The state of Tennessee currently has 20 active clinical trials seeking participants for Pain research studies. These trials are conducted in various cities, including Nashville, Memphis, Knoxville and Chattanooga.
Pain Type and Interstitial Cystitis/Bladder Pain Syndrome Treatment
NCT06299683
Recruiting
Interstitial cystitis/bladder pain syndrome (IC/BPS) is a severe pain condition affecting 3-8 million people in the United States lacking treatments that work. Emotional suffering is common in IC/BPS and known to make physical symptoms worse, and studies show patient sub-groups respond differently to treatment. Individuals with IC/BPS have distinct subgroups, or "phenotypes," largely characterized by the distribution of pain throughout the body. Supported by our preliminary evidence, the overall... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
01/06/2025
Locations: Vanderbilt Urology Cool Springs, Franklin, Tennessee
Conditions: Chronic Interstitial Cystitis, Bladder Pain Syndrome, Painful Bladder Syndrome, Cystitis, Interstitial, Cystitis, Chronic Interstitial, Interstitial Cystitis, Interstitial Cystitis, Chronic, Interstitial Cystitis (Chronic) With Hematuria, Interstitial Cystitis (Chronic) Without Hematuria, Chronic Prostatitis, Chronic Prostatitis With Chronic Pelvic Pain Syndrome
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Low-Dose Ketamine Infusion During Burn Wound Care
NCT06506565
Recruiting
The current standard of care (SOC) (i.e. fentanyl and midazolam) offers limited efficacy for preventing or relieving pain. Ketamine infusions may provide the benefits of analgesia, minimize adverse events, and reduce opioid use. The purpose of this study is to determine if adding a low dose ketamine infusion during wound care will safely provide pain relief for patients with burn injury.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
12/09/2024
Locations: Regional One Health, Memphis, Tennessee
Conditions: Burn, Pain, Dissociation, Opioid
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Reducing Perioperative Oxidative Stress to Prevent Postoperative Chronic Pain Following Total Knee Arthroplasty
NCT06083480
Recruiting
This is a prospective randomized controlled trial that will assess preoperative, perioperative, and long-term oxidative stress (OS); pain; and functional outcomes over a 12 month period and test the hypothesis that a potent antioxidant intervention (glycine + N-acetyl-cysteine(GlyNAC)) reduces oxidative stress and chronic post surgical pain (CPSP) in patients undergoing total knee arthroplasty (TKA).
Gender:
ALL
Ages:
50 years and above
Trial Updated:
12/06/2024
Locations: Vanderbilt University Medical Center, Nashville, Tennessee
Conditions: Osteoarthritis, Knee, Total Knee Arthroplasty, Chronic Postsurgical Pain
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Low-dose Buccal Buprenorphine: Relative Abuse Potential and Analgesia
NCT05988710
Recruiting
The goal of this study is to compare the abuse potential of low-dose equianalgesic buccal buprenorphine to a commonly used full mu opioid receptor (MOR) agonist in a highly controlled experimental setting. This is a translational study in which healthy participants are phenotyped for psychosocial and Opioid-Use-Disorder-risk-related metrics. In a within-subjects crossover design, 60 participants will receive a standard postoperative oral oxycodone dose (10 mg), placebo, and 3 different doses of... Read More
Gender:
ALL
Ages:
Between 18 years and 65 years
Trial Updated:
12/06/2024
Locations: Vanderbilt University Medical Center, Nashville, Tennessee
Conditions: Analgesia, Abuse Opioids, Pain
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Embo Registry; National Registry for Artery Embolization
NCT06477965
Recruiting
Embo Registry is a retrospective and prospective observational study to evaluate real world effectiveness and the use of Artery Embolization as a treatment for chronic pain with patients that have osteoarthritis and localized pain to provide symptomatic relief. This study is to determine the efficacy and validity of procedure and that following procedure patients had decreased pain and improved quality of life.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
10/24/2024
Locations: Southern Tennessee Cardiology, Winchester, Tennessee
Conditions: Chronic Pain, Osteoarthritis, Knee, Osteoarthritis Thumb, Osteoarthritis Shoulder, Pain, Chronic, Tendonitis Elbow, Tendonitis Shoulder, Tendonitis;Achilles, Tenosynovitis
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Stress and Opioid Misuse Risk: The Role of Endogenous Opioid and Endocannabinoid Mechanisms
NCT05142267
Recruiting
The purpose of this study is to see how stress influences the effects of opioid pain medications often used to help relieve back pain. The study will help to learn more about how high stress levels could increase risk for pain medication misuse.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
10/07/2024
Locations: Vanderbilt University Medical Center, Nashville, Tennessee
Conditions: Opioid Use Disorder, Back Pain, Stress
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Opioid Prescribing Practices in Laparoscopic Gynecologic Surgery
NCT06532708
Recruiting
The purpose of this study is to compare opioid prescribing practices by either routine provider prescribing practices, or with the use of a calculator, i.e., the Opioid Calculator, published by the University of Michigan (www.opioidcalculator.org), with the intent of decreasing the number of pills.
Gender:
FEMALE
Ages:
Between 18 years and 80 years
Trial Updated:
07/31/2024
Locations: University of Tennessee Health Science Center, Memphis, Tennessee
Conditions: Opioid Use, Postoperative Pain
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Pain With Differing Insufflation Pressures During Laparoscopic Hysterectomy
NCT06508814
Recruiting
The purpose of this study is to determine the effect of decreased insufflation pressure on postoperative pain, analgesic use, and surgical safety and feasibility for laparoscopic hysterectomy.
Gender:
FEMALE
Ages:
Between 18 years and 80 years
Trial Updated:
07/19/2024
Locations: University of Tennessee Health Science Center, Memphis, Tennessee
Conditions: Post Operative Pain
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