There are currently 24 clinical trials in Norman, Oklahoma looking for participants to engage in research studies. Trials are conducted at various facilities, including Central Sooner Research, Lynn Institute of Norman, Cancer Care Associates - Norman and Alliance for Multispecialty Research, LLC. Whether you're a healthy volunteer looking to participate in paid medical research or seeking trials related to a specific condition, the city provides a diverse range of opportunities near you.
A Study of mRNA-1647 Cytomegalovirus Vaccine in Healthy Participants 9 to 15 Years of Age and Participants 16 to 25 Years of Age
NCT05575492
Recruiting
The main purpose of study is to evaluate the safety and immunogenicity of different dose levels of mRNA-1647 versus control in healthy cytomegalovirus (CMV)-seronegative and CMV-seropositive female and male participants 9 to 15 years of age. In addition, mRNA-1647 will be evaluated in female participants 16 to 25 years as a comparator cohort.
Gender:
ALL
Ages:
Between 9 years and 25 years
Trial Updated:
06/27/2025
Locations: Lynn Institute of Norman - ERN - PPDS, Norman, Oklahoma
Conditions: Cytomegalovirus
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A Phase III Study of AZD0780 on Major Adverse CV Events in Patients With a History of ASCVD Events or at High Risk for a First Event
NCT07000357
Recruiting
The purpose of this phase 3, randomized, placebo controlled, event-driven study is to assess the effect of AZD0780, an oral PCSK9 inhibitor, compared with placebo in reducing the risk of MACE-PLUS in patients with established ASCVD or at high risk for a first ASCVD event. The effect of AZD0780 vs placebo on the risk of MACE-PLUS will be evaluated from randomisation until the primary analysis censoring date (PACD). The Study Closure Visit will be scheduled to occur after the PACD and will be the... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
06/26/2025
Locations: Research Site, Norman, Oklahoma
Conditions: Cardiovascular Disease
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A Research Study to Look at How Well CagriSema Helps People Living With Obesity Lose Weight and Maintain Weight Loss in the Long-term
NCT07011667
Recruiting
This study will look at how well CagriSema helps people living with obesity to lose weight and maintain the weight loss long-term. The study has 2 parts: The first part is called 'the main study' and the second part is called 'the extension study'. In the main study participants will either get CagriSema (a study medicine) or placebo (a dummy medicine that looks like CagriSema but has no active ingredient). Which treatment participants get is decided by chance. Participants are two times more li... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
06/10/2025
Locations: Lynn Institute of Norman, Norman, Oklahoma
Conditions: Obesity
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A Study to Assess the Safety and Efficacy of Oral Armour Thyroid Compared to Synthetic T4 for the Treatment of Primary Hypothyroidism in Adult Participants
NCT06345339
Recruiting
This study will evaluate the efficacy and safety of Armour Thyroid treatment compared with synthetic T4 in subjects who have primary hypothyroidism and are currently stabilized (i.e., in-range thyroid-stimulating hormone \[TSH\]) on synthetic T4 treatment. This study will also therefore evaluate the efficacy and safety of dose conversion from synthetic T4 therapy to Armour Thyroid therapy.
Gender:
ALL
Ages:
Between 18 years and 75 years
Trial Updated:
06/04/2025
Locations: Lynn Institute of Norman /ID# 256785, Norman, Oklahoma
Conditions: Hypothyroidism
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Clinical Performance Evaluation of the Artificial Intelligence (AI)/ Machine Learning (ML) Technologies Utilized by the Origin Medical EXAM ASSISTANT
NCT06952439
Recruiting
A multicenter study will be conducted to assess the role of the AI/ML technologies of Origin Medical EXAM ASSISTANT (OMEA) in interpreting first-trimester fetal ultrasound examinations (11 weeks 0 days - 13 weeks 6 days). The performance of the AI-based system will be compared against the ground truth provided by an independent reading panel of maternal-fetal medicine physicians.
