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Carboplatin Treatment Options
A collection of 1685 research studies where Carboplatin is the interventional treatment. These studies are located in the United States . Carboplatin is used for conditions such as Non-Small Cell Lung Cancer, Ovarian Cancer and Lung Cancer.
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📋 5 providers ranked by true monthly cost
💵 Options starting as low as $149/month
🏥 Only licensed providers using FDA-registered pharmacies
⭐ Real Trustpilot scores included — including the ones with mixed reviews
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A Randomized, Double-blind, Placebo Controlled Phase III Study to Investigate Efficacy and Safety of First-Line Treatment With HLX10 + Chemotherapy (Carboplatin-Nanoparticle Albumin Bound (Nab) Paclitaxel) in Patients With Stage IIIB/IIIC or IV NSCLC
Active Not Recruiting
This study is a randomized, double-blind, multicenter, phase III clinical study to compare the clinical efficacy and safety of HLX10 + chemotherapy vs chemotherapy in subjects with locally advanced or metastatic squamous NSCLC who have not previously received systemic treatment.
Eligible subjects in this study will be randomized to Arm A or Arm B at 2:1 ratio as follows:
Arm A (HLX10 arm): HLX10 + chemotherapy (carboplatin nab paclitaxel) Arm B (placebo arm): Placebo + chemotherapy (carboplati... Read More
This study is a randomized, double-blind, multicenter, phase III clinical study to compare the clinical efficacy and safety of HLX10 + chemotherapy vs chemotherapy in subjects with locally advanced or metastatic squamous NSCLC who have not previously received systemic treatment.
Eligible subjects in this study will be randomized to Arm A or Arm B at 2:1 ratio as follows:
Arm A (HLX10 arm): HLX10 + chemotherapy (carboplatin nab paclitaxel) Arm B (placebo arm): Placebo + chemotherapy (carboplatin nab paclitaxel) The three stratification factors for randomization include: PD-L1 expression level (Tumor Proportion Scores \[TPS\]≥50%, 50%\>TPS≥1%, TPS\<1%), Asian population (yes or no), NSCLC stage (stage IIIB/IIIC or stage IV), and carboplatin AUC (5 or 6). Read Less
Gender:
ALL
Ages:
18 years and above
Trial Updated:
08/07/2023
Locations: Oncology and Hematology Associates of Southwest Virginia, Roanoke, Virginia +91 locations
Oncology and Hematology Associates of Southwest Virginia, Roanoke, Virginia
Anhui Medical University - The Second Hospital, Hefei, Anhui
Anhui Provincial Hospital, Hefei, Anhui
The First Affiliated Hospital Of Anhui Medical University, Hefei, Anhui
The Second Affiliated Hospital of Anhui Medical University, Hefei, Anhui
Beijing Chaoyang Hospital, Beijing, Beijing
Beijing Friendship Hospital, Beijing, Beijing
Peking University First Hospital, Beijing, Beijing
Daping Hospital, Chongqing, Chongqing
The Second Affiliated Hospital of Army Medical University,PLA, Chongqing, Chongqing
Fujian Medical University Union Hospital, Fuzhou, Fujian
Fujian Provincial Cancer Hospital, Fuzhou, Fujian
Fuzhou Pulmonary hospital of Fujian, Fuzhou, Fujian
Gansu Wuwei Tumour Hospital, Wuwei, Gansu
The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, Guangdong
The Fifth Affiliared Hospital Sun Yat-Sen University, Zhuhai, Guangdong
Liuzhou People's Hospital, Liuzhou, Guangxi
Liuzhou Worker's Hospital, Liuzhou, Guangxi
Guangxi Medical University Affiliated Tumor Hospital, Nanning, Guangxi
The People's Hospital of Guangxi Zhuang Autonomous Region, Nanning, Guangxi
The Second Affiliated Hospital of Hainan Medical University, Haikou, Hainan
Affiliated Hospital of Hebei University, Baoding, Hebei
Cangzhou People's Hospital, Cangzhou, Hebei
Tangshan People's Hospital, Tangshan, Hebei
Harbin Medical University - Tumor Hospital (The Third Affiliated Hospital), Ha'erbin, Heilongjiang
The fourth affiliated hospital of Harbin medical university, Ha'erbin, Heilongjiang
Jiamusi Cancer Hospital, Jiamusi, Heilongjiang
The Third Affiliated Hospital of Qiqihar Medical University, Qiqihar, Heilongjiang
The First Affiliated Hospital of Xinxiang Medical University, Xinxiang, Henan
Henan Cancer Hospital, Zhengzhou, Henan
Hubei Cancer Hospital, Wuhan, Hubei
Hunan Cancer Hospital, Changsha, Hunan
The Third Xiangya Hospital of Central South University, Changsha, Hunan
Xuzhou Central Hospital, Xuzhou, Jiangsu
the First Affiliated Hospital of Nanchang University, Nanchang, Jiangxi
China-japan union hospital of jilin university, Changchun, Jilin
Jilin Province Cancer Hospital, Changchun, Jilin
Jilin Province People's Hospital, Changchun, Jilin
The first hospital of Jilin University, Changchun, Jilin
The second Hospital of Jilin University, Changchun, Jilin
Chifeng Municipal Hospital, Chifeng, Neimenggu
General Hospital of Ningxia Medical University, Yinchuan, Ningxia
Shandong Cancer Hospital - Internal Medicine, Jinan, Shandong
Linyi City People Hospital, Linyi, Shandong
Shandong Linyi Tumor Hospital, Linyi, Shandong
Shanghai Eastern Hospital /Affliated Eastern Hospital of Ton, Shanghai, Shanghai
Shanghai Pulmonary Hospital, Shanghai, Shanghai
West China Hospital, Sichuan University, Chengdu, Sichuan
Tianjin Medical University Cancer Hospital, Tianjin, Tianjin
Tianjin Medical University General Hospital, Tianjin, Tianjin
Yunnan cancer hospital, Kunming, Yunnan
Sir Run Run Shaw Hospital, Zhejiang University, Hangzhou, Zhejiang
The First Affiliated Hospital of Zhejiang University, Hangzhou, Zhejiang
The Second Affiliated Hospital of Zhejiang University, Hangzhou, Zhejiang
High Technology Hospital MedCenter LTD, Batumi, Not set
JSC Evex Clinics, St.Nikolozi Medical Centre, Kutaisi, Not set
Acad.F.Todua Medical Center - Research Institute of Clinical Medicine LTD, Tbilisi, Not set
Institute of Clinical Oncology LTD, Tbilisi, Not set
LTD Israeli-Georgian Medical Research Clinic HELSICORE, Tbilisi, Not set
Multiprofile Clinic Consilium Medula LTD, Tbilisi, Not set
New Hospitals LTD, Tbilisi, Not set
Scientific Research Center of Oncology LTD, Tbilisi, Not set
Uniwersytecki Szpital Kliniczny w Białymstoku, Białystok, Not set
Wojew. Wielospecjalistyczne Centrum Onkologii i Traumatologi, Łódź, Not set
LLC "VitaMed ", Moscow, Not set
University Clinic of Headaches, Moscow, Not set
Budgetary Healthcare Institution of Omsk Region "C, Omsk, Not set
GBUZ Orenburg Regional Clinical Oncology Dispensar, Orenburg, Not set
First St. Petersburg State Medical University n. a. Pavlov, Saint Petersburg, Not set
Limited Liability Company "AV Medical Group", Saint Petersburg, Not set
LLC - Strategic Medical systems - Oncology - Oncology, Saint Petersburg, Not set
PMI "Evromedservice", Saint Petersburg, Not set
Volgograd Regional Clinical Oncology Dispensary, Volgograd, Not set
Ankara University Medical Faculty - Oncology, Ankara, Not set
Hacettepe University Medical Faculty - Medical Oncology, Ankara, Not set
Trakya University Medical Faculty, Edirne, Not set
Istanbul University Cerrahpasa Medical Faculty, Istanbul, Not set
Medipol Mega Hospital, Istanbul, Not set
Ege University Medical Faculty, İzmir, Not set
Izmir Medical Park Hospital - Medical Oncology, İzmir, Not set
Kocaeli University Research and Practice Hospital, Kocaeli, Not set
Necmettin Erbakan University Meram Medical Faculty, Konya, Not set
Inonu University Turgut Ozal Medical Center, Malatya, Not set
Komunalna ustanova "Chernivets, Chernivtsi, Not set
Komunalnyi zaklad Miska bahato, Dnipro, Not set
Komunalne nekomertsiine pidpry, Kharkiv, Not set
PE PMC "Acinus", Kirovohrad, Not set
Medychnyi tsentr "Mriya Med-Servis", Kryvyi Rih, Not set
Limited Liability Company "Medical Center "Verum", Kyiv, Not set
Komunalne pidpryiemstvo "Volynskyi oblasnyi medychnyi tsentr onkolohii" Volynskoyi oblasnoyi rady, Luts'k, Not set
Medychnyi tsentr "Onkolaif" LL, Zaporizhzhia, Not set
Zaporozhye Regional Clinical O, Zaporizhzhia, Not set
Conditions: Squamous Non Small Cell Lung Cancer
Vaccine Therapy, Paclitaxel, and Carboplatin in Treating Patients Who Are Undergoing Surgery for Stage III or Stage IV Ovarian Cancer, Primary Peritoneal Cancer, or Fallopian Tube Cancer
Terminated
RATIONALE: Vaccines made from peptides may help the body build an effective immune response to kill tumor cells. Drugs used in chemotherapy, such as paclitaxel and carboplatin, work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing. Giving chemotherapy before surgery may make the tumor smaller and reduce the amount of normal tissue that needs to be removed. Giving vaccine therapy and chemotherapy after surgery may kill any tumor ce... Read More
RATIONALE: Vaccines made from peptides may help the body build an effective immune response to kill tumor cells. Drugs used in chemotherapy, such as paclitaxel and carboplatin, work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing. Giving chemotherapy before surgery may make the tumor smaller and reduce the amount of normal tissue that needs to be removed. Giving vaccine therapy and chemotherapy after surgery may kill any tumor cells that remain after surgery.
PURPOSE: This phase II trial is studying how well giving vaccine therapy together with paclitaxel and carboplatin works in treating patients who are undergoing surgery for stage III or stage IV ovarian cancer, primary peritoneal cancer, or fallopian tube cancer. Read Less
Gender:
FEMALE
Ages:
Between 18 years and 120 years
Trial Updated:
08/25/2022
Locations: University of Virginia Cancer Center, Charlottesville, Virginia
University of Virginia Cancer Center, Charlottesville, Virginia
Carboplatin, Capecitabine, and Radiation Therapy in Treating Patients With Stage III or Stage IV Head and Neck Cancer
Completed
RATIONALE: Drugs used in chemotherapy, such as carboplatin and capecitabine, work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing. Radiation therapy uses high-energy x-rays to kill tumor cells. Giving chemotherapy together with radiation therapy may kill more tumor cells.
PURPOSE: This phase I trial is studying the side effects and best dose of capecitabine when given together with carboplatin followed by radiation therapy in tr... Read More
RATIONALE: Drugs used in chemotherapy, such as carboplatin and capecitabine, work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing. Radiation therapy uses high-energy x-rays to kill tumor cells. Giving chemotherapy together with radiation therapy may kill more tumor cells.
PURPOSE: This phase I trial is studying the side effects and best dose of capecitabine when given together with carboplatin followed by radiation therapy in treating patients with stage III or stage IV head and neck cancer. Read Less
Gender:
ALL
Ages:
18 years and above
Trial Updated:
11/25/2009
Locations: University of Virginia Cancer Center at UV Health System, Charlottesville, Virginia
University of Virginia Cancer Center at UV Health System, Charlottesville, Virginia
Conditions: Head and Neck Cancer
A Study of First-Line Olomorasib (LY3537982) and Pembrolizumab With or Without Chemotherapy in Patients With Advanced KRAS G12C-Mutant Non-small Cell Lung Cancer
Recruiting
The purpose of this study is to assess if adding LY3537982 (olomorasib) in combination with standard of care anti-cancer drugs is more effective than standard of care in participants with untreated advanced NSCLC. NSCLC must have a change in a gene called KRAS G12C. Study participation, including follow-up, could last up to 3 years, depending on how you and your lung cancer are doing.
The purpose of this study is to assess if adding LY3537982 (olomorasib) in combination with standard of care anti-cancer drugs is more effective than standard of care in participants with untreated advanced NSCLC. NSCLC must have a change in a gene called KRAS G12C. Study participation, including follow-up, could last up to 3 years, depending on how you and your lung cancer are doing. Read Less
Gender:
ALL
Ages:
18 years and above
Trial Updated:
08/22/2025
Locations: Clearview Cancer Institute, Huntsville, Alabama +427 locations
Clearview Cancer Institute, Huntsville, Alabama
Banner MD Anderson Cancer Center, Gilbert, Arizona
Banner University Medical Center Phoenix, Phoenix, Arizona
The University of Arizona Cancer Center - North Campus, Tucson, Arizona
Highlands Oncology Group, Springdale, Arkansas
Cedars-Sinai Medical Center, Los Angeles, California
Mercy Cancer Center, Merced, California
Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance, California
BASS Cancer Center, Walnut Creek, California
USO - Rocky Mountain Cancer Centers, Lone Tree, Colorado
Yale University School of Medicine, New Haven, Connecticut
Sibley Memorial Hospital, Washington, District of Columbia
Millennium Oncology Research Clinic, Hollywood, Florida
University of Florida - Jacksonville, Jacksonville, Florida
Miami Cancer Institute at Baptist Health, Inc., Miami, Florida
Ocala Oncology Center PL DBA Florida Cancer Affiliates - Ocala, Ocala, Florida
Comprehensive Hematology Oncology, Saint Petersburg, Florida
Tampa General Hospital, Tampa, Florida
University Cancer & Blood Center, LLC, Athens, Georgia
Emory University School of Medicine- Grady Campus, Atlanta, Georgia
Winship Cancer Institute, Emory University, Atlanta, Georgia
University of Illinois at Chicago, Chicago, Illinois
University of Chicago Hospital, Chicago, Illinois
Springfield Clinic Main Campus, Springfield, Illinois
Parkview Research Center at Parkview Regional Medical Center, Fort Wayne, Indiana
Indiana University Melvin and Bren Simon Cancer Center, Indianapolis, Indiana
Franciscan Health, Indianapolis, Indiana
Community Cancer Center North, Indianapolis, Indiana
The University of Kansas Cancer Center - Westwood, Westwood, Kansas
CHI Saint Joseph Cancer Center - East, Lexington, Kentucky
University of Kentucky Chandler Medical Center, Lexington, Kentucky
Mary Bird Perkins Cancer Center, Baton Rouge, Louisiana
USO - Maryland Oncology Hematology, Annapolis, Maryland
Johns Hopkins Bayview Medical Center, Baltimore, Maryland
Boston Medical Center, Boston, Massachusetts
Lahey Hospital & Medical Center, Burlington, Massachusetts
University of Michigan, Ann Arbor, Michigan
Karmanos Cancer Institute, Detroit, Michigan
The Cancer & Hematology Centers, Grand Rapids, Michigan
Allina Health Cancer Institute - Abbott Northwestern Hospital, Minneapolis, Minnesota
HealthPartners Cancer Research Center, Saint Paul, Minnesota
North Mississippi Hematology and Oncology Associates, Tupelo, Mississippi
Oncology Hematology Associates, Springfield, Missouri
Comprehensive Cancer Centers of Nevada, Las Vegas, Nevada
Dartmouth-Hitchcock Medical Center, Lebanon, New Hampshire
The Valley Hospital, Inc., Paramus, New Jersey
University of New Mexico Comprehensive Cancer Center, Albuquerque, New Mexico
Maimonides Cancer Center, Brooklyn, New York
Northwell Health/ RJ Zuckerberg Cancer Center, Lake Success, New York
Perlmutter Cancer Center at NYU Langone Hospital - Long Island, Mineola, New York
Laura and Isaac Perlmutter Cancer Center, New York, New York
Manhattan Eye, Ear and Throat Hospital, New York, New York
Memorial Sloan Kettering Cancer Center, New York, New York
Clinical Research Alliance, Westbury, New York
University of North Carolina Medical Center, Chapel Hill, North Carolina
Duke Cancer Institute, Durham, North Carolina
UNC REX Cancer Center, Raleigh, North Carolina
USO - Oncology Hematology Care, Cincinnati, Ohio
The James Cancer Hospital and Solove Research Institute at The Ohio State University Comprehensive Cancer -T, Columbus, Ohio
USO - Oncology Associates of Oregon, Eugene, Oregon
Asante Rogue Regional Medical Center, Medford, Oregon
Providence Portland Medical Center, Portland, Oregon
Providence St. Vincent Medical Center, Portland, Oregon
Kaiser Permanente Interstate Medical Office Central, Portland, Oregon
USO - Alliance Cancer Specialists, PC, Horsham, Pennsylvania
Thomas Jefferson University, Sidney Kimmel Cancer Center - Clinical Trials Office, Philadelphia, Pennsylvania
UPMC Hillman Cancer Center, Pittsburgh, Pennsylvania
Lifespan Cancer Institute, Providence, Rhode Island
Medical University of South Carolina, Charleston, South Carolina
Prisma Health Cancer Institute, Greenville, South Carolina
Lexington Medical Center, West Columbia, South Carolina
Tennessee Oncology Chattanooga, Chattanooga, Tennessee
University of Tennessee Medical Center, Knoxville, Tennessee
Baptist Memorial Hospital-Memphis, Memphis, Tennessee
Tennessee Oncology, Nashville, Tennessee
USO - US Oncology Research Network, Nashville, Tennessee
USO - Texas Oncology, Austin, Texas
William Beaumont Army Medical Center, Fort Bliss, Texas
Brooke Army Medical Center, Fort Sam Houston, Texas
Houston Methodist Hospital, Houston, Texas
University of Texas MD Anderson Cancer Center, Houston, Texas
USO - Texas Oncology, Webster, Texas
The University of Vermont Medical Center Inc., Burlington, Vermont
University of Virginia Health System, Charlottesville, Virginia
USO - Virginia Cancer Specialists, Fairfax, Virginia
VCU Health Adult Outpatient Pavillion, Richmond, Virginia
Kadlec Clinic Hematology and Oncology, Kennewick, Washington
Swedish Medical Center, Seattle, Washington
VA Puget Sound Health Care System, Seattle, Washington
USO - Northwest Cancer Specialists, Vancouver, Washington
SSM Health Dean Medical Group - South Madison Campus Health Research/Circuit Clinical, Madison, Wisconsin
Royal Adelaide Hospital, Adelaide, Not set
Icon Cancer Centre Wesley, Auchenflower, Not set
Ballarat Health Services, Ballarat Central, Not set
Sunshine Coast University Hospital, Birtinya, Not set
Gosford Hospital, Gosford, Not set
Mackay Base Hospital, Mackay, Not set
St Vincent's Hospital, Melbourne, Not set
Sir Charles Gairdner Hospital, Perth, Not set
Goulburn Valley Health, Shepparton, Not set
Gold Coast University Hospital, Southport, Not set
The Townsville Hospital, Townsville, Not set
Landeskrankenhaus Feldkirch, Feldkirch, Not set
Ordensklinikum Linz GmbH Elisabethinen, Linz, Not set
Klinik Floridsdorf, Wien, Not set
ZNA Middelheim, Antwerp, Not set
CHIREC - site delta, Auderghem, Not set
AZ Sint-Jan Brugge-Oostende AV, Brugge, Not set
UZ Gent, Gent, Not set
AZ Groeninge Campus Kennedylaan, Kortrijk, Not set
UZ Leuven, Leuven, Not set
AZ Sint-Maarten, Mechelen, Not set
Clinique Saint Pierre, Ottignies, Not set
AZ Glorieux Ronse, Ronse, Not set
Université Catholique de Louvain-Namur - Centre Hospitalier Universitaire Dinant-Godinne - Site Godinne, Yvoir, Not set
Fundação Pio XII - Hospital de Câncer de Barretos, Barretos, Not set
Oncocentro de Minas Gerais, Belo Horizonte, Not set
Hospital Tacchini, Bento Gonçalves, Not set
Hospital São Domingos, Bequimao, Not set
Sirio-Libanes Brasilia - Centro de Oncologia - Asa Sul, Brasilia, Not set
Hospital Universitário Evangélico Mackenzie, Curitiba, Not set
Centro de Pesquisa Clínica do Instituto do Câncer do Ceará, Fortaleza, Not set
ONCOSITE - Centro de Pesquisa Clinica em Oncologia, Ijui, Not set
Hospital Brasilia, Lago sul, Not set
Hospital de Cancer de Londrina, Londrina, Not set
Liga Norte Riograndense Contra o Câncer, Natal, Not set
Hospital São Lucas da PUCRS, Porto Alegre, Not set
Oncominas, Pouso Alegre, Not set
Instituto Nacional de Câncer José Alencar Gomes da Silva - INCA, Rio de Janeiro, Not set
Centro de Tratamento de Tumores Botafogo para Oncoclinicas Rio de Janeiro SA, Rio de Janeiro, Not set
Instituto D'Or Pesquisa e Ensino, Rio de Janeiro, Not set
Clinica Amo - Rio Vermelho, Salvador, Not set
Faculdade de Medicina do ABC, Santo André, Not set
Hospital Sírio Libanês, Sao Paulo, Not set
Hospital BP, Sao Paulo, Not set
Hospital Paulistano, Sao Paulo, Not set
Instituto D'Or de Pesquisa e Ensino (IDOR), Sao Paulo, Not set
Fundação Faculdade Regional de Medicina de São José do Rio Preto, São José do Rio Preto, Not set
COE Ensino e Pesquisa, São José dos Campos, Not set
Icesp - Instituto Do Câncer Do Estado de São Paulo, São Paulo, Not set
Hospital Santa Catarina - Paulista, São Paulo, Not set
Centro Paulista de Oncologia Clínica, São Paulo, Not set
Núcleo de Pesquisa Clínica da Rede São Camilo, São Paulo, Not set
Instituto de Assistência Médica ao Servidor Público Estadual - IAMSPE/HSPE-FMO Conhecer Centro de Oncolog -T, São Paulo, Not set
CEDOES, Vitória, Not set
BC Cancer Abbotsford, Abbotsford, Not set
CIUSSS- saguenay-Lac-Saint-Jean, Chicoutimi, Not set
BC Cancer Vancouver, Vancouver, Not set
Cancer Hospital Chinese Academy of Medical Science, Beijing, Not set
Beijing Cancer hospital, Beijing, Not set
Jilin Cancer Hospital, Changchun, Not set
Hunan Cancer Hospital, Changsha, Not set
Hunan Cancer Hospital, Changsha, Not set
The First People's Hospital of Changzhou, Changzhou, Not set
West China Hospital, Sichuan University, Cheng Du, Not set
The Third People's Hospital of Chengdu (CDTPH), Chengdu, Not set
Sichuan Cancer hospital, Chengdu, Not set
Fujian Cancer Hospital, Fuzhou, Not set
The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, Not set
Hainan General Hospital, Haikou, Not set
The First Affiliated Hospital, Zhejiang University, Hangzhou, Not set
Sir Run Run Shaw Hospital, Hangzhou, Not set
Zhejiang Cancer Hospital, Hangzhou, Not set
Harbin Medical University Cancer Hospital, Harbin, Not set
Jinan Central Hospital, Jinan, Not set
Shandong Cancer Hospital, Jinan, Not set
Taizhou Hospital of Zhejiang Province, Linhai, Not set
LinYi Cancer Hospital, Linyi, Not set
Liuzhou People's Hospital, Liuzhou, Not set
The First Affiliated Hospital of Nanchang University, Nanchang, Not set
Nanjing First Hospital, Nanjing, Not set
