The state of Pennsylvania currently has 43 active clinical trials seeking participants for Hypertension research studies. These trials are conducted in various cities, including Philadelphia, Pittsburgh, Hershey and Allentown.
AGN-193408 SR in the Treatment of Open-angle Glaucoma or Ocular Hypertension
Recruiting
This is a multicenter, open-label, dose escalation (Cohort 1) to masked, randomized, parallel-groups (Cohort 2) and (Cohort 3) study to evaluate the safety and efficacy of AGN-193408 SR in participants with open-angle glaucoma or ocular hypertension
Gender:
ALL
Ages:
18 years and above
Trial Updated:
07/09/2025
Locations: Scott and Christie and Associates /ID# 252284, Cranberry Township, Pennsylvania
Conditions: Open-angle Glaucoma, Ocular Hypertension
DeciPHer-ILD: A Real-world Patient Registry in Group 3 Pulmonary Hypertension Associated With Interstitial Lung Disease (PH-ILD)
Recruiting
This is a prospective, non-interventional, multicenter, registry of patients with pulmonary hypertension associated with interstitial lung disease (PH-ILD).
Gender:
ALL
Ages:
18 years and above
Trial Updated:
07/08/2025
Locations: Thomas Jefferson University - Sidney Kimmel Medical College, Philadelphia, Pennsylvania +1 locations
Conditions: Pulmonary Hypertension Due to Lung Diseases and Hypoxia, Pulmonary Hypertension, Interstitial Lung Disease
Pulmonary Hypertension Screening in Patients With Interstitial Lung Disease for Earlier Detection
Recruiting
Study GMS-PH-001 is a multicenter, open-label, non-randomized study to prospectively evaluate screening strategies of pulmonary hypertension (PH) in patients with interstitial lung disease (ILD).
Gender:
ALL
Ages:
18 years and above
Trial Updated:
06/27/2025
Locations: St. Luke's University Health Network, Bethlehem, Pennsylvania
Conditions: Interstitial Lung Disease, Pulmonary Hypertension
Mobile Health Program for Rural Hypertension
Recruiting
Hypertension (HTN) is the leading modifiable cause of cardiovascular disease. Rural individuals experience challenges of the rural health divide: geographic distance from providers, social isolation, limited social resources, and high rates of low health literacy. This study evaluates a home-based blood pressure monitoring (HBPM) program that provides longitudinal health education, empathic guidance, monitoring, and adaptable patient-centered coaching to rural individuals. Participants in this s... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
06/26/2025
Locations: University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania
Conditions: Hypertension,Essential, Adherence, Medication, Quality of Life
Effectiveness of Two Aspirin Doses for Prevention of Hypertensive Disorders of Pregnancy: ASPIRIN TRIAL
Recruiting
The overall goal of this large, pragmatic, comparative effectiveness trial is to test the hypothesis that among at-risk individuals, 162 mg/day aspirin is superior to 81 mg/day in preventing Hypertensive disorders of pregnancy (HDP), and that there are multiple factors associated with adherence with aspirin therapy that will be important to identify to enable optimal implementation of study findings and population-level benefits.
Gender:
FEMALE
Ages:
Between 14 years and 35 years
Trial Updated:
06/17/2025
Locations: University of Pittsburg Magee, Pittsburg, Pennsylvania
Conditions: Hypertensive Disorders of Pregnancy, Preeclampsia, Gestational Hypertension
Clarifying the Optimal Application of SLT Therapy Trial
Recruiting
The goal of this study is to understand if SLT performed at low energy is as effective as SLT performed at standard energy, and also to see if repeating SLT at low energy once a year will prevent or delay the need for daily eye drop medications better than waiting for SLT to wear off before repeating it.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
06/13/2025
Locations: Eye Care Specialists, Kingston, Pennsylvania +3 locations
Conditions: Glaucoma and Ocular Hypertension
Study to Evaluate Sotatercept (MK-7962) in Children With Pulmonary Arterial Hypertension (PAH) (MK-7962-008)
Recruiting
The primary objectives of the study are to evaluate the safety and tolerability, and pharmacokinetics (PK) of sotatercept over 24 weeks of treatment in children ≥1 to \<18 years of age with PAH World Health Organization (WHO) Group 1 on standard of care (SoC). There is no formal hypothesis.
