There are currently 1122 clinical trials in Cincinnati, Ohio looking for participants to engage in research studies. Trials are conducted at various facilities, including Cincinnati Children's Hospital Medical Center, University of Cincinnati, University of Cincinnati Medical Center and GSK Investigational Site. Whether you're a healthy volunteer looking to participate in paid medical research or seeking trials related to a specific condition, the city provides a diverse range of opportunities near you.
Cricopharyngeal Dysfunction and Esophageal Diverticulum
NCT03187925
Recruiting
Patients undergoing open transcervical or endoscopic approach in which a laser or stapler is used to divide the common wall between the diverticulum and esophagus, or who are not surgical candidates but agree to follow-up.
Gender:
All
Ages:
Between 18 years and 100 years
Trial Updated:
09/12/2023
Locations: UC Health Otolaryngology-Head and Neck Surgery, Cincinnati, Ohio
Conditions: Zenker Diverticulum, Progressive Dysphagia, Pharyngoesophageal Diverticulum
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Evaluate the Safety and Pharmacokinetic Profile of ETR028 and ETR029 in Healthy Adult Subjects
NCT05572190
Recruiting
The goal of this Phase 1 clinical study is to evaluate the safety, tolerability, and pharmacokinetics (PK) of O2P (Oral Overdose Protected) hydrocodone prodrugs (ETR028 and ETR029) relative to hydrocodone bitartrate hemipentahydrate (HCBT) comparator following single oral doses in healthy adult subjects under fasted and fed conditions with naltrexone blockade
Gender:
All
Ages:
Between 18 years and 55 years
Trial Updated:
09/11/2023
Locations: Medpace, Cincinnati, Ohio
Conditions: Acute Pain
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Improving Neurotrauma by Depolarization Inhibition With Combination Therapy (INDICT)
NCT05337618
Recruiting
This study is a randomized Phase 2 trial to determine the feasibility of real-time electrocorticographic monitoring of spreading depolarizations (SD) to guide implementation of a tier-based protocol of intensive care therapies, aimed at SD suppression, for the management of patients who have undergone acute operative treatment of severe traumatic brain injury.
Gender:
All
Ages:
Between 18 years and 80 years
Trial Updated:
09/11/2023
Locations: University of Cincinnati, Cincinnati, Ohio
Conditions: Traumatic Brain Injury
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Study in Pediatrics With HypEREosinophilic Syndrome (SPHERE)
NCT04965636
Recruiting
The purpose of this study is to investigate the efficacy and safety of mepolizumab in children and adolescents with hypereosinophilic syndrome (HES) who are receiving standard of care (SoC) therapy.
Gender:
All
Ages:
Between 6 years and 17 years
Trial Updated:
08/08/2023
Locations: GSK Investigational Site, Cincinnati, Ohio
Conditions: Hypereosinophilic Syndrome
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Therapeutic Response Evaluation and Adherence Trial (TREAT)
NCT02286154
Recruiting
The primary objectives of this prospective study of hydroxyurea for children with sickle cell anemia are 1) Develop and prospectively evaluate a population pharmacokinetic/pharmacodynamics model to predict the maximum tolerated dose (MTD); 2) Identify urine biomarkers of hydroxyurea adherence using a novel metabolomics approach; 3) Identify pharmacogenomics modifiers of hydroxyurea MTD; and 4) Longitudinal monitoring of the effect of hydroxyurea upon organ function and quality of life.
Gender:
All
Ages:
Between 6 months and 21 years
Trial Updated:
07/27/2023
Locations: Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio
Conditions: Anemia, Sickle Cell
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Simple Bone Cysts in Kids
NCT02193841
Recruiting
Simple bone cysts (SBCs) are cysts filled with fluid that occur most frequently in the long bones (arms or legs) of children. There are many ways to treat SBCs but it is unclear if one is better than another. The purpose of this research trial is to compare the effectiveness of two common treatments that are used by surgeons today.
Gender:
All
Ages:
Between 2 years and 21 years
Trial Updated:
07/10/2023
Locations: Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio
Conditions: Bone Cyst
Register for Updates
Feto-Endoscopic Tracheal Occlusion (FETO) for Left Congenital Diaphragmatic Hernia
NCT02986087
Recruiting
Tracheal occlusion IDE approved by FDA for congenital diaphragmatic hernia fetuses.
