Personalized Environment and Genes Study
Recruiting
Despite the overwhelming focus on genetic and genomic causes of human disease over the past two decades, it has been estimated that genetics is currently known to explain only 20% and 40% of the etiology of common disease. Thus, it is becoming increasingly apparent that human disease is a consequence of both genetic susceptibility and environmental exposures. Importantly, while individuals cannot change their genetic composition, we do have the ability both personally and as a society, to influe... Read More
Gender:
All
Ages:
Between 18 years and 120 years
Locations: NIEHS Clinical Research Unit (CRU), Research Triangle Park, North Carolina
Conditions: Diabetes, Heart Disease, Asthma
Investigation of Rifampin to Reduce Pedal Amputations for Osteomyelitis in Diabetics
Recruiting
The purpose of this research study is to determine if rifampin, an antibiotic (a medicine that treats infections), is effective in treating osteomyelitis (infection of the bone) of the foot in diabetic patients. Despite use of powerful antibiotics prescribed over a long period of time, many diabetic patients remain at a high risk for needing an amputation of part of the foot or lower leg because the osteomyelitis is not cured. Some small research studies have shown that addition of rifampin to o... Read More
Gender:
All
Ages:
Between 18 years and 89 years
Locations: Salisbury W.G. (Bill) Hefner VA Medical Center, Salisbury, NC, Salisbury, North Carolina +29 locations
Conditions: Osteomyelitis, Diabetes, Amputation
Effect of Corticosteroid Injections on Blood Glucose
Recruiting
The purpose of this study is to measure the effect of various corticosteroid and other anti-inflammatories administered to the glenohumeral joint in diabetic patients on resultant blood glucose readings.
Gender:
All
Ages:
Between 40 years and 75 years
Locations: Duke Sports Science Institute, Durham, North Carolina
Conditions: Diabetes Mellitus, Steroid Diabetes, Shoulder Pain
Tailored Approaches to Reduce Distress and Improve Self-Management for Veterans With Diabetes
Recruiting
Veterans with diabetes may become overwhelmed with the self-management behaviors needed to maintain optimal health. Veterans may experience diabetes distress (DD), a concept distinct from depression, due the amount and frequency of these behaviors. DD negatively influences the Veteran's engagement in self-management and subsequent HbA1c levels. Previous interventions do not tailor T2D self-management information to a Veteran's DD, which may be one reason interventions are ineffective at reducing... Read More
Gender:
All
Ages:
Between 18 years and 80 years
Locations: Durham VA Medical Center, Durham, NC, Durham, North Carolina
Conditions: Diabetes, Diabetes Distress, Self-Management, Veteran
Onco-primary Care Networking to Support TEAM-based Care
Recruiting
The proposed ONE TEAM Study is an 18-month, cluster randomized controlled trial. This study will use a sequential multiple assignment randomized trial (SMART) design with a second randomization for the intervention group using a dynamic treatment regimen approach. The investigators propose to randomize 800 adults with newly-diagnosed selected cancers treated with curative intent (breast, prostate, colorectal, endometrial, non-small cell lung, and endometrial) and with >1 selected cardiovascular... Read More
Gender:
All
Ages:
Between 18 years and 79 years
Locations: Duke University Medical Center, Durham, North Carolina
Conditions: Blood Pressure, Hypertension, Cancer, Cancer, Breast, Cancer of Prostate, Cancer Colorectal, Cancer, Endometrial, Cancer of Head and Neck, Non Small Cell Lung Cancer, CVD - Cardiovascular Disease, Diabetes Mellitus, Hypercholesterolemia, Diabetes, Cancer of Esophagus, Cancer of Liver, Cancer, Renal Cell, Cancer of Pancreas, Cancer Ovaries
DHS MIND Metabolomics
Recruiting
The study team will evaluate whether metabolomic signatures of neurocognitive decline trajectories are exacerbated by the presence of type 2 diabetes mellitus (T2D) and whether these signatures contribute in part, to ethnic disparities in cognitive decline between European Americans and African Americans with T2D.
