There are currently 548 clinical trials in Charlotte, North Carolina looking for participants to engage in research studies. Trials are conducted at various facilities, including Carolinas Medical Center, Carolinas Medical Center/Levine Cancer Institute, Novant Health Presbyterain Medical Center and Levine Cancer Institute. Whether you're a healthy volunteer looking to participate in paid medical research or seeking trials related to a specific condition, the city provides a diverse range of opportunities near you.
Adapting a Sepsis Transition and Recovery Program for Optimal Scale Up
NCT05997420
Recruiting
The Adapting a Sepsis Transition and Recovery Program for Optimal Scale Up (ASTROS) study is an effectiveness-implementation hybrid design. The effectiveness evaluation is designed as a multiple interrupted time series (mITS) analysis to test the impact of implementing an adapted Sepsis Transition and Recovery (STAR) program on enhancing post sepsis outcomes in new hospital settings.
Gender:
All
Ages:
18 years and above
Trial Updated:
01/29/2024
Locations: Atrium Health, Charlotte, North Carolina
Conditions: Sepsis
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CAPACITY (Cardiac Amyloidosis and Physical ACtivITY) Study
NCT06096675
Recruiting
Exercise training in patients with heart failure and preserved ejection fraction (HFpEF) has been associated with an improvement in cardiorespiratory fitness and quality of life.
Gender:
All
Ages:
18 years and above
Trial Updated:
01/29/2024
Locations: Sanger Heart and Vascular Institute, Charlotte, North Carolina
Conditions: Cardiac Amyloidosis
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Collecting and Storing Tissue From Young Patients With Cancer
NCT00898755
Recruiting
This laboratory study is collecting and storing tissue, blood, and bone marrow samples from young patients with cancer. Collecting and storing samples of tissue, blood, and bone marrow from patients with cancer to study in the laboratory may help doctors learn more about changes that may occur in DNA and identify biomarkers related to cancer.
Gender:
All
Ages:
21 years and below
Trial Updated:
01/29/2024
Locations: Carolinas Medical Center/Levine Cancer Institute, Charlotte, North Carolina
Conditions: Acute Lymphoblastic Leukemia, Rhabdomyosarcoma, Acute Myeloid Leukemia, Central Nervous System Neoplasm, Ewing Sarcoma, Germ Cell Tumor, Leukemia, Lymphoma, Malignant Neoplasm, Neuroblastoma, Osteosarcoma, Retinoblastoma, Rhabdoid Tumor, Soft Tissue Sarcoma
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Xeomin® and Gait Related Mobility After Stroke
NCT04908423
Recruiting
The aim of the present pilot study is to evaluate the association between change in gait related mobility in ambulatory male and female adult hemiparetic patients before and 4-6-weeks after Xeomin® injection into the upper limb, using two standardized tests of physical function in outpatient rehabilitation that are widely used; the 10-meter walk test and the timed 'up and go' test (TUG).
Gender:
All
Ages:
Between 18 years and 79 years
Trial Updated:
01/25/2024
Locations: Carolinas Rehabilitation, Charlotte, North Carolina
Conditions: Stroke
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A Phase 3 Study Evaluating Efficacy and Safety of Lanifibranor Followed by an Active Treatment Extension in Adult Patients With (NASH) and Fibrosis Stages F2 and F3 ( NATiV3 )
NCT04849728
Recruiting
This Phase 3 study is conducted to evaluate lanifibranor in adults with NASH and liver fibrosis histological stage F2 or F3
Gender:
All
Ages:
18 years and above
Trial Updated:
01/24/2024
Locations: Charlotte Gastroenterology and Hepatology - Randolph Road Office, Charlotte, North Carolina
Conditions: NASH - Nonalcoholic Steatohepatitis
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Robotic Mechanical Coring for the Treatment of Moderate to Severe Facial Wrinkles
NCT05091788
Recruiting
This study is a prospective, up to 4 center study of the safety and efficacy of mechanical coring with skin closure of cored holes, intended for the improvement in the appearance of wrinkles of the cheeks in up to 70 subjects after two treatments.
