There are currently 8 active clinical trials seeking participants for Prader-Willi Syndrome research studies. The states with the highest number of trials for Prader-Willi Syndrome participants are California, New York, Texas and Tennessee.
ARD-101 for Treatment of PWS: The Hunger Elimination or Reduction Objective Trial
NCT06828861
Recruiting
The goal of this clinical trial is to learn if ARD-101 works to treat hyperphagia-related behavior in patients with Prader-Willi syndrome (PWS). It will also teach us about the safety of ARD-101. The main questions it aims to answer are: * Does ARD-101 improve the total score of the HQCT-9 (hyperphagia questionnaire for clinical trials, 9 questions)? * What medical problems do participants have when taking ARD-101? Researchers will compare ARD-101 to a placebo (a look-alike substance that con... Read More
Gender:
ALL
Ages:
13 years and above
Trial Updated:
08/04/2025
Locations: Children's of Alabama, Birmingham, Alabama +41 locations
Conditions: Hyperphagia, Prader-Willi Syndrome
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A Clinical Evaluation of Non-Invasive Vagus Nerve Stimulation for Temper Outbursts in People With PWS
NCT06144645
Recruiting
The goal of the VNS4PWS clinical study is to test the efficacy, safety, and acceptability of transcutaneous vagus nerve stimulation (tVNS) treatment in people with PWS.
Gender:
ALL
Ages:
Between 10 years and 40 years
Trial Updated:
07/10/2025
Locations: Stanford University, Palo Alto, California +14 locations
Conditions: Prader-Willi Syndrome
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A Study of Pitolisant in Patients With Prader-Willi Syndrome
NCT06366464
Recruiting
This is a Phase 3, randomized, double-blind, placebo-controlled, multicenter, global clinical study to assess the efficacy and safety of pitolisant in patients living with Prader-Willi syndrome. The primary objective of this study is to evaluate the efficacy of pitolisant in treating excessive daytime sleepiness (EDS) in patients ≥6 years of age with Prader-Willi syndrome. Secondary objectives include assessing the impact of pitolisant on: Irritable and disruptive behaviors Hyperphagia Other... Read More
Gender:
ALL
Ages:
6 years and above
Trial Updated:
07/08/2025
Locations: Santa Monica Clinical Trials, Los Angeles, California +57 locations
Conditions: Prader-Willi Syndrome
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A Single-center Study of Setmelanotide in Patients With Prader-Willi Syndrome
NCT06772597
Recruiting
This is a Phase 2, single-center, open-label study designed to assess the safety and efficacy of setmelanotide in patients with obesity due to Prader-Willi Syndrome (PWS) who are 6 to 65 years of age. Up to 20 patients are planned to be enrolled. Patients will take a daily subcutaneous dose of open-label setmelanotide for up to 26 weeks.
Gender:
ALL
Ages:
Between 6 years and 65 years
Trial Updated:
07/01/2025
Locations: University of Florida, Gainesville, Florida
Conditions: Prader-Willi Syndrome, Obesity, Hyperphagia
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Tirzepatide in PWS, HO and GNSO
NCT06901245
Recruiting
This research study is comparing the effectiveness of a weight loss medication called Tirzepatide in young adults with Prader-Willi Syndrome and/or hypothalamic obesity, as compared to young adults with obesity that is unrelated to a genetic syndrome or underlying medical cause. These groups will be given medication for 1 year to see how weight and other health factors are effected by the medication.
Gender:
ALL
Ages:
Between 18 years and 26 years
Trial Updated:
05/14/2025
Locations: Children's Minnesota, Minneapolis, Minnesota +2 locations
Conditions: Prader-Willi Syndrome, Hypothalamic Obesity, Obesity/Therapy
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Impact of Bright Light Therapy on Prader-Willi Syndrome
NCT05939453
Recruiting
This is a placebo controlled clinical trial to assess the utility of light therapy as a sufficient treatment for excessive daytime sleepiness in patients with Prader-Willi Syndrome
Gender:
ALL
Ages:
Between 6 years and 88 years
Trial Updated:
02/24/2025
Locations: Maimonides Medical Center, Brooklyn, New York
Conditions: Prader-Willi Syndrome, Excessive Daytime Sleepiness, Hyperphagia, Body Weight, Mood, Behavior
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Cerebellar TMS and Satiety in Prader-Willi Syndrome
NCT05938543
Recruiting
This study uses a noninvasive technique called transcranial magnetic stimulation (TMS) to study hyperphagia and satiety in Prader-Willi syndrome. TMS is a noninvasive way of stimulating the brain, using a magnetic field to change activity in the brain. The magnetic field is produced by a coil that is held next to the scalp. In this study, the investigators will be stimulating the brain to learn more about how TMS might improve hyperphagia in Prader-Willi syndrome.
Gender:
ALL
Ages:
Between 18 years and 64 years
Trial Updated:
02/03/2025
Locations: McLean Hospital, Belmont, Massachusetts
Conditions: Prader-Willi Syndrome
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Physical Activity and Community EmPOWERment Project
NCT06740162
Recruiting
Purpose: Conduct a wait-list randomized controlled trial (RCT) of an inclusive physical activity program called PACE for adults with intellectual disability (ID) who are not yet showing signs of Alzheimer's Disease (AD)/age-related dementias (ARD). Participants: Participants include 120 adults with ID, their caregivers, and their coaches (up to 360 individual participants, grouped as triads), recruited through the University of North Carolina at Chapel Hill and the University of Arkansas. Parti... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
01/14/2025
Locations: University of Arkansas, Fayetteville, Arkansas +1 locations
Conditions: Intellectual Disability, Neurodevelopmental Disorders, Autism Spectrum Disorder, Down Syndrome, Fragile X Syndrome, Cri-du-Chat Syndrome, De Lange Syndrome, Mental Retardation, X-Linked, Prader-Willi Syndrome, Rubinstein-Taybi Syndrome, Trisomy 13 Syndrome, WAGR Syndrome, Williams Syndrome
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