Persona OsseoTi Keel Compatibility Study (Total Knee Arthroplasty)
Recruiting
The main objective of the study is to evaluate the safety, performance and clinical benefits of the Persona implant and its instrumentation in primary total knee arthroplasty
Gender:
All
Ages:
18 years and above
Trial Updated:
11/17/2023
Locations: Southern Joint Replacement Institute, Nashville, Tennessee
Conditions: Knee Pain Chronic, Osteoarthritis, Knee, Rheumatoid Arthritis, Traumatic Arthritis, Polyarthritis, Varus Deformity, Valgus Deformity, Flexion Deformity of Knee, Avascular Necrosis
A Global Clinical Study Investigating the Safety and Effectiveness of Smith and Nephew's Porous Knee System in Patients Who Need a Total Knee Replacement Due to Degenerative Arthritis, Post-traumatic Arthritis or Inflammatory Arthritis
Recruiting
A clinical trial investigating the safety and effectiveness of Smith and Nephew's FDA-approved Porous Total Knee System, which is used to replace worn away and diseased knee joints. The aim of this study is to show that most patients who receive the Porous Total Knee System have reduced pain, greater mobility and a long-lasting implant post-surgery.
Gender:
All
Ages:
Between 18 years and 80 years
Trial Updated:
11/10/2023
Locations: Erlanger Health, Chattanooga, Tennessee
Conditions: Osteoarthritis, Post-traumatic Arthritis, Rheumatoid Arthritis
A Study of Retatrutide (LY3437943) in Participants Who Have Obesity or Overweight
Recruiting
The purpose of this study is to evaluate the efficacy and safety of retatrutide in participants who have obesity or overweight (J1I-MC-GZBJ master protocol) including subsets of participants who have knee osteoarthritis (OA) (J1I-MC-GOA1) or who have obstructive sleep apnea (OSA) (J1I-MC-GSA1). This study will last about 89 weeks and will include up to 24 visits.
Gender:
All
Ages:
18 years and above
Trial Updated:
10/18/2023
Locations: Vanderbilt Health One Hundred Oaks, Nashville, Tennessee
Conditions: Obesity, Overweight, Knee Pain Chronic, Knee Osteoarthritis, Obstructive Sleep Apnea
A Study to Determine the Safety and Efficacy of TG-C in Subjects With Kellgren and Lawrence Grade 2 or 3 OA of the Knee
Recruiting
A randomized, double-blind, placebo-controlled, multi-center, phase 3 study to determine the safety and efficacy of TG-C in subjects with Kellgren and Lawrence Grade 2 or 3 Osteoarthritis of the Knee, Osteoarthritis Research Society International (OARSI) medial joint space narrowing (JSN) Grade 1 or 2 of the knee joint. TG-C is to be administered by a single intra-articular injection to the damaged joint area via ultrasound guidance. Patients will be followed for 24 months for safety and efficac... Read More
Gender:
All
Ages:
40 years and above
Trial Updated:
09/25/2023
Locations: Jason Haslam, Nashville, Tennessee
Conditions: Degenerative Osteoarthritis
Open-label Trial to Check the Safety and Tolerability of RTX-GRT7039 Injections for Pain Associated With Osteoarthritis of the Knee
Recruiting
An open-label, single-arm clinical trial to confirm the safety of monoarticular injections or bi-lateral intra-articular injections of RTX-GRT7039 in patients who have pain associated with osteoarthritis of the knee despite standard of care.
Gender:
All
Ages:
18 years and above
Trial Updated:
09/25/2023
Locations: Accellacare-Knoxville, Knoxville, Tennessee
Conditions: Osteoarthritis
Comparison of a Single RTX-GRT7039 and Placebo Intra-articular Injection for Pain Associated With Osteoarthritis of the Knee
Recruiting
A double-blind, randomized, placebo-controlled, parallel-group, multi-site, clinical trial to confirm the efficacy and safety of single injection of RTX-GRT7039 versus placebo in patients who have pain associated with osteoarthritis of the knee despite standard of care.
Gender:
All
Ages:
18 years and above
Trial Updated:
09/25/2023
Locations: Accellacare - Knoxville, Knoxville, Tennessee
Conditions: Osteoarthritis
Exactech Shoulder Post Market Clinical Follow-up Study
Recruiting
The objective of this study is to collect and evaluate long-term clinical and radiographic outcomes data in order to better understand the safety and performance of the shoulder arthroplasty over time. This study will follow subjects long-term for a minimum of 10-years, without an early-term restriction on the amount of time they will be followed.
Gender:
All
Ages:
21 years and above
Trial Updated:
01/27/2023
Locations: Bone and Joint Institute of Tenessee, Franklin, Tennessee
Conditions: Osteo Arthritis Shoulders, Osteonecrosis, Rotator Cuff Tears, Rotator Cuff Tear Arthropathy, Ankylosing Spondylitis, Post-traumatic Osteoarthritis, Rheumatoid Arthritis, Fracture, Infections
Treatment Effects of Subcutaneous Injections of Pentosan Polysulfate Sodium vs Placebo in Participants With Knee OA Pain
Recruiting
The purpose of this study is to measure the change in pain and function with subcutaneous injections of pentosan polysulfate sodium (PPS) compared with subcutaneous injections of placebo in participants with knee osteoarthritis pain. Study details include: The study duration will be up to 28 weeks per participant The treatment duration will be 6 weeks. The visit frequency will be twice weekly during treatment..
Gender:
All
Ages:
18 years and above
Trial Updated:
03/31/2022
Locations: Alliance for Multispecialty Research - Knoxville, Knoxville, Tennessee
Conditions: Osteoarthritis, Knee
ROMTECH PortableConnect Rehabilitation Device Usage Post Unilateral Total Knee Arthroplasty (TKA)
Recruiting
ROMTech is focused on transforming the healthcare market by delivering lower extremity rehabilitation systems that are effective, efficient for patient use, cost-effective, and provide better patient outcomes while simultaneously decreasing rehabilitation and overall recovery times.
Gender:
All
Ages:
18 years and above
Trial Updated:
05/22/2021
Locations: OrthoSouth, Memphis, Tennessee
Conditions: Knee Osteoarthritis, Knee Arthritis, Knee Pain Chronic, Knee Disease, Joint Pain, Osteo Arthritis Knee, Osteoarthritis, Knee
Cycling Intervention on Symptoms of Patients With Knee Osteoarthritis
Recruiting
This study is designed to determine the effect of a cycling training program which modulates frontal and sagittal plane knee joint loading with graded increases of Q-Factor and cycling workrate in persons with symptomatic knee osteoarthritis.
Gender:
All
Ages:
Between 50 years and 75 years
Trial Updated:
04/06/2020
Locations: Biomechanics/Sports Medicine Lab, Knoxville, Tennessee
Conditions: Osteoarthritis, Knee