There are currently 8 active clinical trials seeking participants for Critical Limb Ischemia research studies. The states with the highest number of trials for Critical Limb Ischemia participants are Florida, California, Texas and Massachusetts.
Use of Thermal Imaging Camera to Assess Perfusion Before and After Vascular Intervention
NCT06544135
Recruiting
This is a preliminary prospective observational study measuring change in lower extremity temperature in response to revascularization procedure. The main question this study aims to answer is: - Are temperature measurements from a forward looking infrared (FLIR) camera of the lower extremity useful in predicting outcome of revascularization procedures?
Gender:
ALL
Ages:
Between 18 years and 99 years
Trial Updated:
05/08/2025
Locations: University Hospitals Ahuja Medical Center, Beachwood, Ohio +2 locations
Conditions: Peripheral Arterial Disease, Critical Limb Ischemia, Critical Lower Limb Ischemia
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Temsirolimus Adventitial Delivery to Improve ANGioplasty and/or Atherectomy Revascularization Outcomes Below the Knee
NCT04433572
Recruiting
A multicenter, randomized, double-blind, placebo-controlled trial to evaluate the effect of Temsirolimus Perivascular Injection 0.1 mg/mL on the incidence of ischemia-driven major amputation, clinically driven target lesion revascularization, and clinically relevant target lesion occlusion after revascularization of lesions below the knee in patients with symptomatic Rutherford 3-5 peripheral artery disease. The primary safety endpoint will be gathered at 1-month post-index procedure. The primar... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
07/31/2025
Locations: Cardiovascular Institute of the South, Houma, Louisiana +1 locations
Conditions: Peripheral Artery Disease, Critical Limb Ischemia
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Nutrition in Patient With Critical Limb Ischemia
NCT03529019
Recruiting
A prospective pilot study examining nutritional supplements among vascular surgery patients with Critical Limb Ischemia (CLI). CLI patients have a high rate of malnutrition and has the potential to benefit greatly from nutritional intervention. The investigators plan to evaluate nutrition and functional status of patients by assessing objective lab values and the use of the hand grip strength test. Providing perioperative nutritional supplements to patients has potentially improved their nutriti... Read More
Gender:
ALL
Ages:
Between 18 years and 99 years
Trial Updated:
06/25/2025
Locations: Boston Medical Center, Boston, Massachusetts
Conditions: Critical Limb Ischemia, Malnutrition, Nutritional Supplements
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Serrantor OCT Study
NCT06434194
Recruiting
TA prospective randomized control trial to evaluate the serration angioplasty effect in BTK arteries with varying degrees of calcified plaque.
Gender:
ALL
Ages:
19 years and above
Trial Updated:
05/14/2025
Locations: Columbia University, New York, New York +1 locations
Conditions: Critical Limb Ischemia
Register for Updates
MOTIV BTK Randomized Controlled Trial
NCT05406622
Recruiting
Pre-market clinical evaluation of the MOTIV Sirolimus-Eluting Bioresorbable Scaffold for the planned treatment of infrapopliteal lesions.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
04/01/2025
Locations: Adventist Health, Saint Helena, California +3 locations
Conditions: Critical Limb Ischemia
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CRUSH PAD: Real-world Outcomes Following Use of Shockwave Intravascular Lithotripsy (IVL) Technology in Calcified Common Femoral Lesions
NCT05145478
Recruiting
The primary goal of the study is to obtain effect size data on the use of Shockwave Intravascular Lithotripsy (IVL) technology in calcified common femoral lesions in patients with peripheral artery disease for a series of endpoints, including target lesion revascularization and health status, to enable future planning of comparative effectiveness research.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
02/05/2025
Locations: Yale New Haven Health, New Haven, Connecticut
Conditions: Femoral Arterial Calcification, Peripheral Arterial Disease, Claudication, Critical Limb Ischemia
Register for Updates
Trial to Assess Chelation Therapy in Critical Limb Ischemia
NCT03982693
Recruiting
TACT3a is a double blind, placebo-controlled, randomized trial to test a novel therapy, edetate disodium-based chelation of environmentally acquired toxic metals, to reduce cardiovascular events including amputation in high-risk diabetic patients.
Gender:
ALL
Ages:
50 years and above
Trial Updated:
08/20/2024
Locations: Mount Sinai Medical Center, Miami Beach, Florida
Conditions: Critical Limb Ischemia, Diabetes
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PROMISE III: Percutaneous Deep Vein Arterialization for the Treatment of Late-Stage Chronic Limb-Threatening Ischemia
NCT05313165
Recruiting
A prospective, single-arm, multi-center study designed to gather additional information on the LimFlow System.
Gender:
ALL
Ages:
Between 18 years and 95 years
Trial Updated:
05/31/2024
Locations: University of California, San Diego Health, La Jolla, California +29 locations
Conditions: Critical Limb Ischemia, Peripheral Arterial Disease, Chronic Limb-Threatening Ischemia
Register for Updates