Cyclophosphamide Treatment Options

A collection of 2185 research studies where Cyclophosphamide is the interventional treatment. These studies are located in the United States . Cyclophosphamide is used for conditions such as Breast Cancer, Lymphoma and Leukemia.

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Featured Trial

Paid Clinical Studies Nationwide

Recruiting

Nationwide clinical trials offered in your area. Some trials offering up to several thousand dollars in compensation for participation.

Conditions:

Healthy

Healthy Volunteer Study

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* Compensation for time may be available

Featured Trial

Chronic Cough Research Study

Recruiting

Are you tired of living with chronic cough? Our research study is now looking to enroll people from all backgrounds to help research potential new treatment options for chronic cough.
You are under no obligation to take part and health insurance is not required. Find out more today! We’d love to hear from you!

Conditions:

Chronic Cough

Refractory or Unexplained Chronic Cough

Cough

Asthma

Sinusitis

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Featured Trial

Healthy Participants Needed (Colonoscopy + Cancer Screening)

Recruiting

Earn $325 - $475 in electronic payment card compensation for your time and effort by participating in a clinical study to develop a blood test that may one day help screen for colon cancer. Take a quick quiz to see if you qualify.

Conditions:

Healthy

Healthy Volunteers

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Featured Offer

Lose Weight with GLP-1 Medications

Recruiting

Policy Lab has partnered with OnlineSemaglutide.org to offer trusted access to semaglutide and other GLP-1 medications, including generic alternatives to Ozempic® and Wegovy®.

GLP-1 medications are scientifically backed to help individuals achieve significant weight loss—on average, 15-20% of body weight within a year.

As a valued user, you’re eligible for $100 off your first program with code policy-lab-100.

Conditions:

Overweight

Overweight and Obesity

Obesity

Weight Loss

Morbid Obesity

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T Cell Depleted Allogeneic Hematopoietic Stem Cell Transplantation Conditioned With a Reduced Intensity Regimen in Patients With Hematologic Malignancies and Aplastic Anemia

NCT03531736

Active Not Recruiting

The main purpose of this study is to learn if a new combination of chemotherapy, in combination with low-dose radiation, will be safe for the patient, and at the same time provide the best opportunity to cure the bone marrow cancer. The combination of chemotherapy and radiation described in the study is considered 'low intensity.' Although the chemotherapy agents used in this study and for transplant are FDA approved, the chemotherapy treatment and conditioning regimens or combinations listed in... Read More

Gender:

ALL

Ages:

18 years and above

Trial Updated:

08/18/2025

Locations: Memorial Sloan Kettering Monmouth (Limited Protocol Activities), Middletown, New Jersey +1 locations

Conditions: Myeloid Diseases

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NKX019, Intravenous Allogeneic Chimeric Antigen Receptor Natural Killer Cells (CAR NK), in Participants With Immune-Mediated Diseases (Ntrust-2)

NCT06733935

Recruiting

This is an open-label, multi-center, multi-cohort, non-randomized Phase 1 study to determine the safety and tolerability of NKX019 (allogeneic CAR NK cells targeting CD19) in participants with Immune-Mediated Diseases (IMD) including systemic sclerosis \[SSc\], idiopathic inflammatory myopathies \[IIM\], and antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis \[AAV\].

Gender:

ALL

Ages:

Between 18 years and 65 years

Trial Updated:

08/18/2025

Locations: Nkarta Investigational Site, Orange, California +9 locations

Conditions: Systemic Sclerosis, Idiopathic Inflammatory Myopathies, Antineutrophil Cytoplasmic Antibody-Associated Vasculitis

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Trial of Anti-CD19 and Anti-CD20 Bicistronic Chimeric Antigen Receptor T Cells for Treating B-Cell Malignancies

NCT05797233

Active Not Recruiting

Background: About 23,000 people die from B-cell cancers in the US each year. These cancers, often called leukemia or lymphoma, affect a type of white blood cell called B cells. These cancers are difficult to treat, and the therapies used can have bad side effects. Researchers want to try a new type of treatment. This new treatment uses a patient s own immune cells (T cells) that are modified to carry genes (chimeric antigen receptor, or CAR T cells) to kill cancer cells. Objective: To test a... Read More

