The city of Durham, North Carolina, currently has 3 active clinical trials seeking participants for Depression research studies.
Combining rTMS & Aerobic Exercise to Treat Depression and Improve Post-Stroke Walking
Recruiting
Investigators primary aim is to carry out a two-site, randomized, double-blind, sham-controlled, phase II trial to systematically examine the potential for aerobic exercise (AEx) to enhance the anti-depressant benefits of rTMS in individuals with post-stroke depression (PSD). Investigators propose to determine the efficacy of combining two known anti-depressant treatments shown to be effective in non-stroke depression, aerobic exercise (AEx) and repetitive transcranial magnetic stimulation (rTM... Read More
Gender:
ALL
Ages:
Between 21 years and 70 years
Trial Updated:
06/24/2025
Locations: Duke University School of Medicine, Durham, North Carolina
Conditions: Stroke, Depression - Major Depressive Disorder, Walking Impairment
Treating Psychosocial Distress in Glaucoma
Recruiting
In this study, using three phases, the investigators will use an iterative development approach to refine a behavioral intervention for managing concomitant psychosocial distress in glaucoma. Phase 1: The investigators will begin by developing a baseline intervention using strategies from Acceptance and Commitment Therapy (ACT), and delivered using a mobile application. Phase 2: The investigators will refine the baseline intervention for glaucoma patients using qualitative interviews conducted w... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
06/02/2025
Locations: Duke University Eye Center, Durham, North Carolina
Conditions: Glaucoma, Primary Open Angle, Distress, Emotional, Anxiety, Depression
Adaptive Coping Skills Training to Improve Psychological Distress Among Cardiorespiratory Failure Survivors
Recruiting
Conditions treated in intensive care units (ICUs) such as the acute respiratory distress syndrome (ARDS), congestive heart failure, COVID pneumonia, and sepsis are common. These can lead to high rates of depression, anxiety, and PTSD that worsen quality of life. Yet there are few effective strategies able to overcome barriers of limited access to mental health care. Even less is known about the experiences of patients from racially and ethnically minoritized populations because of they haven't b... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
11/20/2024
Locations: Duke University Medical Center, Durham, North Carolina
Conditions: Depression, Anxiety, Post-traumatic Stress Disorder, Stress, Worries; Pain or Disability, Breath Shortness