Nantong Tumor Hospital, Nantong, Not set
Hwa Mei Hospital University of Chinese Academy of Sciences, Ningbo, Not set
Shanghai Chest Hospital, Shanghai, Not set
Tianjin Medical University Cancer Institute & Hospital, Tianjin, Not set
The First Affiliated Hospital of Xinjiang Medical University, Urumchi, Not set
Xinjiang Medical University Cancer Hospital - Urumqi, Urumqi, Not set
Tongji Hospital Tongji Medical,Science & Technology, Wuhan, Not set
Wuhan Union Hospital, Wuhan, Not set
Renmin Hospital of Wuhan University, Wuhan, Not set
Wannan Medical College Yijishan Hospital, Wuhu, Not set
The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Not set
Xiangyang Central Hospital, Xiangyang, Not set
Yichang Central People's Hospital, Yichang, Not set
Affiliated Hospital of Guangdong Medical University, Zhanjiang, Not set
ZhuZhou Central Hospital, Zhuzhou, Not set
Nemocnice AGEL Ostrava - Vitkovice a.s., Ostrava, Not set
Fakultni nemocnice Bulovka, Prague, Not set
Roskilde University Hospital, Roskilde, Not set
Sainte Catherine Institut du Cancer Avignon Provence, Avignon, Not set
Hospices Civils de Lyon - Hopital Louis Pradel, Bron, Not set
CHU Lille - Institut Coeur Poumon, Lille Cedex, Not set
Centre Leon Berard, Lyon Cedex08, Not set
Centre Antoine-Lacassagne, Nice, Not set
Institut Curie, Paris, Not set
CHU Bordeaux Haut-Leveque, Pessac, Not set
Centre Hospitalier Universitaire de Poitiers, Poitiers, Not set
Institut Jean Godinot, Reims, Not set
Centre Hospitalier Universitaire de Rennes - Hôpital Pontchaillou, Rennes, Not set
Institut de Cancérologie de l'Ouest, Saint Herblain, Not set
Nouvel Hôpital Civil (NHC), Strasbourg, Not set
Hôpital Foch, Suresnes, Not set
Centre Hospitalier intercommunal de Toulon La Seyne sur Mer, Toulon, Not set
CHU de Toulouse - Hopital Larrey, Toulouse, Not set
Centre Hospitalier Régional Universitaire de Nancy - Hôpitaux de Brabois, Vandoeuvre lès Nancy, Not set
Hôpital Robert Schuman, Vantoux, Not set
Gustave Roussy, Villejuif, Not set
Evangelische Lungenklinik Berlin, Berlin, Not set
Charité Campus Virchow-Klinikum, Berlin, Not set
Helios Klinikum Emil von Behring Berlin-Zehlendorf, Berlin, Not set
Klinikum Chemnitz, Chemnitz, Not set
MV-Zentrum für Onkologie und Hämatologie, Cologne, Not set
Onkologiezentrum Donauwörth, Donauwörth, Not set
HELIOS Klinikum Erfurt, Erfurt, Not set
Universitaetsklinikum Freiburg, Freiburg, Not set
Asklepios Fachkliniken München-Gauting, Gauting, Not set
Franziskus-Hospital Harderberg, Georgsmarienhütte, Not set
LungenClinic Grosshansdorf, Grosshansdorf, Not set
Krankenhaus Martha-Maria Halle-Dölau, Halle, Not set
Hämato-Onkologie Hamburg, Prof. Laack und Partner, Hamburg, Not set
Asklepios Klinik Harburg, Hamburg, Not set
Thoraxklinik-Heidelberg gGmbH, Heidelberg, Not set
Universitätsklinikum Münster - Albert Schweitzer Campus, Münster, Not set
Klinikum Nürnberg Nord, Nürnberg, Not set
Universitaetsklinikum Tuebingen, Tübingen, Not set
Agios Savvas Regional Cancer Hospital, Athens, Not set
Errikos Dunant Hospital Center, Athens, Not set
Sotiria Thoracic Diseases Hospital of Athens, Athens, Not set
Attikon General University Hospital, Chaidari, Not set
University General Hospital of Heraklion, Heraklion, Not set
University Hospital of Patras, Patras, Not set
"Theagenio" Cancer Hospital of Thessaloniki, Thessaloniki, Not set
European Interbalkan Medical Center, Thessaloniki, Not set
G. Papanikolaou General Hospital, Thessaloniki, Not set
Országos Korányi Pulmonológiai Intézet, Budapest, Not set
Országos Onkológiai Intézet, Budapest, Not set
Budapesti Uzsoki Utcai Kórház, Budapest, Not set
Farkasgyepui Tudogyogyintezet, Farkasgyepu, Not set
Bacs-Kiskun Megyei Korhaz, Kecskemét, Not set
Hemato Oncology Clinic, Ahmedabad, Not set
KLES Dr. Prabhakar Kore Hospital & M.R.C, Belagavi, Not set
SRV Hospitals, Bengaluru, Not set
All India Institute of Medical Sciences, Bhubaneswar, Not set
Ashwin Hospital, Coimbatore, Not set
Nizam's Institute of Medical Sciences, Hyderabad, Not set
Krishna Institute of Medical Sciences - Karad, Karad, Not set
Kolhapur Cancer Centre Private Limited, Kolhapur, Not set
Tata Memorial Hospital, Mumbai, Not set
HCG Manavata Cancer Centre, Nashik, Not set
Jawaharlal Institute Of Postgraduate Medical Education And Research, Puducherry, Not set
Grant Medical Foundation - Ruby Hall Clinic, Pune, Not set
Sahyadri Super Speciality Hospital, Pune, Not set
Lifepoint Multispeciality Hospital, Pune, Not set
Regional Cancer Centre - Thiruvananthapuram, Thiruvananthapuram, Not set
Pacific Medical College & Hospital, Udaipur, Not set
Tata Memorial Centre - Homi Bhabha Cancer Hospital, Varanasi, Not set
Mahatma Gandhi Cancer Hospital and Research Institute, Visakhapatnam, Not set
Instituto Tumori Giovanni Paolo II, Bari, Not set
IRCCS Azienda Ospedaliero-Universitaria di Bologna, Policlinico di Sant'Orsola, Bologna, Not set
Policlinico "G. Rodolico", Catania, Not set
Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Not set
Istituto Nazionale Tumori IRCCS Fondazione Pascale, Napoli, Not set
Istituto Oncologico Veneto IRCCS, Padova, Not set
Fondazione Policlinico Universitario Agostino Gemelli, Roma, Not set
Istituto Nazionale Tumori Regina Elena, Rome, Not set
Ospedale di Circolo e Fondazione Macchi Varese, Varese, Not set
Azienda Ospedaliera Universitaria Integrata Verona - Ospedale Borgo Trento, Verona, Not set
National Hospital Organization Asahikawa Medical Center, Asahikawa, Not set
Tokyo Metropolitan Komagome Hospital, Bunkyo ku, Not set
Juntendo University Hospital, Bunkyo-ku, Not set
National Hospital Organization Kyushu Cancer Center, Fukuoka, Not set
Kyushu University Hospital, Fukuoka, Not set
Saitama Medical University International Medical Center, Hidaka, Not set
Himeji Medical Center, Himeji, Not set
Kansai Medical University Hospital, Hirakata, Not set
Kanazawa University Hospital, Kanazawa, Not set
Ibaraki Prefectural Central Hospital, Kasama, Not set
National Cancer Center Hospital East, Kashiwa, Not set
Kobe City Medical Center General Hospital, Kobe, Not set
Japanese Foundation for Cancer Research, Koto, Not set
University Hospital,Kyoto Prefectural University of Medicine, Kyoto, Not set
National Hospital Organization Shikoku Cancer Center, Matsuyama, Not set
Shizuoka Cancer Center, Nagaizumi-cho,Sunto-gun, Not set
Nagasaki University Hospital, Nagasaki, Not set
Aichi Cancer Center Hospital, Nagoya, Not set
Miyagi Cancer Center, Natori, Not set
Niigata Cancer Center Hospital, Niigata-shi, Not set
Okayama University Hospital, Okayama, Not set
Kindai University Hospital- Osakasayama Campus, Osakasayama, Not set
National Hospital Organization Kinki-chuo Chest Medical Center, Sakai, Not set
Hokkaido University Hospital, Sapporo, Not set
National Hospital Organization Yamaguchi Ube Medical Center, Ube, Not set
Tochigi Cancer Center, Utsunomiya, Not set
Wakayama Medical University Hospital, Wakayama, Not set
Kanagawa Cardiovascular and Respiratory Center, Yokohama, Not set
Kanagawa cancer center, Yokohama, Not set
Tottori University Hospital, Yonago, Not set
Chungbuk National University Hospital, Cheongju-si, Not set
Keimyung University Dongsan Hospital, Daegu, Not set
Kyungpook National University Chilgok Hospital, Deagu, Not set
Gangnam Severance Hospital, Yonsei University Health System, Gangnam-gu, Not set
National Cancer Center, Goyang-si, Not set
Chonnam National University Hwasun Hospital, Hwasun, Not set
Korea University Anam Hospital, Seoul, Not set
Severance Hospital, Yonsei University Health System, Seoul, Not set
Hanyang University Seoul Hospital, Seoul, Not set
Asan Medical Center, Seoul, Not set
Samsung Medical Center, Seoul, Not set
The Catholic University of Korea, Yeouido St. Mary's Hospital, Seoul, Not set
Korea University Guro Hospital, Seoul, Not set
The Catholic University Of Korea St. Vincent's Hospital, Suwon-si, Not set
Pusan National University Yangsan Hospital, Yangsan, Not set
Health Pharma Professional Research S.A. de C.V:, Ciudad de México, Not set
CIO - Centro de Inmuno-Oncología de Occidente, Guadalajara, Not set
PanAmerican Clinical Research - Guadalajara, Guadalajara, Not set
Actualidad Basada en la Investigación del Cáncer, Guadalajara, Not set
Renati Innovation, Guadalajara, Not set
Health Pharma Querétaro, Juriquilla, Not set
Preparaciones Oncológicas S.C., León, Not set
Centro Onco-Hematológico Roma (COHR), Mexico City, Not set
Higiea Oncologia, Mexico City, Not set
Hospital Universitario "Dr. Jose Eleuterio Gonzalez", Monterrey, Not set
Avix Investigación Clinica, S.C., Monterrey, Not set
Centro de Investigacion Clinica de Oaxaca, Oaxaca, Not set
Clinica Integral Internacional de Oncología, Puebla, Not set
Oncare - Unidad Valle, San Pedro Garza García, Not set
Arké SMO S.A de C.V, Veracruz, Not set
Jeroen Bosch Hospital, Den Bosch, Not set
Medisch Spectrum Twente, Enschede, Not set
Ziekenhuis St. Jansdal, Harderwijk, Not set
Tergooiziekenhuizen, locatie Hilversum, Hilversum, Not set
Medische Centrum Leeuwarden, Leeuwarden, Not set
Leids Universitair Medisch Centrum, Leiden, Not set
Erasmus Medisch Centrum, Rotterdam, Not set
ETZ Elisabeth, Tilburg, Not set
St. Antonius Ziekenhuis, locatie Utrecht, Utrecht, Not set
Haukeland Universitetssjukehus, Bergen, Not set
Drammen Sykehus, Vestre Viken HF, Drammen, Not set
Sykehuset Innlandet HF Gjøvik, Gjøvik, Not set
Akershus Universitetssykehus, Lørenskog, Not set
Oslo universitetssykehus, Radiumhospitalet, Oslo, Not set
Stavanger Universitetssykehus, Stavanger, Not set
St. Olavs Hospital, Trondheim, Not set
Swietokrzyskie Centrum Onkologii, Samodzielny Publiczny Zaklad Opieki Zdrowotnej, Kielce, Not set
One Day Med, Szczecin, Not set
MICS Centrum Medyczne Torun, Torun, Not set
Centro Hospitalar E Universitário De Coimbra, Coimbra, Not set
Hospital da Luz Lisboa, Lisboa, Not set
Champalimaud Foundation, Lisbon, Not set
Hospital Pulido Valente, Lisbon, Not set
Centro Hospitalar do Porto - Hospital de Santo António, Porto, Not set
Hospital CUF Porto, Porto, Not set
Instituto Português de Oncologia do Porto Francisco Gentil, EPE, Porto, Not set
Lotus-Med, Bucharest, Not set
SC Memorial Healthcare International SRL, Bucharest, Not set
Gral Medical Diagnostic Center, București, Not set
Institutul Oncologic, Cluj, Not set
Centrul de Oncologie "Sfântul Nectarie", Craiova, Not set
Ovidius Clinical Hospital OCH, Ovidiu, Not set
S C Oncocenter Oncologie Clinica S R L, Timișoara, Not set
Cabinet Medical Oncomed, Timișoara, Not set
CHUAC-Hospital Teresa Herrera, A Coruña, Not set
Hospital Infanta Cristina, Badajoz, Not set
OSI Ezkerraldea-Enkarterri-Cruces - Hospital Universitario Cruces, Barakaldo, Not set
Parc de Salut Mar - Hospital del Mar, Barcelona, Not set
Hospital Universitari Dexeus, Barcelona, Not set
Hospital Universitari Vall d'Hebron, Barcelona, Not set
Instituto Catalan de Oncologia - Hospital Duran i Reynals, Hospitalet, Not set
Hospital Jerez de la Frontera, Jerez de la Frontera, Not set
Hospital Insular de Gran Canaria, Las Palmas de Gran Canaria, Not set
Complejo Asistencial Universitario de León - Hospital de León, León, Not set
Hospital Universitario Ramón y Cajal, Madrid, Not set
Hospital Universitario 12 de Octubre, Madrid, Not set
H.R.U Málaga - Hospital General, Málaga, Not set
Hospital Universitari Son Espases, Palma, Not set
Complejo Hospitalario de Navarra, Pamplona, Not set
Hospital Universitario Quironsalud Madrid, Pozuelo de Alarcon, Not set
CHUS - Hospital Clinico Universitario, Santiago de Compostela, Not set
Hospital Universitario Virgen Del Rocio, Sevilla, Not set
Hospital Clinico de Valencia, Valencia, Not set
Hospital Clínico Universitario Lozano Blesa, Zaragoza, Not set
Mälarsjukhuset, Eskilstuna, Not set
Västmanlands Sjukhus Västerås, Västerås, Not set
CHUV (centre hospitalier universitaire vaudois), Lausanne, Not set
Kantonsspital Winterthur, Winterthur, Not set
UniversitätsSpital Zürich, Zürich, Not set
Changhua Christian Hospital, Changhua County, Not set
Buddhist Dalin Tzu Chi General Hospital, Chiayi, Not set
National Taiwan University Hospital Yun-Lin Branch Dou-Liou Region, Douliu City, Not set
Hualien Tzu Chi Medical Center, Hualien City, Not set
Chang Gung Memorial Hospital at Kaohsiung, Kaohsiung Niao Sung Dist, Not set
Kaohsiung Medical University Chung-Ho Memorial Hospital, Kaohsiung, Not set
New Taipei Municipal TuCheng Hospital, New Taipei City, Not set
Chung Shan Medical University Hospital, Taichung City, Not set
Taichung Veterans General Hospital, Taichung, Not set
Chi Mei Medical Center, Tainan City, Not set
Chi Mei Hospital - Liouying Branch, Tainan City, Not set
National Cheng Kung University Hospital, Tainan, Not set
National Taiwan University Cancer Center (NTUCC), Taipei City, Not set
National Taiwan University Hospital, Taipei, Not set
Taipei Veterans General Hospital, Taipei, Not set
Chang Gung Medical Foundation-Linkou Branch, Taoyuan, Not set
National Taiwan University Hospital - Hsinchu branch, Zhu Bei City, Not set
Adana Medical Park Seyhan Hastanesi, Adana, Not set
Adana City Hospital, Adana, Not set
Ankara Etlik City Hospital, Ankara, Not set
Abdurrahman Yurtaslan Ankara Oncology, education and Research Hospital, Ankara, Not set
Ankara Bilkent Şehir Hastanesi, Ankara, Not set
Akdeniz Universitesi Hastanesi, Antalya, Not set
Memorial Antalya Hospital, Antalya, Not set
Uludag Universitesi, Bursa, Not set
Dicle Üniversitesi, Diyarbakir, Not set
Bezmialem Vakf Üniversitesi, Istanbul, Not set
İ.A.Ü VM Medical Park Florya Hastanesi, Istanbul, Not set
TC Saglik Bakanligi Goztepe Prof. Dr. Suleyman Yalcin Sehir Hastanesi, Istanbul, Not set
Ege Universitesi Hastanesi, Izmir, Not set
zmir Katip Çelebi Üniversitesi Atatürk Eitim Ve Aratrma Hastanesi, Izmir, Not set
Kocaeli Üniversitesi, Kocaeli, Not set
Ondokuz Mayıs Universitesi, Samsun, Not set
Aberdeen Royal Infirmary, Aberdeen, Not set
Cheltenham General Hospital, Cheltenham, Not set
Ninewells Hospital and Medical School, Dundee, Not set
Huddersfield Royal Infirmary, Huddersfield, Not set
St James's University Hospital, Leeds, Not set
The Christie NHS Foundation Trust, Manchester, Not set
Mount Vernon Hospital, Northwood, Not set
Weston Park Hospital, Sheffield, Not set
New Cross Hospital, Wolverhampton, Not set
Conditions: Carcinoma, Non-Small-Cell Lung, Neoplasm Metastasis
A Study of the Drugs Selumetinib vs. Carboplatin and Vincristine in Patients With Low-Grade Glioma
Recruiting
This phase III trial compares the effect of selumetinib versus the standard of care treatment with carboplatin and vincristine (CV) in treating patients with newly diagnosed or previously untreated low-grade glioma (LGG) that does not have a genetic abnormality called BRAFV600E mutation and is not associated with systemic neurofibromatosis type 1. Selumetinib works by blocking some of the enzymes needed for cell growth and may kill tumor cells. Carboplatin and vincristine are chemotherapy drugs... Read More
This phase III trial compares the effect of selumetinib versus the standard of care treatment with carboplatin and vincristine (CV) in treating patients with newly diagnosed or previously untreated low-grade glioma (LGG) that does not have a genetic abnormality called BRAFV600E mutation and is not associated with systemic neurofibromatosis type 1. Selumetinib works by blocking some of the enzymes needed for cell growth and may kill tumor cells. Carboplatin and vincristine are chemotherapy drugs that work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing. The overall goal of this study is to see if selumetinib works just as well as the standard treatment of CV for patients with LGG. Another goal of this study is to compare the effects of selumetinib versus CV in subjects with LGG to find out which is better. Additionally, this trial will also examine if treatment with selumetinib improves the quality of life for subjects who take it. Read Less
Gender:
ALL
Ages:
Between 2 years and 21 years
Trial Updated:
08/22/2025
Locations: Children's Hospital of Alabama, Birmingham, Alabama +131 locations
Children's Hospital of Alabama, Birmingham, Alabama
Banner Children's at Desert, Mesa, Arizona
Phoenix Childrens Hospital, Phoenix, Arizona
Arkansas Children's Hospital, Little Rock, Arkansas
Loma Linda University Medical Center, Loma Linda, California
Miller Children's and Women's Hospital Long Beach, Long Beach, California
Children's Hospital Los Angeles, Los Angeles, California
Cedars Sinai Medical Center, Los Angeles, California
Mattel Children's Hospital UCLA, Los Angeles, California
Kaiser Permanente-Oakland, Oakland, California
Children's Hospital of Orange County, Orange, California
Lucile Packard Children's Hospital Stanford University, Palo Alto, California
Rady Children's Hospital - San Diego, San Diego, California
UCSF Medical Center-Mission Bay, San Francisco, California
Children's Hospital Colorado, Aurora, Colorado
Connecticut Children's Medical Center, Hartford, Connecticut
Yale University, New Haven, Connecticut
Alfred I duPont Hospital for Children, Wilmington, Delaware
Children's National Medical Center, Washington, District of Columbia
Golisano Children's Hospital of Southwest Florida, Fort Myers, Florida
University of Florida Health Science Center - Gainesville, Gainesville, Florida
Memorial Regional Hospital/Joe DiMaggio Children's Hospital, Hollywood, Florida
Nemours Children's Clinic-Jacksonville, Jacksonville, Florida
University of Miami Miller School of Medicine-Sylvester Cancer Center, Miami, Florida
Nicklaus Children's Hospital, Miami, Florida
AdventHealth Orlando, Orlando, Florida
Arnold Palmer Hospital for Children, Orlando, Florida
Nemours Children's Hospital, Orlando, Florida
Nemours Children's Clinic - Pensacola, Pensacola, Florida
Sacred Heart Hospital, Pensacola, Florida
Johns Hopkins All Children's Hospital, Saint Petersburg, Florida
Saint Joseph's Hospital/Children's Hospital-Tampa, Tampa, Florida
Children's Healthcare of Atlanta - Arthur M Blank Hospital, Atlanta, Georgia
Kapiolani Medical Center for Women and Children, Honolulu, Hawaii
Saint Luke's Cancer Institute - Boise, Boise, Idaho
Lurie Children's Hospital-Chicago, Chicago, Illinois
University of Illinois, Chicago, Illinois
University of Chicago Comprehensive Cancer Center, Chicago, Illinois
Saint Jude Midwest Affiliate, Peoria, Illinois
Southern Illinois University School of Medicine, Springfield, Illinois
Riley Hospital for Children, Indianapolis, Indiana
Ascension Saint Vincent Indianapolis Hospital, Indianapolis, Indiana
Blank Children's Hospital, Des Moines, Iowa
University of Iowa/Holden Comprehensive Cancer Center, Iowa City, Iowa
University of Kentucky/Markey Cancer Center, Lexington, Kentucky
Norton Children's Hospital, Louisville, Kentucky
Children's Hospital New Orleans, New Orleans, Louisiana
Eastern Maine Medical Center, Bangor, Maine
Maine Children's Cancer Program, Scarborough, Maine
Johns Hopkins University/Sidney Kimmel Cancer Center, Baltimore, Maryland
Walter Reed National Military Medical Center, Bethesda, Maryland
Massachusetts General Hospital Cancer Center, Boston, Massachusetts
Dana-Farber Cancer Institute, Boston, Massachusetts
C S Mott Children's Hospital, Ann Arbor, Michigan
Children's Hospital of Michigan, Detroit, Michigan
Corewell Health Grand Rapids Hospitals - Helen DeVos Children's Hospital, Grand Rapids, Michigan
Corewell Health Children's, Royal Oak, Michigan
Children's Hospitals and Clinics of Minnesota - Minneapolis, Minneapolis, Minnesota
University of Minnesota/Masonic Cancer Center, Minneapolis, Minnesota
Mayo Clinic in Rochester, Rochester, Minnesota
University of Mississippi Medical Center, Jackson, Mississippi
Children's Mercy Hospitals and Clinics, Kansas City, Missouri
Cardinal Glennon Children's Medical Center, Saint Louis, Missouri
Washington University School of Medicine, Saint Louis, Missouri
Children's Hospital and Medical Center of Omaha, Omaha, Nebraska
University of Nebraska Medical Center, Omaha, Nebraska
Morristown Medical Center, Morristown, New Jersey
Albany Medical Center, Albany, New York
Roswell Park Cancer Institute, Buffalo, New York
NYU Langone Hospital - Long Island, Mineola, New York
The Steven and Alexandra Cohen Children's Medical Center of New York, New Hyde Park, New York
Laura and Isaac Perlmutter Cancer Center at NYU Langone, New York, New York
Memorial Sloan Kettering Cancer Center, New York, New York
University of Rochester, Rochester, New York
State University of New York Upstate Medical University, Syracuse, New York
New York Medical College, Valhalla, New York
UNC Lineberger Comprehensive Cancer Center, Chapel Hill, North Carolina
Carolinas Medical Center/Levine Cancer Institute, Charlotte, North Carolina
Duke University Medical Center, Durham, North Carolina
East Carolina University, Greenville, North Carolina
Wake Forest University Health Sciences, Winston-Salem, North Carolina
Sanford Broadway Medical Center, Fargo, North Dakota
Children's Hospital Medical Center of Akron, Akron, Ohio
Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio
Rainbow Babies and Childrens Hospital, Cleveland, Ohio
Nationwide Children's Hospital, Columbus, Ohio
Dayton Children's Hospital, Dayton, Ohio
University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma
Oregon Health and Science University, Portland, Oregon
Geisinger Medical Center, Danville, Pennsylvania
Penn State Children's Hospital, Hershey, Pennsylvania
Children's Hospital of Philadelphia, Philadelphia, Pennsylvania
Saint Christopher's Hospital for Children, Philadelphia, Pennsylvania