Gender:

ALL

Ages:

Between 18 years and 75 years

Trial Updated:

08/16/2025

Locations: National Institutes of Health Clinical Center, Bethesda, Maryland

Conditions: Chronic Lymphocytic Leukemia, B-Cell Chronic Lymphocytic Leukemia, Lymphoma, B-Cell

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A Phase II Study of Adjuvant Immunotherapy Targeting KRAS G12D, KRAS G12V, or TP53 R175H for Participants With Advanced Gastrointestinal Malignancies

NCT06690281

Suspended

Background: Gastrointestinal (GI) cancer affects the organs (such as the stomach, large and small intestine, pancreas, colon, liver, and biliary system) of the digestive tract. In some participants who have had surgery for GI cancer, blood tests show that the cancer has spread despite being unable to be identified by scans. Certain gene mutations (changes) in GI cancer (such as KRAS or TP53) can be targeted by T cells, a type of immune cell, in individuals with specific HLA types (genes that help proteins in the body know what is self and non-self). Researchers want to see if they can stop GI cancer from returning or spreading in people with these gene mutations and specific HLA types. Objective: To test therapy with modified T-cells to prevent or delay the return of GI cancer after standard treatment. T-cells play a role in the body s immune system. Eligibility: People aged 18 to 72 years with GI cancer that was treated with standard therapy and is not seen on imaging scans. They must have specific gene mutations and HLA types. They also must have certain clinical or blood tests showing the cancer is spreading (elevating CA19-9 or detectable ctDNA). Design: Participants will be divided into 2 groups. Participants nor the study team can choose what Group to participate in; this is done by randomization , like flipping a coin. Participants will have a 1-to-1 chance of being in Group 1 or Group 2. Group 1 will receive T-cell therapy. Their own T-cells will be collected. In a lab, the cells will be combined with a virus that carries a protein to target cancer cells. Group 1 participants will stay in the hospital for 3 weeks or more. They will have chemotherapy, and their modified T-cells will be infused through a tube attached to a needle inserted into a vein. Group 1 participants will visit the clinic every 3 months for 1 year and then every 6 months for 5 years. Then they will have follow-up visits for another 10 years under a different protocol. Group 2 participants will not receive treatment with T-cells. They will visit the clinic every 3 months for 1 year and then every 6 months for 5 years. Read Less

Gender:

ALL

Ages:

Between 18 years and 72 years

Trial Updated:

08/16/2025

Locations: National Institutes of Health Clinical Center, Bethesda, Maryland

Conditions: Gastrointestinal Carcinoma, Pancreatic Cancer, Hepatocellular Cancer, Cholangiocarcinoma, Duodenal Cancer, Colorectal Cancer, Small Bowel Cancer, Metastatic Cancers

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A Study to Compare Standard Therapy to Treat Hodgkin Lymphoma to the Use of Two Drugs, Brentuximab Vedotin and Nivolumab

