There are currently 122 active clinical trials seeking participants for Mild Cognitive Impairment research studies. The states with the highest number of trials for Mild Cognitive Impairment participants are Florida, California, New York and Texas.
ADRC Clinical Cohort (Alzheimer's Disease)
Recruiting
The purpose of the study is to establish a clinical cohort for the Duke/UNC Alzheimer's Disease Research Center (ADRC). The cohort will be composed of subjects ages 25 to 44 at enrollment with normal cognition and subjects ages 45 to 80 at enrollment with normal cognition, mild cognitive impairment, or a dementia diagnosis. Initial data including demographics, medical and family history, physical exam, and neuropsychological testing will be obtained. Participants will be asked to contribute a bl... Read More
Gender:
ALL
Ages:
Between 25 years and 80 years
Trial Updated:
08/21/2025
Locations: Duke University, Durham, North Carolina
Conditions: Alzheimer Disease, Mild Cognitive Impairment, Dementia
Psilocybin for Depression in People With Mild Cognitive Impairment or Early Alzheimer's Disease
Recruiting
This open-label pilot study examines whether the hallucinogenic drug, psilocybin, given under supportive conditions, is safe and effective for depression in people with Mild Cognitive Impairment (MCI) or early Alzheimer's Disease (AD). This study will also assess whether psilocybin may improve quality of life in those individuals.
Gender:
ALL
Ages:
Between 18 years and 85 years
Trial Updated:
08/14/2025
Locations: Behavioral Pharmacology Research Unit, Baltimore, Maryland
Conditions: Depressive Symptoms, Depression, Alzheimer Disease, Mild Cognitive Impairment
Evaluation of the Effects of a Nutritional Intervention of Ketogenic Medium-chain Triglycerides and B-vitamins on Cognitive Functioning in Older Adults With Mild Cognitive Impairment (COGNIKET-MCI)
Recruiting
Evaluation of the Effects of a Nutritional Intervention of Ketogenic Medium-chain Triglycerides and B-vitamins on Cognitive Functioning in Older Adults With Mild Cognitive Impairment (COGNIKET-MCI)
Gender:
ALL
Ages:
60 years and above
Trial Updated:
08/11/2025
Locations: Stein Gerontological Institute Inc, Miami, Florida +29 locations
Conditions: Mild Cognitive Impairment
Autoimmune Features of Neurodegenerative Disorders
Recruiting
This study is being conducted to better understand the role of inflammation in Parkinson's disease (PD) and Alzheimer's disease (AD). The investigators plan to recruit 30 PD, 30 AD/Amnestic Mild Cognitive Impairment (aMCI), and 60 age matched healthy controls in this study to study the role of immune response in PD and AD. The study involves up to two study visits involving brief questionnaires and blood draw of up to 250cc (approximately 17 tablespoons) to be collected. More ways to participat... Read More
Gender:
ALL
Ages:
Between 55 years and 90 years
Trial Updated:
08/07/2025
Locations: Columbia University Medical Center, New York, New York
Conditions: Parkinson Disease, Alzheimer Disease, Mild Cognitive Impairment
Neurofeedback to Improve Working Memory in Mild Cognitive Impairment
Recruiting
Mild cognitive impairment (MCI) has been identified as an early phase of Alzheimer's disease (AD), a neurodegenerative disorder expected to affect 13.9 million Americans by 2060. AD causes a progressive cognitive decline, including problems related to learning and memory, that adversely affects life quality. Treatment intervention at the MCI stage of the disease could potentially slow down the rate at which people may convert from MCI to AD. Increasing evidence suggests that abnormal activity in... Read More
Gender:
ALL
Ages:
Between 50 years and 85 years
Trial Updated:
08/05/2025
Locations: University of California at San Diego, La Jolla, California
Conditions: Mild Cognitive Impairment
TREAD: Time Restricted Eating Intervention for Alzheimer's Disease
Recruiting
The goal of this clinical trial is to learn if restricting the time of eating to allow for prolonged fasting at night may reduce sleep disturbances, cognitive decay, and pathology in patients diagnosed with Mild Cognitive Impairment (MCI) or early to moderate Alzheimer's disease (AD). It will also learn about the feasibility of practicing 14 h of nightly fasting in this group of older adults. The main questions it aims to answer are: * Does prolonged nightly fasting of 14 h can reduce markers o... Read More
Gender:
ALL
Ages:
60 years and above
Trial Updated:
08/03/2025
Locations: Shiley Marcos Alzheimer's Disease Center, San Diego, California
Conditions: Mild Cognitive Impairment, Alzheimer Disease, Alzheimer's Disease
Evaluate the Effect of Atorvastatin on Cerebrovascular Reactivity in Mild Cognitive Impairment (MCI)
Recruiting
The purpose of this study is to evaluate the effect of atorvastatin on brain vessel reactivity and with it on blood flow in people with mild cognitive impairment.