Children's Hospital of Pittsburgh of UPMC, Pittsburgh, Pennsylvania
Rhode Island Hospital, Providence, Rhode Island
Medical University of South Carolina, Charleston, South Carolina
Prisma Health Richland Hospital, Columbia, South Carolina
BI-LO Charities Children's Cancer Center, Greenville, South Carolina
East Tennessee Childrens Hospital, Knoxville, Tennessee
Saint Jude Children's Research Hospital, Memphis, Tennessee
Vanderbilt University/Ingram Cancer Center, Nashville, Tennessee
Dell Children's Medical Center of Central Texas, Austin, Texas
UT Southwestern/Simmons Cancer Center-Dallas, Dallas, Texas
El Paso Children's Hospital, El Paso, Texas
Cook Children's Medical Center, Fort Worth, Texas
Baylor College of Medicine/Dan L Duncan Comprehensive Cancer Center, Houston, Texas
M D Anderson Cancer Center, Houston, Texas
Covenant Children's Hospital, Lubbock, Texas
UMC Cancer Center / UMC Health System, Lubbock, Texas
Children's Hospital of San Antonio, San Antonio, Texas
Methodist Children's Hospital of South Texas, San Antonio, Texas
University of Texas Health Science Center at San Antonio, San Antonio, Texas
Primary Children's Hospital, Salt Lake City, Utah
University of Vermont and State Agricultural College, Burlington, Vermont
Children's Hospital of The King's Daughters, Norfolk, Virginia
VCU Massey Comprehensive Cancer Center, Richmond, Virginia
Carilion Children's, Roanoke, Virginia
Seattle Children's Hospital, Seattle, Washington
Providence Sacred Heart Medical Center and Children's Hospital, Spokane, Washington
Mary Bridge Children's Hospital and Health Center, Tacoma, Washington
Madigan Army Medical Center, Tacoma, Washington
West Virginia University Healthcare, Morgantown, West Virginia
University of Wisconsin Carbone Cancer Center - University Hospital, Madison, Wisconsin
Children's Hospital of Wisconsin, Milwaukee, Wisconsin
British Columbia Children's Hospital, Vancouver, British Columbia
Janeway Child Health Centre, Saint John's, Newfoundland and Labrador
IWK Health Centre, Halifax, Nova Scotia
The Montreal Children's Hospital of the MUHC, Montreal, Quebec
Centre Hospitalier Universitaire Sainte-Justine, Montreal, Quebec
Centre Hospitalier Universitaire de Sherbrooke-Fleurimont, Sherbrooke, Quebec
CHU de Quebec-Centre Hospitalier de l'Universite Laval (CHUL), Quebec, Not set
HIMA San Pablo Oncologic Hospital, Caguas, Not set
Conditions: Low Grade Glioma, Low Grade Astrocytoma, Metastatic Low Grade Astrocytoma, Metastatic Low Grade Glioma
Chemotherapy Combined With Immunotherapy Versus Immunotherapy Alone for Older Adults With Stage IIIB-IV Lung Cancer, The ACHIEVE Trial
Recruiting
This phase III trial compares the effect of adding chemotherapy to immunotherapy (pembrolizumab) versus immunotherapy alone in treating patients with stage IIIB-IV lung cancer. Immunotherapy with monoclonal antibodies, such as pembrolizumab, may help the body's immune system attack the cancer, and may interfere with the ability of tumor cells to grow and spread. Chemotherapy drugs work in different ways to stop the growth of tumor cells, either by killing the cells, by stopping them from dividin... Read More
This phase III trial compares the effect of adding chemotherapy to immunotherapy (pembrolizumab) versus immunotherapy alone in treating patients with stage IIIB-IV lung cancer. Immunotherapy with monoclonal antibodies, such as pembrolizumab, may help the body's immune system attack the cancer, and may interfere with the ability of tumor cells to grow and spread. Chemotherapy drugs work in different ways to stop the growth of tumor cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading. Giving pembrolizumab and chemotherapy may help stabilize lung cancer. Read Less
Gender:
ALL
Ages:
70 years and above
Trial Updated:
08/22/2025
Locations: Highlands Oncology Group - Fayetteville, Fayetteville, Arkansas +295 locations
Highlands Oncology Group - Fayetteville, Fayetteville, Arkansas
Mercy Hospital Fort Smith, Fort Smith, Arkansas
Highlands Oncology Group - Rogers, Rogers, Arkansas
Highlands Oncology Group, Springdale, Arkansas
Kaiser Permanente Dublin, Dublin, California
Kaiser Permanente-Fremont, Fremont, California
Kaiser Permanente-Fresno, Fresno, California
Kaiser Permanente-Modesto, Modesto, California
Kaiser Permanente-Oakland, Oakland, California
VA Palo Alto Health Care System, Palo Alto, California
Kaiser Permanente-Roseville, Roseville, California
Kaiser Permanente Downtown Commons, Sacramento, California
Kaiser Permanente-South Sacramento, Sacramento, California
Kaiser Permanente-San Francisco, San Francisco, California
Kaiser Permanente-Santa Teresa-San Jose, San Jose, California
Kaiser Permanente San Leandro, San Leandro, California
Kaiser San Rafael-Gallinas, San Rafael, California
Kaiser Permanente Medical Center - Santa Clara, Santa Clara, California
Kaiser Permanente-Santa Rosa, Santa Rosa, California
Kaiser Permanente-South San Francisco, South San Francisco, California
Kaiser Permanente-Vallejo, Vallejo, California
Kaiser Permanente-Walnut Creek, Walnut Creek, California
Stamford Hospital/Bennett Cancer Center, Stamford, Connecticut
UM Sylvester Comprehensive Cancer Center at Aventura, Aventura, Florida
UM Sylvester Comprehensive Cancer Center at Coral Gables, Coral Gables, Florida
UM Sylvester Comprehensive Cancer Center at Deerfield Beach, Deerfield Beach, Florida
Holy Cross Hospital, Fort Lauderdale, Florida
Malcom Randall Veterans Administration Medical Center, Gainesville, Florida
University of Miami Miller School of Medicine-Sylvester Cancer Center, Miami, Florida
UM Sylvester Comprehensive Cancer Center at Kendall, Miami, Florida
Sacred Heart Hospital, Pensacola, Florida
UM Sylvester Comprehensive Cancer Center at Plantation, Plantation, Florida
Moffitt Cancer Center-International Plaza, Tampa, Florida
Moffitt Cancer Center - McKinley Campus, Tampa, Florida
Moffitt Cancer Center, Tampa, Florida
Moffitt Cancer Center at Wesley Chapel, Wesley Chapel, Florida
CTCA at Southeastern Regional Medical Center, Newnan, Georgia
Kaiser Permanente Moanalua Medical Center, Honolulu, Hawaii
Saint Alphonsus Cancer Care Center-Boise, Boise, Idaho
Saint Alphonsus Cancer Care Center-Caldwell, Caldwell, Idaho
Kootenai Health - Coeur d'Alene, Coeur d'Alene, Idaho
Saint Alphonsus Cancer Care Center-Nampa, Nampa, Idaho
Kootenai Clinic Cancer Services - Post Falls, Post Falls, Idaho
Kootenai Clinic Cancer Services - Sandpoint, Sandpoint, Idaho
Rush-Copley Medical Center, Aurora, Illinois
Advocate Good Shepherd Hospital, Barrington, Illinois
University of Illinois, Chicago, Illinois
Advocate Illinois Masonic Medical Center, Chicago, Illinois
AMG Crystal Lake - Oncology, Crystal Lake, Illinois
Carle at The Riverfront, Danville, Illinois
Cancer Care Specialists of Illinois - Decatur, Decatur, Illinois
Decatur Memorial Hospital, Decatur, Illinois
Advocate Good Samaritan Hospital, Downers Grove, Illinois
Carle Physician Group-Effingham, Effingham, Illinois
Crossroads Cancer Center, Effingham, Illinois
Advocate Sherman Hospital, Elgin, Illinois
Advocate South Suburban Hospital, Hazel Crest, Illinois
AMG Libertyville - Oncology, Libertyville, Illinois
Condell Memorial Hospital, Libertyville, Illinois
Carle Physician Group-Mattoon/Charleston, Mattoon, Illinois
Loyola University Medical Center, Maywood, Illinois
SSM Health Good Samaritan, Mount Vernon, Illinois
Cancer Care Center of O'Fallon, O'Fallon, Illinois
Advocate Christ Medical Center, Oak Lawn, Illinois
Advocate Lutheran General Hospital, Park Ridge, Illinois
UW Health Carbone Cancer Center Rockford, Rockford, Illinois
Memorial Hospital East, Shiloh, Illinois
Southern Illinois University School of Medicine, Springfield, Illinois
Springfield Clinic, Springfield, Illinois
Springfield Memorial Hospital, Springfield, Illinois
Carle Cancer Center, Urbana, Illinois
Northwest Cancer Center - Main Campus, Crown Point, Indiana
Northwest Oncology LLC, Dyer, Indiana
Northwest Cancer Center - Hobart, Hobart, Indiana
Saint Mary Medical Center, Hobart, Indiana
Saint Catherine Hospital, Indianapolis, Indiana
The Community Hospital, Munster, Indiana
Women's Diagnostic Center - Munster, Munster, Indiana
Northwest Cancer Center - Valparaiso, Valparaiso, Indiana
UI Health Care Mission Cancer and Blood - Ankeny Clinic, Ankeny, Iowa
Mercy Hospital, Cedar Rapids, Iowa
Oncology Associates at Mercy Medical Center, Cedar Rapids, Iowa
Mercy Cancer Center-West Lakes, Clive, Iowa
UI Health Care Mission Cancer and Blood - West Des Moines Clinic, Clive, Iowa
UI Health Care Mission Cancer and Blood - Des Moines Clinic, Des Moines, Iowa
Mercy Medical Center - Des Moines, Des Moines, Iowa
UI Health Care Mission Cancer and Blood - Laurel Clinic, Des Moines, Iowa
UI Health Care Mission Cancer and Blood - Waukee Clinic, Waukee, Iowa
University of Kansas Clinical Research Center, Fairway, Kansas
HaysMed, Hays, Kansas
University of Kansas Cancer Center, Kansas City, Kansas
Lawrence Memorial Hospital, Lawrence, Kansas
The University of Kansas Cancer Center - Olathe, Olathe, Kansas
University of Kansas Cancer Center-Overland Park, Overland Park, Kansas
University of Kansas Hospital-Indian Creek Campus, Overland Park, Kansas
Salina Regional Health Center, Salina, Kansas
University of Kansas Health System Saint Francis Campus, Topeka, Kansas
University of Kansas Hospital-Westwood Cancer Center, Westwood, Kansas
University of Kentucky/Markey Cancer Center, Lexington, Kentucky
The James Graham Brown Cancer Center at University of Louisville, Louisville, Kentucky
UofL Health Medical Center Northeast, Louisville, Kentucky
Lafayette Family Cancer Center-EMMC, Brewer, Maine
University of Maryland/Greenebaum Cancer Center, Baltimore, Maryland
Sinai Hospital of Baltimore, Baltimore, Maryland
William E Kahlert Regional Cancer Center/Sinai Hospital, Westminster, Maryland
Tufts Medical Center, Boston, Massachusetts
Dana-Farber Cancer Institute at Boston Medical Center - Brighton, Brighton, Massachusetts
Dana-Farber Cancer Institute at Foxborough, Foxboro, Massachusetts
Dana Farber-Merrimack Valley, Methuen, Massachusetts
Dana-Farber/Brigham and Women's Cancer Center at Milford Regional, Milford, Massachusetts
Dana-Farber/Brigham and Women's Cancer Center at South Shore, South Weymouth, Massachusetts
UMass Memorial Medical Center - University Campus, Worcester, Massachusetts
Bronson Battle Creek, Battle Creek, Michigan
Trinity Health IHA Medical Group Hematology Oncology - Brighton, Brighton, Michigan
Trinity Health IHA Medical Group Hematology Oncology - Canton, Canton, Michigan
Trinity Health IHA Medical Group Hematology Oncology - Chelsea Hospital, Chelsea, Michigan
Cancer Hematology Centers - Flint, Flint, Michigan
Genesee Hematology Oncology PC, Flint, Michigan
Genesys Hurley Cancer Institute, Flint, Michigan
Hurley Medical Center, Flint, Michigan
Corewell Health Grand Rapids Hospitals - Butterworth Hospital, Grand Rapids, Michigan
Trinity Health Grand Rapids Hospital, Grand Rapids, Michigan
Bronson Methodist Hospital, Kalamazoo, Michigan
West Michigan Cancer Center, Kalamazoo, Michigan
University of Michigan Health - Sparrow Lansing, Lansing, Michigan
Trinity Health Saint Mary Mercy Livonia Hospital, Livonia, Michigan
Trinity Health Muskegon Hospital, Muskegon, Michigan
Corewell Health Lakeland Hospitals - Niles Hospital, Niles, Michigan
Cancer and Hematology Centers of Western Michigan - Norton Shores, Norton Shores, Michigan
Michigan Healthcare Professionals Pontiac, Pontiac, Michigan
Trinity Health Saint Joseph Mercy Oakland Hospital, Pontiac, Michigan
Corewell Health Reed City Hospital, Reed City, Michigan
MyMichigan Medical Center Saginaw, Saginaw, Michigan
Oncology Hematology Associates of Saginaw Valley PC, Saginaw, Michigan
Corewell Health Lakeland Hospitals - Marie Yeager Cancer Center, Saint Joseph, Michigan
Corewell Health Lakeland Hospitals - Saint Joseph Hospital, Saint Joseph, Michigan
MyMichigan Medical Center Tawas, Tawas City, Michigan
Munson Medical Center, Traverse City, Michigan
Saint Mary's Oncology/Hematology Associates of West Branch, West Branch, Michigan
University of Michigan Health - West, Wyoming, Michigan
Trinity Health IHA Medical Group Hematology Oncology Ann Arbor Campus, Ypsilanti, Michigan
Sanford Joe Lueken Cancer Center, Bemidji, Minnesota
Minnesota Oncology - Burnsville, Burnsville, Minnesota
Mercy Hospital, Coon Rapids, Minnesota
Essentia Health - Deer River Clinic, Deer River, Minnesota
Essentia Health Cancer Center, Duluth, Minnesota
Fairview Southdale Hospital, Edina, Minnesota
Essentia Health Hibbing Clinic, Hibbing, Minnesota
Mayo Clinic Health Systems-Mankato, Mankato, Minnesota
Abbott-Northwestern Hospital, Minneapolis, Minnesota
Park Nicollet Clinic - Saint Louis Park, Saint Louis Park, Minnesota
Regions Hospital, Saint Paul, Minnesota
United Hospital, Saint Paul, Minnesota
Essentia Health Sandstone, Sandstone, Minnesota
Saint Francis Regional Medical Center, Shakopee, Minnesota
Essentia Health Virginia Clinic, Virginia, Minnesota
Saint Francis Medical Center, Cape Girardeau, Missouri
Siteman Cancer Center at West County Hospital, Creve Coeur, Missouri
University Health Truman Medical Center, Kansas City, Missouri
Kansas City Veterans Affairs Medical Center, Kansas City, Missouri
University of Kansas Cancer Center - North, Kansas City, Missouri
University of Kansas Cancer Center - Lee's Summit, Lee's Summit, Missouri
Lake Regional Hospital, Osage Beach, Missouri
Washington University School of Medicine, Saint Louis, Missouri
Mercy Hospital South, Saint Louis, Missouri
Siteman Cancer Center-South County, Saint Louis, Missouri
Siteman Cancer Center at Christian Hospital, Saint Louis, Missouri
Siteman Cancer Center at Saint Peters Hospital, Saint Peters, Missouri
Community Hospital of Anaconda, Anaconda, Montana
Billings Clinic Cancer Center, Billings, Montana
Bozeman Health Deaconess Hospital, Bozeman, Montana
Benefis Sletten Cancer Institute, Great Falls, Montana
Logan Health Medical Center, Kalispell, Montana
Community Medical Center, Missoula, Montana
Dartmouth Hitchcock Medical Center/Dartmouth Cancer Center, Lebanon, New Hampshire
The Dana-Farber Cancer Institute at Londonderry, Londonderry, New Hampshire
Jefferson Cherry Hill Hospital, Cherry Hill, New Jersey
Inspira Medical Center Mullica Hill, Mullica Hill, New Jersey
Penn Medicine Princeton Health, Plainsboro, New Jersey
Sidney Kimmel Cancer Center Washington Township, Sewell, New Jersey
Montefiore Medical Center-Einstein Campus, Bronx, New York
Montefiore Medical Center - Moses Campus, Bronx, New York
Glens Falls Hospital, Glens Falls, New York
Upstate Cancer Center at Oswego, Oswego, New York
University of Rochester, Rochester, New York
Stony Brook University Medical Center, Stony Brook, New York
State University of New York Upstate Medical University, Syracuse, New York
SUNY Upstate Medical Center-Community Campus, Syracuse, New York
Upstate Cancer Center at Verona, Verona, New York
Wilmot Cancer Institute at Webster, Webster, New York
Durham VA Medical Center, Durham, North Carolina
Sanford Bismarck Medical Center, Bismarck, North Dakota
Sanford Broadway Medical Center, Fargo, North Dakota
Sanford Roger Maris Cancer Center, Fargo, North Dakota
UH Seidman Cancer Center at UH Avon Health Center, Avon, Ohio
UHHS-Chagrin Highlands Medical Center, Beachwood, Ohio
Strecker Cancer Center-Belpre, Belpre, Ohio
Aultman Health Foundation, Canton, Ohio
Miami Valley Hospital South, Centerville, Ohio
Adena Regional Medical Center, Chillicothe, Ohio
Case Western Reserve University, Cleveland, Ohio
MetroHealth Medical Center, Cleveland, Ohio
Ohio State University Comprehensive Cancer Center, Columbus, Ohio
The Mark H Zangmeister Center, Columbus, Ohio
Miami Valley Hospital, Dayton, Ohio
Premier Blood and Cancer Center, Dayton, Ohio
Miami Valley Hospital North, Dayton, Ohio
Atrium Medical Center-Middletown Regional Hospital, Franklin, Ohio
Miami Valley Cancer Care and Infusion, Greenville, Ohio
Mount Carmel Grove City Hospital, Grove City, Ohio
Memorial Hospital, Marysville, Ohio
UH Seidman Cancer Center at Lake Health Mentor Campus, Mentor, Ohio
Knox Community Hospital, Mount Vernon, Ohio
Licking Memorial Hospital, Newark, Ohio
Mercy Health - Perrysburg Hospital, Perrysburg, Ohio
Springfield Regional Cancer Center, Springfield, Ohio
Mercy Health - Saint Anne Hospital, Toledo, Ohio
Upper Valley Medical Center, Troy, Ohio
Genesis Healthcare System Cancer Care Center, Zanesville, Ohio
Mercy Hospital Oklahoma City, Oklahoma City, Oklahoma
Saint Alphonsus Cancer Care Center-Ontario, Ontario, Oregon
Bryn Mawr Hospital, Bryn Mawr, Pennsylvania
Lancaster General Ann B Barshinger Cancer Institute, Lancaster, Pennsylvania
Riddle Memorial Hospital, Media, Pennsylvania
Paoli Memorial Hospital, Paoli, Pennsylvania
ECOG-ACRIN Cancer Research Group, Philadelphia, Pennsylvania
Thomas Jefferson University Hospital, Philadelphia, Pennsylvania
Jefferson Torresdale Hospital, Philadelphia, Pennsylvania
Reading Hospital McGlinn Cancer Institute at Phoenixville, Phoenixville, Pennsylvania
Guthrie Medical Group PC-Robert Packer Hospital, Sayre, Pennsylvania
Reading Hospital, West Reading, Pennsylvania
Asplundh Cancer Pavilion, Willow Grove, Pennsylvania
Lankenau Medical Center, Wynnewood, Pennsylvania
Ralph H Johnson VA Medical Center, Charleston, South Carolina
Medical University of South Carolina, Charleston, South Carolina
Rapid City Regional Hospital, Rapid City, South Dakota
Sanford Cancer Center Oncology Clinic, Sioux Falls, South Dakota
Sanford USD Medical Center - Sioux Falls, Sioux Falls, South Dakota
Parkland Memorial Hospital, Dallas, Texas
UT Southwestern Simmons Cancer Center - RedBird, Dallas, Texas
UT Southwestern/Simmons Cancer Center-Dallas, Dallas, Texas
UT Southwestern/Simmons Cancer Center-Fort Worth, Fort Worth, Texas
UT Southwestern Clinical Center at Richardson/Plano, Richardson, Texas
Dartmouth Cancer Center - North, Saint Johnsbury, Vermont
White River Junction Veteran Administration Medical Center, White River Junction, Vermont
University of Virginia Cancer Center, Charlottesville, Virginia
VCU Massey Cancer Center at Stony Point, Richmond, Virginia
VCU Massey Comprehensive Cancer Center, Richmond, Virginia
Swedish Cancer Institute-Edmonds, Edmonds, Washington
Swedish Cancer Institute-Issaquah, Issaquah, Washington
Swedish Medical Center-First Hill, Seattle, Washington
Edwards Comprehensive Cancer Center, Huntington, West Virginia
Langlade Hospital and Cancer Center, Antigo, Wisconsin
ThedaCare Regional Cancer Center, Appleton, Wisconsin
Duluth Clinic Ashland, Ashland, Wisconsin
ThedaCare Cancer Care - Berlin, Berlin, Wisconsin
Aurora Cancer Care-Southern Lakes VLCC, Burlington, Wisconsin
Aurora Saint Luke's South Shore, Cudahy, Wisconsin
Marshfield Medical Center-EC Cancer Center, Eau Claire, Wisconsin
Mayo Clinic Health System-Eau Claire Clinic, Eau Claire, Wisconsin
Aurora Health Care Germantown Health Center, Germantown, Wisconsin
Aurora Cancer Care-Grafton, Grafton, Wisconsin
Aurora BayCare Medical Center, Green Bay, Wisconsin
Mercyhealth Hospital and Cancer Center - Janesville, Janesville, Wisconsin
Aurora Cancer Care-Kenosha South, Kenosha, Wisconsin
Gundersen Lutheran Medical Center, La Crosse, Wisconsin
Aurora Bay Area Medical Group-Marinette, Marinette, Wisconsin
Marshfield Medical Center-Marshfield, Marshfield, Wisconsin
Aspirus Medford Hospital, Medford, Wisconsin
Aurora Cancer Care-Milwaukee, Milwaukee, Wisconsin
Aurora Saint Luke's Medical Center, Milwaukee, Wisconsin
Aurora Sinai Medical Center, Milwaukee, Wisconsin
Marshfield Medical Center - Minocqua, Minocqua, Wisconsin
ProHealth D N Greenwald Center, Mukwonago, Wisconsin
ThedaCare Regional Medical Center - Neenah, Neenah, Wisconsin
ThedaCare Cancer Care - New London, New London, Wisconsin
ProHealth Oconomowoc Memorial Hospital, Oconomowoc, Wisconsin
ThedaCare Cancer Care - Oshkosh, Oshkosh, Wisconsin
Vince Lombardi Cancer Clinic - Oshkosh, Oshkosh, Wisconsin
Aurora Cancer Care-Racine, Racine, Wisconsin
Aspirus Cancer Care - James Beck Cancer Center, Rhinelander, Wisconsin
Marshfield Medical Center-Rice Lake, Rice Lake, Wisconsin
ThedaCare Cancer Care - Shawano, Shawano, Wisconsin
Vince Lombardi Cancer Clinic-Sheboygan, Sheboygan, Wisconsin
Aspirus Cancer Care - Stevens Point, Stevens Point, Wisconsin
Marshfield Medical Center-River Region at Stevens Point, Stevens Point, Wisconsin
Aurora Medical Center in Summit, Summit, Wisconsin
Vince Lombardi Cancer Clinic-Two Rivers, Two Rivers, Wisconsin
ProHealth Waukesha Memorial Hospital, Waukesha, Wisconsin
UW Cancer Center at ProHealth Care, Waukesha, Wisconsin
ThedaCare Cancer Care - Waupaca, Waupaca, Wisconsin
Aspirus Regional Cancer Center, Wausau, Wisconsin
Aurora Cancer Care-Milwaukee West, Wauwatosa, Wisconsin
Aurora West Allis Medical Center, West Allis, Wisconsin
Marshfield Medical Center - Weston, Weston, Wisconsin
Aspirus Cancer Care - Wisconsin Rapids, Wisconsin Rapids, Wisconsin
Conditions: Advanced Lung Non-Small Cell Carcinoma, Stage IIIB Lung Cancer AJCC v8, Stage IIIC Lung Cancer AJCC v8, Stage IV Lung Cancer AJCC v8
Study of AZD5305 as Monotherapy and in Combination With Anti-cancer Agents in Patients With Advanced Solid Malignancies
Active Not Recruiting
This research is designed to determine if experimental treatment with PARP inhibitor, AZD5305, alone, or in combination with anti-cancer agents is safe, tolerable, and has anti-cancer activity in patients with advanced solid tumors.
