Eribulin Mesylate and Cisplatin in Treating Patients With Advanced Solid Tumors
NCT00415324
Completed
This trial is studying the side effects and best dose of eribulin mesylate and cisplatin in treating patients with advanced solid tumors.Drugs used in chemotherapy, such as eribulin mesylate and cisplatin, work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing. Giving more than one drug (combination chemotherapy) may kill more tumor cells.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
05/19/2014
Locations: City of Hope Medical Center, Duarte, California +3 locations
Conditions: Unspecified Adult Solid Tumor, Protocol Specific
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A Study of VEGF-Antisense Oligonucleotide in Combination With Pemetrexed and Cisplatin for the Treatment of Advanced Malignant Mesothelioma
NCT00668499
Withdrawn
This will be a single institution non-randomized phase I/II trial for patients with malignant mesothelioma stage II and above, who have not received prior chemotherapy for their disease. The purpose of this phase is to select a dose of VEGF-AS (antiangiogenesis drug)to be given with standard doses of pemetrexed followed by cisplatin on day 1 of a 21-day cycle.
Gender:
ALL
Ages:
Between 18 years and 90 years
Trial Updated:
05/19/2014
Locations: USC/Norris Comprehensive Cancer Center, Los Angeles, California
Conditions: Mesothelioma
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Combination Chemotherapy Plus Radiation Therapy in Treating Patients With Esophageal Cancer
NCT00021320
Completed
RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. Radiation therapy uses high-energy x-rays to damage tumor cells. PURPOSE: Phase II trial to study the effectiveness of combination chemotherapy with or without radiation therapy in treating patients who have esophageal cancer.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
05/07/2014
Locations: Fox Chase Cancer Center, Philadelphia, Pennsylvania
Conditions: Esophageal Cancer
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Gefitinib, Cisplatin, Irinotecan, and Radiation Therapy Before Surgery in Treating Patients With Esophageal Cancer or Gastroesophageal Junction Cancer That Can Be Removed By Surgery
NCT00290719
Terminated
RATIONALE: Gefitinib may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth. Drugs used in chemotherapy, such as cisplatin and irinotecan, work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing. Radiation therapy uses high-energy x-rays to kill tumor cells. Giving gefitinib together with chemotherapy and radiation therapy before surgery may make the tumor smaller and reduce the amount of normal ti... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
05/07/2014
Locations: UCSF Helen Diller Family Comprehensive Cancer Center, San Francisco, California
Conditions: Esophageal Cancer
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Cisplatin and Flavopiridol in Treating Patients With Advanced Ovarian Epithelial Cancer or Primary Peritoneal Cancer
NCT00083122
Completed
This phase II trial is studying how well giving cisplatin together with flavopiridol works in treating patients with advanced ovarian epithelial cancer or primary peritoneal cancer. Drugs used in chemotherapy, such as cisplatin and flavopiridol, work in different ways to stop tumor cells from dividing so they stop growing or die. Combining more than one drug may kill more tumor cells.
Gender:
FEMALE
Ages:
18 years and above
Trial Updated:
05/06/2014
Locations: Mayo Clinic, Rochester, Minnesota
Conditions: Recurrent Ovarian Epithelial Cancer, Recurrent Primary Peritoneal Cavity Cancer, Stage IIIA Ovarian Epithelial Cancer, Stage IIIA Primary Peritoneal Cavity Cancer, Stage IIIB Ovarian Epithelial Cancer, Stage IIIB Primary Peritoneal Cavity Cancer, Stage IIIC Ovarian Epithelial Cancer, Stage IIIC Primary Peritoneal Cavity Cancer, Stage IV Ovarian Epithelial Cancer, Stage IV Primary Peritoneal Cavity Cancer
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Tirapazamine Combined With Chemo and RT in Limited-Stage Small Cell Lung Cancer
NCT00066742
Completed
This phase II trial is studying how well giving tirapazamine together with cisplatin, etoposide, and radiation therapy works in treating patients with limited-stage small cell lung cancer. Drugs used in chemotherapy, such as cisplatin and etoposide, work in different ways to stop tumor cells from dividing so they stop growing or die. Radiation therapy uses high-energy x-rays to damage tumor cells. Tirapazamine may make the tumor cells more sensitive to chemotherapy and radiation therapy. Combini... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
04/29/2014
Locations: Southwest Oncology Group (SWOG) Research Base, San Antonio, Texas
Conditions: Limited Stage Small Cell Lung Cancer
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Cisplatin, Etoposide, and Bevacizumab in Treating Patients With Previously Untreated Extensive Stage Small Cell Lung Cancer
