The state of Tennessee currently has 5 active clinical trials seeking participants for Healthy research studies. These trials are conducted in various cities, including Nashville, Memphis, Knoxville and Chattanooga.
Study of an Investigational Pentavalent Meningococcal ABCYW Vaccine in Adults and Adolescents
Recruiting
The purpose of VAN00010 study is to assess the safety and immunogenicity of the investigational pentavalent meningococcal ABCYW vaccine in adults and adolescents. The study duration will be up to 12 months for all participants.
Gender:
All
Ages:
Between 10 years and 25 years
Trial Updated:
02/20/2024
Locations: Pediatric Clinical Trials Tullahoma Site Number : 8400020, Tullahoma, Tennessee
Conditions: Meningococcal Infection, Healthy Volunteers
Study of a Respiratory Syncytial Virus/Human Metapneumovirus Vaccine Candidate
Recruiting
The purpose of this study is to assess the safety and immunogenicity of a single intramuscular (IM) injection of different doses of an respiratory syncytial virus (RSV) and human metapneumovirus (hMPV) vaccine candidate, in adult participants aged 60 years and older. In addition, the study will evaluate the safety and immunogenicity of a booster vaccination administered 12 months after the primary vaccination in a subset of the study population.
Gender:
All
Ages:
60 years and above
Trial Updated:
02/08/2024
Locations: AMR Knoxville Site Number : 8400010, Knoxville, Tennessee
Conditions: Respiratory Syncytial Virus Infection, Healthy Volunteers, Human Metapneumovirus
Trial of Antibody Responses by Vitamin Supplementation
Recruiting
Streptococcus pneumoniae, commonly called pneumococcus, can cause a wide range of diseases in children from mild ear infections to deadly pneumonia or meningitis. Vaccination is currently the single best way to protect children. Nutrition, especially the amount of vitamin A, may play a role in how well your body responds to infection or a vaccine. We call this an immune response. This research will look to see if children who take a vitamin with their vaccine have a better immune response than c... Read More
Gender:
All
Ages:
Between 1 year and 4 years
Trial Updated:
02/06/2024
Locations: St. Jude Children's Research Hospital, Memphis, Tennessee
Conditions: Healthy Participants
Risk and Resilience in Pulmonary Arterial Hypertension and Genetically Susceptible Individuals
Recruiting
Pulmonary arterial hypertension (PAH) is a severe disease with a delayed diagnosis and markedly elevated mortality. High-risk populations, such as those with known genetic defects, provide a unique opportunity to determine the features of susceptibility and resilience to PAH. This proposal will fundamentally overturn the prevailing understanding of PAH by creating molecularly-driven signatures of susceptibility and resilience, provide novel insight into disease severity, and potentially identify... Read More
Gender:
All
Ages:
Between 15 years and 80 years
Trial Updated:
01/10/2024
Locations: Vanderbilt University Medical Center, Nashville, Tennessee
Conditions: Idiopathic Pulmonary Arterial Hypertension, Heritable Pulmonary Arterial Hypertension, Unaffected Mutation Carriers: Healthy Participants With a Known BMPR2 Gene Mutation and Normal Pulmonary Pressure and RV Function on Echo, Healthy Individuals With no Cardiopulmonary Disease
Role of Sympathetic Vasoconstriction on Insulin-Mediated Microvascular Recruitment and Glucose Uptake in Obesity
Recruiting
The purpose of this study is to better understand the contribution of sympathetic vasoconstriction to impaired insulin-mediated vasodilation and subsequently insulin-mediated glucose uptake. The investigators will test the hypothesis that removal of sympathetic vasoconstriction can result in improvement in insulin-mediated vasodilation and subsequently sensitivity to insulin-mediated glucose uptake.
Gender:
All
Ages:
Between 18 years and 60 years
Trial Updated:
04/27/2023
Locations: Autonomic Dysfunction Center, Nashville, Tennessee
Conditions: Insulin Resistance, Healthy, Obesity