The state of North Carolina currently has 55 active clinical trials seeking participants for Diabetes research studies. These trials are conducted in various cities, including Durham, Winston-Salem, Charlotte and Chapel Hill.
The Bennett Kids PowerUP Project
Recruiting
The study proposes a randomized pilot and feasibility study of a lifestyle modification program to promote healthy diet and activity in rural-dwelling children to reduce Type 2 Diabetes risks. Intervention participants will receive 6 months of programming to include: 16 activity packs; 9 health coach sessions; unlimited access to a resource toolbox. Control participants will receive 6 activity packs promoting science, technology, engineering, and math (STEM) learning and 6 check-in calls to s... Read More
Gender:
All
Ages:
Between 7 years and 10 years
Trial Updated:
03/13/2024
Locations: Wake Forest University Health Sciences, Winston-Salem, North Carolina
Conditions: Obesity, Childhood, Type2diabetes
A Study of Daily Oral Orforglipron (LY3502970) Compared With Insulin Glargine in Participants With Type 2 Diabetes and Obesity or Overweight at Increased Cardiovascular Risk
Recruiting
The main purpose of this study is to determine safety and efficacy of orforglipron compared with insulin glargine in participants with type 2 diabetes and obesity or overweight at increased cardiovascular risk. The study will last approximately 2 years may include up to 27 visits.
Gender:
All
Ages:
18 years and above
Trial Updated:
03/12/2024
Locations: University of North Carolina Medical Center, Chapel Hill, North Carolina +6 locations
Conditions: Type 2 Diabetes, Obesity, Overweight or Obesity, Overweight, Cardiovascular Diseases, Chronic Kidney Disease
Phase 2 Trial of BMF-219 in Participants With Type 1 Diabetes Mellitus
Recruiting
Phase 2 Trial of BMF-219 in Participants with Type 1 Diabetes Mellitus.
Gender:
All
Ages:
Between 18 years and 60 years
Trial Updated:
03/04/2024
Locations: Lucas Research, Inc., Morehead City, North Carolina
Conditions: Type 1 Diabetes Mellitus
CardioRenal Effects of SGLT2 Inhibition in Kidney Transplant Recipients
Recruiting
CREST-KT is a single-center, double-blinded, randomized trial of empagliflozin therapy in 72 kidney transplant recipients with (n=36) and without type 2 diabetes (n=36). After evenly dividing patients by type 2 diabetes diagnosis, patients will be randomized 2:1 to empagliflozin 10mg versus placebo.
Gender:
All
Ages:
18 years and above
Trial Updated:
02/26/2024
Locations: Duke University Medical Center, Durham, North Carolina
Conditions: Kidney Transplant; Complications, Diabetes Mellitus, Type 2
Study to Determine the Prevalence of Hypercortisolism in Patients With Type 2 Diabetes and Treatment With Korlym® (Mifepristone) (CATALYST)
Recruiting
This is a Phase 4 study with 2 parts: Part 1 (Prevalence Phase) is non-interventional and will assess the prevalence of hypercortisolism in a population with difficult to control type 2 diabetes (T2D) (hemoglobin A1c ≥7.5%) despite receiving standard-of-care therapies. Part 2 (Treatment Phase) is a randomized, prospective, placebo-controlled, double-blind multi-center trial that will assess the safety and efficacy of mifepristone treatment in patients with hypercortisolism who have difficult to... Read More
Gender:
All
Ages:
Between 18 years and 80 years
Trial Updated:
02/22/2024
Locations: Site 181, Chapel Hill, North Carolina +1 locations
Conditions: Hypercortisolism, Diabetes Mellitus, Type 2
A Study Called FINE-REAL to Learn More About the Use of the Drug Finerenone in a Routine Medical Care Setting
Recruiting
This is an observational study in people with chronic kidney disease (CKD) and type 2 diabetes (T2D) who will be receiving finerenone. Kidneys filter extra water and waste out of the blood and make urine. CKD is a long-term, progressive, decrease in the kidneys' ability to filter the blood properly. In people with T2D, the body does not make enough of a hormone called insulin, or does not use insulin well enough, resulting in high blood sugar levels that can cause damage to the kidneys. As a re... Read More
Gender:
All
Ages:
18 years and above
Trial Updated:
02/19/2024
Locations: Gaffney Health Services, Charlotte, North Carolina +2 locations
Conditions: Chronic Kidney Disease, Type 2 Diabetes Mellitus
In-Home Study With MiniMed™ 780G Pump Automated Control in Type 2-Evaluation of the AHCL System in Adults With Insulin-requiring Type 2 Diabetes
Recruiting
The objective of the study is to assess the safety and effectiveness of MiniMed™ 780G system in adult subjects with insulin-requiring type 2 diabetes in a home setting. The combined run-in period and study period will be approximately 135 days long.
