Carboplatin, Paclitaxel, and Bevacizumab With or Without Erlotinib Hydrochloride in Treating Non-Smokers With Advanced Non-Small Cell Lung Cancer
NCT00976677
Terminated
This randomized phase II trial studies how well carboplatin, paclitaxel, and bevacizumab work with or without erlotinib hydrochloride in treating non-smokers with advanced non-small cell lung cancer. Drugs used in chemotherapy, such as carboplatin and paclitaxel, work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing. Monoclonal antibodies, such as bevacizumab, can block tumor growth in different ways. Some block the ability of tum... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
05/23/2014
Locations: The Medical Center of Aurora, Aurora, Colorado +107 locations
Conditions: Recurrent Non-small Cell Lung Cancer, Stage IIIB Non-small Cell Lung Cancer, Stage IV Non-small Cell Lung Cancer
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Ph I/II Nab-Paclitaxel & Carboplatin w/Concurrent Radiation Therapy for Unresectable Stg III NSCLC
NCT00544648
Terminated
RATIONALE: Drugs used in chemotherapy, such as carboplatin, work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing. Radiation therapy uses high-energy x-rays to kill tumor cells. Nab-paclitaxel (paclitaxel albumin-stabilized nanoparticle formulation) may make tumor cells more sensitive to radiation therapy. Giving nab-paclitaxel together with radiation therapy and carboplatin may kill more tumor cells. PURPOSE: This phase I/II tri... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
05/21/2014
Locations: Purchase Cancer Group - Paducah, Paducah, Kentucky +5 locations
Conditions: Lung Cancer
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Estramustine, Docetaxel, and Carboplatin for Patients With Hormone Refractory Prostate Cancer Progressing After Mitoxantrone-Based Chemotherapy.
NCT00183924
Completed
This study is for patients with prostate cancer that is metastatic, progressive, and resistant to hormonal manipulation and mitoxantrone chemotherapy.Patients have previously been treated with surgical removal of the testes or hormone therapy, and subsequently with chemotherapy that included the drug, mitoxantrone (Novantrone). Patients will have prostate cancer that has worsened despite these treatments. We hope to learn whether the combination chemotherapy decreases cancer symptoms and tests,... Read More
Gender:
MALE
Ages:
18 years and above
Trial Updated:
05/20/2014
Locations: Norris Comprehensive Cancer Center, Los Angeles, California
Conditions: Prostate Adenocarcinoma
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Study of Combretastatin and Paclitaxel/Carboplatin in the Treatment of Anaplastic Thyroid Cancer
NCT00507429
Terminated
The purpose of the study is to determine the safety and efficacy of combretastatin combined with paclitaxel and carboplatin in the treatment of anaplastic thyroid cancer (ATC).
Gender:
ALL
Ages:
18 years and above
Trial Updated:
05/12/2014
Locations: USC/Norris Comprehensive Cancer Center, Los Angeles, California +40 locations
Conditions: Anaplastic Thyroid Cancer
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Chemotherapy Followed By Vaccine Therapy in Treating Patients With Extensive-Stage Small Cell Lung Cancer
NCT00049218
Completed
RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. Vaccines made from a gene-modified virus may make the body build an immune response to kill tumor cells. Combining vaccine therapy with chemotherapy may kill more tumor cells. PURPOSE: Phase I/II trial to study the effectiveness of chemotherapy followed by adenovirus p53 vaccine therapy in treating patients who have extensive-stage small cell lung cancer.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
05/08/2014
Locations: H. Lee Moffitt Cancer Center and Research Institute, Tampa, Florida
Conditions: Lung Cancer
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Trastuzumab, Ixabepilone, and Carboplatin in Treating Patients With HER2/Neu-Positive Metastatic Breast Cancer
NCT00077376
Completed
This phase II trial is studying how well giving trastuzumab together with ixabepilone and carboplatin works in treating patients with HER2/neu-positive metastatic breast cancer. Monoclonal antibodies, such as trastuzumab, can locate tumor cells and either kill them or deliver tumor-killing substances to them without harming normal cells. Drugs used in chemotherapy, such as ixabepilone and carboplatin, work in different ways to stop tumor cells from dividing so they stop growing or die. Combining... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