Gender:
All
Ages:
Between 22 years and 75 years
Trial Updated:
01/24/2024
Locations: Dermatology, Laser & Vein Specialists of the Carolinas, PLLC, Charlotte, North Carolina
Conditions: Wrinkle
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Evaluating the SUBLOCADE Treatment Exit Strategy
NCT05878210
Recruiting
The purpose of this study is to observe and assess the successful taper and opioid withdrawal experience after participants stop receiving SUBLOCADE because their healthcare provider determines their disease symptoms have been controlled for at least 9 months and they, together with their healthcare provider, plan to discontinue MOUD.
Gender:
All
Ages:
18 years and above
Trial Updated:
01/23/2024
Locations: Onsite Clinical Solutions, Charlotte, North Carolina
Conditions: Opioid Use Disorder
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Epithelium-On Corneal Cross-linking in Subjects 8 to 45 Years of Age With Keratoconus
NCT06100952
Recruiting
A Multicenter, Randomized, Double-Masked, Sham-Controlled, Parallel-Group Phase 3 Study to Evaluate the Efficacy and Safety of Epithelium-On Corneal Cross-linking in Subjects 8 to 45 Years of Age With Keratoconus
Gender:
All
Ages:
Between 8 years and 45 years
Trial Updated:
01/23/2024
Locations: Providence Eye and Laser Specialists, Charlotte, North Carolina
Conditions: Keratoconus
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Cephea Early Feasibility Study
NCT05061004
Recruiting
The objective of this study is to evaluate the preliminary safety and effectiveness of the Cephea Mitral Valve System for the treatment of symptomatic patients with mitral valve disease (including mitral regurgitation, mitral stenosis and mixed mitral valve disease) in whom transcatheter therapy is deemed more appropriate than open heart surgery.
Gender:
All
Ages:
18 years and above
Trial Updated:
01/22/2024
Locations: Carolinas Medical Center, Charlotte, North Carolina
Conditions: Mitral Regurgitation
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A Study of U3-1402 (Patritumab Deruxtecan) in Subjects With Metastatic Breast Cancer
NCT04699630
Recruiting
This study is to evaluate safety and efficacy of an antibody drug conjugate U3-1402 (patritumab deruxtecan) in patients with locally advanced or metastatic breast cancer (MBC).
Gender:
All
Ages:
18 years and above
Trial Updated:
01/22/2024
Locations: Levine Cancer Institute, Charlotte, North Carolina
Conditions: Metastatic Breast Cancer, Locally Advanced Breast Cancer
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Reducing Risk for Infective Endocarditis
NCT05721781
Recruiting
This clinical trial is studying if bacteria found in a participant's bloodstream after brushing their teeth can be prevented with a dental cleaning and more education on how to best brush and care for their teeth. One group of participants will have a dental cleaning and oral health instructions and the other group of participants will not. Researchers will compare the blood test results from the two groups to see if the education made a difference in preventing bacteria and how long it stays in... Read More
Gender:
All
Ages:
18 years and above
Trial Updated:
01/19/2024
Locations: Atrium Health's Carolinas Medical Center, Charlotte, North Carolina
Conditions: Bacteremia, Infective Endocarditis
Register for Updates
Evaluation of the GORE® EXCLUDER® Thoracoabdominal Branch Endoprosthesis in the Treatment of Thoracoabdominal and Pararenal Aortic Aneurysms
NCT03728985
Recruiting
Prospective, non-randomized, , multicenter study with two independent arms: Primary Study Arm - TAAA and Pararenal aneurysms requiring only TAMBE System. Hypothesis-driven analysis. Up to 65 additional subjects may be implanted in Continued Access Phase under the Primary Study Arm only Secondary Study Arm - TAAA requiring TAMBE System and CTAG Device(s). Non hypothesis-driven analysis. Minimum: 122 implanted subjects. Maximum: 202 implanted subjects with up to 65 additional subjects implanted... Read More
Gender:
All
Ages:
19 years and above
Trial Updated:
01/18/2024
Locations: Sanger Heart & Vascular Institute, Charlotte, North Carolina
Conditions: Thoracoabdominal Aortic Aneurysm
Register for Updates