There are currently 30 active clinical trials seeking participants for Osteoarthritis research studies. The states with the highest number of trials for Osteoarthritis participants are Florida, California, Texas and Pennsylvania.
Multi-Vendor Multi-Site Novel Accelerated MRI Relaxometry
NCT04536103
Recruiting
Currently the diagnosis of OA is based on radiographs and clinical findings, which is limited to detecting late-stage disease. There is a pressing, unmet clinical need for robust assessment of early changes in cartilage health. Towards this goal, extensive efforts are ongoing to develop quantitative MRI for cartilage matrix analysis. MR T1ρ and T2 relaxation times have shown to be promising imaging biomarkers for early cartilage degeneration and prediction of disease progression. However, many c... Read More
Gender:
All
Ages:
Between 18 years and 50 years
Trial Updated:
03/06/2024
Locations: Cleveland Clinic Foundation, Cleveland, Ohio
Conditions: Bone Diseases, Infectious, Musculoskeletal Diseases, Joint Diseases, Osteoarthritis, ACL Tear, Cartilage Degeneration
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Geniculate Artery Embolization for Osteoarthritis
NCT04456569
Recruiting
The need for exploration of more definitive and cost effective non-arthroplasty treatments of osteoarthritis (OA) has been demonstrated by the orthopedic and health economic research. Embolotherapy of neovessels associated with OA joints has been shown to be promising in patients with knee OA. There is a need for level one evidence drawn from randomized clinical trials to prove the safety, feasibility and efficacy of knee embolotherapy compared to standard of care. This randomized pilot study... Read More
Gender:
All
Ages:
Between 40 years and 70 years
Trial Updated:
06/20/2024
Locations: University of Minnesota, Minneapolis, Minnesota
Conditions: Osteo Arthritis Knee, Arthritis, Osteoarthritis, Osteoarthritis, Knee
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Actis Total Hip System 2 Year Follow-up
NCT02783274
Recruiting
Two-year (2 year) information regarding the performance of the commercially available Actis™ Total Hip System in order to obtain and evaluate the clinical outcomes on a series of cementless primary total hip arthroplasty (THA) and hemi-hip arthroplasty procedures using clinical, radiographic and device and procedure related adverse event assessments.
Gender:
All
Ages:
21 years and above
Trial Updated:
06/18/2024
Locations: Not set, Louisville, Kentucky +9 locations
Conditions: Osteoarthritis, Traumatic Arthritis, Rheumatoid Arthritis, Congenital Hip Dysplasia, Avascular Necrosis of the Femoral Head, Acute Traumatic Fracture of the Femoral Head or Neck, Certain Cases of Ankylosis, Non-union of Femoral Neck Fractures, Certain High Sub-Capital & Femoral Neck Fractures in Elderly
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Postoperative Hip Precautions After Total Hip Arthroplasty Via the Posterior Approach: A Prospective Randomized Trial
NCT02686528
Recruiting
The purpose of this study is to determine if hip precautions, which are instructions that limit functional use of a hip replacement after surgery, affect the rate of dislocation in the first six weeks after primary total hip replacement surgery. The impact of hip precautions on a patient's return to activities of daily living and overall patient satisfaction will also be investigated. The overall cost effectiveness of hip precautions will be determined.
Gender:
All
Ages:
18 years and above
Trial Updated:
06/12/2024
Locations: Rush University Medical Center, Chicago, Illinois
Conditions: Osteoarthritis, Degenerative Joint Disease
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Anti-Inflammatory Effects Of Frequency Specific Microcurrent (FSM) In Osteoarthritic Adults
NCT06390137
Recruiting
It is hypothesized that application of frequency specific microcurrent can decrease inflammation in osteoarthritis patients resulting in decreased pain and potentially decrease disease progression. Participants will received the microcurrent treatment for one hour and a total of five blood draws to measure inflammatory markers. Participants will also complete a pre and post treatment pain questionnaire.
Gender:
All
Ages:
Between 18 years and 100 years
Trial Updated:
05/17/2024
Locations: Robinson Family Clinic, Lakeland, Florida
Conditions: Osteoarthritis
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Understanding Cognition, Oxytocin & Pain in Elders
NCT03878589
Recruiting
Osteoarthritis (OA) represents a significant cause of disability worldwide and the knee is the most commonly affected joint. Oxytocin (OT) is a mediator of endogenous analgesia in animal and human studies. This proposal will test the efficacy and safety of self-administered intranasal OT over 4-weeks in older individuals relative to placebo (P) evaluating its effects on pain and function in aging and testing potential underlying neurobiological mechanisms.
