There are currently 18 active clinical trials seeking participants for Aortic Valve Stenosis research studies. The states with the highest number of trials for Aortic Valve Stenosis participants are California, New York, Pennsylvania and Texas.
MRI in Transcatheter Aortic Valve Replacement Patients
NCT05603026
Recruiting
The hypothesis is that SEV result in superior valvular hemodynamics (more pronounced during exercise) and exercise capacity relative to BEV. Furthermore, the hypothesis is that stress CMR will be able to demonstrate differences in these hemodynamic parameters. CMR will also provide refined assessment of paravalvular leak and its impact on ventricular function and on clinical outcomes.
Gender:
All
Ages:
Between 18 years and 105 years
Trial Updated:
11/28/2023
Locations: University Hospitals Cleveland Medical Center, Cleveland, Ohio
Conditions: Aortic Valve Stenosis
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ALLIANCE AVIV: Safety and Effectiveness of the SAPIEN X4 Transcatheter Heart Valve in Failing Aortic Bioprosthetic Valves
NCT05172973
Recruiting
The objective of this study is to establish the safety and effectiveness of the Edwards SAPIEN X4 Transcatheter Heart Valve (THV) in subjects who are at high or greater risk with a failing aortic bioprosthetic valve.
Gender:
All
Ages:
All
Trial Updated:
06/21/2024
Locations: Hoag Memorial Hospital Presbyterian, Newport Beach, California +23 locations
Conditions: Aortic Valve Insufficiency, Aortic Valve Stenosis
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ENVISION IDE Trial: Safety and Effectiveness of NAVITOR in Transcatheter Aortic Valve Implantation
NCT05932615
Recruiting
The objective of ENVISION is to evaluate the safety and effectiveness of the Navitor Transcatheter Aortic Valve Implantation (TAVI) System for treating patients with symptomatic, severe native aortic stenosis who are considered intermediate or low risk for surgical mortality.
Gender:
All
Ages:
18 years and above
Trial Updated:
04/29/2024
Locations: Arkansas Heart Hospital, Little Rock, Arkansas +20 locations
Conditions: Aortic Valve Stenosis, Heart Valve Diseases, Aortic Valve Disease, Heart Disease Structural Disorder
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PROGRESS: Management of Moderate Aortic Stenosis by Clinical Surveillance or TAVR
NCT04889872
Recruiting
This study objective is to establish the safety and effectiveness of the Edwards SAPIEN 3 / SAPIEN 3 Ultra / SAPIEN 3 Ultra RESILIA Transcatheter Heart Valve systems in subjects with moderate, calcific aortic stenosis. Following completion of enrollment, subjects will be eligible for enrollment in the continued access phase of the trial.
Gender:
All
Ages:
65 years and above
Trial Updated:
04/26/2024
Locations: Heart Center LLC, Huntsville, Huntsville, Alabama +79 locations
Conditions: Aortic Stenosis, Calcific, Aortic Valve Stenosis
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Controlled Arterial Protection to Ultimately Remove Embolic Material
NCT06103591
Recruiting
The objective of this study is to demonstrate device feasibility, safety and investigate performance of the EmStop Embolic Protection System when used as indicated in 15 subjects at 2 investigational sites in the U.S.