This research is designed to determine if experimental treatment with PARP inhibitor, AZD5305, alone, or in combination with anti-cancer agents is safe, tolerable, and has anti-cancer activity in patients with advanced solid tumors. Read Less
Gender:
ALL
Ages:
Between 18 years and 130 years
Trial Updated:
08/22/2025
Locations: Research Site, Boston, Massachusetts +67 locations
Research Site, Boston, Massachusetts
Research Site, Boston, Massachusetts
Research Site, New York, New York
Research Site, Oklahoma City, Oklahoma
Research Site, Houston, Texas
Research Site, Heidelberg, Not set
Research Site, Melbourne, Not set
Research Site, Vancouver, British Columbia
Research Site, Toronto, Ontario
Research Site, Montreal, Quebec
Research Site, Montreal, Quebec
Research Site, Beijing, Not set
Research Site, Changchun, Not set
Research Site, Changsha, Not set
Research Site, Chengdu, Not set
Research Site, Chongqing, Not set
Research Site, Guangzhou, Not set
Research Site, Harbin, Not set
Research Site, Jining, Not set
Research Site, Shandong, Not set
Research Site, Shanghai, Not set
Research Site, Shanghai, Not set
Research Site, Taiyuan, Not set
Research Site, Wuhan, Not set
Research Site, Xi'an, Not set
Research Site, Brno, Not set
Research Site, Praha, Not set
Research Site, Budapest, Not set
Research Site, Budapest, Not set
Research Site, Budapest, Not set
Research Site, Milano, Not set
Research Site, Milan, Not set
Research Site, Modena, Not set
Research Site, Napoli, Not set
Research Site, Padova, Not set
Research Site, Roma, Not set
Research Site, Chuo-ku, Not set
Research Site, Koto-ku, Not set
Research Site, Seoul, Not set
Research Site, Seoul, Not set
Research Site, Seoul, Not set
Research Site, Seoul, Not set
Research Site, Bydgoszcz, Not set
Research Site, Gdańsk, Not set
Research Site, Gdynia, Not set
Research Site, Grzepnica, Not set
Research Site, Toruń, Not set
Research Site, Warszawa, Not set
Research Site, Łódź, Not set
Research Site, Moscow, Not set
Research Site, Moscow, Not set
Research Site, Moscow, Not set
Research Site, Moscow, Not set
Research Site, Barcelona, Not set
Research Site, Madrid, Not set
Research Site, Madrid, Not set
Research Site, Madrid, Not set
Research Site, Málaga, Not set
Research Site, Pozuelo de Alarcon, Not set
Research Site, Sevilla, Not set
Research Site, Chernivtsі, Not set
Research Site, Ivano-Frankivsk, Not set
Research Site, Kyiv, Not set
Research Site, Uzhgorod, Not set
Research Site, Cambridge, Not set
Research Site, Manchester, Not set
Research Site, Oxford, Not set
Research Site, Sutton, Not set
Conditions: Ovarian Cancer, Breast Cancer, Pancreatic Cancer, Prostate Cancer, Additional Indications Below for Module 4 and 5, Non-small Cell Lung Cancer, Colorectal Cancer, Bladder Cancer, Gastric Cancer, Biliary Cancer, Cervical Cancer, Endometrial Cancer, Small Cell Lung Cancer Only in Module 5
Paclitaxel With or Without Carboplatin and/or Bevacizumab Followed by Doxorubicin and Cyclophosphamide in Treating Patients With Breast Cancer That Can Be Removed by Surgery
Active Not Recruiting
This randomized phase II trial studies how well paclitaxel with or without carboplatin and/or bevacizumab followed by doxorubicin and cyclophosphamide works in treating patients with breast cancer that can be removed by surgery. Drugs used in chemotherapy, such as paclitaxel, carboplatin, doxorubicin, and cyclophosphamide, work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing. Bevacizumab may stop the growth of tumor cells by bloc... Read More
This randomized phase II trial studies how well paclitaxel with or without carboplatin and/or bevacizumab followed by doxorubicin and cyclophosphamide works in treating patients with breast cancer that can be removed by surgery. Drugs used in chemotherapy, such as paclitaxel, carboplatin, doxorubicin, and cyclophosphamide, work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing. Bevacizumab may stop the growth of tumor cells by blocking blood flow to the tumor. Giving chemotherapy together with bevacizumab before surgery may make the tumor smaller and reduce the amount of normal tissue that needs to be removed. Read Less
Gender:
ALL
Ages:
18 years and above
Trial Updated:
08/22/2025
Locations: NEA Baptist Memorial Hospital and Fowler Family Cancer Center - Jonesboro, Jonesboro, Arkansas +447 locations
NEA Baptist Memorial Hospital and Fowler Family Cancer Center - Jonesboro, Jonesboro, Arkansas
NEA Baptist Memorial Hospital, Jonesboro, Arkansas
Highlands Oncology Group - Rogers, Rogers, Arkansas
Alta Bates Summit Medical Center-Herrick Campus, Berkeley, California
Providence Saint Joseph Medical Center/Disney Family Cancer Center, Burbank, California
Mills-Peninsula Medical Center, Burlingame, California
East Bay Radiation Oncology Center, Castro Valley, California
Eden Hospital Medical Center, Castro Valley, California
Valley Medical Oncology Consultants-Castro Valley, Castro Valley, California
City of Hope Comprehensive Cancer Center, Duarte, California
Bay Area Breast Surgeons Inc, Emeryville, California
Epic Care Partners in Cancer Care, Emeryville, California
Valley Medical Oncology Consultants-Fremont, Fremont, California
Contra Costa Regional Medical Center, Martinez, California
El Camino Hospital, Mountain View, California
Palo Alto Medical Foundation-Camino Division, Mountain View, California
Sutter Cancer Research Consortium, Novato, California
Wilma Chan Highland Hospital, Oakland, California
Alta Bates Summit Medical Center - Summit Campus, Oakland, California
Bay Area Tumor Institute, Oakland, California
Hematology and Oncology Associates-Oakland, Oakland, California
Tom K Lee Inc, Oakland, California
Saint Joseph Hospital - Orange, Orange, California
Desert Regional Medical Center, Palm Springs, California
Palo Alto Medical Foundation Health Care, Palo Alto, California
Valley Care Health System - Pleasanton, Pleasanton, California
Valley Medical Oncology Consultants, Pleasanton, California
Salinas Valley Memorial, Salinas, California
California Pacific Medical Center-Pacific Campus, San Francisco, California
Doctors Medical Center- JC Robinson Regional Cancer Center, San Pablo, California
Breastlink Medical Group Inc, Santa Ana, California
Sutter Pacific Medical Foundation, Santa Rosa, California
Sutter Solano Medical Center/Cancer Center, Vallejo, California
The Medical Center of Aurora, Aurora, Colorado
Boulder Community Foothills Hospital, Boulder, Colorado
Penrose-Saint Francis Healthcare, Colorado Springs, Colorado
AdventHealth Porter, Denver, Colorado
Presbyterian - Saint Lukes Medical Center - Health One, Denver, Colorado
Saint Joseph Hospital - Cancer Centers of Colorado, Denver, Colorado
Rose Medical Center, Denver, Colorado
Western States Cancer Research NCORP, Denver, Colorado
Swedish Medical Center, Englewood, Colorado
Poudre Valley Hospital, Fort Collins, Colorado
Saint Mary's Hospital and Regional Medical Center, Grand Junction, Colorado
Banner North Colorado Medical Center, Greeley, Colorado
Saint Anthony Hospital, Lakewood, Colorado
AdventHealth Littleton, Littleton, Colorado
Sky Ridge Medical Center, Lone Tree, Colorado
Longmont United Hospital, Longmont, Colorado
Banner McKee Medical Center, Loveland, Colorado
AdventHealth Parker, Parker, Colorado
Saint Mary Corwin Medical Center, Pueblo, Colorado
North Suburban Medical Center, Thornton, Colorado
Intermountain Health Lutheran Hospital, Wheat Ridge, Colorado
Hartford HealthCare - Saint Vincent's Medical Center, Bridgeport, Connecticut
Greenwich Hospital, Greenwich, Connecticut
Hartford Hospital, Hartford, Connecticut
Manchester Memorial Hospital, Manchester, Connecticut
Norwalk Hospital, Norwalk, Connecticut
Beebe Medical Center, Lewes, Delaware
Christiana Care Health System-Christiana Hospital, Newark, Delaware
MedStar Georgetown University Hospital, Washington, District of Columbia
Sibley Memorial Hospital, Washington, District of Columbia
Holy Cross Hospital, Fort Lauderdale, Florida
Jupiter Medical Center, Jupiter, Florida
Cancer Center of South Florida-Lake Worth, Lake Worth, Florida
Mount Sinai Medical Center, Miami Beach, Florida
AdventHealth Orlando, Orlando, Florida
Phoebe Putney Memorial Hospital, Albany, Georgia
Piedmont Hospital, Atlanta, Georgia
Atlanta Regional CCOP, Atlanta, Georgia
Emory Saint Joseph's Hospital, Atlanta, Georgia
Northside Hospital, Atlanta, Georgia
WellStar Cobb Hospital, Austell, Georgia
John B Amos Cancer Center, Columbus, Georgia
Emory Decatur Hospital, Decatur, Georgia
Piedmont Fayette Hospital, Fayetteville, Georgia
Northeast Georgia Medical Center-Gainesville, Gainesville, Georgia
Northside Hospital - Gwinnett, Lawrenceville, Georgia
Wellstar Kennestone Hospital, Marietta, Georgia
Southern Regional Medical Center, Riverdale, Georgia
Harbin Clinic Medical Oncology and Clinical Research, Rome, Georgia
Memorial Health University Medical Center, Savannah, Georgia
Lewis Cancer and Research Pavilion at Saint Joseph's/Candler, Savannah, Georgia
Pali Momi Medical Center, 'Aiea, Hawaii
Hawaii Cancer Care Inc - Waterfront Plaza, Honolulu, Hawaii
Queen's Medical Center, Honolulu, Hawaii
Straub Clinic and Hospital, Honolulu, Hawaii
University of Hawaii Cancer Center, Honolulu, Hawaii
Hawaii Cancer Care Inc-Liliha, Honolulu, Hawaii
Queen's Cancer Center - Kuakini, Honolulu, Hawaii
The Cancer Center of Hawaii-Liliha, Honolulu, Hawaii
Kapiolani Medical Center for Women and Children, Honolulu, Hawaii
Castle Medical Center, Kailua, Hawaii
Wilcox Memorial Hospital and Kauai Medical Clinic, Lihue, Hawaii
Maui Memorial Medical Center, Wailuku, Hawaii
Pacific Cancer Institute of Maui, Wailuku, Hawaii
Mount Sinai Hospital Medical Center, Chicago, Illinois
John H Stroger Jr Hospital of Cook County, Chicago, Illinois
University of Illinois, Chicago, Illinois
Presence Resurrection Medical Center, Chicago, Illinois
University of Chicago Comprehensive Cancer Center, Chicago, Illinois
Weiss Memorial Hospital, Chicago, Illinois
Advocate Good Samaritan Hospital, Downers Grove, Illinois
AMITA Health Adventist Medical Center, La Grange, Illinois
West Suburban Medical Center, River Forest, Illinois
Swedish American Hospital, Rockford, Illinois
Franciscan Saint Francis Health-Beech Grove, Beech Grove, Indiana
Elkhart Clinic, Elkhart, Indiana
Michiana Hematology Oncology PC-Elkhart, Elkhart, Indiana
Elkhart General Hospital, Elkhart, Indiana
Fort Wayne Medical Oncology and Hematology Inc-Parkview, Fort Wayne, Indiana
Community Howard Regional Health, Kokomo, Indiana
IU Health La Porte Hospital, La Porte, Indiana
Michiana Hematology Oncology PC-Mishawaka, Mishawaka, Indiana
Saint Joseph Regional Medical Center-Mishawaka, Mishawaka, Indiana
Michiana Hematology Oncology PC-Plymouth, Plymouth, Indiana
Reid Health, Richmond, Indiana
Memorial Hospital of South Bend, South Bend, Indiana
South Bend Clinic, South Bend, Indiana
Northern Indiana Cancer Research Consortium, South Bend, Indiana
Michiana Hematology Oncology PC-Westville, Westville, Indiana
Physicians' Clinic of Iowa PC, Cedar Rapids, Iowa
Saint Luke's Hospital, Cedar Rapids, Iowa
Mercy Hospital, Cedar Rapids, Iowa
University of Iowa/Holden Comprehensive Cancer Center, Iowa City, Iowa
Siouxland Regional Cancer Center, Sioux City, Iowa
Mercy Medical Center-Sioux City, Sioux City, Iowa
Saint Luke's Regional Medical Center, Sioux City, Iowa
Cancer Center of Kansas - Chanute, Chanute, Kansas
Cancer Center of Kansas - Dodge City, Dodge City, Kansas
Cancer Center of Kansas - El Dorado, El Dorado, Kansas
Cancer Center of Kansas - Fort Scott, Fort Scott, Kansas
HaysMed, Hays, Kansas
Hutchinson Regional Medical Center, Hutchinson, Kansas
Cancer Center of Kansas-Independence, Independence, Kansas
University of Kansas Cancer Center, Kansas City, Kansas
Cancer Center of Kansas-Kingman, Kingman, Kansas
Lawrence Memorial Hospital, Lawrence, Kansas
Cancer Center of Kansas-Liberal, Liberal, Kansas
Cancer Center of Kansas - McPherson, McPherson, Kansas
Cancer Center of Kansas - Newton, Newton, Kansas
Menorah Medical Center, Overland Park, Kansas
Saint Luke's South Hospital, Overland Park, Kansas
Cancer Center of Kansas - Parsons, Parsons, Kansas
Mercy Hospital Pittsburg, Pittsburg, Kansas
Kansas City NCI Community Oncology Research Program, Prairie Village, Kansas
Cancer Center of Kansas - Pratt, Pratt, Kansas
Cancer Center of Kansas - Salina, Salina, Kansas
Salina Regional Health Center, Salina, Kansas
AdventHealth Shawnee Mission, Shawnee Mission, Kansas
University of Kansas Health System Saint Francis Campus, Topeka, Kansas
Cancer Center of Kansas - Wellington, Wellington, Kansas
Associates In Womens Health, Wichita, Kansas
Cancer Center of Kansas-Wichita Medical Arts Tower, Wichita, Kansas
Ascension Via Christi Hospitals Wichita, Wichita, Kansas
Cancer Center of Kansas - Wichita, Wichita, Kansas
Wichita NCI Community Oncology Research Program, Wichita, Kansas
Cancer Center of Kansas - Winfield, Winfield, Kansas
Eastern Maine Medical Center, Bangor, Maine
New England Cancer Specialists, Westbrook, Maine
University of Maryland/Greenebaum Cancer Center, Baltimore, Maryland
Greater Baltimore Medical Center, Baltimore, Maryland
MedStar Franklin Square Medical Center/Weinberg Cancer Institute, Baltimore, Maryland
Walter Reed National Military Medical Center, Bethesda, Maryland
Christiana Care - Union Hospital, Elkton, Maryland
Frederick Memorial Hospital, Frederick, Maryland
TidalHealth Peninsula Regional, Salisbury, Maryland
Massachusetts General Hospital Cancer Center, Boston, Massachusetts
Brigham and Women's Hospital, Boston, Massachusetts
Beth Israel Deaconess Medical Center, Boston, Massachusetts
Dana-Farber Cancer Institute, Boston, Massachusetts
Lahey Hospital and Medical Center, Burlington, Massachusetts
Addison Gilbert Hospital, Gloucester, Massachusetts
Dana-Farber/Brigham and Women's Cancer Center at Milford Regional, Milford, Massachusetts
Newton-Wellesley Hospital, Newton, Massachusetts
Bixby Medical Center, Adrian, Michigan
Hickman Cancer Center, Adrian, Michigan
OSF Saint Francis Hospital and Medical Group, Escanaba, Michigan
Bronson Methodist Hospital, Kalamazoo, Michigan
West Michigan Cancer Center, Kalamazoo, Michigan
Beacon Kalamazoo, Kalamazoo, Michigan
MyMichigan Medical Center Midland, Midland, Michigan
Mercy Memorial Hospital, Monroe, Michigan
Toledo Clinic Cancer Centers-Monroe, Monroe, Michigan
Corewell Health Lakeland Hospitals - Niles Hospital, Niles, Michigan
Corewell Health Lakeland Hospitals - Marie Yeager Cancer Center, Saint Joseph, Michigan
Corewell Health Lakeland Hospitals - Saint Joseph Hospital, Saint Joseph, Michigan
Fairview Ridges Hospital, Burnsville, Minnesota
Mercy Hospital, Coon Rapids, Minnesota
Essentia Health Cancer Center, Duluth, Minnesota
Essentia Health Saint Mary's Medical Center, Duluth, Minnesota
Miller-Dwan Hospital, Duluth, Minnesota
Fairview Southdale Hospital, Edina, Minnesota
Unity Hospital, Fridley, Minnesota
Hutchinson Area Health Care, Hutchinson, Minnesota
Minnesota Oncology Hematology PA-Maplewood, Maplewood, Minnesota
Saint John's Hospital - Healtheast, Maplewood, Minnesota
Abbott-Northwestern Hospital, Minneapolis, Minnesota
Hennepin County Medical Center, Minneapolis, Minnesota
New Ulm Medical Center, New Ulm, Minnesota
North Memorial Medical Health Center, Robbinsdale, Minnesota
Metro Minnesota Community Oncology Research Consortium, Saint Louis Park, Minnesota
Park Nicollet Clinic - Saint Louis Park, Saint Louis Park, Minnesota
Regions Hospital, Saint Paul, Minnesota
United Hospital, Saint Paul, Minnesota
Saint Francis Regional Medical Center, Shakopee, Minnesota
Lakeview Hospital, Stillwater, Minnesota
Ridgeview Medical Center, Waconia, Minnesota
Rice Memorial Hospital, Willmar, Minnesota
Minnesota Oncology Hematology PA-Woodbury, Woodbury, Minnesota
University of Mississippi Medical Center, Jackson, Mississippi
Central Care Cancer Center - Bolivar, Bolivar, Missouri
Cox Cancer Center Branson, Branson, Missouri
Mercy Cancer Center - Cape Girardeau, Cape Girardeau, Missouri
Saint Luke's Hospital, Chesterfield, Missouri
MU Health - University Hospital/Ellis Fischel Cancer Center, Columbia, Missouri
MU Health Care Goldschmidt Cancer Center, Jefferson City, Missouri
University Health Truman Medical Center, Kansas City, Missouri
Saint Luke's Hospital of Kansas City, Kansas City, Missouri
Saint Joseph Health Center, Kansas City, Missouri
North Kansas City Hospital, Kansas City, Missouri
Heartland Hematology and Oncology Associates Incorporated, Kansas City, Missouri
Research Medical Center, Kansas City, Missouri
Saint Luke's East - Lee's Summit, Lee's Summit, Missouri
Liberty Hospital, Liberty, Missouri
Mercy Clinic-Rolla-Cancer and Hematology, Rolla, Missouri
Phelps Health Delbert Day Cancer Institute, Rolla, Missouri
Heartland Regional Medical Center, Saint Joseph, Missouri
SSM Health Saint Louis University Hospital, Saint Louis, Missouri
Washington University School of Medicine, Saint Louis, Missouri
Missouri Baptist Medical Center, Saint Louis, Missouri
Center for Cancer Care and Research, Saint Louis, Missouri
Comprehensive Cancer Care PC, Saint Louis, Missouri
Cancer Research for the Ozarks NCORP, Springfield, Missouri
Mercy Hospital Springfield, Springfield, Missouri
CoxHealth South Hospital, Springfield, Missouri
Billings Clinic Cancer Center, Billings, Montana
Saint Vincent Healthcare, Billings, Montana
Montana Cancer Consortium NCORP, Billings, Montana
Saint Vincent Frontier Cancer Center, Billings, Montana
Bozeman Health Deaconess Hospital, Bozeman, Montana
Saint James Community Hospital and Cancer Treatment Center, Butte, Montana
Benefis Sletten Cancer Institute, Great Falls, Montana
Great Falls Clinic, Great Falls, Montana
Northern Montana Hospital, Havre, Montana
Saint Peter's Community Hospital, Helena, Montana
Glacier Oncology PLLC, Kalispell, Montana
Kalispell Medical Oncology, Kalispell, Montana
Logan Health Medical Center, Kalispell, Montana
Montana Cancer Specialists, Missoula, Montana
Saint Patrick Hospital - Community Hospital, Missoula, Montana
New Hampshire Oncology Hematology PA-Concord, Concord, New Hampshire
Exeter Hospital, Exeter, New Hampshire
LRGHealthcare-Lakes Region General Hospital, Laconia, New Hampshire
Dartmouth Hitchcock Medical Center/Dartmouth Cancer Center, Lebanon, New Hampshire
Dartmouth Cancer Center - Manchester, Manchester, New Hampshire
Elliot Hospital, Manchester, New Hampshire
Solinsky Center for Cancer Care, Manchester, New Hampshire
Cooper Hospital University Medical Center, Camden, New Jersey
Monmouth Medical Center, Long Branch, New Jersey
Virtua Memorial, Mount Holly, New Jersey
Rutgers New Jersey Medical School, Newark, New Jersey
Virtua Voorhees, Voorhees, New Jersey
Maimonides Medical Center, Brooklyn, New York
Coney Island Hospital, Brooklyn, New York
Roswell Park Cancer Institute, Buffalo, New York
Hematology Oncology Associates of Central New York-East Syracuse, East Syracuse, New York
Elmhurst Hospital Center, Elmhurst, New York
Glens Falls Hospital, Glens Falls, New York
Queens Hospital Center, Jamaica, New York
Garnet Health Medical Center, Middletown, New York
Mount Sinai Union Square, New York, New York
Mount Sinai West, New York, New York
Mount Sinai Hospital, New York, New York
Memorial Sloan Kettering Cancer Center, New York, New York
Staten Island University Hospital, Staten Island, New York
State University of New York Upstate Medical University, Syracuse, New York
Randolph Hospital, Asheboro, North Carolina
Mission Hospital, Asheville, North Carolina
UNC Lineberger Comprehensive Cancer Center, Chapel Hill, North Carolina
Novant Health Presbyterian Medical Center, Charlotte, North Carolina
Wayne Memorial Hospital, Goldsboro, North Carolina
Cone Health Cancer Center, Greensboro, North Carolina
ECU Health Oncology Kinston, Kinston, North Carolina
FirstHealth of the Carolinas-Moore Regional Hospital, Pinehurst, North Carolina
UNC Rex Healthcare, Raleigh, North Carolina
Annie Penn Memorial Hospital, Reidsville, North Carolina
Nash UNC HealthCare, Rocky Mount, North Carolina
Rutherford Hospital, Rutherfordton, North Carolina
Iredell Memorial Hospital, Statesville, North Carolina
Novant Health Forsyth Medical Center, Winston-Salem, North Carolina
Southeast Clinical Oncology Research Consortium NCORP, Winston-Salem, North Carolina
Altru Cancer Center, Grand Forks, North Dakota
Summa Health System - Akron Campus, Akron, Ohio
Cleveland Clinic Akron General, Akron, Ohio
Summa Health System - Barberton Campus, Barberton, Ohio
Toledo Clinic Cancer Centers-Bowling Green, Bowling Green, Ohio
Aultman Health Foundation, Canton, Ohio
North Coast Cancer Care-Clyde, Clyde, Ohio
Ohio State University Comprehensive Cancer Center, Columbus, Ohio
Grandview Hospital, Dayton, Ohio
Good Samaritan Hospital - Dayton, Dayton, Ohio
Miami Valley Hospital, Dayton, Ohio
Miami Valley Hospital North, Dayton, Ohio