Gender:
ALL
Ages:
Between 1 year and 17 years
Trial Updated:
06/11/2025
Locations: Children's Hospital of Philadelphia (CHOP) ( Site 1608), Philadelphia, Pennsylvania
Conditions: Pulmonary Arterial Hypertension
A Study of Mosliciguat in PH-ILD
Recruiting
This is a Phase 2, randomized, double-blind, placebo-controlled, multi-center clinical study to evaluate the safety and efficacy of inhaled mosliciguat in participants with pulmonary hypertension associated with interstitial lung disease (PH-ILD).
Gender:
ALL
Ages:
Between 18 years and 80 years
Trial Updated:
06/11/2025
Locations: Lewis Katz School of Medicine, Philadelphia, Pennsylvania
Conditions: Pulmonary Hypertension, Interstitial Lung Disease, Lung Diseases, Vascular Diseases, Cardiovascular Diseases, Fibrosis
Treatment With Aspirin After Preeclampsia: TAP Trial
Recruiting
The objective of this research project is to conduct a single-site pilot trial to assess the feasibility and effect of low-dose aspirin to augment vascular recovery in the immediate postpartum period after preeclampsia through two specific aims: 1) to pilot test the feasibility of conducting a randomized controlled trial of postpartum low dose aspirin vs. placebo, and 2) to assess the effect of postpartum aspirin on endothelial function and blood pressure. Our central hypothesis is that postpart... Read More
Gender:
FEMALE
Ages:
Between 18 years and 55 years
Trial Updated:
06/02/2025
Locations: University of Pittsburgh Magee-Womens Hospital, Pittsburgh, Pennsylvania
Conditions: Hypertensive Disorder of Pregnancy, Pre-Eclampsia, Hypertension, Eclampsia, Gestational Hypertension, Cardiovascular Diseases, Toxemia, Pregnancy Complications, Vascular Diseases, Hypertension, Pregnancy Induced, Hypertension;Pre-Eclamptic
LiveSMART Trial to Prevent Falls in Patients With Cirrhosis
Recruiting
This multicenter trial is being conducted to determine if sequential lactulose and Tele (virtual) Tai-Chi reduces the rate of injurious fall, non-injurious falls, incident overt Hepatic Encephalopathy (HE), and death or liver transplant over 24 weeks. Participants that are enrolled will be randomized to stage one of this project for approximately 12 weeks. After completing stage one, participants will be re-randomized to stage 2 of the project that will last approximately 12 more weeks. The st... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
05/03/2025
Locations: University of Pennsylvania, Philadelphia, Pennsylvania
Conditions: Cirrhosis, Liver, Portal Hypertension
Advanced Neuroimaging in Idiopathic Intracranial Hypertension
Recruiting
Idiopathic intracranial hypertension (IIH) is characterized by elevated intracranial pressure leading to symptoms like papilledema, headache, and cognitive dysfunction. While the etiology is complex, abnormal cerebrospinal fluid dynamics due to venous outflow restriction from transverse sinus stenosis (TSS) is common. TSS may disrupt the glymphatic system, a brain-wide network facilitating cerebrospinal fluid and interstitial fluid exchange, by impairing CSF absorption, altering perivascular spa... Read More
Gender:
ALL
Ages:
Between 18 years and 55 years
Trial Updated:
04/22/2025
Locations: Jefferson Headache Center, Philadelphia, Pennsylvania
Conditions: Idiopathic Intracranial Hypertension (IIH), Glymphatic System
Penn Medicine Healthy Heart
Recruiting
To leverage access to patients across the primary care network, EPIC tools for identifying eligible patients, and the Way to Health platform to launch and enroll a program that will be evaluated in a clinical trial that is focused on changing patient behavior and powered to detect differences in improving blood pressure and cholesterol over 6 months for Penn Medicine patients in West/Southwest Philadelphia and Lancaster.
Gender:
ALL
Ages:
Between 35 years and 80 years
Trial Updated:
04/17/2025
Locations: Penn Medicine, Philadelphia, Pennsylvania
Conditions: Hypertension, Hyperlipidemias