Gender:
Female
Ages:
Between 18 years and 50 years
Trial Updated:
07/05/2023
Locations: Cincinnati Children's Hospital Medical Center (CCHMC), Cincinnati, Ohio
Conditions: Congenital Diaphragmatic Hernia, Pulmonary Hypoplasia, Pulmonary; Hypertension
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A Study of Orally Administered JBI-802, an LSD1/HDAC6 Inhibitor, in Patients With Advanced Solid Tumors
NCT05268666
Recruiting
The purpose of this study is to determine the maximum-tolerated dose (MTD) and recommended Phase 2 dose (RP2D) of JBI-802 in patients with Advanced Solid Tumors.The efficacy of the RP2D will be evaluated in phase 2 in patients with solid tumors of neuroendocrine differentiation.
Gender:
All
Ages:
18 years and above
Trial Updated:
06/12/2023
Locations: The Christ Hospital, Cincinnati, Ohio
Conditions: Locally Advanced Solid Tumor, Metastatic Solid Tumor
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SBRT +/- Pembrolizumab in Patients With Local-Regionally Recurrent or Second Primary Head and Neck Carcinoma
NCT03546582
Recruiting
This phase II trial with a safety run-in component will evaluate whether the addition of pembrolizumab to Stereotactic Body Radiation Therapy (SBRT) re-irradiation will improve the progression-free survival for patients with recurrent or new second primary Head and Neck Squamous Cell Carcinoma (HNSCC).
Gender:
All
Ages:
18 years and above
Trial Updated:
06/01/2023
Locations: University of Cincinnati Cancer Center - UC Medical Center, Cincinnati, Ohio
Conditions: Head and Neck Squamous Cell Carcinoma (HNSCC)
Register for Updates
Setting Families on a Positive Path to Recovery After Pediatric TBI: Road-to-Recovery
NCT05622461
Recruiting
This study has two main goals: 1) to refine and enhance the R2R-TBI intervention; and 2) to examine the efficacy of the R2R-TBI intervention in a randomized control trial. To achieve the second goal, we will employ a between-groups randomized treatment design with repeated measures at baseline, one-month post-randomization, and at a six-month follow-up. The two conditions will be: a) usual medical care plus access to internet resources regarding pediatric brain injury (Internet Resources Compari... Read More
Gender:
All
Ages:
18 years and above
Trial Updated:
05/31/2023
Locations: Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio
Conditions: Traumatic Brain Injury, Head Injury, Head Injuries, Closed, Brain Hemorrhage, Traumatic, Brain Edema, Intracranial Edema
Register for Updates
Impact of Topical Tranexamic Acid on Pre- and Post-operative Hemoglobin/Hematocrit
NCT05357079
Recruiting
This multi-center, prospective study will evaluate the use of topical tranexamic acid (TXA - Cyklokapron; Pfizer, New York, NY) on pre-operative and post-operative hemoglobin (Hb)/hematocrit (Hct) in patients undergoing operative repair of isolated posterior wall (PW) acetabular fractures.
Gender:
All
Ages:
18 years and above
Trial Updated:
05/17/2023
Locations: University of Cincinnati College of Medicine, Cincinnati, Ohio
Conditions: Fracture of Posterior Wall of Acetabulum
Register for Updates
Increased Home-based Physical Therapy Adherence Using BAND Connect's VirtuaCare™ Platform
NCT05876208
Recruiting
This study aims to enhance at-home therapy by introducing a new device called the BAND Connect's VirtuaCare™ platform. The study aims to determine whether patients can improve their adherence to at-home exercises using this device. Currently, research indicates that only 35% of patients undergoing physical therapy treatment fully comply with their prescribed plans of care, often neglecting their at-home exercises. To address this issue, a set of smart exercise tools called VirtuaCare™ has been d... Read More
Gender:
All
Ages:
18 years and above
Trial Updated:
05/16/2023
Locations: University of Cincinnati, Cincinnati, Ohio
Conditions: Shoulder Injuries
Register for Updates