05/02/2014
Locations: Eastern Cooperative Oncology Group, Boston, Massachusetts
Conditions: HER2-positive Breast Cancer, Male Breast Cancer, Recurrent Breast Cancer, Stage IV Breast Cancer
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Chemotherapy and Proton Radiation for the Treatment of Locally Advanced Lung Cancer
NCT00614484
Terminated
The purpose of this study is to determine the effectiveness of proton beam radiotherapy combined with chemotherapy for treatment of locally advanced non-small cell lung cancer.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
04/28/2014
Locations: Loma Linda University Medical Center, Loma Linda, California
Conditions: Locally Advanced Non-Small Cell Lung Cancer
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Biomarker-Integrated Approach of Targeted Therapy for Lung Cancer Elimination Plus External Beam Radiation Therapy (BATTLE-XRT)
NCT02044601
Withdrawn
The goal of the Phase I part of this clinical research study is to find the highest tolerable dose of onartuzumab that can be given with erlotinib and standard chemoradiation (paclitaxel and carboplatin) to patients with NSCLC. The goal of Phase II is to learn if onartuzumab plus erlotinib and chemoradiation can help to control NSCLC. The safety of this drug will also be studied.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
04/22/2014
Locations: University of Texas MD Anderson Cancer Center, Houston, Texas
Conditions: Lung Cancer
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A Study for Participants With Recurrent or Metastatic Squamous Cell Head and Neck Cancer
NCT01087970
Completed
The purpose of this study is to look for an improvement in progression free survival with the combination of pemetrexed, carboplatin (or cisplatin) and cetuximab in participants with recurrent or metastatic squamous cell carcinoma of the head and neck.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
04/18/2014
Locations: For additional information regarding investigative sites for this trial, contact 1-877-CTLILLY (1-877-285-4559, 1-317-615-4559) Mon - Fri from 9 AM to 5 PM Eastern Time (UTC/GMT - 5 hours, EST), or speak with your personal physician., Jonesboro, Arkansas +20 locations
Conditions: Head and Neck Neoplasms
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AMG 531 in Patients With Advanced Malignancy Receiving Treatment With Carboplatin
NCT00147225
Completed
The goal of this clinical research study is to find the highest safe dose of AMG 531 that will decrease the risk and severity of thrombocytopenia (low platelet counts) in patients who have received chemotherapy. Researchers will also look at the safety and effectiveness of AMG 531 (Romiplostim). Primary Objectives: 1. To determine the clinical safety and tolerability of AMG 531 administered following chemotherapy in patients with advanced malignancy 2. To determine an optimal biologic dose (OB... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
04/07/2014
Locations: UT MD Anderson Cancer Center, Houston, Texas
Conditions: Solid Tumors, Advanced Cancer
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Chemotherapy Plus Peripheral Stem Cell Transplantation in Treating Infants With Malignant Brain or Spinal Cord Tumors
NCT00003141
Completed
RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. Combining chemotherapy with peripheral stem cell transplantation may allow the doctors to give higher doses of chemotherapy drugs and kill more tumor cells. PURPOSE: Phase I trial to study the effectiveness of combination chemotherapy plus peripheral stem cell transplantation in treating infants with malignant brain or spinal cord tumors.
Gender:
ALL
Ages:
2 years and below
Trial Updated:
03/27/2014
Locations: City of Hope Comprehensive Cancer Center, Duarte, California +70 locations
Conditions: Brain Tumors, Central Nervous System Tumors, Neuroblastoma, Sarcoma
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RAD001 Plus Carboplatin in Breast Cancer Patients
NCT01127763
Completed
This study investigates the effectiveness of combination of carboplatin and investigational agent RAD001 in triple-negative breast cancer.
Gender:
FEMALE
Ages:
18 years and above
Trial Updated:
03/11/2014
Locations: NYU Clinical Cancer Center, New York, New York
Conditions: Breast Cancer
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