A Dose Ascending Study of Gemcitabine Elaidate (CO-101) in Combination With Cisplatin
NCT01641575
Terminated
The purpose of the first part of the study is to evaluate the safety, tolerability, and pharmacokinetics of ascending doses of gemcitabine elaidate in combination with cisplatin given to patients with advanced solid tumors, and to select a dose for further evaluation in the second part of the study. The purpose of the second part of the study is to determine the safety, tolerability, and exploratory clinical activity of gemcitabine elaidate in combination with cisplatin given to patients with S... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
03/08/2014
Locations: Florida Cancer Specialists, Sarasota, Florida +3 locations
Conditions: Solid Tumor, Non-small-cell Lung Cancer, Lung Cancer
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Combination Chemotherapy in Treating Patients With Advanced Solid Tumors
NCT00046917
Completed
Phase I trial to study the effectiveness of combining alvocidib, irinotecan hydrochloride, and cisplatin in treating patients who have advanced solid tumors. Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. Combining more than one drug may kill more tumor cells.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
02/21/2014
Locations: Memorial Sloan-Kettering Cancer Center, New York, New York
Conditions: Unspecified Adult Solid Tumor, Protocol Specific
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Combination Chemotherapy Plus Peripheral Stem Cell Transplantation in Treating Children With Newly Diagnosed Neuroblastoma
NCT00017368
Completed
RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. Combining more than one drug may kill more tumor cells. Peripheral stem cell transplantation may allow the doctor to give higher doses of chemotherapy drugs and kill more tumor cells. PURPOSE: Phase II trial to study the effectiveness of combination chemotherapy followed by peripheral stem cell transplantation in treating children who have newly diagnosed neuroblastoma.
Gender:
ALL
Ages:
30 years and below
Trial Updated:
02/12/2014
Locations: AFLAC Cancer Center and Blood Disorders Service of Children's Healthcare of Atlanta - Scottish RiteCampus, Atlanta, Georgia +8 locations
Conditions: Neuroblastoma
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Radiation Therapy Compared With Combination Chemotherapy in Treating Patients With Advanced Endometrial Cancer
NCT00002493
Completed
RATIONALE: Radiation therapy uses high-energy x-rays to damage tumor cells. Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. It is not yet known which treatment regimen is more effective for endometrial cancer. PURPOSE: Randomized phase III trial to compare radiation therapy with chemotherapy in treating patients who have advanced endometrial cancer.
Gender:
FEMALE
Ages:
All
Trial Updated:
02/12/2014
Locations: University of Alabama Comprehensive Cancer Center, Birmingham, Alabama +57 locations
Conditions: Endometrial Cancer, Psychosocial Effects of Cancer and Its Treatment
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Induction Chemotherapy Using Cyclophosphamide and Topotecan in Treating Patients Who Are Undergoing Autologous Peripheral Stem Cell Transplantation for Newly Diagnosed or Progressive Neuroblastoma
NCT00070200
Completed
RATIONALE: Drugs used in chemotherapy, such as topotecan and cyclophosphamide, use different ways to stop tumor cells from dividing so they stop growing or die. Combining chemotherapy with autologous stem cell transplantation may allow the doctor to give higher doses of chemotherapy drugs and kill more tumor cells. PURPOSE: This phase I trial is studying the side effects of induction chemotherapy using cyclophosphamide and topotecan in treating patients who are undergoing surgery and autologous... Read More
Gender:
ALL
Ages:
30 years and below
Trial Updated:
02/12/2014
Locations: UCSF Comprehensive Cancer Center, San Francisco, California +5 locations
Conditions: Neuroblastoma
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Combination Chemotherapy With or Without Bevacizumab in Treating Patients With Malignant Mesothelioma
NCT00027703
Completed
This randomized phase II trial is to see if combination chemotherapy works better with or without bevacizumab in treating patients who have malignant mesothelioma. Drugs used in chemotherapy work in different ways to stop tumor cells from dividing so they stop growing or die. Monoclonal antibodies, such as bevacizumab, can block cancer growth in different ways. Some block the ability of cancer cells to grow and spread. Others find cancer cells and help kill them or deliver cancer-killing substan... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
02/10/2014
Locations: University of Chicago, Chicago, Illinois
Conditions: Advanced Malignant Mesothelioma, Epithelial Mesothelioma, Localized Malignant Mesothelioma, Recurrent Malignant Mesothelioma, Sarcomatous Mesothelioma