Gender:
ALL
Ages:
Between 60 years and 95 years
Trial Updated:
08/01/2025
Locations: Johns Hopkins University, Bayview Medical Center, Baltimore, Maryland
Conditions: Mild Cognitive Impairment
Tennessee Alzheimer's Project
Recruiting
The primary objective of the Vanderbilt Alzheimer's Disease Research Center (VADRC) is to provide local and national researchers with access to a well-characterized and diverse clinical cohort, including participant referrals, biosamples, clinical data, and neuroimaging data. The VADRC Clinical Core will create an infrastructure to support research efforts of both local and national investigator studies to develop early detection, prevention, and treatment strategies for Alzheimer's disease. The... Read More
Gender:
ALL
Ages:
60 years and above
Trial Updated:
08/01/2025
Locations: Vanderbilt University Medical Center, Nashville, Tennessee
Conditions: Aging, Alzheimer Disease, Biomarker, Cognitive Dysfunction, Mild Cognitive Impairment, Dementia, Cognition
Wake Forest Alzheimer's Disease Clinical Core
Recruiting
Efforts to find treatments for AD have yielded only modest benefits, likely because longstanding AD pathological processes induce irreversible neurological compromise. These processes begin years before the onset of clinical symptoms. This possibility has been incorporated into a model describing stages of AD development, articulated by the NIA/Alzheimer's Association preclinical workgroup of which the Co-Director of the Kulynych Alzheimer's Research Center, Dr. Suzanne Craft, was a member. Acco... Read More
Gender:
ALL
Ages:
55 years and above
Trial Updated:
07/25/2025
Locations: Wake Forest Baptist Health, Winston-Salem, North Carolina
Conditions: Alzheimer's Disease, Mild Cognitive Impairment, Prediabetic State
Brain Energy for Amyloid Transformation in Alzheimer's Disease Study
Recruiting
The Brain Energy for Amyloid Transformation in AD (Alzheimer's disease) or BEAT-AD study will compare the effects of a ketogenic low-carbohydrate diet and a low-fat diet in adults with mild cognitive impairment. The data collected will help determine whether diet interventions induce changes in cognitive function, cerebral blood flow, and levels of certain proteins and hormones in body fluids. The study will include volunteers who have mild cognitive impairment, who will be randomly assigned to... Read More
Gender:
ALL
Ages:
Between 55 years and 85 years
Trial Updated:
07/25/2025
Locations: Wake Forest Baptist Medical Center, Winston-Salem, North Carolina
Conditions: Alzheimer Disease, Mild Cognitive Impairment
The Caffeine, Postoperative Delirium, and Change in Outcomes After Surgery (CAPACHINOS-2) Study
Recruiting
The objective of this study is to test the effects of caffeine on neurocognitive and clinical recovery after major surgery. Specifically, this trial tests the primary hypothesis that caffeine will reduce the incidence of postoperative delirium.
Gender:
ALL
Ages:
70 years and above
Trial Updated:
07/22/2025
Locations: Michigan Medicine, Ann Arbor, Michigan
Conditions: Postoperative Delirium, Postoperative Cognitive Dysfunction, Mild Cognitive Impairment
Race-Based Stress and Cognitive Training for MCI
Recruiting
This a two phase project that aims to pilot a new adaptation (Phase 1) of Motivationally Enhanced Compensatory Cognitive Training for Mild Cognitive Impairment (ME-CCT; an originally VA-based cognitive rehabilitation manualized intervention for older adults with MCI, with a focus on the impact of stress on cognitive functioning; that integrates components from the Race Based Stress and Empowerment (RBSE) group for an increased focus on race-based stress and discrimination for racial minority old... Read More
Gender:
ALL
Ages:
65 years and above
Trial Updated:
07/21/2025
Locations: Rosalind Franklin University of Medicine and Science, Chicago, Illinois
Conditions: Mild Cognitive Impairment