There are currently 24 clinical trials in Norman, Oklahoma looking for participants to engage in research studies. Trials are conducted at various facilities, including Central Sooner Research, Lynn Institute of Norman, Cancer Care Associates - Norman and Alliance for Multispecialty Research, LLC. Whether you're a healthy volunteer looking to participate in paid medical research or seeking trials related to a specific condition, the city provides a diverse range of opportunities near you.
Study of Plozasiran (ARO-APOC3) in Adults With Severe Hypertriglyceridemia
NCT06347003
Recruiting
This Phase 3 study will evaluate the safety and efficacy of plozasiran injection (ARO-APOC3) in adult participants with severe hypertriglyceridemia (SHTG). After providing informed consent eligible participants will be randomized to receive 4 doses (once every 3 months) of plozasiran or placebo, and be evaluated for efficacy and safety. After month 12, eligible participants will be offered an opportunity to continue in an optional open-label extension under a separate protocol.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
03/17/2025
Locations: Lynn Institute of Norman, Norman, Oklahoma
Conditions: Severe Hypertriglyceridemia
Register for Updates
A Study to Assess the Efficacy and Safety of RO7790121 for Induction and Maintenance Therapy in Participants With Moderately to Severely Active Ulcerative Colitis
NCT06589986
Recruiting
This Phase III, multicenter, double-blind, placebo-controlled, treat-through study will evaluate the efficacy and safety of RO7790121 compared with placebo in participants with moderately to severely active ulcerative colitis (UC).
Gender:
ALL
Ages:
Between 16 years and 80 years
Trial Updated:
03/10/2025
Locations: Central Sooner Research, Norman, Oklahoma
Conditions: Moderately to Severely Active Ulcerative Colitis
Register for Updates
A Study Evaluating the Efficacy and Safety of Oral Etrasimod in the Treatment of Adult Participants With Moderately to Severely Active Crohn's Disease
NCT04173273
Recruiting
This is a Phase 2/3 study that comprises 5 substudies designed to evaluate the efficacy, safety, and tolerability of oral etrasimod as therapy in adult participants with moderately to severely active Crohn's disease (CD) who are refractory or intolerant to at least 1 of the current therapies for CD (ie, corticosteroids, immunosuppressants, or biologics). The overall duration of this study is up to 282 weeks, inclusive of the Screening Period, Treatment Period of up to 274 weeks (Induction, Exten... Read More
Gender:
ALL
Ages:
Between 18 years and 80 years
Trial Updated:
02/12/2025
Locations: Norman Endoscopy Center, Norman, Oklahoma +1 locations
Conditions: Crohn's Disease
Register for Updates
A Study to Learn About the Study Medicine Called PF-07976016 in Adults With Obesity
NCT06717425
Recruiting
The purpose of this clinical trial is to learn about the safety and effects of the study medicine (called PF-07976016) for the potential treatment of obesity. The study will compare the experiences of participants taking the study medicine (PF-07976016) to those of participants who take placebo (a lookalike substance that contains no active study medicine). The aim is to measure the body's response to the study medicine, including any changes in participants' body weight and how well they tolera... Read More
Gender:
ALL
Ages:
Between 18 years and 74 years
Trial Updated:
12/19/2024
Locations: Alliance for Multispecialty Research, LLC, Norman, Oklahoma +1 locations
Conditions: Obesity
Register for Updates
A Study in Patients with Mixed Dyslipidemia
NCT06497127
Recruiting
A Phase 2 in Patients With Mixed Dyslipidemia
Gender:
ALL
Ages:
Between 18 years and 75 years
Trial Updated:
12/16/2024
Locations: Alliance for Multispecialty Research, LLC, Norman, Oklahoma
Conditions: Mixed Dyslipidemia
Register for Updates
Neuromodulation and Fatigue
NCT05487131
Recruiting
In this project, we aim to determine any potential effects of a weak electrical current applied to the neck or thoracic area on functional capacity and muscle activation. Healthy individuals will participate in one familiarization followed by three experimental sessions. Fatigability and motor function will be assessed in each test session.
