The state of Tennessee currently has 13 active clinical trials seeking participants for Depression research studies. These trials are conducted in various cities, including Nashville, Memphis, Knoxville and Chattanooga.
Pharmacy-led Transitions of Care Intervention to Improve Medication Adherence
Recruiting
Socioeconomically disadvantaged populations with multiple chronic conditions have high rates of nonadherence to essential chronic disease medications after hospital discharge. Medication nonadherence after hospital discharge is significantly associated with increased mortality and higher rates of readmissions and costs among these patients. Major patient-reported barriers to essential medication use after hospital discharge among low-income individuals are related to social determinants of healt... Read More
Gender:
All
Ages:
18 years and above
Trial Updated:
04/23/2024
Locations: University of Tennessee Medical Center, Knoxville, Tennessee +1 locations
Conditions: Diabetes, Hypertension, High Cholesterol/Hyperlipidemia, Coronary Artery Disease, Congestive Heart Failure, Chronic Lung Disease, Chronic Kidney Diseases, Arrythmia, Stroke, Depression, Anxiety, Pulmonary Embolism, Heart Attack
Intervention for IPV-exposed Pregnant Women
Recruiting
The overarching goal of the proposed project is to evaluate a randomized clinical trial of the Pregnant Moms' Empowerment Program aimed at detecting its effects on maternal mental health, re-victimization, parenting sensitivity, and infant development. The project also seeks to examine theoretically-grounded mechanisms of change, including social support and empowerment. Women participating in the study will receive either the PMEP or participate in a contact-equivalent active control group duri... Read More
Gender:
Female
Ages:
Between 3 months and 55 years
Trial Updated:
04/01/2024
Locations: University of Memphis, Memphis, Tennessee
Conditions: Postpartum Depression, Posttraumatic Stress Disorder, Infant Behavior, Violence, Parenting
Cognitive Enhancement in Depression (The COG-D Study)
Recruiting
This study will investigate whether transcranial direct current stimulation (tDCS) enhances the effects of cognitive training in older adults with depression.
Gender:
All
Ages:
60 years and above
Trial Updated:
03/26/2024
Locations: Vanderbilt University Medical Center, Nashville, Tennessee
Conditions: Aging, Depression, Cognitive Symptom
Dopaminergic Dysfunction in Late-Life Depression
Recruiting
Late-Life Depression (LLD), or depression in older adults, often presents with motivational deficits, deficits in performance in cognitive domains including processing speed and executive dysfunction, and mobility impairments. This triad of findings implicate dopaminergic dysfunction as a core pathophysiologic feature in depression, and may contribute to cognitive decline and motor disability. Normal aging results in brain-wide dopamine declines, decreased D1/D2 receptor density, and loss of dop... Read More
Gender:
All
Ages:
60 years and above
Trial Updated:
03/13/2024
Locations: Vanderbilt Psychiatric Hospital, Nashville, Tennessee
Conditions: Late Life Depression, Cognitive Decline, Depressive Disorder, Treatment-Resistant, Levodopa, Gait Impairment
A Prospective, Multi-center, Randomized Controlled Blinded Trial Demonstrating the Safety and Effectiveness of VNS Therapy® System as Adjunctive Therapy Versus a No Stimulation Control in Subjects With Treatment-Resistant Depression
Recruiting
Objectives of this study are to determine whether active VNS Therapy treatment is superior to a no stimulation control in producing a reduction in baseline depressive symptom severity, based on multiple depression scale assessment tools at 12 months from randomization.
Gender:
All
Ages:
18 years and above
Trial Updated:
03/11/2024
Locations: Neuroscience and TMS Treatment Center, Brentwood, Tennessee
Conditions: Treatment Resistant Depression
A Study to Assess the Efficacy and Safety of REL-1017 as Adjunctive Treatment for Major Depressive Disorder (MDD)
Recruiting
This is an outpatient, 2-arm, Phase 3, multicenter, randomized, double-blind, placebo-controlled study to assess the efficacy and safety of REL-1017 once daily (QD) as an adjunctive treatment of Major Depressive Disorder. Study participants will continue to take their current antidepressant therapy in addition to the study drug or placebo for the duration of the treatment period.
