose expansion study to examine the maximum tolerated dose, (MTD), minimum effective dose (MED) and/or recommended dose for expansion (RDE) of intratumoral ONM-501 as monotherapy and in combination with a PD-1 checkpoint inhibitor in patients with advanced solid tumors and lymphomas.

Gender:

ALL

Ages:

18 years and above

Trial Updated:

03/18/2025

Locations: California Research Institute, Los Angeles, California +14 locations

Conditions: Triple Negative Breast Cancer, Diffuse Large B Cell Lymphoma, Follicular Lymphoma, Lymphoma, Non-Hodgkin, Mantle Cell Lymphoma, Bladder Cancer, Uveal Melanoma, Recurrent, Cervix Cancer, Carcinoma in Situ, Head and Neck Squamous Cell Carcinoma, Skin Cancer, Metastatic Cancer, Tumor, Solid, Tumor Recurrence

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