Gender:
ALL
Ages:
Between 18 years and 50 years
Trial Updated:
12/05/2024
Locations: University of Oklahoma, Norman, Oklahoma
Conditions: Healthy Aging, Fatigue
Register for Updates
The Effects of Acute Melatonin Supplementation on Cardiovascular Responses to Sympathetic Activation
NCT04831398
Recruiting
the purpose of this experiment is to determine if acute melatonin supplementation alters central and peripheral cardiovascular responses to a cold pressor test at rest and during dynamic exercise.
Gender:
ALL
Ages:
Between 18 years and 35 years
Trial Updated:
12/05/2024
Locations: Department of Health and Exercise Science, Norman, Oklahoma
Conditions: Healthy
Register for Updates
Fatigue and Cognitive Demand With Aging
NCT05121272
Recruiting
This study will determine the influence of a cognitive task performed during fatiguing contractions.
Gender:
ALL
Ages:
Between 18 years and 90 years
Trial Updated:
09/05/2024
Locations: University of Oklahoma, Norman, Oklahoma
Conditions: Fatigue
Register for Updates
A Study Evaluating the Efficacy of Budesonide, Glycopyrronium and Formoterol Fumarate Metered Dosed Inhaler on Cardiopulmonary Outcomes in Chronic Obstructive Pulmonary Disease
NCT06283966
Recruiting
This study will evaluate the effect of triple ICS/LAMA/LABA therapy with BGF MDI 320/14.4/9.6 μg on cardiopulmonary outcomes relative to LAMA/LABA therapy with GFF MDI 14.4/9.6 μg in a population with COPD and elevated cardiopulmonary risk.
Gender:
ALL
Ages:
Between 40 years and 80 years
Trial Updated:
07/23/2024
Locations: Research Site, Norman, Oklahoma
Conditions: COPD (Chronic Obstructive Pulmonary Disease)
Register for Updates
Endothelial Derived Hyperpolarization Factor and Vascular Control
NCT05176379
Recruiting
Most cardiometabolic diseases are characterized by increased muscle sympathetic nerve activity (MSNA) during rest and exercise which contributes to poor health outcomes. In healthy humans during muscle contraction, there is a blunting of skeletal muscle vascular responsiveness to increases in MSNA. However, the exact mechanisms involved are unknown although, best evidence suggests that the mechanism is endothelium derived, but nitric oxide (NO) and prostaglandin (PG) independent. Endothelium-der... Read More
Gender:
ALL
Ages:
Between 18 years and 30 years
Trial Updated:
07/19/2024
Locations: Department of Health and Exercise Science, Norman, Oklahoma
Conditions: Healthy
Register for Updates
Intensive Glycemic Targets in Overweight and Obese Women With Gestational Diabetes
NCT05124808
Recruiting
This is a multicenter randomized clinical trial of 828 overweight and obese individuals with gestational diabetes designed to compare standard to intensive glycemic targets.
Gender:
FEMALE
Ages:
Between 18 years and 45 years
Trial Updated:
06/09/2024
Locations: University of Oklahoma, Norman, Oklahoma
Conditions: Gestational Diabetes, Pregnancy, High Risk, Overweight and Obesity
Register for Updates
Pharmacokinetics, Safety and Efficacy of Nemolizumab in Participants With Moderate-to-Severe Atopic Dermatitis
NCT04921345
Recruiting
The purpose of this study is to assess the pharmacokinetics (PK), efficacy, and safety of nemolizumab in pediatric participants with moderate-to-severe atopic dermatitis (AD).
Gender:
ALL
Ages:
Between 2 years and 12 years
Trial Updated:
04/05/2023
Locations: Galderma Investigational Site #8206, Norman, Oklahoma
Conditions: Moderate-to-Severe Atopic Dermatitis
Register for Updates