Gender:
All
Ages:
Between 18 years and 80 years
Trial Updated:
02/15/2024
Locations: Physicians East, Greenville, North Carolina
Conditions: Type 2 Diabetes Treated With Insulin
DIALYSIS-TIR Study
Recruiting
This study will look at control of blood sugar levels in persons with type 2 diabetes mellitus currently on chronic dialysis. Researchers will compare blood sugar levels in people taking semaglutide to people taking "dummy" medicine. The treatment participants get will be decided randomly. Participants will need to inject the study medication once a week. The study will last for 1 year and a month. Participants will be asked to wear a sensor that measures blood sugar levels for a period of 10 d... Read More
Gender:
All
Ages:
18 years and above
Trial Updated:
02/11/2024
Locations: University of North Carolina, Chapel Hill, North Carolina
Conditions: Type 2 Diabetes, End Stage Renal Disease on Dialysis
Study of BMF-219 in Healthy Adult Subjects and in Adult Subjects With Type 2 Diabetes Mellitus (T2D)
Recruiting
A Phase 1/ 2 Randomized, Double-Blind, Placebo-Controlled Single and Multiple Ascending Dose Study to Evaluate the Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of BMF-219, an Oral Covalent Menin Inhibitor, in Healthy Adult Subjects and in Adult Subjects with Type 2 Diabetes Mellitus.
Gender:
All
Ages:
Between 18 years and 65 years
Trial Updated:
02/09/2024
Locations: Tyron Medical Partners, Charlotte, North Carolina +2 locations
Conditions: Type 2 Diabetes Mellitus
Rural Area Pharmacist Intervention for Diabetes
Recruiting
The goal of the project is to inform the system leaders regarding the feasibility and utility of having an embedded telehealth-based clinical pharmacist at rural primary care practices for supportive disease management of patients with Type 2 diabetes (T2D) and whether continuing and expanding the program within the system is worthwhile.
Gender:
All
Ages:
Between 18 years and 75 years
Trial Updated:
02/05/2024
Locations: Wake Forest University Health Sciences, Winston-Salem, North Carolina
Conditions: Type 2 Diabetes
The HARMONY Study: A Intervention to Reduce Cardiometabolic Risk in African American Women
Recruiting
This study will test whether a culturally-tailored nutrition and exercise intervention designed for African-American women will lead to sustained improvements in exercise and healthy eating through improvements in self-management mediators: mindfulness, stress management, positive reappraisal, self-regulation, and self-efficacy.
Gender:
Female
Ages:
18 years and above
Trial Updated:
01/29/2024
Locations: The University of North Carolina at Chapel Hill, Chapel Hill, North Carolina
Conditions: Heart Diseases, Stroke, Pre-diabetes, Hypertension, Obesity, Overweight, Stress
Optimizing In-hospital Use of Evidence-based Therapies for Patients With Cardio-Renal-Metabolic Disease
Recruiting
This study will be a prospective randomized implementation trial for patients hospitalized with heart failure, chronic kidney disease, and/or type 2 diabetes mellitus within Duke University Medical Center. The primary hypothesis is that a virtual quality improvement-based consult intervention will improve the rate of in-hospital evidence-based cardio-renal-metabolic medication use, particularly SGLT2 inhibitor therapy. Approximately 200 patients meeting eligibility criteria will be included in t... Read More
Gender:
All
Ages:
18 years and above
Trial Updated:
01/09/2024
Locations: Duke University Medical Center, Durham, North Carolina
Conditions: Heart Failure, Type 2 Diabetes, Chronic Kidney Diseases