Dayton NCI Community Oncology Research Program, Dayton, Ohio
Hematology Oncology Center Incorporated, Elyria, Ohio
Mercy Cancer Center-Elyria, Elyria, Ohio
Blanchard Valley Hospital, Findlay, Ohio
Atrium Medical Center-Middletown Regional Hospital, Franklin, Ohio
Wayne Hospital, Greenville, Ohio
Kettering Medical Center, Kettering, Ohio
Saint Rita's Medical Center, Lima, Ohio
Lima Memorial Hospital, Lima, Ohio
OhioHealth Mansfield Hospital, Mansfield, Ohio
Saint Luke's Hospital, Maumee, Ohio
Toledo Clinic Cancer Centers-Maumee, Maumee, Ohio
Toledo Radiation Oncology at Northwest Ohio Onocolgy Center, Maumee, Ohio
Fisher-Titus Medical Center, Norwalk, Ohio
Saint Charles Hospital, Oregon, Ohio
Toledo Clinic Cancer Centers-Oregon, Oregon, Ohio
North Coast Cancer Care, Sandusky, Ohio
ProMedica Flower Hospital, Sylvania, Ohio
Mercy Hospital of Tiffin, Tiffin, Ohio
ProMedica Toledo Hospital/Russell J Ebeid Children's Hospital, Toledo, Ohio
Mercy Health - Saint Vincent Hospital, Toledo, Ohio
University of Toledo, Toledo, Ohio
Toledo Community Hospital Oncology Program CCOP, Toledo, Ohio
Mercy Health - Saint Anne Hospital, Toledo, Ohio
Toledo Clinic Cancer Centers-Toledo, Toledo, Ohio
Upper Valley Medical Center, Troy, Ohio
Fulton County Health Center, Wauseon, Ohio
Clinton Memorial Hospital/Foster J Boyd Regional Cancer Center, Wilmington, Ohio
Greene Memorial Hospital, Xenia, Ohio
University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma
Cancer Care Associates, Oklahoma City, Oklahoma
Integris Cancer Institute of Oklahoma, Oklahoma City, Oklahoma
Bay Area Hospital, Coos Bay, Oregon
Saint Luke's University Hospital-Bethlehem Campus, Bethlehem, Pennsylvania
Butler Memorial Hospital, Butler, Pennsylvania
Adams Cancer Center, Gettysburg, Pennsylvania
WellSpan Medical Oncology and Hematology, Hanover, Pennsylvania
Penn State Milton S Hershey Medical Center, Hershey, Pennsylvania
Lewistown Hospital, Lewistown, Pennsylvania
Jefferson Torresdale Hospital, Philadelphia, Pennsylvania
Einstein Medical Center Philadelphia, Philadelphia, Pennsylvania
Guthrie Medical Group PC-Robert Packer Hospital, Sayre, Pennsylvania
Mount Nittany Medical Center, State College, Pennsylvania
WellSpan Health-York Hospital, York, Pennsylvania
Rhode Island Hospital, Providence, Rhode Island
Women and Infants Hospital, Providence, Rhode Island
Miriam Hospital, Providence, Rhode Island
Kent Hospital, Warwick, Rhode Island
AnMed Health Cancer Center, Anderson, South Carolina
AnMed Health Hospital, Anderson, South Carolina
Prisma Health Cancer Institute - Spartanburg, Boiling Springs, South Carolina
Roper Hospital, Charleston, South Carolina
Prisma Health Cancer Institute - Easley, Easley, South Carolina
Saint Francis Hospital, Greenville, South Carolina
Prisma Health Cancer Institute - Butternut, Greenville, South Carolina
Prisma Health Cancer Institute - Faris, Greenville, South Carolina
Prisma Health Greenville Memorial Hospital, Greenville, South Carolina
Prisma Health Cancer Institute - Eastside, Greenville, South Carolina
Self Regional Healthcare, Greenwood, South Carolina
Prisma Health Cancer Institute - Greer, Greer, South Carolina
Prisma Health Cancer Institute - Seneca, Seneca, South Carolina
Spartanburg Medical Center, Spartanburg, South Carolina
Lexington Medical Center, West Columbia, South Carolina
Sanford Cancer Center Oncology Clinic, Sioux Falls, South Dakota
Avera Cancer Institute, Sioux Falls, South Dakota
Medical X-Ray Center, Sioux Falls, South Dakota
Avera McKennan Hospital and University Health Center, Sioux Falls, South Dakota
Sanford USD Medical Center - Sioux Falls, Sioux Falls, South Dakota
Erlanger Medical Center, Chattanooga, Tennessee
Thompson Cancer Survival Center, Knoxville, Tennessee
Nashville Oncology Associates PC, Nashville, Tennessee
Meharry Medical College, Nashville, Tennessee
Doctor's Hospital of Laredo, Laredo, Texas
Texas Tech University Health Sciences Center-Lubbock, Lubbock, Texas
American Fork Hospital / Huntsman Intermountain Cancer Center, American Fork, Utah
Sandra L Maxwell Cancer Center, Cedar City, Utah
Logan Regional Hospital, Logan, Utah
Intermountain Medical Center, Murray, Utah
McKay-Dee Hospital Center, Ogden, Utah
Utah Valley Regional Medical Center, Provo, Utah
Saint George Regional Medical Center, Saint George, Utah
Intermountain Health Care, Salt Lake City, Utah
Utah Cancer Specialists-Salt Lake City, Salt Lake City, Utah
LDS Hospital, Salt Lake City, Utah
Fredericksburg Oncology Inc, Fredericksburg, Virginia
Hematology Oncology Associates of Fredericksburg Inc, Fredericksburg, Virginia
Virginia Oncology Associates-Hampton, Hampton, Virginia
Cancer Care Center at Island Hospital, Anacortes, Washington
MultiCare Auburn Medical Center, Auburn, Washington
PeaceHealth Saint Joseph Medical Center, Bellingham, Washington
Highline Medical Center-Main Campus, Burien, Washington
Providence Regional Cancer System-Centralia, Centralia, Washington
Saint Francis Hospital, Federal Way, Washington
Swedish Cancer Institute-Issaquah, Issaquah, Washington
Kadlec Clinic Hematology and Oncology, Kennewick, Washington
Saint Clare Hospital, Lakewood, Washington
Skagit Valley Hospital, Mount Vernon, Washington
Providence - Saint Peter Hospital, Olympia, Washington
Harrison HealthPartners Hematology and Oncology-Poulsbo, Poulsbo, Washington
MultiCare Good Samaritan Hospital, Puyallup, Washington
Harborview Medical Center, Seattle, Washington
Minor and James Medical PLLC, Seattle, Washington
Fred Hutchinson Cancer Center, Seattle, Washington
Kaiser Permanente Washington, Seattle, Washington
Swedish Medical Center-First Hill, Seattle, Washington
University of Washington Medical Center - Montlake, Seattle, Washington
PeaceHealth United General Medical Center, Sedro-Woolley, Washington
Saint Michael Cancer Center, Silverdale, Washington
Cancer Care Northwest - Spokane South, Spokane, Washington
Evergreen Hematology and Oncology PS, Spokane, Washington
MultiCare Allenmore Hospital, Tacoma, Washington
MultiCare Tacoma General Hospital, Tacoma, Washington
Northwest NCI Community Oncology Research Program, Tacoma, Washington
Saint Joseph Medical Center, Tacoma, Washington
Providence Saint Mary Regional Cancer Center, Walla Walla, Washington
Wenatchee Valley Hospital and Clinics, Wenatchee, Washington
Saint Mary's Medical Center, Huntington, West Virginia
Princeton Community Hospital, Princeton, West Virginia
Fox Valley Surgical Associates Limited, Appleton, Wisconsin
ThedaCare Regional Cancer Center, Appleton, Wisconsin
Aurora Cancer Care-Southern Lakes VLCC, Burlington, Wisconsin
Aurora Cancer Care-Franklin, Franklin, Wisconsin
Aurora Health Care Germantown Health Center, Germantown, Wisconsin
Aurora Cancer Care-Glendale, Glendale, Wisconsin
Green Bay Oncology at Saint Vincent Hospital, Green Bay, Wisconsin
Saint Vincent Hospital Cancer Center Green Bay, Green Bay, Wisconsin
Saint Vincent Hospital Cancer Center at Saint Mary's, Green Bay, Wisconsin
Aurora BayCare Medical Center, Green Bay, Wisconsin
Aurora Cancer Care-Kenosha South, Kenosha, Wisconsin
Gundersen Lutheran Medical Center, La Crosse, Wisconsin
Holy Family Memorial Hospital, Manitowoc, Wisconsin
Aurora Bay Area Medical Group-Marinette, Marinette, Wisconsin
Bay Area Medical Center, Marinette, Wisconsin
Aurora Saint Luke's Medical Center, Milwaukee, Wisconsin
Saint Vincent Hospital Cancer Center at Oconto Falls, Oconto Falls, Wisconsin
Aurora Cancer Care-Racine, Racine, Wisconsin
HSHS Saint Nicholas Hospital, Sheboygan, Wisconsin
Aurora Medical Center in Summit, Summit, Wisconsin
Aurora Cancer Care-Waukesha, Waukesha, Wisconsin
Aurora Cancer Care-Milwaukee West, Wauwatosa, Wisconsin
Aurora West Allis Medical Center, West Allis, Wisconsin
Rocky Mountain Oncology, Casper, Wyoming
Welch Cancer Center, Sheridan, Wyoming
Conditions: Male Breast Carcinoma, Stage IIA Breast Cancer AJCC v6 and v7, Stage IIB Breast Cancer AJCC v6 and v7, Stage IIIA Breast Cancer AJCC v7, Triple-Negative Breast Carcinoma
Testing the Addition of a New Immunotherapy Drug, Atezolizumab (MPDL3280A), to the Usual Chemoradiation (CRT) Therapy Treatment for Limited Stage Small Cell Lung Cancer (LS-SCLC)
Active Not Recruiting
This phase III trial studies how well chemotherapy and radiation therapy (chemoradiation) with or without atezolizumab works in treating patients with limited stage small cell lung cancer. Drugs used in chemotherapy, such as etoposide, cisplatin, and carboplatin, work in different ways to stop the growth of tumor cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading. Radiation therapy uses high energy x-rays to kill tumor cells and shrink tumors.... Read More
This phase III trial studies how well chemotherapy and radiation therapy (chemoradiation) with or without atezolizumab works in treating patients with limited stage small cell lung cancer. Drugs used in chemotherapy, such as etoposide, cisplatin, and carboplatin, work in different ways to stop the growth of tumor cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading. Radiation therapy uses high energy x-rays to kill tumor cells and shrink tumors. Immunotherapy with monoclonal antibodies, such as atezolizumab, may help the body's immune system attack the cancer, and may interfere with the ability of tumor cells to grow and spread. Giving chemoradiation with or without atezolizumab may work better in treating patients with limited stage small cell lung cancer. Read Less
Gender:
ALL
Ages:
18 years and above
Trial Updated:
08/22/2025
Locations: University of Alabama at Birmingham Cancer Center, Birmingham, Alabama +543 locations
University of Alabama at Birmingham Cancer Center, Birmingham, Alabama
Fairbanks Memorial Hospital, Fairbanks, Alaska
Banner MD Anderson Cancer Center, Gilbert, Arizona
CTCA at Western Regional Medical Center, Goodyear, Arizona
Banner University Medical Center - Tucson, Tucson, Arizona
University of Arizona Cancer Center-North Campus, Tucson, Arizona
NEA Baptist Memorial Hospital and Fowler Family Cancer Center - Jonesboro, Jonesboro, Arkansas
University of Arkansas for Medical Sciences, Little Rock, Arkansas
Sutter Auburn Faith Hospital, Auburn, California
Alta Bates Summit Medical Center-Herrick Campus, Berkeley, California
City of Hope Comprehensive Cancer Center, Duarte, California
Los Angeles General Medical Center, Los Angeles, California
USC / Norris Comprehensive Cancer Center, Los Angeles, California
Memorial Medical Center, Modesto, California
UC Irvine Health/Chao Family Comprehensive Cancer Center, Orange, California
Sutter Roseville Medical Center, Roseville, California
Sutter Medical Center Sacramento, Sacramento, California
University of California Davis Comprehensive Cancer Center, Sacramento, California
California Pacific Medical Center-Pacific Campus, San Francisco, California
Gene Upshaw Memorial Tahoe Forest Cancer Center, Truckee, California
UCHealth University of Colorado Hospital, Aurora, Colorado
Penrose-Saint Francis Healthcare, Colorado Springs, Colorado
UCHealth Memorial Hospital Central, Colorado Springs, Colorado
Memorial Hospital North, Colorado Springs, Colorado
AdventHealth Porter, Denver, Colorado
Poudre Valley Hospital, Fort Collins, Colorado
Cancer Care and Hematology-Fort Collins, Fort Collins, Colorado
UCHealth Greeley Hospital, Greeley, Colorado
AdventHealth Littleton, Littleton, Colorado
Medical Center of the Rockies, Loveland, Colorado
AdventHealth Parker, Parker, Colorado
Beebe South Coastal Health Campus, Millville, Delaware
Helen F Graham Cancer Center, Newark, Delaware
Medical Oncology Hematology Consultants PA, Newark, Delaware
Beebe Health Campus, Rehoboth Beach, Delaware
GenesisCare USA - Aventura FP, Aventura, Florida
GenesisCare USA - Aventura, Aventura, Florida
Boca Raton Regional Hospital, Boca Raton, Florida
UM Sylvester Comprehensive Cancer Center at Coral Gables, Coral Gables, Florida
UM Sylvester Comprehensive Cancer Center at Deerfield Beach, Deerfield Beach, Florida
Holy Cross Hospital, Fort Lauderdale, Florida
Lee Memorial Health System, Fort Myers, Florida
Regional Cancer Center-Lee Memorial Health System, Fort Myers, Florida
University of Florida Health Science Center - Gainesville, Gainesville, Florida
The Watson Clinic, Lakeland, Florida
University of Miami Miller School of Medicine-Sylvester Cancer Center, Miami, Florida
Miami Cancer Institute, Miami, Florida
Orlando Health Cancer Institute, Orlando, Florida
Sacred Heart Hospital, Pensacola, Florida
UM Sylvester Comprehensive Cancer Center at Plantation, Plantation, Florida
Moffitt Cancer Center, Tampa, Florida
Grady Health System, Atlanta, Georgia
Emory University Hospital Midtown, Atlanta, Georgia
Piedmont Hospital, Atlanta, Georgia
Emory University Hospital/Winship Cancer Institute, Atlanta, Georgia
Emory Saint Joseph's Hospital, Atlanta, Georgia
Piedmont Fayette Hospital, Fayetteville, Georgia
CTCA at Southeastern Regional Medical Center, Newnan, Georgia
Piedmont Newnan Hospital, Newnan, Georgia
Memorial Health University Medical Center, Savannah, Georgia
Lewis Cancer and Research Pavilion at Saint Joseph's/Candler, Savannah, Georgia
Hawaii Cancer Care - Westridge, 'Aiea, Hawaii
Pali Momi Medical Center, 'Aiea, Hawaii
The Cancer Center of Hawaii-Pali Momi, 'Aiea, Hawaii
Hawaii Cancer Care Inc - Waterfront Plaza, Honolulu, Hawaii
Queen's Cancer Cenrer - POB I, Honolulu, Hawaii
Queen's Medical Center, Honolulu, Hawaii
Straub Clinic and Hospital, Honolulu, Hawaii
Kuakini Medical Center, Honolulu, Hawaii
Queen's Cancer Center - Kuakini, Honolulu, Hawaii
The Cancer Center of Hawaii-Liliha, Honolulu, Hawaii
Saint Alphonsus Cancer Care Center-Boise, Boise, Idaho
Saint Luke's Cancer Institute - Boise, Boise, Idaho
Saint Alphonsus Cancer Care Center-Caldwell, Caldwell, Idaho
Saint Luke's Cancer Institute - Fruitland, Fruitland, Idaho
Saint Luke's Cancer Institute - Meridian, Meridian, Idaho
Saint Alphonsus Cancer Care Center-Nampa, Nampa, Idaho
Saint Luke's Cancer Institute - Nampa, Nampa, Idaho
Saint Luke's Cancer Institute - Twin Falls, Twin Falls, Idaho
Alton Memorial Hospital, Alton, Illinois
Rush-Copley Medical Center, Aurora, Illinois
Illinois CancerCare-Bloomington, Bloomington, Illinois
Illinois CancerCare-Canton, Canton, Illinois
Illinois CancerCare-Carthage, Carthage, Illinois
Northwestern University, Chicago, Illinois
Rush University Medical Center, Chicago, Illinois
University of Illinois, Chicago, Illinois
Advocate Illinois Masonic Medical Center, Chicago, Illinois
AMG Crystal Lake - Oncology, Crystal Lake, Illinois
Carle at The Riverfront, Danville, Illinois
Decatur Memorial Hospital, Decatur, Illinois
Advocate Good Samaritan Hospital, Downers Grove, Illinois
Carle Physician Group-Effingham, Effingham, Illinois
Crossroads Cancer Center, Effingham, Illinois
Elmhurst Memorial Hospital, Elmhurst, Illinois
Illinois CancerCare-Eureka, Eureka, Illinois
NorthShore University HealthSystem-Evanston Hospital, Evanston, Illinois
Illinois CancerCare-Galesburg, Galesburg, Illinois
Western Illinois Cancer Treatment Center, Galesburg, Illinois
NorthShore University HealthSystem-Glenbrook Hospital, Glenview, Illinois
Ingalls Memorial Hospital, Harvey, Illinois
Advocate South Suburban Hospital, Hazel Crest, Illinois
NorthShore University HealthSystem-Highland Park Hospital, Highland Park, Illinois
Illinois CancerCare-Kewanee Clinic, Kewanee, Illinois
Northwestern Medicine Lake Forest Hospital, Lake Forest, Illinois
AMG Libertyville - Oncology, Libertyville, Illinois
Illinois CancerCare-Macomb, Macomb, Illinois
Carle Physician Group-Mattoon/Charleston, Mattoon, Illinois
Loyola University Medical Center, Maywood, Illinois
SSM Health Good Samaritan, Mount Vernon, Illinois
Edward Hospital/Cancer Center, Naperville, Illinois
Advocate Christ Medical Center, Oak Lawn, Illinois
Illinois CancerCare-Ottawa Clinic, Ottawa, Illinois
Advocate Lutheran General Hospital, Park Ridge, Illinois
Illinois CancerCare-Pekin, Pekin, Illinois
Illinois CancerCare-Peoria, Peoria, Illinois
OSF Saint Francis Radiation Oncology at Peoria Cancer Center, Peoria, Illinois
Methodist Medical Center of Illinois, Peoria, Illinois
OSF Saint Francis Medical Center, Peoria, Illinois
Illinois CancerCare-Peru, Peru, Illinois
Edward Hospital/Cancer Center?Plainfield, Plainfield, Illinois
Illinois CancerCare-Princeton, Princeton, Illinois
Springfield Memorial Hospital, Springfield, Illinois
Carle Cancer Center, Urbana, Illinois
Illinois CancerCare - Washington, Washington, Illinois
Midwestern Regional Medical Center, Zion, Illinois
IU Health North Hospital, Carmel, Indiana
Parkview Regional Medical Center, Fort Wayne, Indiana
Goshen Center for Cancer Care, Goshen, Indiana
Indiana University/Melvin and Bren Simon Cancer Center, Indianapolis, Indiana
Community Cancer Center East, Indianapolis, Indiana
Community Cancer Center South, Indianapolis, Indiana
Franciscan Health Indianapolis, Indianapolis, Indiana
Community Cancer Center North, Indianapolis, Indiana
Community Howard Regional Health, Kokomo, Indiana
Franciscan Health Mooresville, Mooresville, Indiana
Baptist Health Floyd, New Albany, Indiana
McFarland Clinic - Ames, Ames, Iowa
Physicians' Clinic of Iowa PC, Cedar Rapids, Iowa
Mercy Hospital, Cedar Rapids, Iowa
Oncology Associates at Mercy Medical Center, Cedar Rapids, Iowa
Mercy Cancer Center-West Lakes, Clive, Iowa
UI Health Care Mission Cancer and Blood - West Des Moines Clinic, Clive, Iowa
Greater Regional Medical Center, Creston, Iowa
Mercy Medical Center - Des Moines, Des Moines, Iowa
UI Health Care Mission Cancer and Blood - Laurel Clinic, Des Moines, Iowa
Mercy Medical Center-West Lakes, West Des Moines, Iowa
University of Kansas Cancer Center, Kansas City, Kansas
The University of Kansas Cancer Center - Olathe, Olathe, Kansas
University of Kansas Cancer Center-Overland Park, Overland Park, Kansas
Salina Regional Health Center, Salina, Kansas
University of Kansas Health System Saint Francis Campus, Topeka, Kansas
University of Kansas Hospital-Westwood Cancer Center, Westwood, Kansas
Ascension Via Christi Hospitals Wichita, Wichita, Kansas
Saint Elizabeth Healthcare Edgewood, Edgewood, Kentucky
Baptist Health Hardin, Elizabethtown, Kentucky
Baptist Health Lexington, Lexington, Kentucky
Saint Joseph Hospital East, Lexington, Kentucky
Norton Hospital Pavilion and Medical Campus, Louisville, Kentucky
The James Graham Brown Cancer Center at University of Louisville, Louisville, Kentucky
Baptist Health Louisville, Louisville, Kentucky
Norton Audubon Hospital and Medical Campus, Louisville, Kentucky
Norton Brownsboro Hospital and Medical Campus, Louisville, Kentucky
Baptist Health Paducah, Paducah, Kentucky
LSU Health Baton Rouge-North Clinic, Baton Rouge, Louisiana
Our Lady of the Lake Physician Group, Baton Rouge, Louisiana
Louisiana Hematology Oncology Associates LLC, Baton Rouge, Louisiana
Mary Bird Perkins Cancer Center, Baton Rouge, Louisiana
Medical Center of Baton Rouge, Baton Rouge, Louisiana
Mary Bird Perkins Cancer Center - Covington, Covington, Louisiana
Mary Bird Perkins Cancer Center - Houma, Houma, Louisiana
Terrebonne General Medical Center, Houma, Louisiana
University Medical Center New Orleans, New Orleans, Louisiana
Ochsner Medical Center Jefferson, New Orleans, Louisiana
MaineHealth Coastal Cancer Treatment Center, Bath, Maine
MaineHealth Waldo Hospital, Belfast, Maine
MaineHealth Maine Medical Center - Biddeford, Biddeford, Maine
MaineHealth Stephens Hospital, Norway, Maine
MaineHealth Maine Medical Center - Portland, Portland, Maine
Penobscot Bay Medical Center, Rockport, Maine
MaineHealth Cancer Care and IV Therapy - Sanford, Sanford, Maine
MaineHealth Cancer Care Center of York County, Sanford, Maine
MaineHealth Maine Medical Center- Scarborough, Scarborough, Maine
MaineHealth Cancer Care and IV Therapy - South Portland, South Portland, Maine
University of Maryland/Greenebaum Cancer Center, Baltimore, Maryland
Saint Agnes Hospital, Baltimore, Maryland
UM Upper Chesapeake Medical Center, Bel Air, Maryland
Central Maryland Radiation Oncology in Howard County, Columbia, Maryland
UM Baltimore Washington Medical Center/Tate Cancer Center, Glen Burnie, Maryland
Dana-Farber Cancer Institute, Boston, Massachusetts
Dana-Farber Cancer Institute at Boston Medical Center - Brighton, Brighton, Massachusetts
UMass Memorial Medical Center - University Campus, Worcester, Massachusetts
Trinity Health Saint Joseph Mercy Hospital Ann Arbor, Ann Arbor, Michigan
Bronson Battle Creek, Battle Creek, Michigan
McLaren Cancer Institute-Bay City, Bay City, Michigan
Trinity Health Medical Center - Brighton, Brighton, Michigan
Henry Ford Cancer Institute-Downriver, Brownstown, Michigan
Trinity Health Medical Center - Canton, Canton, Michigan
Caro Cancer Center, Caro, Michigan
Chelsea Hospital, Chelsea, Michigan
McLaren Cancer Institute-Clarkston, Clarkston, Michigan
Michigan Healthcare Professionals Clarkston, Clarkston, Michigan
