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Dementia Clinical Trials in Durham, NC
A listing of 11 Dementia clinical trials in Durham, NC actively recruiting volunteers for paid trials and research studies in various therapeutic areas.
1 - 11 of 11
The city of Durham, North Carolina, currently has 11 active clinical trials seeking participants for Dementia research studies.
Featured Trial
Paid Clinical Studies Nationwide
Recruiting
Nationwide clinical trials offered in your area. Some trials offering up to several thousand dollars in compensation for participation.
Featured Trial
Healthy Volunteer Trials
Recruiting
Healthy trials near you are looking for participants to help push medical research forward. Click through to learn more!
Conditions:
Healthy
Featured Trial
Salivary Biomarkers for People with Frontotemporal Dementia (FTD)
Recruiting
Participants for this study included anyone ages 45 to 85+ years of age with Frontotemporal Dementia (FTD). In this research study, you will be potentially required to give a saliva sample. This saliva sample will be obtained by a cotton pad being placed within the participant's mouth absorbing the saliva. In addition, Prior to the salivary collection, you will be potentially asked to take a general survey about your diagnosis and other health questions to verify if you fit the criteria for the study. The purpose of this study is to provide insight into how we can use the proteins Tau and TDP-43 can be used to identify Frontotemporal Dementia early. Another important aspect of this research is to create a non-invasive biomarker using saliva that can benefit the efficiency of identifying disease
Conditions:
Frontotemporal Dementia
Frontotemporal Degeneration
FTD
Frontotemporal Dementia (FTD)
Frontal Temporal Dementia (FTD)
Featured Trial
Mild To Moderate Alzheimer's Disease Study
Recruiting
Join the effort to help research an investigational drug for Alzheimer's Disease. Those who qualify may receive:
o Compensation for time
o Reimbursement for study-related travel
o Study-related care from local doctors
o Study drug
o Compensation for time
o Reimbursement for study-related travel
o Study-related care from local doctors
o Study drug
Conditions:
Alzheimer Disease
Alzheimer's Disease
Alzheimer Dementia
Dementia Alzheimers
Dementia
Featured Trial
Cardiovascular Disease Trials
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Cardiovascular Disease trials near you are looking for participants to help push medical research forward. Click through to learn more!
Conditions:
Cardiovascular Disease
Featured Trial
Overweight Trials
Recruiting
Overweight trials near you are looking for participants to help push medical research forward. Click through to learn more!
Conditions:
Overweight
Alzheimer's Disease Neuroimaging Initiative 4
Recruiting
Since its launch in 2004, the overarching aim of the Alzheimer's Disease Neuroimaging Initiative (ADNI) Study has been to validate biomarkers for Alzheimer's disease (AD) clinical trials. ADNI4 continues the previously funded ADNI1, ADNI-GO, ADNI2, and ADNI3 studies that have combined public/private collaborations between academia and industry to determine the relationships between the clinical, cognitive, imaging, genetic and biochemical biomarker characteristics of the entire spectrum of AD.
Gender:
All
Ages:
Between 55 years and 90 years
Trial Updated:
06/19/2024
Locations: Duke University Medical Center, Durham, North Carolina
Ferritin and Iron Burden in SAH sIRB
Recruiting
Ruptured cerebral aneurysms lead to subarachnoid hemorrhage (SAH),that has a high morbidity and mortality rate, the severity of which is predicted by the "Hunt-Hess grade" (HHG).
SAH leads to iron (Fe) and hemoglobin (Hb) accumulation in the brain, which is toxic for neurons. Ferritin (iron reported in the brian) and iron overload leads to brain atrophy, specifically in the mesial temporal lobe (hippocampus, impairing patients' cognition. It is estimated that 50% of survivors have cognitive def... Read More
Gender:
All
Ages:
Between 18 years and 75 years
Trial Updated:
06/18/2024
Locations: Duke University Health System, Durham, North Carolina
Conditions: SAH, Dementia
A Study to Learn About the Safety of BIIB080 and Whether it Can Improve Symptoms of Participants With Mild Cognitive Impairment Due to Alzheimer's Disease (AD) or Mild AD Dementia Between 50 to 80 Years of Age
Recruiting
In this study, researchers will learn more about a study drug called BIIB080. The study will focus on participants with mild cognitive impairment or mild dementia due to AD.
The main question researchers are trying to answer is if BIIB080 can slow the worsening of AD more than placebo. It will focus on what dose of BIIB080 slows worsening of AD the most.
To help answer this question, researchers will use the Clinical Dementia Rating-Sum of Boxes, also known as the CDR-SB.
Clinicians use the C... Read More
Gender:
All
Ages:
Between 50 years and 80 years
Trial Updated:
06/18/2024
Locations: Duke University, Durham, North Carolina
Conditions: Mild Cognitive Impairment Due to Alzheimer's Disease, Alzheimer's Disease Dementia
Stress Management Toolkit for People Living With Dementia and Their Care Partners
Recruiting
The purpose of this study is to develop a prototype of a home-based, dyadic tangible toolkit comprised of simple tools to help people living with dementia (PLWD) and their care partners manage stress at home.