Gender:
All
Ages:
18 years and above
Locations: Wake Forest University Health Sciences, Winston-Salem, North Carolina
Conditions: Diabetes
Comparative Effectiveness of Telemedicine in Primary Care
Recruiting
Leveraging a natural experiment approach, the investigators will examine rapidly changing telemedicine and in-person models of care during and after the COVID-19 crisis to determine whether certain patients could safely choose to continue telemedicine or telemedicine-supplemented care, rather than return to in-person care.
Gender:
All
Ages:
19 years and above
Locations: University of North Carolina, Chapel Hill, North Carolina +3 locations
Conditions: Asthma, Chronic Obstructive Pulmonary Disease (COPD, Congestive Heart Failure, Diabetes, Hypertension
NC Works4Health: Reducing Chronic Disease Risks in Socioeconomically Disadvantaged, Unemployed Populations
Recruiting
The proposed study, NC Works4Health (NCW4H), builds on the strengths of long-standing academic-community research partnerships between this UNC at Chapel Hill (UNC) team of investigators and key stakeholders across health, social service, employment, and economic development sectors. The overall goal of this study is to test the effectiveness of a multilevel intervention that can be readily adopted by communities to reduce chronic disease risks in socioeconomically disadvantaged populations by (... Read More
Gender:
All
Ages:
Between 18 years and 64 years
Locations: University of North Carolina at Chapel Hill, Chapel Hill, North Carolina
Conditions: Diabetes, Chronic Disease, Psychological Distress
Electronic Frailty Index (eFI)Cacious-Diabetes Care
Recruiting
The purpose of this research is to explore whether a pharmacist-led diabetes management program can help optimize diabetes care for older adults. Participation in this study will involve meeting with a pharmacist who works with subjects' doctors, getting some routine bloodwork typical for people with diabetes, and potentially adjusting the subject's diabetes medications to reach American Diabetes Association guidelines. This study aims to bring older adults with diabetes whose measurements and m... Read More
Gender:
All
Ages:
65 years and above
Locations: Atrium Health Wake Forest Baptist Health, Winston-Salem, North Carolina
Conditions: Diabetes, Type2 Diabetes
Iron Reduction for the Treatment of Diabetes and Nonalcoholic Fatty Liver Disease
Recruiting
This is a treatment study to determine if reducing the body's iron stores by blood donation will improve diabetes control and other problems associated with diabetes such as fatty liver disease.
Gender:
All
Ages:
Between 40 years and 75 years
Locations: University of North Carolina at Chapel Hill (UNC), Chapel Hill, North Carolina +1 locations
Conditions: Iron, Diabetes, Nonalcoholic Fatty Liver
Rare and Atypical Diabetes Network
Recruiting
RADIANT is a network of 14 clinical sites and several laboratories dedicated to the study of atypical diabetes. The objective of this study is to define new forms of diabetes and the unique mechanisms underlying these forms of atypical diabetes. The specific aims are to: Identify and enroll individuals and families with undiagnosed rare and atypical forms of diabetes. Determine the etiologic basis of the metabolic disorder among individuals and families with novel forms of rare and atypical di... Read More
Gender:
All
Ages:
All
Locations: University of North Carolina at Chapel Hill, Chapel Hill, North Carolina +13 locations
Conditions: Diabetes Mellitus, Diabetes Mellitus Progression, Glucose Intolerance, Glucose Metabolism Disorders, Metabolic Disease, Endocrine; Complications, Endocrine System Diseases
Continuous Monitoring and Control of Hypoglycemia
Recruiting
Evaluate safety of non-adjunctive CGM use in CGM naive participants.
Gender:
All
Ages:
2 years and above
Locations: Mountain Diabetes and Endocrine Center, Asheville, North Carolina +24 locations
Conditions: Diabetes