Henry Ford Macomb Hospital-Clinton Township, Clinton Township, Michigan
Corewell Health Dearborn Hospital, Dearborn, Michigan
Henry Ford Hospital, Detroit, Michigan
Henry Ford Health Saint John Hospital, Detroit, Michigan
Michigan Healthcare Professionals Farmington, Farmington Hills, Michigan
Corewell Health Farmington Hills Hospital, Farmington Hills, Michigan
Genesys Hurley Cancer Institute, Flint, Michigan
McLaren Cancer Institute-Flint, Flint, Michigan
Singh and Arora Hematology Oncology PC, Flint, Michigan
Corewell Health Grand Rapids Hospitals - Butterworth Hospital, Grand Rapids, Michigan
Allegiance Health, Jackson, Michigan
West Michigan Cancer Center, Kalamazoo, Michigan
Karmanos Cancer Institute at McLaren Greater Lansing, Lansing, Michigan
Mid-Michigan Physicians-Lansing, Lansing, Michigan
University of Michigan Health - Sparrow Lansing, Lansing, Michigan
McLaren Cancer Institute-Lapeer Region, Lapeer, Michigan
Trinity Health Saint Mary Mercy Livonia Hospital, Livonia, Michigan
Michigan Healthcare Professionals Macomb, Macomb, Michigan
Michigan Healthcare Professionals Madison Heights, Madison Heights, Michigan
McLaren Cancer Institute-Macomb, Mount Clemens, Michigan
Trinity Health Muskegon Hospital, Muskegon, Michigan
Cancer and Hematology Centers of Western Michigan - Norton Shores, Norton Shores, Michigan
Henry Ford Health Providence Novi Hospital, Novi, Michigan
McLaren Cancer Institute-Northern Michigan, Petoskey, Michigan
Michigan Healthcare Professionals Pontiac, Pontiac, Michigan
McLaren-Port Huron, Port Huron, Michigan
Corewell Health William Beaumont University Hospital, Royal Oak, Michigan
MyMichigan Medical Center Saginaw, Saginaw, Michigan
Oncology Hematology Associates of Saginaw Valley PC, Saginaw, Michigan
Corewell Health Lakeland Hospitals - Marie Yeager Cancer Center, Saint Joseph, Michigan
Corewell Health Lakeland Hospitals - Saint Joseph Hospital, Saint Joseph, Michigan
Henry Ford Macomb Health Center - Shelby Township, Shelby, Michigan
Henry Ford Health Providence Southfield Hospital, Southfield, Michigan
MyMichigan Medical Center Tawas, Tawas City, Michigan
Corewell Health Beaumont Troy Hospital, Troy, Michigan
Michigan Healthcare Professionals Troy, Troy, Michigan
Henry Ford Health Warren Hospital, Warren, Michigan
Saint Mary's Oncology/Hematology Associates of West Branch, West Branch, Michigan
University of Michigan Health - West, Wyoming, Michigan
Mayo Clinic Health System in Albert Lea, Albert Lea, Minnesota
Sanford Joe Lueken Cancer Center, Bemidji, Minnesota
Fairview Ridges Hospital, Burnsville, Minnesota
Minnesota Oncology - Burnsville, Burnsville, Minnesota
Mercy Hospital, Coon Rapids, Minnesota
Saint Luke's Hospital of Duluth, Duluth, Minnesota
Fairview Southdale Hospital, Edina, Minnesota
Unity Hospital, Fridley, Minnesota
Mayo Clinic Health Systems-Mankato, Mankato, Minnesota
Minnesota Oncology Hematology PA-Maplewood, Maplewood, Minnesota
Abbott-Northwestern Hospital, Minneapolis, Minnesota
Hennepin County Medical Center, Minneapolis, Minnesota
North Memorial Medical Health Center, Robbinsdale, Minnesota
Mayo Clinic in Rochester, Rochester, Minnesota
Coborn Cancer Center at Saint Cloud Hospital, Saint Cloud, Minnesota
Park Nicollet Clinic - Saint Louis Park, Saint Louis Park, Minnesota
Regions Hospital, Saint Paul, Minnesota
United Hospital, Saint Paul, Minnesota
Baptist Cancer Center-Grenada, Grenada, Mississippi
Baptist Memorial Hospital and Cancer Center-Union County, New Albany, Mississippi
Baptist Memorial Hospital and Cancer Center-Oxford, Oxford, Mississippi
Baptist Memorial Hospital and Cancer Center-Desoto, Southhaven, Mississippi
Parkland Health Center-Bonne Terre, Bonne Terre, Missouri
Saint Francis Medical Center, Cape Girardeau, Missouri
Saint Luke's Hospital, Chesterfield, Missouri
Siteman Cancer Center at West County Hospital, Creve Coeur, Missouri
Parkland Health Center - Farmington, Farmington, Missouri
MU Health Care Goldschmidt Cancer Center, Jefferson City, Missouri
Freeman Health System, Joplin, Missouri
University of Kansas Cancer Center - North, Kansas City, Missouri
University of Kansas Cancer Center - Lee's Summit, Lee's Summit, Missouri
University of Kansas Cancer Center at North Kansas City Hospital, North Kansas City, Missouri
Phelps Health Delbert Day Cancer Institute, Rolla, Missouri
Heartland Regional Medical Center, Saint Joseph, Missouri
Washington University School of Medicine, Saint Louis, Missouri
Siteman Cancer Center-South County, Saint Louis, Missouri
Missouri Baptist Medical Center, Saint Louis, Missouri
Siteman Cancer Center at Christian Hospital, Saint Louis, Missouri
Mercy Hospital Saint Louis, Saint Louis, Missouri
Siteman Cancer Center at Saint Peters Hospital, Saint Peters, Missouri
Sainte Genevieve County Memorial Hospital, Sainte Genevieve, Missouri
Mercy Hospital Springfield, Springfield, Missouri
CoxHealth South Hospital, Springfield, Missouri
Missouri Baptist Sullivan Hospital, Sullivan, Missouri
BJC Outpatient Center at Sunset Hills, Sunset Hills, Missouri
Billings Clinic Cancer Center, Billings, Montana
Bozeman Health Deaconess Hospital, Bozeman, Montana
Saint James Community Hospital and Cancer Treatment Center, Butte, Montana
Benefis Sletten Cancer Institute, Great Falls, Montana
Logan Health Medical Center, Kalispell, Montana
Nebraska Cancer Specialists/Oncology Hematology West PC, Grand Island, Nebraska
CHI Health Good Samaritan, Kearney, Nebraska
Cancer Partners of Nebraska, Lincoln, Nebraska
Nebraska Methodist Hospital, Omaha, Nebraska
Alegent Health Immanuel Medical Center, Omaha, Nebraska
Alegent Health Bergan Mercy Medical Center, Omaha, Nebraska
University of Nebraska Medical Center, Omaha, Nebraska
OptumCare Cancer Care at Charleston, Las Vegas, Nevada
Radiation Oncology Centers of Nevada Central, Las Vegas, Nevada
Radiation Oncology Centers of Nevada Southeast, Las Vegas, Nevada
OptumCare Cancer Care at Fort Apache, Las Vegas, Nevada
Renown Regional Medical Center, Reno, Nevada
New Hampshire Oncology Hematology PA-Concord, Concord, New Hampshire
Dartmouth Hitchcock Medical Center/Dartmouth Cancer Center, Lebanon, New Hampshire
Solinsky Center for Cancer Care, Manchester, New Hampshire
Ocean University Medical Center, Brick, New Jersey
The Cancer Institute of New Jersey Hamilton, Hamilton, New Jersey
Monmouth Medical Center Southern Campus, Lakewood, New Jersey
Monmouth Medical Center, Long Branch, New Jersey
Southern Ocean County Medical Center, Manahawkin, New Jersey
Jersey Shore Medical Center, Neptune, New Jersey
Rutgers Cancer Institute of New Jersey, New Brunswick, New Jersey
Capital Health Medical Center-Hopewell, Pennington, New Jersey
Riverview Medical Center/Booker Cancer Center, Red Bank, New Jersey
Robert Wood Johnson University Hospital Somerset, Somerville, New Jersey
Community Medical Center, Toms River, New Jersey
University of New Mexico Cancer Center, Albuquerque, New Mexico
Montefiore Medical Center-Einstein Campus, Bronx, New York
Montefiore Medical Center - Moses Campus, Bronx, New York
The Cancer Institute at Saint Francis Hospital, East Hills, New York
Hematology Oncology Associates of Central New York-East Syracuse, East Syracuse, New York
Arnot Ogden Medical Center/Falck Cancer Center, Elmira, New York
Glens Falls Hospital, Glens Falls, New York
Mount Sinai Chelsea, New York, New York
Mount Sinai West, New York, New York
Mount Sinai Hospital, New York, New York
University of Rochester, Rochester, New York
State University of New York Upstate Medical University, Syracuse, New York
Good Samaritan University Hospital, West Islip, New York
Atrium Health Stanly/LCI-Albemarle, Albemarle, North Carolina
Randolph Hospital, Asheboro, North Carolina
Messino Cancer Centers, Asheville, North Carolina
Cone Health Cancer Center at Alamance Regional, Burlington, North Carolina
Carolinas Medical Center/Levine Cancer Institute, Charlotte, North Carolina
Novant Health Presbyterian Medical Center, Charlotte, North Carolina
Atrium Health Pineville/LCI-Pineville, Charlotte, North Carolina
Levine Cancer Institute-SouthPark, Charlotte, North Carolina
Atrium Health University City/LCI-University, Charlotte, North Carolina
Levine Cancer Institute-Ballantyne, Charlotte, North Carolina
Atrium Health Cabarrus/LCI-Concord, Concord, North Carolina
Cone Health Cancer Center, Greensboro, North Carolina
Margaret R Pardee Memorial Hospital, Hendersonville, North Carolina
Novant Health Cancer Institute - Kernersville, Kernersville, North Carolina
Atrium Health Union/LCI-Union, Monroe, North Carolina
Novant Health Cancer Institute - Mount Airy, Mount Airy, North Carolina
Novant Health Cancer Institute - Wilkesboro, North Wilkesboro, North Carolina
FirstHealth of the Carolinas-Moore Regional Hospital, Pinehurst, North Carolina
Novant Health Cancer Institute - Statesville, Statesville, North Carolina
Novant Health Cancer Institute - Thomasville, Thomasville, North Carolina
Novant Health Forsyth Medical Center, Winston-Salem, North Carolina
Wake Forest University Health Sciences, Winston-Salem, North Carolina
Sanford Bismarck Medical Center, Bismarck, North Dakota
Sanford Roger Maris Cancer Center, Fargo, North Dakota
Altru Cancer Center, Grand Forks, North Dakota
Trinity Cancer Care Center, Minot, North Dakota
Summa Health System - Akron Campus, Akron, Ohio
Summa Health System - Barberton Campus, Barberton, Ohio
UHHS-Chagrin Highlands Medical Center, Beachwood, Ohio
Cleveland Clinic Mercy Hospital, Canton, Ohio
Aultman Health Foundation, Canton, Ohio
Geauga Hospital, Chardon, Ohio
Adena Regional Medical Center, Chillicothe, Ohio
University of Cincinnati Cancer Center-UC Medical Center, Cincinnati, Ohio
Case Western Reserve University, Cleveland, Ohio
MetroHealth Medical Center, Cleveland, Ohio
Cleveland Clinic Cancer Center/Fairview Hospital, Cleveland, Ohio
Cleveland Clinic Foundation, Cleveland, Ohio
Ohio State University Comprehensive Cancer Center, Columbus, Ohio
Mount Carmel East Hospital, Columbus, Ohio
Riverside Methodist Hospital, Columbus, Ohio
Grant Medical Center, Columbus, Ohio
The Mark H Zangmeister Center, Columbus, Ohio
Mount Carmel Health Center West, Columbus, Ohio
Doctors Hospital, Columbus, Ohio
Delaware Health Center-Grady Cancer Center, Delaware, Ohio
Dublin Methodist Hospital, Dublin, Ohio
Mount Carmel Grove City Hospital, Grove City, Ohio
Cleveland Clinic Cancer Center Independence, Independence, Ohio
Saint Rita's Medical Center, Lima, Ohio
OhioHealth Mansfield Hospital, Mansfield, Ohio
Cleveland Clinic Cancer Center Mansfield, Mansfield, Ohio
Marietta Memorial Hospital, Marietta, Ohio
Hillcrest Hospital Cancer Center, Mayfield Heights, Ohio
Summa Health Medina Medical Center, Medina, Ohio
UH Seidman Cancer Center at Lake Health Mentor Campus, Mentor, Ohio
UH Seidman Cancer Center at Southwest General Hospital, Middleburg Heights, Ohio
Licking Memorial Hospital, Newark, Ohio
University Hospitals Parma Medical Center, Parma, Ohio
Mercy Health - Perrysburg Hospital, Perrysburg, Ohio
Southern Ohio Medical Center, Portsmouth, Ohio
University Hospitals Portage Medical Center, Ravenna, Ohio
North Coast Cancer Care, Sandusky, Ohio
UH Seidman Cancer Center at Firelands Regional Medical Center, Sandusky, Ohio
Cleveland Clinic Cancer Center Strongsville, Strongsville, Ohio
Mercy Health - Saint Vincent Hospital, Toledo, Ohio
Mercy Health - Saint Anne Hospital, Toledo, Ohio
University Hospitals Sharon Health Center, Wadsworth, Ohio
University of Cincinnati Cancer Center-West Chester, West Chester, Ohio
Saint Ann's Hospital, Westerville, Ohio
UH Seidman Cancer Center at Saint John Medical Center, Westlake, Ohio
UHHS-Westlake Medical Center, Westlake, Ohio
Cleveland Clinic Wooster Family Health and Surgery Center, Wooster, Ohio
Genesis Healthcare System Cancer Care Center, Zanesville, Ohio
Cancer Centers of Southwest Oklahoma Research, Lawton, Oklahoma
University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma
Mercy Hospital Oklahoma City, Oklahoma City, Oklahoma
Cancer Treatment Centers of America, Tulsa, Oklahoma
Legacy Mount Hood Medical Center, Gresham, Oregon
Providence Newberg Medical Center, Newberg, Oregon
Legacy Good Samaritan Hospital and Medical Center, Portland, Oregon
Providence Portland Medical Center, Portland, Oregon
Providence Saint Vincent Medical Center, Portland, Oregon
Lehigh Valley Hospital-Cedar Crest, Allentown, Pennsylvania
Lehigh Valley Hospital - Muhlenberg, Bethlehem, Pennsylvania
Crozer-Keystone Regional Cancer Center at Broomall, Broomall, Pennsylvania
Bryn Mawr Hospital, Bryn Mawr, Pennsylvania
Carlisle Regional Cancer Center, Carlisle, Pennsylvania
Christiana Care Health System-Concord Health Center, Chadds Ford, Pennsylvania
Geisinger Medical Center, Danville, Pennsylvania
Northeast Radiation Oncology Center, Dunmore, Pennsylvania
Ephrata Cancer Center, Ephrata, Pennsylvania
UPMC Cancer Center at UPMC Horizon, Farrell, Pennsylvania
Adams Cancer Center, Gettysburg, Pennsylvania
Crozer Regional Cancer Center at Brinton Lake, Glen Mills, Pennsylvania
WellSpan Medical Oncology and Hematology, Hanover, Pennsylvania
UPMC Pinnacle Cancer Center/Community Osteopathic Campus, Harrisburg, Pennsylvania
Lancaster General Ann B Barshinger Cancer Institute, Lancaster, Pennsylvania
Lancaster General Hospital, Lancaster, Pennsylvania
Sechler Family Cancer Center, Lebanon, Pennsylvania
Geisinger Medical Oncology-Lewisburg, Lewisburg, Pennsylvania
UPMC Hillman Cancer Center at Rocco And Nancy Ortenzio Cancer Pavilion, Mechanicsburg, Pennsylvania
Riddle Memorial Hospital, Media, Pennsylvania
Bryn Mawr Health Center, Newtown Square, Pennsylvania
Paoli Memorial Hospital, Paoli, Pennsylvania
Thomas Jefferson University Hospital, Philadelphia, Pennsylvania
Jefferson Torresdale Hospital, Philadelphia, Pennsylvania
Eastern Regional Medical Center, Philadelphia, Pennsylvania
Allegheny General Hospital, Pittsburgh, Pennsylvania
University of Pittsburgh Cancer Institute (UPCI), Pittsburgh, Pennsylvania
UPMC-Shadyside Hospital, Pittsburgh, Pennsylvania
Guthrie Medical Group PC-Robert Packer Hospital, Sayre, Pennsylvania
Reading Hospital, West Reading, Pennsylvania
Geisinger Wyoming Valley/Henry Cancer Center, Wilkes-Barre, Pennsylvania
Lankenau Medical Center, Wynnewood, Pennsylvania
WellSpan Health-York Cancer Center, York, Pennsylvania
UPMC Memorial, York, Pennsylvania
Rhode Island Hospital, Providence, Rhode Island
AnMed Health Cancer Center, Anderson, South Carolina
Saint Joseph's/Candler - Bluffton Campus, Bluffton, South Carolina
Medical University of South Carolina, Charleston, South Carolina
Saint Francis Hospital, Greenville, South Carolina
Prisma Health Cancer Institute - Faris, Greenville, South Carolina
Saint Francis Cancer Center, Greenville, South Carolina
Prisma Health Cancer Institute - Eastside, Greenville, South Carolina
Prisma Health Cancer Institute - Greer, Greer, South Carolina
Gibbs Cancer Center-Pelham, Greer, South Carolina
South Carolina Cancer Specialists PC, Hilton Head Island, South Carolina
The Radiation Oncology Center-Hilton Head/Bluffton, Hilton Head Island, South Carolina
Carolina Regional Cancer Center, Myrtle Beach, South Carolina
Rock Hill Radiation Therapy Center, Rock Hill, South Carolina
Levine Cancer Institute-Rock Hill, Rock Hill, South Carolina
Prisma Health Cancer Institute - Seneca, Seneca, South Carolina
Spartanburg Medical Center, Spartanburg, South Carolina
Rapid City Regional Hospital, Rapid City, South Dakota
Sanford Cancer Center Oncology Clinic, Sioux Falls, South Dakota
Sanford USD Medical Center - Sioux Falls, Sioux Falls, South Dakota
Baptist Memorial Hospital and Cancer Center-Collierville, Collierville, Tennessee
Thompson Cancer Survival Center, Knoxville, Tennessee
Baptist Memorial Hospital and Cancer Center-Memphis, Memphis, Tennessee
MD Anderson in The Woodlands, Conroe, Texas
Houston Methodist Hospital, Houston, Texas
M D Anderson Cancer Center, Houston, Texas
MD Anderson West Houston, Houston, Texas
Houston Methodist West Hospital, Houston, Texas
MD Anderson League City, League City, Texas
Covenant Medical Center-Lakeside, Lubbock, Texas
Houston Methodist Saint John Hospital, Nassau Bay, Texas
MD Anderson in Sugar Land, Sugar Land, Texas
Houston Methodist Sugar Land Hospital, Sugar Land, Texas
Houston Methodist The Woodlands Hospital, The Woodlands, Texas
Huntsman Cancer Institute/University of Utah, Salt Lake City, Utah
Central Vermont Medical Center/National Life Cancer Treatment, Berlin, Vermont
University of Vermont Medical Center, Burlington, Vermont
Dartmouth Cancer Center - North, Saint Johnsbury, Vermont
University of Virginia Cancer Center, Charlottesville, Virginia
Augusta Health Center for Cancer and Blood Disorders, Fishersville, Virginia
VCU Massey Cancer Center at Stony Point, Richmond, Virginia
VCU Massey Comprehensive Cancer Center, Richmond, Virginia
Providence Regional Cancer System-Aberdeen, Aberdeen, Washington
Providence Regional Cancer System-Lacey, Lacey, Washington
Saint Michael Cancer Center, Silverdale, Washington
Legacy Salmon Creek Hospital, Vancouver, Washington
Edwards Comprehensive Cancer Center, Huntington, West Virginia
West Virginia University Healthcare, Morgantown, West Virginia
Wheeling Hospital/Schiffler Cancer Center, Wheeling, West Virginia
Langlade Hospital and Cancer Center, Antigo, Wisconsin
ThedaCare Regional Cancer Center, Appleton, Wisconsin
Aurora Cancer Care-Southern Lakes VLCC, Burlington, Wisconsin
Marshfield Medical Center-EC Cancer Center, Eau Claire, Wisconsin
Mayo Clinic Health System-Eau Claire Clinic, Eau Claire, Wisconsin
Aurora Health Care Germantown Health Center, Germantown, Wisconsin
Aurora Cancer Care-Grafton, Grafton, Wisconsin
Bellin Memorial Hospital, Green Bay, Wisconsin
Aurora BayCare Medical Center, Green Bay, Wisconsin
University of Wisconsin Carbone Cancer Center - Johnson Creek, Johnson Creek, Wisconsin
Aurora Cancer Care-Kenosha South, Kenosha, Wisconsin
Gundersen Lutheran Medical Center, La Crosse, Wisconsin
Mayo Clinic Health System-Franciscan Healthcare, La Crosse, Wisconsin
University of Wisconsin Carbone Cancer Center - University Hospital, Madison, Wisconsin
Aurora Bay Area Medical Group-Marinette, Marinette, Wisconsin
Marshfield Medical Center-Marshfield, Marshfield, Wisconsin
Aurora Cancer Care-Milwaukee, Milwaukee, Wisconsin
Aurora Saint Luke's Medical Center, Milwaukee, Wisconsin
Aurora Sinai Medical Center, Milwaukee, Wisconsin
Zablocki Veterans Administration Medical Center, Milwaukee, Wisconsin
Marshfield Medical Center - Minocqua, Minocqua, Wisconsin
ProHealth D N Greenwald Center, Mukwonago, Wisconsin
Cancer Center of Western Wisconsin, New Richmond, Wisconsin
ProHealth Oconomowoc Memorial Hospital, Oconomowoc, Wisconsin
Vince Lombardi Cancer Clinic - Oshkosh, Oshkosh, Wisconsin
Aurora Cancer Care-Racine, Racine, Wisconsin
Marshfield Medical Center-Rice Lake, Rice Lake, Wisconsin
Vince Lombardi Cancer Clinic-Sheboygan, Sheboygan, Wisconsin
Marshfield Medical Center-River Region at Stevens Point, Stevens Point, Wisconsin
Aurora Medical Center in Summit, Summit, Wisconsin
Vince Lombardi Cancer Clinic-Two Rivers, Two Rivers, Wisconsin
UW Cancer Center at ProHealth Care, Waukesha, Wisconsin
Aspirus Regional Cancer Center, Wausau, Wisconsin
Aurora Cancer Care-Milwaukee West, Wauwatosa, Wisconsin
Aurora West Allis Medical Center, West Allis, Wisconsin
Diagnostic and Treatment Center, Weston, Wisconsin
Marshfield Medical Center - Weston, Weston, Wisconsin
Aspirus Cancer Care - Wisconsin Rapids, Wisconsin Rapids, Wisconsin
Tohoku University School of Medicine, Sendai, Aoba-ku
Ehime University Hospital, Toon, Ehime
Hokkaido University Hospital, Sapporo, Hokkaido
Kagoshima City Hospital, Kagoshima City, Kagoshima
Gunma University Hospital, Gunma, Maebashi
Niigata University Medical and Dental Hospital, Niigata City, Niigata
Kyorin University Hospital, Mitaka-shi, Tokyo
Hiroshima University Hospital, Hiroshima City, Not set
Shikoku Cancer Center, Matsuyama, Not set
Saitama Medical University International Medical Center, Saitama, Not set
Conditions: Limited Stage Lung Small Cell Carcinoma, Stage I Lung Cancer AJCC v8, Stage II Lung Cancer AJCC v8, Stage III Lung Cancer AJCC v8
A Trial to Learn if the Combination of Fianlimab, Cemiplimab, and Chemotherapy is Safe and Works Better Than the Combination of Cemiplimab and Chemotherapy in Adult Patients With Non-Small Cell Lung Cancer That Can be Treated With Surgery
Recruiting
This study is researching an experimental drug called fianlimab (also called REGN3767) with two other medications called cemiplimab and platinum-doublet chemotherapy, individually called a "study drug" or collectively called "study drugs", when combined in this study. The study is being conducted in patients who have resectable stage II to IIIB (N2) non-small cell lung cancer (NSCLC) that can be treated with surgery.
