Search
Pain Clinical Trials in Durham, NC
A listing of 18 Pain clinical trials in Durham, NC actively recruiting volunteers for paid trials and research studies in various therapeutic areas.
1 - 12 of 18
The city of Durham, North Carolina, currently has 18 active clinical trials seeking participants for Pain research studies.
Featured Trial
Paid Clinical Studies Nationwide
Recruiting
Nationwide clinical trials offered in your area. Some trials offering up to several thousand dollars in compensation for participation.
Featured Offer
Lose Weight with GLP-1 Medications
Recruiting
Policy Lab has partnered with OnlineSemaglutide.org to offer trusted access to semaglutide and other GLP-1 medications, including generic alternatives to Ozempic® and Wegovy®.
GLP-1 medications are scientifically backed to help individuals achieve significant weight loss—on average, 15-20% of body weight within a year.
As a valued user, you’re eligible for $100 off your first program with code policy-lab-100.
GLP-1 medications are scientifically backed to help individuals achieve significant weight loss—on average, 15-20% of body weight within a year.
As a valued user, you’re eligible for $100 off your first program with code policy-lab-100.
Conditions:
Overweight
Overweight and Obesity
Obesity
Weight Loss
Morbid Obesity
Trajectories of Recovery After Intravenous Propofol Versus Inhaled VolatilE Anesthesia Trial
Recruiting
The investigators will conduct a 13,000-patient randomized multi-center trial to determine (i) which general anesthesia technique yields superior patient recovery experiences in any of three surgical categories ((a) major inpatient surgery, (b) minor inpatient surgery, (c) outpatient surgery) and (ii) whether TIVA confers no more than a small (0.2 %) increased risk of intraoperative awareness than INVA in patients undergoing both outpatient and inpatient surgeries
Gender:
ALL
Ages:
18 years and above
Trial Updated:
07/30/2025
Locations: Duke University, Durham, North Carolina
Conditions: Surgery-Complications, Anesthesia Complication, Anesthesia Awareness, Anesthesia, Surgery, Quality of Life, Pain, Postoperative, Anesthesia Morbidity
Anesthetics and Analgesics in Children
Recruiting
The purpose of this study is to characterize the pharmacokinetic (PK) and safety profile of anesthetics and analgesics in children and adolescents.
Gender:
ALL
Ages:
Between 0 years and 17 years
Trial Updated:
07/29/2025
Locations: Duke University Medical Center, Durham, North Carolina
Conditions: Anesthesia, Pain
Opioids, Low Nicotine Cigarettes, and Chronic Pain
Recruiting
The purpose of this study is to evaluate the effects of switching to very low nicotine content (VLNC) cigarettes versus normal nicotine content (NNC) cigarettes on craving, withdrawal, and pain among individuals with chronic pain who smoke cigarettes daily and are attending office-based buprenorphine treatment (OBBT).
Gender:
ALL
Ages:
21 years and above
Trial Updated:
07/23/2025
Locations: North Pavilion, Durham, North Carolina
Conditions: Chronic Pain, Tobacco Use, Opioid Substitution Treatment
Web-based Pain Coping Skills Training for Breast Cancer Survivors With AI-Associated Arthralgia
Recruiting
The main goal of this clinical trial is to test benefits of completing online pain coping skills training program in women who have been diagnosed with stage I-III breast cancer, who have completed their primary cancer treatment, who are taking an AI medication, and who have arthralgia. Arthralgia is a type of joint, bone, and muscle pain that is a common side effect of AI medications. The main questions it aims to answer are:
1. Whether online pain coping skills training reduces the severity o... Read More
Gender:
FEMALE
Ages:
18 years and above
Trial Updated:
07/22/2025
Locations: Duke University, Durham, North Carolina
Optimization of Pediatric Tonsillectomy to IMprove AnaLgesia
Recruiting
The purpose of this study is to compare the use of short acting opioids (fentanyl/hydromorphone) with long acting opioids (methadone) for pain control following tonsillectomy surgery in children and adolescents.
Gender:
ALL
Ages:
Between 3 years and 17 years
Trial Updated:
07/22/2025
Locations: Duke University Medical Center, Durham, North Carolina
Conditions: Pain, Postoperative, Tonsillar Hypertrophy, Tonsillitis, Pediatric Sleep Apnea, Sleep-Disordered Breathing
Leveraging Exercise Stress Echocardiography for Heart Failure With Preserved Ejection Fraction
Recruiting
The purpose of this study is to find out if additional images taken during a stress echocardiogram study and risk score calculation will help the doctor determine if shortness of breath or chest pain are caused by stiff heart (heart failure with preserved ejection fraction or HFpEF).