NCT00079040
Completed
This phase II trial is studying how well giving cisplatin and etoposide together with bevacizumab works in treating patients with previously untreated extensive-stage small cell lung cancer. Drugs used in chemotherapy, such as cisplatin and etoposide, work in different ways to stop tumor cells from dividing so they stop growing or die. Monoclonal antibodies, such as bevacizumab, can block tumor growth in different ways. Some block the ability of tumor cells to grow and spread. Others find tumor... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
04/28/2014
Locations: Eastern Cooperative Oncology Group, Boston, Massachusetts
Conditions: Extensive Stage Small Cell Lung Cancer
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A Study for Participants With Recurrent or Metastatic Squamous Cell Head and Neck Cancer
NCT01087970
Completed
The purpose of this study is to look for an improvement in progression free survival with the combination of pemetrexed, carboplatin (or cisplatin) and cetuximab in participants with recurrent or metastatic squamous cell carcinoma of the head and neck.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
04/18/2014
Locations: For additional information regarding investigative sites for this trial, contact 1-877-CTLILLY (1-877-285-4559, 1-317-615-4559) Mon - Fri from 9 AM to 5 PM Eastern Time (UTC/GMT - 5 hours, EST), or speak with your personal physician., Jonesboro, Arkansas +20 locations
Conditions: Head and Neck Neoplasms
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R-(-)-Gossypol Acetic Acid, Cisplatin, and Etoposide in Treating Patients With Advanced Solid Tumors or Extensive Stage Small Cell Lung Cancer
NCT00544596
Completed
This phase I trial is studying the side effects and best dose of R-(-)-gossypol acetic acid when given together with cisplatin and etoposide in treating patients with advanced solid tumors or extensive stage small cell lung cancer. R-(-)-gossypol acetic acid may stop the growth of cancer by blocking blood flow to the tumor. Drugs used in chemotherapy, such as cisplatin and etoposide, work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from di... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
04/01/2014
Locations: Sanford Cancer Center-Oncology Clinic, Sioux Falls, South Dakota +3 locations
Conditions: Extensive Stage Small Cell Lung Cancer, Unspecified Adult Solid Tumor, Protocol Specific
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Chemotherapy Plus Peripheral Stem Cell Transplantation in Treating Infants With Malignant Brain or Spinal Cord Tumors
NCT00003141
Completed
RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. Combining chemotherapy with peripheral stem cell transplantation may allow the doctors to give higher doses of chemotherapy drugs and kill more tumor cells. PURPOSE: Phase I trial to study the effectiveness of combination chemotherapy plus peripheral stem cell transplantation in treating infants with malignant brain or spinal cord tumors.
Gender:
ALL
Ages:
2 years and below
Trial Updated:
03/27/2014
Locations: City of Hope Comprehensive Cancer Center, Duarte, California +70 locations
Conditions: Brain Tumors, Central Nervous System Tumors, Neuroblastoma, Sarcoma
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Extrapleural Pneumonectomy With Intraoperative Intrathoracic/Intraperitoneal Heated Cisplatin With Amifostine and Sodium Thiosulfate
NCT00165516
Completed
The purposes of this study are: to evaluate the effects (good and bad) that administering heated cisplatin into the chest and abdomen cavity following surgical resection has on malignant mesothelioma; to collect data on the toxicity of cisplatin given directly into the chest and abdomen, and the levels of the cisplatin in the body; to determine if this treatment method has the possibility of helping patients with pleural mesothelioma live longer; and to determine if this treatment method can hel... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
03/26/2014
Locations: Brigham and Women's Hospital, Boston, Massachusetts +1 locations
Conditions: Pleural Mesothelioma, Malignant Pleural Mesothelioma
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Pleurectomy/Decortication Followed by Intrathoracic/Intraperitoneal Heated Cisplatin for Malignant Pleural Mesothelioma
NCT00165555
Completed
The purpose of this study it to determine the safety and maximally tolerated dose (MTD) of cisplatin administered in the operating room and put into the chest and abdomen for one hour. We are also looking at the effects of heating the chemotherapy to a temperature of 42 degrees celsius.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
03/26/2014
Locations: Brigham and Women's Hospital, Boston, Massachusetts +1 locations
Conditions: Pleural Mesothelioma, Malignant Pleural Mesothelioma
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