The aim of the study is to see how effective the combination of fianlimab, cem... Read More
This study is researching an experimental drug called fianlimab (also called REGN3767) with two other medications called cemiplimab and platinum-doublet chemotherapy, individually called a "study drug" or collectively called "study drugs", when combined in this study. The study is being conducted in patients who have resectable stage II to IIIB (N2) non-small cell lung cancer (NSCLC) that can be treated with surgery.
The aim of the study is to see how effective the combination of fianlimab, cemiplimab, and chemotherapy is in comparison with cemiplimab and chemotherapy as peri-operative therapy in participants with NSCLC.
The study is looking at several other research questions, including:
* What side effects may happen from taking the study drugs
* How much of each study drug is in the blood at different times
* Whether the body makes antibodies against the study drugs (which could make the drugs less effective or could lead to side effects)
* How administering the study drugs might affect quality of life Read Less
Gender:
ALL
Ages:
18 years and above
Trial Updated:
08/22/2025
Locations: University of Alabama at Birmingham, Birmingham, Alabama +117 locations
University of Alabama at Birmingham, Birmingham, Alabama
Clermont Oncology Center, Clermont, Florida
Mid Florida Hematology and Oncology Center, Orange City, Florida
University of Illinois, Chicago, Illinois
University of Kansas Cancer Center-Westwood, Westwood, Kansas
Henry Ford Health System, Detroit, Michigan
Mercy South, Saint Louis, Missouri
Summit Medical Group, Florham Park, New Jersey
University of Rochester, Rochester, New York
Kaiser Permanente Northwest, Portland, Oregon
Virginia Cancer Care Specialist, PC, Fairfax, Virginia
Eastern Health, Box Hill, Victoria
St Vincent's Hospital, Fitzroy, Victoria
St John of God Murdoch Hospital, Murdoch, Western Australia
Orlandi Oncologia, Providencia, Metropolitan Region
Clinica Santa Maria, Santiago, Providencia
Centro de Oncologia de Precision, Las Condes, Region Metropolitana, Santiago
Oncocentro APYS, Vina del Mar, Valparaiso
Centre de Oncologie de Gentilly, Nancy, Grand Est
Chi Creteil, Creteil, Ile De France
Institut de Cancerologie de l'Ouest, Saint Herblain, Nantes
Centre Hospitalier Universitaire (CHU) Bordeaux, Bordeaux, Nouvelle Aquitaine
CHU Limoges, Limoges, Nouvelle Aquitaine
APHP - Hopital Ambroise Pare, Boulogne-Billancourt, Not set
CHU Dijon, Dijon, Not set
Uneos - Hopital R Schuman, Metz-Vantoux, Not set
Centre Hospitalier Universitaire de Nantes Hopital Guillaume et Rene Laennec, Nantes, Not set
Llc Todua Clinic, Tbilisi, Caucasus
Cancer Center of Adjara, Batumi, Not set
Israeli Georgian Medical Research Clinic Helsicore, Tbilisi, Not set
LTD New Hospitals, Tbilisi, Not set
High Technology Medical Center, University Clinic Tbilisi, Tbilisi, Not set
Institute of Clinical Oncology, Tbilisi, Not set
JSC K. Eristavi National Center of Experimental and Clinical Surgery, Tbilisi, Not set
TIM - Tbilisi Institute of Medicine, Tbilisi, Not set
Multiprofile Clinic Consilium Medulla, Tbilisi, Not set
LKI LUngenfachklinik Immenhausen, Immenhausen, Hesse
Evang. Kliniken Essen-Mitte, Essen, North Rhine Westphalia
LungenClinic, Grosshansdorf, Schleswig-Holstein
Klinikum Esslingen, Esslingen, Not set
Asklepios Klinikum Harburg, Hamburg, Not set
MVZ fuer Haematologie und Onkologie Rhein-Kreis GmbH, Neuss, Not set
UOC Oncoematologia AOU Vanvitelli, Naples, Campania
AUSL Piacenza, Piacenza, Emilia Romagna
Azienda Ospedaliero-Universitaria Ferrara (AOU Ferrara), Ferrara, Emilia-Romagna
ASST Ospedale Papa Giovanni XXIII, Bergamo, Lombardy
Azienda Sanitaria Territoriale di Pesaro e Urbino, Pesaro, Pesaro And Urbino
Azienda Ospedaliera Nazionale SS Antonio e Biagio e Cesare Arrigo, Alessandria, Piedmont
Centro di Riferimento Oncologico (CRO) - Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS), Aviano, Pordenone
FPO- IRCCS, Istituto di Candiolo, Candiolo, Turin
UOC Oncologia Medica Ospedale Civile di Livorno Azienda Usl Toscana Nord Ovest, Livorno, Not set
Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milano, Not set
Niguarda Cancer Center, Milano, Not set
Azienda Ospedaliero-Universitaria Maggiore della Carita, Novara, Not set
Fondazione IRCCS Policlinico San Matteo, Pavia, Not set
Fondazione Policlinico Universitario Campus Bio-Medico, Roma, Not set
Instituto Fisioterapici Ospitalieri (IFO) Istituto Regina Elena, Rome, Not set
The Catholic University of Korea St Vincents Hospital, Suwon-si, Gyeonggi-do
Ajou University Hospital, Suwon-si, Gyeonggi-do
National Cancer Center, Gyeonggi do, Gyeonggi
Gachon University Gil Medical Center, Incheon, Namdong-Gu
Chonnam National University Hwasun Hospital, Hwasun, South Jeolla
Inha University Hospital, Incheon, Not set
Asan Medical Center, Seoul, Not set
Korea University Guro Hospital, Seoul, Not set
Ulsan University Hospital, Ulsan, Not set
University of Malaya Medical Centre, Kuala Lumpur, Negeri / Wilayah Persekutuan
Hospital Pulau Pinang, Georgetown, Pulau Pinang
Hospital Kuala Lumpur, Kuala Lumpur, Wilayah Persekutuan
Hospital Umum Sarawak, Kuching, Not set
Institute of Oncology Bucharest, Bucharest, Bucuresti
Cardiomed, Cluj-Napoca, Cluj
Medisprof Cancer Center, Cluj-Napoca, Cluj
Oncocenter Oncologie Clinica S.R.L, Timisoara, Timis
Oncomed, Timisoara, Timis
Sc Focus Lab Plus Srl (Centrul Medical Focus), Bucharest, Not set
Hospital Clinico Universitario Santiago de Compostela, Santiago de Compostela, A Coruna
Hospital Universitario Virgen de las Nieves, Granada, Andalusia
Hospital Universitario Central de Asturias, Oviedo, Asturias
Son Espases, Palma, Balearic Islands
IOB Institute of Oncology Quiron, Barcelona, Catalonia
Instituto Oncologico Dr Rosell, Barcelona, Catalunya
Hospital Universitario Puerta de Hierro - Majadahonda, Majadahonda, Madrid
Hospital Universitario Virgen de la Arrixaca, El Palmar, Murcia
Hospital Universitario de Navarra, Pamplona, Navarra
Alvaro Cunqueiro Hospital, Vigo, Pontevedra
Althaia - Xarxa Assistencial Universitaria de Manresa - Orde Hospitalaria de Sant Joan de Deu, Barcelona, Not set
Catalan Institute of Oncology, Girona, Not set
Hospital Universitario Lucus Augusti, Lugo, Not set
Fundacion Jimenez Diaz, Madrid, Not set
Hospital 12 de Octubre, Madrid, Not set
Hospital De Valme, Sevilla, Not set
Fundacion IVO, Valencia, Not set
Universitat de Valencia - Hospital Universitari i Politecnic La Fe de Valencia (Hospital La Fe Bulevar Sur), Valencia, Not set
Changhua Christian Hospital, Changhua City, Changhua County
Kaohsiung Medical University Chung-Ho Memorial Hospital, Kaohsiung, Sanmin
Hualien Tzu Chi Hospital, Hualien City, Not set
Taipei Medical University Shuang Ho Hospital, New Taipei City, Not set
Chung Shan Medical University, Taichung, Not set
Tri-Service General Hospital, Taipei City, Not set
National Taiwan University Hospital, Taipei, Not set
Taipei Medical University Hospital, Taipei, Not set
Taipei Municipal Wan Fang Hospital, Taipei, Not set
Ege University Faculty of Medicine, Bornova, Izmir
Kocaeli University Hospital, Kocaeli, Marmara
Faculty of Medicine of Sakarya University, Sakarya, Marmara
Necmettin Erbakan University Meram Faculty of Medicine, Konya, Meram
Ondokuz Mayıs University, Kurupelit, Samsun
Acibadem Adana Hastanesi, Adana, Seyhan
Adana City Education and Research Hospital, Adana, Yuregir
Gulhane Training and Research Hospital, Ankara, Not set
Liv Hospital Ankara, Ankara, Not set
Hacettepe University Cancer Institute, Ankara, Not set
Memorial Ankara Hospital, Ankara, Not set
Medical Point Gaziantep Hastanesi, Gaziantep, Not set
Koc University, Istanbul, Not set
Bezmialem Vakif University, Istanbul, Not set
Istanbul Medeniyet University Prof.Dr.Suleyman Yalcin Şehir Hospital, Istanbul, Not set
Conditions: Resectable Non-small Cell Lung Cancer
Dinutuximab With Chemotherapy, Surgery and Stem Cell Transplantation for the Treatment of Children With Newly Diagnosed High Risk Neuroblastoma
Recruiting
This phase III trial tests how well the addition of dinutuximab to Induction chemotherapy along with standard of care surgical resection of the primary tumor, radiation, stem cell transplantation, and immunotherapy works for treating children with newly diagnosed high-risk neuroblastoma. Dinutuximab is a monoclonal antibody that binds to a molecule called GD2, which is found on the surface of neuroblastoma cells, but is not present on many healthy or normal cells in the body. When dinutuximab bi... Read More
This phase III trial tests how well the addition of dinutuximab to Induction chemotherapy along with standard of care surgical resection of the primary tumor, radiation, stem cell transplantation, and immunotherapy works for treating children with newly diagnosed high-risk neuroblastoma. Dinutuximab is a monoclonal antibody that binds to a molecule called GD2, which is found on the surface of neuroblastoma cells, but is not present on many healthy or normal cells in the body. When dinutuximab binds to the neuroblastoma cells, it helps signal the immune system to kill the tumor cells. This helps the cells of the immune system kill the cancer cells, this is a type of immunotherapy. When chemotherapy and immunotherapy are given together, during the same treatment cycle, it is called chemoimmunotherapy. This clinical trial randomly assigns patients to receive either standard chemotherapy and surgery or chemoimmunotherapy (chemotherapy plus dinutuximab) and surgery during Induction therapy. Chemotherapy drugs administered during Induction include, cyclophosphamide, topotecan, cisplatin, etoposide, vincristine, and doxorubicin. These drugs work in different ways to stop the growth of cancer cells, either by killing the cells, by stopping them from dividing or by stopping them from spreading. Upon completion of 5 cycles of Induction therapy, a disease evaluation is completed to determine how well the treatment worked. If the tumor responds to therapy, patients receive a tandem transplantation with stem cell rescue. If the tumor has little improvement or worsens, patients receive chemoimmunotherapy on Extended Induction. During Extended Induction, dinutuximab is given with irinotecan, temozolomide. Patients with a good response to therapy move on to Consolidation therapy, when very high doses of chemotherapy are given at two separate points to kill any remaining cancer cells. Following, transplant, radiation therapy is given to the site where the cancer originated (primary site) and to any other areas that are still active at the end of Induction. The final stage of therapy is Post-Consolidation. During Post-Consolidation, dinutuximab is given with isotretinoin, with the goal of maintaining the response achieved with the previous therapy. Adding dinutuximab to Induction chemotherapy along with standard of care surgical resection of the primary tumor, radiation, stem cell transplantation, and immunotherapy may be better at treating children with newly diagnosed high-risk neuroblastoma. Read Less
Gender:
ALL
Ages:
30 years and below
Trial Updated:
08/22/2025
Locations: Children's Hospital of Alabama, Birmingham, Alabama +162 locations
Children's Hospital of Alabama, Birmingham, Alabama
USA Health Strada Patient Care Center, Mobile, Alabama
Banner Children's at Desert, Mesa, Arizona
Phoenix Childrens Hospital, Phoenix, Arizona
Banner University Medical Center - Tucson, Tucson, Arizona
Arkansas Children's Hospital, Little Rock, Arkansas
Kaiser Permanente Downey Medical Center, Downey, California
City of Hope Comprehensive Cancer Center, Duarte, California
Loma Linda University Medical Center, Loma Linda, California
Miller Children's and Women's Hospital Long Beach, Long Beach, California
Children's Hospital Los Angeles, Los Angeles, California
Cedars Sinai Medical Center, Los Angeles, California
Mattel Children's Hospital UCLA, Los Angeles, California
Valley Children's Hospital, Madera, California
UCSF Benioff Children's Hospital Oakland, Oakland, California
Kaiser Permanente-Oakland, Oakland, California
Children's Hospital of Orange County, Orange, California
Lucile Packard Children's Hospital Stanford University, Palo Alto, California
University of California Davis Comprehensive Cancer Center, Sacramento, California
UCSF Medical Center-Mission Bay, San Francisco, California
Children's Hospital Colorado, Aurora, Colorado
Connecticut Children's Medical Center, Hartford, Connecticut
Yale University, New Haven, Connecticut
Alfred I duPont Hospital for Children, Wilmington, Delaware
Children's National Medical Center, Washington, District of Columbia
Broward Health Medical Center, Fort Lauderdale, Florida
Golisano Children's Hospital of Southwest Florida, Fort Myers, Florida
University of Florida Health Science Center - Gainesville, Gainesville, Florida
Memorial Regional Hospital/Joe DiMaggio Children's Hospital, Hollywood, Florida
Nemours Children's Clinic-Jacksonville, Jacksonville, Florida
University of Miami Miller School of Medicine-Sylvester Cancer Center, Miami, Florida
Nicklaus Children's Hospital, Miami, Florida
AdventHealth Orlando, Orlando, Florida
Arnold Palmer Hospital for Children, Orlando, Florida
Nemours Children's Hospital, Orlando, Florida
Johns Hopkins All Children's Hospital, Saint Petersburg, Florida
Saint Mary's Medical Center, West Palm Beach, Florida
Children's Healthcare of Atlanta - Arthur M Blank Hospital, Atlanta, Georgia
Lurie Children's Hospital-Chicago, Chicago, Illinois
University of Illinois, Chicago, Illinois
University of Chicago Comprehensive Cancer Center, Chicago, Illinois
Advocate Children's Hospital-Oak Lawn, Oak Lawn, Illinois
Advocate Children's Hospital-Park Ridge, Park Ridge, Illinois
Saint Jude Midwest Affiliate, Peoria, Illinois
Southern Illinois University School of Medicine, Springfield, Illinois
Riley Hospital for Children, Indianapolis, Indiana
Blank Children's Hospital, Des Moines, Iowa
University of Iowa/Holden Comprehensive Cancer Center, Iowa City, Iowa
Wesley Medical Center, Wichita, Kansas
University of Kentucky/Markey Cancer Center, Lexington, Kentucky
Norton Children's Hospital, Louisville, Kentucky
Children's Hospital New Orleans, New Orleans, Louisiana
Eastern Maine Medical Center, Bangor, Maine
Maine Children's Cancer Program, Scarborough, Maine
University of Maryland/Greenebaum Cancer Center, Baltimore, Maryland
Sinai Hospital of Baltimore, Baltimore, Maryland
Johns Hopkins University/Sidney Kimmel Cancer Center, Baltimore, Maryland
Massachusetts General Hospital Cancer Center, Boston, Massachusetts
Dana-Farber Cancer Institute, Boston, Massachusetts
C S Mott Children's Hospital, Ann Arbor, Michigan
Children's Hospital of Michigan, Detroit, Michigan
Corewell Health Grand Rapids Hospitals - Helen DeVos Children's Hospital, Grand Rapids, Michigan
Bronson Methodist Hospital, Kalamazoo, Michigan
Corewell Health Children's, Royal Oak, Michigan
Children's Hospitals and Clinics of Minnesota - Minneapolis, Minneapolis, Minnesota
University of Minnesota/Masonic Cancer Center, Minneapolis, Minnesota
Mayo Clinic in Rochester, Rochester, Minnesota
University of Mississippi Medical Center, Jackson, Mississippi
Children's Mercy Hospitals and Clinics, Kansas City, Missouri
Washington University School of Medicine, Saint Louis, Missouri
Mercy Hospital Saint Louis, Saint Louis, Missouri
Children's Hospital and Medical Center of Omaha, Omaha, Nebraska
University of Nebraska Medical Center, Omaha, Nebraska
Dartmouth Hitchcock Medical Center/Dartmouth Cancer Center, Lebanon, New Hampshire
Hackensack University Medical Center, Hackensack, New Jersey
Morristown Medical Center, Morristown, New Jersey
Saint Peter's University Hospital, New Brunswick, New Jersey
Rutgers Cancer Institute of New Jersey-Robert Wood Johnson University Hospital, New Brunswick, New Jersey
Saint Joseph's Regional Medical Center, Paterson, New Jersey
University of New Mexico Cancer Center, Albuquerque, New Mexico
Albany Medical Center, Albany, New York
Montefiore Medical Center - Moses Campus, Bronx, New York
Roswell Park Cancer Institute, Buffalo, New York
NYU Langone Hospital - Long Island, Mineola, New York
The Steven and Alexandra Cohen Children's Medical Center of New York, New Hyde Park, New York
Laura and Isaac Perlmutter Cancer Center at NYU Langone, New York, New York
NYP/Columbia University Medical Center/Herbert Irving Comprehensive Cancer Center, New York, New York
University of Rochester, Rochester, New York
New York Medical College, Valhalla, New York
Mission Hospital, Asheville, North Carolina
UNC Lineberger Comprehensive Cancer Center, Chapel Hill, North Carolina
Carolinas Medical Center/Levine Cancer Institute, Charlotte, North Carolina
Novant Health Presbyterian Medical Center, Charlotte, North Carolina
Duke University Medical Center, Durham, North Carolina
East Carolina University, Greenville, North Carolina
Wake Forest University Health Sciences, Winston-Salem, North Carolina
Sanford Broadway Medical Center, Fargo, North Dakota
Children's Hospital Medical Center of Akron, Akron, Ohio
Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio
Rainbow Babies and Childrens Hospital, Cleveland, Ohio
Cleveland Clinic Foundation, Cleveland, Ohio
Nationwide Children's Hospital, Columbus, Ohio
Dayton Children's Hospital, Dayton, Ohio
ProMedica Toledo Hospital/Russell J Ebeid Children's Hospital, Toledo, Ohio
University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma
Natalie Warren Bryant Cancer Center at Saint Francis, Tulsa, Oklahoma
Legacy Emanuel Children's Hospital, Portland, Oregon
Oregon Health and Science University, Portland, Oregon
Geisinger Medical Center, Danville, Pennsylvania
Children's Hospital of Philadelphia, Philadelphia, Pennsylvania
Saint Christopher's Hospital for Children, Philadelphia, Pennsylvania
Children's Hospital of Pittsburgh of UPMC, Pittsburgh, Pennsylvania
Rhode Island Hospital, Providence, Rhode Island
Medical University of South Carolina, Charleston, South Carolina
Prisma Health Richland Hospital, Columbia, South Carolina
BI-LO Charities Children's Cancer Center, Greenville, South Carolina
Sanford USD Medical Center - Sioux Falls, Sioux Falls, South Dakota
East Tennessee Childrens Hospital, Knoxville, Tennessee
Saint Jude Children's Research Hospital, Memphis, Tennessee