NCT05675410

Recruiting

This phase III trial compares the effect of adding immunotherapy (brentuximab vedotin and nivolumab) to standard treatment (chemotherapy with or without radiation) to the standard treatment alone in improving survival in patients with stage I and II classical Hodgkin lymphoma. Brentuximab vedotin is in a class of medications called antibody-drug conjugates. It is made of a monoclonal antibody called brentuximab that is linked to a cytotoxic agent called vedotin. Brentuximab attaches to CD30 positive lymphoma cells in a targeted way and delivers vedotin to kill them. A monoclonal antibody is a type of protein that can bind to certain targets in the body, such as molecules that cause the body to make an immune response (antigens). Immunotherapy with monoclonal antibodies, such as nivolumab, may help the body's immune system attack the cancer, and may interfere with the ability of tumor cells to grow and spread. Chemotherapy drugs such as doxorubicin hydrochloride, bleomycin sulfate, vinblastine sulfate, dacarbazine, and procarbazine hydrochloride work in different ways to stop the growth of cancer cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading. Cyclophosphamide is in a class of medications called alkylating agents. It works by damaging the cell's deoxyribonucleic acid (DNA) and may kill cancer cells. It may also lower the body's immune response. Etoposide is in a class of medications known as podophyllotoxin derivatives. It blocks a certain enzyme needed for cell division and DNA repair and may kill cancer cells. Vincristine is in a class of medications called vinca alkaloids. It works by stopping cancer cells from growing and dividing and may kill them. Prednisone is in a class of medications called corticosteroids. It is used to reduce inflammation and lower the body's immune response to help lessen the side effects of chemotherapy drugs. Radiation therapy uses high energy x-rays to kill tumor cells and shrink tumors. Adding immunotherapy to the standard treatment of chemotherapy with or without radiation may increase survival and/or fewer short-term or long-term side effects in patients with classical Hodgkin lymphoma compared to the standard treatment alone. Read Less

Gender:

ALL

Ages:

Between 5 years and 60 years

Trial Updated:

08/16/2025

Locations: Children's Hospital of Alabama, Birmingham, Alabama +352 locations

Children's Hospital of Alabama, Birmingham, Alabama

USA Health Strada Patient Care Center, Mobile, Alabama

Providence Alaska Medical Center, Anchorage, Alaska

CTCA at Western Regional Medical Center, Goodyear, Arizona

Phoenix Childrens Hospital, Phoenix, Arizona

Arkansas Children's Hospital, Little Rock, Arkansas

City of Hope Corona, Corona, California

Kaiser Permanente Downey Medical Center, Downey, California

City of Hope Comprehensive Cancer Center, Duarte, California

Kaiser Permanente Dublin, Dublin, California

Kaiser Permanente-Fremont, Fremont, California

Kaiser Permanente-Fresno, Fresno, California

City of Hope Seacliff, Huntington Beach, California

UCI Health - Chao Family Comprehensive Cancer Center and Ambulatory Care, Irvine, California

