There are currently 36 active clinical trials seeking participants for Acute Kidney Injury research studies. The states with the highest number of trials for Acute Kidney Injury participants are Ontario, California, Texas and Pennsylvania.
A Study of Auxora in Patients With AKI and Injurious Lung "Crosstalk"
Recruiting
Approximately 150 patients with acute kidney injury (AKI) associated with acute hypoxemic respiratory failure (AHRF) will be randomized at up to 40 sites. Patients will be randomly assigned to either Auxora or matching placebo. Study drug infusions will occur every 24 hours for five consecutive days for a total of five infusions.
Gender:
All
Ages:
18 years and above
Trial Updated:
06/21/2024
Locations: Lundquist Institute for Biomedical Innovation at UCLA-Harbor Medical Center, Torrance, California +3 locations
Conditions: Acute Kidney Injury
Liberation From Acute Dialysis
Recruiting
The goal of the LIBERATE-D clinical trial is to improve outcomes for patients recovering from dialysis-requiring acute kidney injury (AKI-D). The impact of a conservative dialysis strategy compared to standard clinical practice of thrice-weekly dialysis will be examined to help generate knowledge for how to guide delivery of dialysis to facilitate renal recovery.
Gender:
All
Ages:
18 years and above
Trial Updated:
06/10/2024
Locations: University of Califonia, San Francisco, San Francisco, California +3 locations
Conditions: Acute Kidney Injury, Kidney; Disease, Acute, Dialysis Related Complication
Neutrophil and Monocyte Deactivation Via the SeLective CytopheretIc Device - A Randomized Clinical Trial in Acute Kidney Injury
Recruiting
This randomized, controlled, pivotal study is intended to determine whether up to ten sequential 24-hour treatments with the Selective Cytopheretic Device (SCD) will improve survival in patients with Acute Kidney Injury (AKI) requiring continuous kidney replacement therapy (CKRT) when compared to CKRT alone (standard of care). This study is further intended to determine whether SCD therapy will reduce the duration of maintenance dialysis secondary to AKI. This study will enroll approximately 200... Read More
Gender:
All
Ages:
18 years and above
Trial Updated:
06/10/2024
Locations: University of Alabama Birmingham Hospital, Birmingham, Alabama +24 locations
Conditions: Acute Kidney Injury
Deferoxamine for the Prevention of Cardiac Surgery-Associated Acute Kidney Injury
Recruiting
Multiple lines of evidence support a central role of iron in causing acute kidney injury (AKI), including the finding that prophylactic administration of iron chelators attenuates AKI in animal models. Patients undergoing cardiac surgery may be particularly susceptible to iron-mediated kidney injury due to the profound hemolysis that often occurs from cardiopulmonary bypass. The investigators will test in a phase 2, randomized, double-blind, placebo-controlled trial whether prophylactic administ... Read More
Gender:
All
Ages:
18 years and above
Trial Updated:
05/18/2024
Locations: Massachusetts General Hospital, Boston, Massachusetts +2 locations
Conditions: Acute Kidney Injury
An Early Real-Time Electronic Health Record Risk Algorithm for the Prevention and Treatment of Acute Kidney Injury
Recruiting
This is a single center randomized trial that seeks to determine if the use of an automated real-time electronic medical record Acute Kidney Injury (AKI) risk score can improve patient outcomes through the use of an early standardized nephrology focused intervention.