The Children's Hospital at TriStar Centennial, Nashville, Tennessee
Vanderbilt University/Ingram Cancer Center, Nashville, Tennessee
Dell Children's Medical Center of Central Texas, Austin, Texas
Driscoll Children's Hospital, Corpus Christi, Texas
Medical City Dallas Hospital, Dallas, Texas
UT Southwestern/Simmons Cancer Center-Dallas, Dallas, Texas
El Paso Children's Hospital, El Paso, Texas
Cook Children's Medical Center, Fort Worth, Texas
Baylor College of Medicine/Dan L Duncan Comprehensive Cancer Center, Houston, Texas
M D Anderson Cancer Center, Houston, Texas
Covenant Children's Hospital, Lubbock, Texas
UMC Cancer Center / UMC Health System, Lubbock, Texas
Children's Hospital of San Antonio, San Antonio, Texas
Methodist Children's Hospital of South Texas, San Antonio, Texas
University of Texas Health Science Center at San Antonio, San Antonio, Texas
Primary Children's Hospital, Salt Lake City, Utah
University of Virginia Cancer Center, Charlottesville, Virginia
Naval Medical Center - Portsmouth, Portsmouth, Virginia
Seattle Children's Hospital, Seattle, Washington
Providence Sacred Heart Medical Center and Children's Hospital, Spokane, Washington
Mary Bridge Children's Hospital and Health Center, Tacoma, Washington
University of Wisconsin Carbone Cancer Center - University Hospital, Madison, Wisconsin
Marshfield Medical Center-Marshfield, Marshfield, Wisconsin
Children's Hospital of Wisconsin, Milwaukee, Wisconsin
Sydney Children's Hospital, Randwick, New South Wales
The Children's Hospital at Westmead, Westmead, New South Wales
Queensland Children's Hospital, South Brisbane, Queensland
Royal Children's Hospital, Parkville, Victoria
Perth Children's Hospital, Perth, Western Australia
Alberta Children's Hospital, Calgary, Alberta
University of Alberta Hospital, Edmonton, Alberta
British Columbia Children's Hospital, Vancouver, British Columbia
CancerCare Manitoba, Winnipeg, Manitoba
IWK Health Centre, Halifax, Nova Scotia
McMaster Children's Hospital at Hamilton Health Sciences, Hamilton, Ontario
Children's Hospital, London, Ontario
Children's Hospital of Eastern Ontario, Ottawa, Ontario
Hospital for Sick Children, Toronto, Ontario
The Montreal Children's Hospital of the MUHC, Montreal, Quebec
Centre Hospitalier Universitaire Sainte-Justine, Montreal, Quebec
Centre Hospitalier Universitaire de Sherbrooke-Fleurimont, Sherbrooke, Quebec
Jim Pattison Children's Hospital, Saskatoon, Saskatchewan
CHU de Quebec-Centre Hospitalier de l'Universite Laval (CHUL), Quebec, Not set
Starship Children's Hospital, Grafton, Auckland
Conditions: Neuroblastoma, Ganglioneuroblastoma, Nodular
Evaluating the Addition of the Immunotherapy Drug Atezolizumab to Standard Chemotherapy Treatment for Advanced or Metastatic Neuroendocrine Carcinomas That Originate Outside the Lung
Recruiting
This phase II/III trial compares the effect of immunotherapy with atezolizumab in combination with standard chemotherapy with a platinum drug (cisplatin or carboplatin) and etoposide versus standard therapy alone for the treatment of poorly differentiated extrapulmonary (originated outside the lung) neuroendocrine cancer that may have spread from where it first started to nearby tissue, lymph nodes, or distant parts of the body (advanced) or that has spread from where it first started (primary s... Read More
This phase II/III trial compares the effect of immunotherapy with atezolizumab in combination with standard chemotherapy with a platinum drug (cisplatin or carboplatin) and etoposide versus standard therapy alone for the treatment of poorly differentiated extrapulmonary (originated outside the lung) neuroendocrine cancer that may have spread from where it first started to nearby tissue, lymph nodes, or distant parts of the body (advanced) or that has spread from where it first started (primary site) to other places in the body (metastatic). The other aim of this trial is to compare using atezolizumab just at the beginning of treatment versus continuing it beyond the initial treatment. Immunotherapy with monoclonal antibodies, such as atezolizumab, may help the body's immune system attack the cancer, and may interfere with the ability of tumor cells to grow and spread. Cisplatin and carboplatin are in a class of medications known as platinum-containing compounds that work by killing, stopping or slowing the growth of cancer cells. Etoposide is in a class of medications known as podophyllotoxin derivatives. It blocks a certain enzyme needed for cell division and DNA repair, and it may kill cancer cells. Giving atezolizumab in combination with a platinum drug (cisplatin or carboplatin) and etoposide may work better in treating patients with poorly differentiated extrapulmonary neuroendocrine cancer compared to standard therapy with a platinum drug (cisplatin or carboplatin) and etoposide alone. Read Less
Gender:
ALL
Ages:
18 years and above
Trial Updated:
08/22/2025
Locations: Alaska Women's Cancer Care, Anchorage, Alaska +221 locations
Alaska Women's Cancer Care, Anchorage, Alaska
Cancer Center at Saint Joseph's, Phoenix, Arizona
Mayo Clinic Hospital in Arizona, Phoenix, Arizona
Kaiser Permanente-Anaheim, Anaheim, California
Sutter Auburn Faith Hospital, Auburn, California
Sutter Cancer Centers Radiation Oncology Services-Auburn, Auburn, California
Kaiser Permanente-Baldwin Park, Baldwin Park, California
Kaiser Permanente-Bellflower, Bellflower, California
Alta Bates Summit Medical Center-Herrick Campus, Berkeley, California
Sutter Cancer Centers Radiation Oncology Services-Cameron Park, Cameron Park, California
Mercy Cancer Center - Carmichael, Carmichael, California
Mercy San Juan Medical Center, Carmichael, California
Mercy Cancer Center - Elk Grove, Elk Grove, California
Kaiser Permanente-Fontana, Fontana, California
Palo Alto Medical Foundation-Fremont, Fremont, California
Kaiser Permanente South Bay, Harbor City, California
Kaiser Permanente-Irvine, Irvine, California
Kaiser Permanente Los Angeles Medical Center, Los Angeles, California
Kaiser Permanente West Los Angeles, Los Angeles, California
Memorial Medical Center, Modesto, California
Palo Alto Medical Foundation-Camino Division, Mountain View, California
Kaiser Permanente-Ontario, Ontario, California
Palo Alto Medical Foundation Health Care, Palo Alto, California
Kaiser Permanente - Panorama City, Panorama City, California
Kaiser Permanente-Riverside, Riverside, California
Mercy Cancer Center - Rocklin, Rocklin, California
Sutter Cancer Centers Radiation Oncology Services-Roseville, Roseville, California
Sutter Roseville Medical Center, Roseville, California
Mercy Cancer Center - Sacramento, Sacramento, California
Sutter Medical Center Sacramento, Sacramento, California
Kaiser Permanente-San Diego Zion, San Diego, California
California Pacific Medical Center-Pacific Campus, San Francisco, California
Kaiser Permanente-San Marcos, San Marcos, California
Palo Alto Medical Foundation-Santa Cruz, Santa Cruz, California
Sutter Pacific Medical Foundation, Santa Rosa, California
Palo Alto Medical Foundation-Sunnyvale, Sunnyvale, California
Sutter Solano Medical Center/Cancer Center, Vallejo, California
Kaiser Permanente-Woodland Hills, Woodland Hills, California
Woodland Memorial Hospital, Woodland, California
AdventHealth Porter, Denver, Colorado
AdventHealth Parker, Parker, Colorado
Smilow Cancer Hospital-Derby Care Center, Derby, Connecticut
Smilow Cancer Hospital Care Center-Fairfield, Fairfield, Connecticut
Smilow Cancer Hospital Care Center at Glastonbury, Glastonbury, Connecticut
Smilow Cancer Hospital Care Center at Greenwich, Greenwich, Connecticut
Smilow Cancer Hospital Care Center - Guilford, Guilford, Connecticut
Smilow Cancer Hospital Care Center at Saint Francis, Hartford, Connecticut
Yale University, New Haven, Connecticut
Yale-New Haven Hospital North Haven Medical Center, North Haven, Connecticut
Smilow Cancer Hospital Care Center at Long Ridge, Stamford, Connecticut
Smilow Cancer Hospital-Torrington Care Center, Torrington, Connecticut
Smilow Cancer Hospital Care Center-Trumbull, Trumbull, Connecticut
Smilow Cancer Hospital-Waterbury Care Center, Waterbury, Connecticut
Smilow Cancer Hospital Care Center - Waterford, Waterford, Connecticut
Holy Cross Hospital, Fort Lauderdale, Florida
Mayo Clinic in Florida, Jacksonville, Florida
Moffitt Cancer Center, Tampa, Florida
Hawaii Cancer Care - Westridge, 'Aiea, Hawaii
Pali Momi Medical Center, 'Aiea, Hawaii
The Queen's Medical Center - West Oahu, 'Ewa Beach, Hawaii
Hawaii Cancer Care Inc - Waterfront Plaza, Honolulu, Hawaii
Queen's Cancer Cenrer - POB I, Honolulu, Hawaii
Queen's Medical Center, Honolulu, Hawaii
Straub Clinic and Hospital, Honolulu, Hawaii
Queen's Cancer Center - Kuakini, Honolulu, Hawaii
Centralia Oncology Clinic, Centralia, Illinois
Northwestern University, Chicago, Illinois
University of Chicago Comprehensive Cancer Center, Chicago, Illinois
Carle at The Riverfront, Danville, Illinois
Cancer Care Specialists of Illinois - Decatur, Decatur, Illinois
Decatur Memorial Hospital, Decatur, Illinois
Northwestern Medicine Cancer Center Kishwaukee, DeKalb, Illinois
Carle Physician Group-Effingham, Effingham, Illinois
Crossroads Cancer Center, Effingham, Illinois
Northwestern Medicine Cancer Center Delnor, Geneva, Illinois
Northwestern Medicine Glenview Outpatient Center, Glenview, Illinois
Northwestern Medicine Grayslake Outpatient Center, Grayslake, Illinois
Ingalls Memorial Hospital, Harvey, Illinois
Northwestern Medicine Lake Forest Hospital, Lake Forest, Illinois
Carle Physician Group-Mattoon/Charleston, Mattoon, Illinois
UC Comprehensive Cancer Center at Silver Cross, New Lenox, Illinois
Cancer Care Center of O'Fallon, O'Fallon, Illinois
Northwestern Medicine Orland Park, Orland Park, Illinois
University of Chicago Medicine-Orland Park, Orland Park, Illinois
UW Health Carbone Cancer Center Rockford, Rockford, Illinois
Southern Illinois University School of Medicine, Springfield, Illinois
Springfield Clinic, Springfield, Illinois
Springfield Memorial Hospital, Springfield, Illinois
Carle Cancer Center, Urbana, Illinois
Northwestern Medicine Cancer Center Warrenville, Warrenville, Illinois
Mary Greeley Medical Center, Ames, Iowa
McFarland Clinic - Ames, Ames, Iowa
UI Health Care Mission Cancer and Blood - Ankeny Clinic, Ankeny, Iowa
McFarland Clinic - Boone, Boone, Iowa
Saint Anthony Regional Hospital, Carroll, Iowa
Mercy Cancer Center-West Lakes, Clive, Iowa
UI Health Care Mission Cancer and Blood - West Des Moines Clinic, Clive, Iowa
Greater Regional Medical Center, Creston, Iowa
Iowa Methodist Medical Center, Des Moines, Iowa
UI Health Care Mission Cancer and Blood - Des Moines Clinic, Des Moines, Iowa
Broadlawns Medical Center, Des Moines, Iowa
Mercy Medical Center - Des Moines, Des Moines, Iowa
UI Health Care Mission Cancer and Blood - Laurel Clinic, Des Moines, Iowa
McFarland Clinic - Trinity Cancer Center, Fort Dodge, Iowa
McFarland Clinic - Jefferson, Jefferson, Iowa
McFarland Clinic - Marshalltown, Marshalltown, Iowa
UI Health Care Mission Cancer and Blood - Waukee Clinic, Waukee, Iowa
Mercy Medical Center-West Lakes, West Des Moines, Iowa
LSU Health Baton Rouge-North Clinic, Baton Rouge, Louisiana
Our Lady of the Lake Physician Group, Baton Rouge, Louisiana
East Jefferson General Hospital, Metairie, Louisiana
LSU Healthcare Network / Metairie Multi-Specialty Clinic, Metairie, Louisiana
University Medical Center New Orleans, New Orleans, Louisiana
Trinity Health Saint Joseph Mercy Hospital Ann Arbor, Ann Arbor, Michigan
University of Michigan Comprehensive Cancer Center, Ann Arbor, Michigan
Bronson Battle Creek, Battle Creek, Michigan
Trinity Health IHA Medical Group Hematology Oncology - Brighton, Brighton, Michigan
Trinity Health Medical Center - Brighton, Brighton, Michigan
Henry Ford Cancer Institute-Downriver, Brownstown, Michigan
Trinity Health IHA Medical Group Hematology Oncology - Canton, Canton, Michigan
Trinity Health Medical Center - Canton, Canton, Michigan
Chelsea Hospital, Chelsea, Michigan
Trinity Health IHA Medical Group Hematology Oncology - Chelsea Hospital, Chelsea, Michigan
Henry Ford Macomb Hospital-Clinton Township, Clinton Township, Michigan
Corewell Health Dearborn Hospital, Dearborn, Michigan
Wayne State University/Karmanos Cancer Institute, Detroit, Michigan
Henry Ford Hospital, Detroit, Michigan
Henry Ford Health Saint John Hospital, Detroit, Michigan
Weisberg Cancer Treatment Center, Farmington Hills, Michigan
Corewell Health Farmington Hills Hospital, Farmington Hills, Michigan
Cancer Hematology Centers - Flint, Flint, Michigan
Genesee Hematology Oncology PC, Flint, Michigan
Genesys Hurley Cancer Institute, Flint, Michigan
Hurley Medical Center, Flint, Michigan
Corewell Health Grand Rapids Hospitals - Butterworth Hospital, Grand Rapids, Michigan
Trinity Health Grand Rapids Hospital, Grand Rapids, Michigan
Bronson Methodist Hospital, Kalamazoo, Michigan
West Michigan Cancer Center, Kalamazoo, Michigan
Karmanos Cancer Institute at McLaren Greater Lansing, Lansing, Michigan
Trinity Health Saint Mary Mercy Livonia Hospital, Livonia, Michigan
Trinity Health Muskegon Hospital, Muskegon, Michigan
Corewell Health Lakeland Hospitals - Niles Hospital, Niles, Michigan
Cancer and Hematology Centers of Western Michigan - Norton Shores, Norton Shores, Michigan
Henry Ford Medical Center-Columbus, Novi, Michigan
Trinity Health Saint Joseph Mercy Oakland Hospital, Pontiac, Michigan
Corewell Health Reed City Hospital, Reed City, Michigan
Corewell Health William Beaumont University Hospital, Royal Oak, Michigan
Corewell Health Lakeland Hospitals - Marie Yeager Cancer Center, Saint Joseph, Michigan
Corewell Health Lakeland Hospitals - Saint Joseph Hospital, Saint Joseph, Michigan
Munson Medical Center, Traverse City, Michigan
Corewell Health Beaumont Troy Hospital, Troy, Michigan
Henry Ford Health Warren Hospital, Warren, Michigan
Henry Ford West Bloomfield Hospital, West Bloomfield, Michigan
University of Michigan Health - West, Wyoming, Michigan
Huron Gastroenterology PC, Ypsilanti, Michigan
Trinity Health IHA Medical Group Hematology Oncology Ann Arbor Campus, Ypsilanti, Michigan
Minnesota Oncology - Burnsville, Burnsville, Minnesota
Saint Luke's Hospital of Duluth, Duluth, Minnesota
Fairview Southdale Hospital, Edina, Minnesota
Abbott-Northwestern Hospital, Minneapolis, Minnesota
Mayo Clinic in Rochester, Rochester, Minnesota
Park Nicollet Clinic - Saint Louis Park, Saint Louis Park, Minnesota
Regions Hospital, Saint Paul, Minnesota
Saint Francis Regional Medical Center, Shakopee, Minnesota
Saint Francis Medical Center, Cape Girardeau, Missouri
Mercy Hospital Joplin, Joplin, Missouri
Mercy Hospital South, Saint Louis, Missouri
CoxHealth South Hospital, Springfield, Missouri
Saint Vincent Frontier Cancer Center, Billings, Montana
Dartmouth Hitchcock Medical Center/Dartmouth Cancer Center, Lebanon, New Hampshire
Roswell Park Cancer Institute, Buffalo, New York
Mount Sinai Hospital, New York, New York
Stony Brook University Medical Center, Stony Brook, New York
Duke Cancer Center Cary, Cary, North Carolina
Carolinas Medical Center/Levine Cancer Institute, Charlotte, North Carolina
Levine Cancer Institute-SouthPark, Charlotte, North Carolina
Atrium Health University City/LCI-University, Charlotte, North Carolina
Levine Cancer Institute-Ballantyne, Charlotte, North Carolina
Southeastern Medical Oncology Center-Clinton, Clinton, North Carolina
Atrium Health Cabarrus/LCI-Concord, Concord, North Carolina
Duke University Medical Center, Durham, North Carolina
Levine Cancer Institute-Gaston, Gastonia, North Carolina
Southeastern Medical Oncology Center-Goldsboro, Goldsboro, North Carolina
Southeastern Medical Oncology Center-Jacksonville, Jacksonville, North Carolina
FirstHealth of the Carolinas-Moore Regional Hospital, Pinehurst, North Carolina
Duke Cancer Center Raleigh, Raleigh, North Carolina
Ohio State University Comprehensive Cancer Center, Columbus, Ohio
Toledo Clinic Cancer Centers-Toledo, Toledo, Ohio
Cancer Centers of Southwest Oklahoma Research, Lawton, Oklahoma
University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma
Mercy Hospital Oklahoma City, Oklahoma City, Oklahoma
Saint Charles Health System, Bend, Oregon
Providence Cancer Institute Clackamas Clinic, Clackamas, Oregon
Providence Newberg Medical Center, Newberg, Oregon
Providence Willamette Falls Medical Center, Oregon City, Oregon
Providence Portland Medical Center, Portland, Oregon
Providence Saint Vincent Medical Center, Portland, Oregon
Smilow Cancer Hospital Care Center - Westerly, Westerly, Rhode Island
Medical University of South Carolina, Charleston, South Carolina
Rapid City Regional Hospital, Rapid City, South Dakota
Vanderbilt University/Ingram Cancer Center, Nashville, Tennessee
Parkland Memorial Hospital, Dallas, Texas
UT Southwestern Simmons Cancer Center - RedBird, Dallas, Texas
UT Southwestern/Simmons Cancer Center-Dallas, Dallas, Texas
UT Southwestern/Simmons Cancer Center-Fort Worth, Fort Worth, Texas
Baylor College of Medicine/Dan L Duncan Comprehensive Cancer Center, Houston, Texas
Ben Taub General Hospital, Houston, Texas
UT Southwestern Clinical Center at Richardson/Plano, Richardson, Texas
Huntsman Cancer Institute/University of Utah, Salt Lake City, Utah
Dartmouth Cancer Center - North, Saint Johnsbury, Vermont
Fred Hutchinson Cancer Center, Seattle, Washington
University of Washington Medical Center - Montlake, Seattle, Washington
United Hospital Center, Bridgeport, West Virginia
West Virginia University Healthcare, Morgantown, West Virginia
Marshfield Medical Center-EC Cancer Center, Eau Claire, Wisconsin
Gundersen Lutheran Medical Center, La Crosse, Wisconsin
Marshfield Medical Center-Marshfield, Marshfield, Wisconsin
Medical College of Wisconsin, Milwaukee, Wisconsin
Marshfield Medical Center - Minocqua, Minocqua, Wisconsin
Marshfield Medical Center-Rice Lake, Rice Lake, Wisconsin
Marshfield Medical Center-River Region at Stevens Point, Stevens Point, Wisconsin
Marshfield Medical Center - Weston, Weston, Wisconsin
Conditions: Advanced Extrapulmonary Neuroendocrine Carcinoma, Metastatic Extrapulmonary Neuroendocrine Carcinoma, Recurrent Extrapulmonary Neuroendocrine Carcinoma, Unresectable Extrapulmonary Neuroendocrine Carcinoma
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