Gender:
All
Ages:
Between 45 years and 100 years
Trial Updated:
04/23/2024
Locations: Department of Community Dentistry and Behavioral Science, Gainesville, Florida +1 locations
Conditions: Knee Osteoarthritis, Osteoarthritis
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Ketorolac in Upper Extremity Tendinopathy and Arthropathy
NCT05292339
Recruiting
Osteoarthritis (OA) and inflammatory conditions of the tendons and joints of the shoulder, elbow, hand, and wrist are common yet disabling diseases. Standard management utilizes conservative measures to minimize pain and improve function. Conservative pharmacological management commonly includes corticosteroid and ketorolac injections which have been well investigated as a modality of pain control and improved function in large joint OA. However, fewer studies yielding mixed results on the durat... Read More
Gender:
All
Ages:
18 years and above
Trial Updated:
03/25/2024
Locations: Emory Saint Joseph's Hospital, Atlanta, Georgia +3 locations
Conditions: Osteoarthritis, Tendinopathy, Arthropathy
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Cemented vs Cementless Persona Keel RCT
NCT05630053
Recruiting
The main objective of this study is to evaluate the safety, performance, and clinical benefits of the Persona Keel cementless and cemented knee.
Gender:
All
Ages:
18 years and above
Trial Updated:
03/04/2024
Locations: Centura Health, Westminster, Colorado +6 locations
Conditions: Knee Pain Chronic, Rheumatoid Arthritis, Osteoarthritis, Traumatic Arthritis, Polyarthritis, Avascular Necrosis, Varus Deformity, Valgus Deformity, Flexion Deformity of Knee
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Patient Observational Pain and Activity Survey (POPAS) Study Using RS-4i Sequential Stimulator With Intersperse Technology in Axial Spine and Peripheral Joint Pain
NCT05478265
Recruiting
Spine pain and joint pain are among the most common worldwide ailments and directly contributes to disability as well as increased duration of care. Spine and joint pain affect work sick leave, production and increased financial costs to healthcare. Non-invasive treatments for spine and joint pain can vary widely from lifestyle changes, physical therapy, oral medication, and select medical devices, that can improve pain level and help improve the quality of life of individuals. Thus, the general... Read More
Gender:
All
Ages:
Between 18 years and 89 years
Trial Updated:
02/22/2024
Locations: University of California at Irvine Medical Center, Orange, California
Conditions: Osteoarthritis
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A Prospective, Clinical Investigation of the Vanguard 360 Revision Knee
NCT01542580
Recruiting
The purpose of this study is to evaluate performance of the Vanguard 360 revision knee system utilizing offset on either the tibial component, femoral component, or both in terms of the restoration of mechanical alignment, clinical outcomes and survivorship.
Gender:
All
Ages:
18 years and above
Trial Updated:
02/13/2024
Locations: Illinois Bone and Joint, Morton Grove, Illinois +11 locations
Conditions: Osteoarthritis, Rheumatoid Arthritis, Traumatic Arthritis, Post Traumatic Deformity, Complications; Arthroplasty, Deformity of Limb
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Low Level Laser Therapy (LLLT) for the Treatment of Hand Osteoarthritis.
NCT04692597
Recruiting
This study is a randomized, control trial of Active Duty and DoD Beneficiaries, age 18 years or older, with complaints of hand osteoarthritis. Subjects will be randomized into one of two groups receiving either LLLT or sham LLLT. Subjects will receive LLLT or sham LLLT weekly over a period of six weeks. At each visit, patients will rate their pain using the Defense and Veterans Pain Rating Scale (DVPRS) and assess their functionality using the Disabilities of the Arm, Shoulder, and Hand (DASH) q... Read More
Gender:
All
Ages:
18 years and above
Trial Updated:
01/22/2024
Locations: Mike O'Callaghan Military Medical Center, Nellis Air Force Base, Nevada
Conditions: Low Level Laser Therapy, Osteoarthritis, Family Medicine, Pain Management, Integrative Medicine
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Surgical Weight-Loss to Improve Functional Status Trajectories Following Total Knee Arthroplasty (SWIFT Trial)
NCT02598531
Recruiting
The purpose of the SWIFT Trial is to answer two research questions. Does bariatric surgery before total knee arthroplasty (TKA) improve both perioperative and long-term outcomes of TKA in extreme obesity? Does bariatric surgery before TKA delay or possibly negate the need for arthroplasty?
Gender:
All
Ages:
Between 22 years and 75 years
Trial Updated:
12/18/2023
Locations: Geisinger Health System, Danville, Pennsylvania
Conditions: Obesity, Osteoarthritis
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