Gender:
All
Ages:
Between 18 years and 65 years
Trial Updated:
02/15/2024
Locations: Relmada Site, Memphis, Tennessee
Conditions: Major Depressive Disorder, Depression
Randomized, Double-Blind, Placebo-Controlled Trial of REL-1017 as Adjunctive Treatment for MDD
Recruiting
A Phase 3, randomized, double-blind, placebo-controlled, multicenter trial of REL-1017 in patients with major depressive disorder (MDD).
Gender:
All
Ages:
Between 18 years and 65 years
Trial Updated:
02/15/2024
Locations: Relmada Site, Franklin, Tennessee +1 locations
Conditions: Major Depressive Disorder, Depression
Latino Teen Depression Treatment Study
Recruiting
Despite experiencing higher rates of depressive symptoms (Center for Disease Control and Prevention, 2020) and similar rates of Major Depressive Disorder (MDD; Substance Abuse and Mental Health Services Administration (SAMHSA), 2019), Latino adolescents in the U.S. are significantly less likely than their non-Latino White peers to receive treatment for MDD (SAMHSA, 2019). The purpose of this study is to identify a stakeholder-preferred implementation strategy that may improve psychotherapy atten... Read More
Gender:
All
Ages:
13 years and above
Trial Updated:
12/07/2023
Locations: Researchmatch.org, Nashville, Tennessee
Conditions: Depression
Prevention of Anhedonia in Children
Recruiting
This trial will test the effects of a positive emotion-focused preventive intervention on reward responsiveness in children of mothers with histories of depression and anhedonia.
Gender:
All
Ages:
Between 8 years and 12 years
Trial Updated:
11/13/2023
Locations: Jesup/Hobbs Building, Nashville, Tennessee
Conditions: Anhedonia, Depression
CBT Enhanced With Social Cognitive Training vs. CBT Only With Depressed Youth
Recruiting
Depression in youth is a serious public health concern for which more personalized treatments are needed. This randomized controlled trial will test the effect of an intervention aimed at enhancing social cognitive capacities (e.g., ability to take another's perspective), thereby making treatment of depression in youth more efficient and effective. Participants in the R33 (N=82) will be youth between ages 13- through 17-years-old currently experiencing depression. Youth will be randomized to eit... Read More
Gender:
All
Ages:
Between 13 years and 17 years
Trial Updated:
08/17/2023
Locations: Judy Garber, Nashville, Tennessee
Conditions: Depression
Psychosocial, Behavioral, and Radiologic Changes Following Radiosurgery for Benign Neurologic Disease
Recruiting
A number of studies from the literature suggest important behavioral, psychosocial, or radiologic changes occur following significant neurologic events or interventions such as stroke, neurosurgery, medications, radiation, systemic therapy, or injury. The purpose of this study is to describe these changes with advanced neurologic imaging and targeted neurologic and neuropsychiatric assessments. This is a non-interventional observational study of minimal risk to participants as there is no medica... Read More
Gender:
All
Ages:
18 years and above
Trial Updated:
07/21/2023
Locations: Vanderbilt University Medical Center, Nashville, Tennessee
Conditions: Obsessive-Compulsive Disorder, Pain, Intractable, Depression
Academic-Community EPINET (AC-EPINET)
Recruiting
The investigators propose to examine the effects of CSC services delivered via TH (CSC-TH) versus the standard clinic-based CSC model (CSC-SD) on engagement and outcomes in a 12-month, randomized trial.
Gender:
All
Ages:
Between 16 years and 35 years
Trial Updated:
05/16/2023
Locations: Vanderbilt's Early Psychosis Program - Vanderbilt University, Nashville, Tennessee
Conditions: Schizophrenia, Schizoaffective Disorder, Schizophreniform Disorders, Major Depression With Psychotic Features, Bipolar Disorder With Psychotic Features