The city of Charleston, South Carolina, currently has 2 active clinical trials seeking participants for Crohn's Disease research studies.
Transmural Healing and Disease-Modifying Effect of Guselkumab in Crohn's Disease Patients
Recruiting
The purpose of this study is to evaluate the efficacy of guselkumab in healing of all layers of the digestive tract (transmural healing) with the help of a score called Magnetic Resonance Index of Activity (MaRIA) based on a scan at Week 48.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
08/18/2025
Locations: Medical University of South Carolina, Charleston, South Carolina
Conditions: Crohn's Disease
VECTORS - A Study to Evaluate Transmural Healing as a Treatment Target in Crohn's Disease
Recruiting
Transmural healing (TMH) is recognized as a potentially important measure of Crohn's disease (CD) activity but not a formal target. Observational studies suggest that TMH may be associated with better long-term outcomes. The study will evaluate TMH using noninvasive intestinal ultrasound (IUS), a patient-friendly technique that can be performed routinely in clinical practice. The aim of the study is to determine if treating to a target of corticosteroid-free (CS-free) IUS outcomes + clinical sym... Read More
Gender:
ALL
Ages:
Between 18 years and 80 years
Trial Updated:
02/20/2025
Locations: Medical University of South Carolina (MUSC), Charleston, South Carolina
Conditions: Moderately to Severely Active Crohn's Disease, Crohn Disease, Disease Crohn