A human-centered design approach will be used to develop and user-test a prototype of a dyadic, tangible stress-management toolkit with and for PLWD and their care partners; and to explore the feasibility of collecting several stress-related outcomes. A total of 4 focus groups (n=3-4 dyads... Read More
Gender:
All
Ages:
21 years and above
Trial Updated:
06/18/2024
Locations: Caregiver and dementia community support organizations, Durham, North Carolina
Pragmatic Evaluation of Events And Benefits of Lipid-lowering in Older Adults
Recruiting
PREVENTABLE is a multi-center, randomized, parallel group, placebo-controlled superiority study. Participants will be randomized 1:1 to atorvastatin 40 mg or placebo. This large study conducted in community-dwelling older adults without cardiovascular disease (CVD) or dementia will demonstrate the benefit of statins for reducing the primary composite of death, dementia, and persistent disability and secondary composites including mild cognitive impairment (MCI) and cardiovascular events.
Gender:
All
Ages:
75 years and above
Trial Updated:
06/14/2024
Locations: PREVENTABLE Tele-Site, Durham, North Carolina +2 locations
Family Involvement Hospital Ethnography
Recruiting
The goal of this observational study is to learn about the role of family members in caring for hospitalized older adults with cognitive impairment. The main questions it aims to answer are:
What features of the healthcare system facilitate or hinder family involvement in care from the perspective of patients, families, and healthcare workers?
How do hospital leaders understand the facilitators and barriers to family involvement?
Data collection will occur via semi-structure interviews, direct... Read More
Gender:
All
Ages:
18 years and above
Trial Updated:
05/23/2024
Locations: Duke Regional Hospital, Durham, North Carolina
Conditions: Dementia
Long Term, Extension Study of the Safety and Efficacy of AVP-786 for the Treatment of Agitation in Patients With Dementia of the Alzheimer's Type
Recruiting
This is an extension study of the Phase 3 Studies 15-AVP-786-301, 15-AVP-786-302, and 17-AVP-786-305, which also allows participants from the Phase 2 Study 12-AVR-131 to be included.
Gender:
All
Ages:
Between 50 years and 90 years
Trial Updated:
05/22/2024
Locations: Duke University Medical Center, Durham, North Carolina
Conditions: Agitation in Patients With Dementia of the Alzheimer's Type
Clinical Procedures to Support Research in ALS
Recruiting
The purpose of the Clinical Procedures To Support Research (CAPTURE) study is to utilize information collected in the medical record to learn more about a disease called amyotrophic lateral sclerosis (ALS) and related disorders.
Gender:
All
Ages:
18 years and above
Trial Updated:
05/17/2024
Locations: Duke University, Durham, North Carolina
Conditions: Amyotrophic Lateral Sclerosis, ALS-Frontotemporal Dementia, Primary Lateral Sclerosis, Progressive Muscular Atrophy
Retinal Imaging in Neurodegenerative Disease
Recruiting
This study aims to develop and evaluate biomarkers using non-invasive optical coherence tomography (OCT) and OCT angiography (OCTA) as well as ultra-widefield (UWF) fundus photography to assess the structure and function of the retinal and choroidal microvasculature and structure in persons with mild cognitive impairment (MCI) and Alzheimer's Disease (AD), Parkinson's Disease (PD), or other neurodegenerative disease, diseases as outlined.
Gender:
All
Ages:
18 years and above
Trial Updated:
01/29/2024
Locations: Duke University Medical Center, Durham, North Carolina
Conditions: Mild Cognitive Impairment, Multiple Sclerosis, Huntington Disease, Neuro-Degenerative Disease, Alzheimer's Disease, Parkinson's Disease, Lewy Body Dementia, Frontotemporal Dementia, Amyotrophic Lateral Sclerosis (ALS), APOE-4 Positive, Traumatic Brain Injury, Concussion, Post-Traumatic Stress Disorder, Down Syndrome, Normal Cognition
Trial of Parkinson's And Zoledronic Acid
Recruiting
This home-based study is a randomized (1:1) placebo-controlled trial of a single infusion of zoledronic acid-5 mg (ZA) for the prevention of fractures in men and women aged 60 years and older with Parkinson's disease and parkinsonism with at least 2 years of follow-up. A total of 3500 participants will be enrolled and randomized in the United States. Participants, follow-up outcome assessors, and study investigators will be blinded to assigned study treatment. This trial is funded by the Nationa... Read More
Gender:
All
Ages:
60 years and above
Trial Updated:
07/24/2023
Locations: Duke University, Durham, North Carolina
Conditions: Parkinson Disease, Osteoporosis, Parkinsonism, Parkinson's Disease and Parkinsonism, Atypical Parkinsonism, Progressive Supranuclear Palsy, Multiple System Atrophy, Vascular Parkinsonism, Dementia With Lewy Bodies
Preventing Alzheimer's With Cognitive Training
Recruiting
Dementia is the most expensive medical condition in the US and increases in prevalence with age. More than 5 million Americans have Alzheimer's disease, the most common form of dementia. Mild cognitive impairment is a transitional stage between normal cognitive aging and Alzheimer's disease or another type of dementia, and is indicative of higher risk for dementia. In addition to the obvious health and quality-of-life ramifications of dementia, there are high direct (e.g., subsidizing residentia... Read More
Gender:
All
Ages:
65 years and above
Trial Updated:
11/21/2022
Locations: Duke Health, Durham, North Carolina
Conditions: Age-related Cognitive Decline, Alzheimer's Disease and Related Dementias
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