Gender:
All
Ages:
Between 21 years and 90 years
Trial Updated:
02/15/2024
Locations: Mission Health, Asheville, North Carolina +1 locations
Conditions: Aortic Valve Stenosis
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Comparison of Left Bundle Branch Area Versus Right Ventricular Septal Pacing in Patients With High-degree Conduction Disease After Transcatheter Aortic Valve Replacement (Left Bundle BRAVE)
NCT05541679
Recruiting
The purpose of the study is to investigate the superiority of chronic left bundle branch area pacing compared to traditional right ventricular (RV) septal pacing in patients with high-grade conduction disease after transcatheter aortic valve replacement (TAVR). In this investigator initiated, multicenter, prospective, double-blinded, crossover study, chronic left bundle branch area pacing will be compared to chronic right ventricular septal pacing using echocardiographic measures of left ventric... Read More
Gender:
All
Ages:
18 years and above
Trial Updated:
01/29/2024
Locations: Kansas City Heart Rhythm Institute, Overland Park, Kansas +3 locations
Conditions: Complete Heart Block, High Degree Second Degree Atrioventricular Block, Pacemaker-Induced Cardiomyopathy, Aortic Valve Stenosis
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Effect of Fetal Aortic Valvuloplasty on Outcomes
NCT05386173
Recruiting
In one of the most severe congenital heart defects, hypoplastic left heart syndrome (HLHS), the left ventricle is underdeveloped and the prognosis is worse than in most other heart defects. The underdevelopment can occur gradually during fetal growth caused by a narrowing of the aortic valve. At some international centers, such fetuses are treated with a balloon dilation of the narrowed valve, but there is no scientifically sound evidence that this treatment is effective. The aim of this study... Read More
Gender:
All
Ages:
Between 23 weeks and 31 weeks
Trial Updated:
11/18/2023
Locations: Fetal Cardiovascular Program, University of California San Francisco, San Francisco, California +12 locations
Conditions: Congenital Heart Disease, Aortic Valve Stenosis, Fetal Cardiac Disorder, Hypoplastic Left Heart Syndrome
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Evaluation of Safety and Effectiveness of the EMBLOK EPS During TAVR
NCT05295628
Recruiting
The objective of the study is to evaluate the safety, effectiveness, and performance of the EMBLOK EPS during TAVR by randomized comparison with a commercially available embolic protection device. The targeted study population consists of patients meeting FDA-approved indications for TAVR with commercially available transcatheter heart valve systems. This prospective, multicenter, single-blind, randomized controlled trial will enroll up to a total of 532 subjects undergoing TAVR at up to 30 inv... Read More
Gender:
All
Ages:
Between 18 years and 90 years
Trial Updated:
11/07/2023
Locations: UPMC Pinnacle Harrisburg, Harrisburg, Pennsylvania
Conditions: Aortic Valve Stenosis, Aortic Valve Disease, Aortic Valve Insufficiency, Aortic Valve Replacement
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Portico Re-sheathable Transcatheter Aortic Valve System US IDE Trial
NCT02000115
Recruiting
The objective of the PORTICO pivotal IDE trial is to evaluate the safety and effectiveness of the St Jude Medical (SJM) Portico Transcatheter Heart Valve and Delivery Systems (Portico) in the treatment of severe symptomatic aortic stenosis via transfemoral and alternative delivery methods in high risk and extreme risk patients.
Gender:
All
Ages:
21 years and above
Trial Updated:
10/24/2023
Locations: University Hospital - Univ. of Alabama at Birmingham (UAB), Birmingham, Alabama +69 locations
Conditions: Aortic Valve Stenosis
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Standardized Invasive Hemodynamics for Elevated Gradients Post TAVR (DISCORDANCE TAVR)
NCT04827238
Recruiting
The DISCORDANCE TAVR study will determine the discordance between echocardiography-derived and invasive transaortic gradients, as determined by a consistent and reproducible technique (Standardized Invasive Hemodynamics) post-TAVR.
Gender:
All
Ages:
All
Trial Updated:
06/06/2023
Locations: PIMA Heart Centre, Tucson, Arizona +9 locations
Conditions: Aortic Stenosis, Aortic Valve Stenosis
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Defining Exercise Hemodynamics and Function After Transcatheter Aortic Valve Replacement (DEFINE-TAVR) Study.
NCT05567809
Recruiting
The purpose of this study is to help understand how the replacement valve functions over time, both at rest and during exercise.
Gender:
All
Ages:
18 years and above
Trial Updated:
06/06/2023
Locations: Yale New Haven Hospital, New Haven, Connecticut
Conditions: Aortic Valve Stenosis
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Intravascular Lithotripsy in High Risk Calcified Iliac Anatomy for Transfemoral TAVR
NCT05862558
Recruiting
To assess the efficacy and safety of Intravascular Lithotripsy (IVL) in subjects undergoing transfemoral TAVR in patients with severe iliac disease, prohibitive for transfemoral TAVR in patients with severe symptomatic aortic stenosis, otherwise considered for alternative access TAVR. (e.g. trans-carotid)
Gender:
All
Ages:
Between 18 years and 90 years
Trial Updated:
05/08/2023
Locations: Baylor Scott and White Heart Hospital, Plano, Texas
Conditions: Iliac Disease, Aortic Valve Stenosis
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