Gender:
All
Ages:
18 years and above
Trial Updated:
05/06/2024
Locations: University of Chicago Medical Center, Chicago, Illinois
Conditions: Acute Kidney Injury
Combining Biomarkers and Electronic Risk Scores to Predict AKI in Hospitalized Patients
Recruiting
The study's objective is to evaluate the additive value of renal biomarkers (from blood and urine) for identifying individuals at high risk for severe acute kidney injury (AKI) above that of a novel natural language processing (NLP)-based AKI risk algorithm. The risk algorithm is based on electronic health records (EHR) data (labs, vitals, clinical notes, and test reports). Patients will enroll at the University of Chicago Medical Center and the University of Wisconsin Hospital, where the risk s... Read More
Gender:
All
Ages:
18 years and above
Trial Updated:
05/03/2024
Locations: University of Chicago Medical Center, Chicago, Illinois +1 locations
Conditions: Acute Kidney Injury, Biomarkers
SGLT2 Inhibitors After Acute Kidney Injury With Indications Pilot
Recruiting
SGLT2i have been shown to reduce risk for mortality, progression of chronic kidney disease, and cardiovascular outcomes in these populations. Yet, because SGLT2i can have an acute hemodynamic effect on kidney function, in clinical practice providers are wary of providing these medications to patients who have established indications but recently had acute kidney injury (AKI). This is a pilot interventional study to collect process-data (measures of recruitment and measures of adherence) that ca... Read More
Gender:
All
Ages:
Between 40 years and 75 years
Trial Updated:
05/02/2024
Locations: University of Minnesota, Minneapolis, Minnesota
Conditions: Acute Kidney Injury
SAfety of Regional Citrate Anticoagulation (SARCA Study)
Recruiting
This is an Open-label, Prospective, Multicenter Study to Assess the SAfety of Regional Citrate Anticoagulation Delivered by the multiFiltratePRO system in Adult Patients Requiring Continuous Renal Replacement Therapy (SARCA Study).
Gender:
All
Ages:
18 years and above
Trial Updated:
05/01/2024
Locations: University of Arkansas for Medical Sciences (UAMS), Little Rock, Arkansas +3 locations
Conditions: Acute Kidney Injury, ESRD
Low Dose Vasopressin vs Phenylephrine in Cardiac Surgery
Recruiting
This is a randomized, open label study to investigate vasopressin versus phenylephrine as a first line pressor in cardiac surgery. All patients >18 years of age presenting for coronary artery bypass graft (CABG), valve surgery, or combined CABG and valve surgery will be screened for inclusion. Patients with ejection fraction < 35%, > moderate pulmonary hypertension, > mild right ventricular dysfunction, a planned radial arterial graft, or circulatory arrest will be excluded. Patients will be ran... Read More
Gender:
All
Ages:
18 years and above
Trial Updated:
03/27/2024
Locations: Thomas Jefferson Univesity, Philadelphia, Pennsylvania
Conditions: Acute Kidney Injury
Learning Alerts for Acute Kidney Injury
Recruiting
The primary objective of this study is to determine whether the use of uplift (also known as Conditional Average Treatment Effect - CATE) modeling to empirically identify patients expected to benefit the most from AKI alerting and to target AKI alerts to these patients will reduce the rates of AKI progression, dialysis, and mortality.
Gender:
All
Ages:
18 years and above
Trial Updated:
03/15/2024
Locations: Yale New Haven Hospital, New Haven, Connecticut
Conditions: Acute Kidney Injury
KIDney Injury in Times of COVID-19 (KIDCOV)
Recruiting
There is an unmet need to evaluate the impact of sub-clinical/mild COVID19 disease in the outpatient setting on prevalent and incident renal injury, as this data is currently unavailable. To capture the diversity of race/ethnic risk and COVID19 related municipal shelter-in-place guidance, the investigators will enroll COVID19-negative and COVID19-positive samples balanced by race/ethnicity from 3 different states, California, Michigan, and Illinois. Study endpoints will be assayed from urine sam... Read More
Gender:
All
Ages:
18 years and above
Trial Updated:
03/14/2024
Locations: UCSF, San Francisco, California +2 locations
Conditions: SARS-CoV Infection, Covid19, Corona Virus Infection, Acute Kidney Injury, Kidney Injury
A Study of Facilitators and Barriers to Improve Acute Kidney Injury in Children Through Mobile Health Intervention
Recruiting
The purpose of this study is to improve patient-centered care for acute kidney injury (AKI) in order to decrease the adverse health outcomes associated with this common condition.
Gender:
All
Ages:
Between 1 year and 18 years
Trial Updated:
02/29/2024
Locations: Duke University Medical Center, Durham, North Carolina
Conditions: Acute Kidney Injury