Gender:
ALL
Ages:
50 years and above
Trial Updated:
07/18/2025
Locations: Duke University Medical Center, Durham, North Carolina
Conditions: Chest Pain, Shortness of Breath
A Single-arm Study Evaluating the Effectiveness and Safety of Suzetrigine (SUZ) for Acute Pain After Selected Surgeries
Recruiting
The purpose of this study is to evaluate the effectiveness, safety, and tolerability of SUZ for acute pain after laparoscopic procedures of the intraperitoneal or retroperitoneal cavities or arthroscopic orthopedic procedures.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
07/16/2025
Locations: Eximia Research-Durham, Durham, North Carolina +1 locations
Conditions: Acute Pain
COA-APTIC Cognitive Interview Study of Caregiver and Clinician Assessment of Acute Pain in Infants and Young Children
Recruiting
Evaluate the content validity and comprehensibility of a caregiver observer-reported outcome assessment and clinician-reported assessments for acute pain in children aged 0 to \<2 years. The primary objective of the Qualitative Protocol in the UH3 phase study is to establish or create reliable Clinical Outcome Assessments (COAs) and endpoints that can assess acute pain during clinical trials of pain therapeutics specifically designed for infants and young children (0 - \<2 years).
Gender:
ALL
Ages:
18 years and above
Trial Updated:
07/15/2025
Locations: Duke Clinical Research Institute, Durham, North Carolina
Conditions: Acute Pain
Optimizing Perioperative Analgesia to Lower Pain Following Cleft Palate Surgery
Recruiting
The purpose of this study is to compare the use of short acting opioids (fentanyl/hydromorphone) with long acting opioids (methadone) for pain control following cleft palate surgery in infants and young children.
Gender:
ALL
Ages:
Between 6 months and 4 years
Trial Updated:
06/11/2025
Locations: Duke University Medical Center, Durham, North Carolina
Conditions: Cleft Palate, Pain, Postoperative Care, Perioperative Care, Children
Implementation of the ACP Guideline for Low Back Pain (IMPACt-LBP)
Recruiting
The purpose of this study is to assess whether the primary spine practitioner (PSP) model of care will lead to improvements in patient outcomes, as compared to usual care, based on change in patient-reported PROMIS Pain Interference and Physical Function from baseline to 3 months in patients aged 18 years and older with a primary complaint of low back pain (LBP).
Gender:
ALL
Ages:
18 years and above
Trial Updated:
04/22/2025
Locations: Duke Health, Durham, North Carolina
Conditions: Pain, Back
Neuroimaging of Opioid Phase (OPAL)
Recruiting
The purpose of this study is to compare activity in the brains of female adults with chronic pain and/or opioid use, and healthy female adults that may help to develop new and targeted treatments for adults with chronic pain and alternatives to opioid therapy.
Gender:
FEMALE
Ages:
18 years and above
Trial Updated:
04/11/2025
Locations: Duke University Medical Center, Durham, North Carolina
Conditions: Chronic Pain, Opioid Use
Pharmacokinetics, Pharmacodynamics, and Safety Profile of Understudied Drugs Administered to Children Per Standard of Care (POPS)
Recruiting
The study investigators are interested in learning more about how drugs, that are given to children by their health care provider, act in the bodies of children and young adults in hopes to find the most safe and effective dose for children. The primary objective of this study is to evaluate the PK of understudied drugs currently being administered to children per SOC as prescribed by their treating provider.
Gender:
ALL
Ages:
Between 0 years and 20 years
Trial Updated:
03/11/2025
Locations: Duke University Health System, Durham, North Carolina
Conditions: Coronavirus Infection (COVID-19), Pulmonary Arterial Hypertension, Urinary Tract Infections in Children, Hypertension, Pain, Hyperphosphatemia, Primary Hyperaldosteronism, Edema, Hypokalemia, Heart Failure, Menorrhagia, Insomnia, Pneumonia, Skin Infection, Arrythmia, Asthma in Children, Bronchopulmonary Dysplasia, Adrenal Insufficiency, Fibrinolysis; Hemorrhage, Hemophilia, Attention Deficit Hyperactivity Disorder, Multisystem Inflammatory Syndrome in Children (MIS-C), Kawasaki Disease, Coagulation Disorder, Down Syndrome
1 - 12 of 18