Gender:
FEMALE
Ages:
18 years and above
Trial Updated:
05/09/2025
Locations: The Nest 4D Ultrasound LLC, DBA InFocus Ultrasound DBA Little Peanut 4D Ultrasound, Norman, Oklahoma
Conditions: To Validate the Clinical Performance of AI/ML Technologies in First-trimester Pregnant Participants, First Trimester Pregnancy
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A Study of Efficacy and Safety of Rosnilimab in Subjects with Moderate to Severe Ulcerative Colitis (ROSETTA)
NCT06127043
Recruiting
ROSETTA STUDY: This study will evaluate the safety, tolerability, and efficacy of Rosnilimab in subjects with moderate to severe ulcerative colitis (UC)
Gender:
ALL
Ages:
18 years and above
Trial Updated:
03/22/2025
Locations: AnaptysBio Investigational Site 10-120, Norman, Oklahoma
Conditions: Ulcerative Colitis
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Study of Plozasiran (ARO-APOC3) in Adults With Severe Hypertriglyceridemia
NCT06347003
Recruiting
This Phase 3 study will evaluate the safety and efficacy of plozasiran injection (ARO-APOC3) in adult participants with severe hypertriglyceridemia (SHTG). After providing informed consent eligible participants will be randomized to receive 4 doses (once every 3 months) of plozasiran or placebo, and be evaluated for efficacy and safety. After month 12, eligible participants will be offered an opportunity to continue in an optional open-label extension under a separate protocol.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
03/17/2025
Locations: Lynn Institute of Norman, Norman, Oklahoma
Conditions: Severe Hypertriglyceridemia
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Neuromodulation and Fatigue
NCT05487131
Recruiting
In this project, we aim to determine any potential effects of a weak electrical current applied to the neck or thoracic area on functional capacity and muscle activation. Healthy individuals will participate in one familiarization followed by three experimental sessions. Fatigability and motor function will be assessed in each test session.
Gender:
ALL
Ages:
Between 18 years and 50 years
Trial Updated:
12/05/2024
Locations: University of Oklahoma, Norman, Oklahoma
Conditions: Healthy Aging, Fatigue
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The Effects of Acute Melatonin Supplementation on Cardiovascular Responses to Sympathetic Activation
NCT04831398
Recruiting
the purpose of this experiment is to determine if acute melatonin supplementation alters central and peripheral cardiovascular responses to a cold pressor test at rest and during dynamic exercise.
Gender:
ALL
Ages:
Between 18 years and 35 years
Trial Updated:
12/05/2024
Locations: Department of Health and Exercise Science, Norman, Oklahoma
Conditions: Healthy
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Fatigue and Cognitive Demand With Aging
NCT05121272
Recruiting
This study will determine the influence of a cognitive task performed during fatiguing contractions.
Gender:
ALL
Ages:
Between 18 years and 90 years
Trial Updated:
09/05/2024
Locations: University of Oklahoma, Norman, Oklahoma
Conditions: Fatigue
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Endothelial Derived Hyperpolarization Factor and Vascular Control
NCT05176379
Recruiting
Most cardiometabolic diseases are characterized by increased muscle sympathetic nerve activity (MSNA) during rest and exercise which contributes to poor health outcomes. In healthy humans during muscle contraction, there is a blunting of skeletal muscle vascular responsiveness to increases in MSNA. However, the exact mechanisms involved are unknown although, best evidence suggests that the mechanism is endothelium derived, but nitric oxide (NO) and prostaglandin (PG) independent. Endothelium-der... Read More
Gender:
ALL
Ages:
Between 18 years and 30 years
Trial Updated:
07/19/2024
Locations: Department of Health and Exercise Science, Norman, Oklahoma
Conditions: Healthy
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Intensive Glycemic Targets in Overweight and Obese Women With Gestational Diabetes
NCT05124808
Recruiting
This is a multicenter randomized clinical trial of 828 overweight and obese individuals with gestational diabetes designed to compare standard to intensive glycemic targets.
Gender:
FEMALE
Ages:
Between 18 years and 45 years
Trial Updated:
06/09/2024
Locations: University of Oklahoma, Norman, Oklahoma
Conditions: Gestational Diabetes, Pregnancy, High Risk, Overweight and Obesity
Register for Updates