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Cetuximab and Cisplatin in Treating Patients With Advanced, Persistent, or Recurrent Cervical Cancer
NCT00101192
Completed
RATIONALE: Monoclonal antibodies, such as cetuximab, can block tumor growth in different ways. Some block the ability of tumor cells to grow and spread. Others find tumor cells and help kill them or carry tumor-killing substances to them. Cetuximab may also help cisplatin work better by making tumor cells more sensitive to the drug. Drugs used in chemotherapy, such as cisplatin, work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividin... Read More
Gender:
FEMALE
Ages:
18 years and above
Trial Updated:
02/03/2014
Locations: Providence Saint Joseph Medical Center - Burbank, Burbank, California +17 locations
Conditions: Cervical Cancer
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Radiation Therapy With or Without Chemotherapy in Treating Patients With Advanced Cancer of the Larynx
NCT00002496
Completed
RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. Radiation therapy uses high-energy x-rays to damage tumor cells. It is not yet known if chemotherapy plus radiation therapy is more effective than radiation therapy alone in treating patients with advanced cancer of the larynx. PURPOSE: Randomized phase III trial to compare the effectiveness of radiation therapy with or without chemotherapy in treating patients with advanced c... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
01/23/2014
Locations: CCOP - Colorado Cancer Research Program, Inc., Denver, Colorado +17 locations
Conditions: Head and Neck Cancer
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Radiation Therapy With or Without Chemotherapy in Treating Patients With Head and Neck Cancer That Has Been Removed During Surgery
NCT00002670
Completed
RATIONALE: Radiation therapy uses high-energy x-rays to damage tumor cells. Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. It is not yet known whether radiation therapy plus cisplatin is more effective than radiation therapy alone in treating patients with head and neck cancer. PURPOSE: Randomized phase III trial to compare the effectiveness of radiation therapy plus cisplatin with radiation therapy alone in treating patients with he... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
01/23/2014
Locations: H. Lee Moffitt Cancer Center and Research Institute, Tampa, Florida +22 locations
Conditions: Head and Neck Cancer
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Sorafenib, Tamoxifen, and Cisplatin in Treating Patients With High-Risk Stage III Melanoma
NCT00492505
Unknown
RATIONALE: Sorafenib may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth and by blocking blood flow to the tumor. Drugs used in chemotherapy, such as tamoxifen and cisplatin, work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing. Giving sorafenib together with tamoxifen and cisplatin after surgery may kill any tumor cells that remain after surgery. PURPOSE: This phase II trial is studying the... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
01/09/2014
Locations: San Diego Pacific Oncology and Hematology Associates, Incorporated - Encinitas, Encinitas, California
Conditions: Melanoma (Skin)
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Bexarotene, Tretinoin, and Combination Chemotherapy in Treating Patients With Stage III or Stage IV Non-Small Cell Lung Cancer
NCT00514293
Unknown
RATIONALE: Bexarotene and tretinoin may cause tumor cells to look more like normal cells, and to grow and spread more slowly. Drugs used in chemotherapy, such as cisplatin, carboplatin, docetaxel, and capecitabine, work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing. Giving bexarotene and tretinoin together with combination chemotherapy may kill more tumor cells. PURPOSE: This phase II trial is studying the side effects and how... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
01/09/2014
Locations: R. Nandan M.D. Incorporated, Lakewood, California
Conditions: Lung Cancer
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Sunitinib, Tamoxifen, and Cisplatin in Treating Patients With High-Risk Ocular Melanoma
NCT00489944
Unknown
RATIONALE: Sunitinib may stop the growth of tumor cells by blocking blood flow to the tumor and by blocking some of the enzymes needed for cell growth. Drugs used in chemotherapy, such as tamoxifen and cisplatin, work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing. Giving sunitinib together with tamoxifen and cisplatin may kill more tumor cells. PURPOSE: This phase II trial is studying the side effects and how well giving sunit... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
01/09/2014
Locations: San Diego Pacific Oncology and Hematology Associates, Incorporated - Encinitas, Encinitas, California
Conditions: Intraocular Melanoma
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