City of Hope at Irvine Lennar, Irvine, California

City of Hope Antelope Valley, Lancaster, California

Loma Linda University Medical Center, Loma Linda, California

Miller Children's and Women's Hospital Long Beach, Long Beach, California

City of Hope at Long Beach Elm, Long Beach, California

Children's Hospital Los Angeles, Los Angeles, California

Cedars Sinai Medical Center, Los Angeles, California

Kaiser Permanente-Modesto, Modesto, California

City of Hope Newport Beach, Newport Beach, California

Kaiser Permanente-Oakland, Oakland, California

Children's Hospital of Orange County, Orange, California

UC Irvine Health/Chao Family Comprehensive Cancer Center, Orange, California

Kaiser Permanente Downtown Commons, Sacramento, California

Kaiser Permanente-South Sacramento, Sacramento, California

Rady Children's Hospital - San Diego, San Diego, California

Naval Medical Center -San Diego, San Diego, California

Kaiser Permanente-San Francisco, San Francisco, California

Kaiser Permanente-Santa Teresa-San Jose, San Jose, California

Kaiser Permanente San Leandro, San Leandro, California

Kaiser San Rafael-Gallinas, San Rafael, California

Kaiser Permanente-Santa Rosa, Santa Rosa, California

City of Hope South Pasadena, South Pasadena, California

Kaiser Permanente-South San Francisco, South San Francisco, California

City of Hope South Bay, Torrance, California

City of Hope Upland, Upland, California

Kaiser Permanente-Vallejo, Vallejo, California

Kaiser Permanente-Walnut Creek, Walnut Creek, California

Children's Hospital Colorado, Aurora, Colorado

Smilow Cancer Hospital-Derby Care Center, Derby, Connecticut

Smilow Cancer Hospital Care Center-Fairfield, Fairfield, Connecticut

Smilow Cancer Hospital Care Center at Glastonbury, Glastonbury, Connecticut

Smilow Cancer Hospital Care Center at Greenwich, Greenwich, Connecticut

Smilow Cancer Hospital Care Center - Guilford, Guilford, Connecticut

Smilow Cancer Hospital Care Center at Saint Francis, Hartford, Connecticut

Connecticut Children's Medical Center, Hartford, Connecticut

Yale University, New Haven, Connecticut

Yale-New Haven Hospital North Haven Medical Center, North Haven, Connecticut

Smilow Cancer Hospital Care Center at Long Ridge, Stamford, Connecticut

Smilow Cancer Hospital-Torrington Care Center, Torrington, Connecticut

Smilow Cancer Hospital Care Center-Trumbull, Trumbull, Connecticut

Smilow Cancer Hospital-Waterbury Care Center, Waterbury, Connecticut

Smilow Cancer Hospital Care Center - Waterford, Waterford, Connecticut

Alfred I duPont Hospital for Children, Wilmington, Delaware

MedStar Georgetown University Hospital, Washington, District of Columbia

Children's National Medical Center, Washington, District of Columbia

Broward Health Medical Center, Fort Lauderdale, Florida

Golisano Children's Hospital of Southwest Florida, Fort Myers, Florida

University of Florida Health Science Center - Gainesville, Gainesville, Florida

Memorial Regional Hospital/Joe DiMaggio Children's Hospital, Hollywood, Florida

Nemours Children's Clinic-Jacksonville, Jacksonville, Florida

Nicklaus Children's Hospital, Miami, Florida

AdventHealth Orlando, Orlando, Florida

Arnold Palmer Hospital for Children, Orlando, Florida

Nemours Children's Hospital, Orlando, Florida

Nemours Children's Clinic - Pensacola, Pensacola, Florida

Sacred Heart Hospital, Pensacola, Florida

Johns Hopkins All Children's Hospital, Saint Petersburg, Florida

Tampa General Hospital, Tampa, Florida

Saint Joseph's Hospital/Children's Hospital-Tampa, Tampa, Florida

Saint Mary's Medical Center, West Palm Beach, Florida

Grady Health System, Atlanta, Georgia

Emory Proton Therapy Center, Atlanta, Georgia

Emory University Hospital Midtown, Atlanta, Georgia

Emory University Hospital/Winship Cancer Institute, Atlanta, Georgia

Children's Healthcare of Atlanta - Arthur M Blank Hospital, Atlanta, Georgia

Emory Saint Joseph's Hospital, Atlanta, Georgia

Augusta University Medical Center, Augusta, Georgia

Atrium Health Navicent, Macon, Georgia

Kapiolani Medical Center for Women and Children, Honolulu, Hawaii

Saint Luke's Cancer Institute - Boise, Boise, Idaho

Saint Luke's Cancer Institute - Fruitland, Fruitland, Idaho

Saint Luke's Cancer Institute - Meridian, Meridian, Idaho

Saint Luke's Cancer Institute - Nampa, Nampa, Idaho

Saint Luke's Cancer Institute - Twin Falls, Twin Falls, Idaho

Rush-Copley Medical Center, Aurora, Illinois

Advocate Good Shepherd Hospital, Barrington, Illinois

Mount Sinai Hospital Medical Center, Chicago, Illinois

Lurie Children's Hospital-Chicago, Chicago, Illinois

Northwestern University, Chicago, Illinois

University of Illinois, Chicago, Illinois

University of Chicago Comprehensive Cancer Center, Chicago, Illinois

Advocate Illinois Masonic Medical Center, Chicago, Illinois

AMG Crystal Lake - Oncology, Crystal Lake, Illinois

Carle at The Riverfront, Danville, Illinois

Decatur Memorial Hospital, Decatur, Illinois

Northwestern Medicine Cancer Center Kishwaukee, DeKalb, Illinois

Advocate Good Samaritan Hospital, Downers Grove, Illinois

Carle Physician Group-Effingham, Effingham, Illinois

Crossroads Cancer Center, Effingham, Illinois

Advocate Sherman Hospital, Elgin, Illinois

Elmhurst Memorial Hospital, Elmhurst, Illinois

Northwestern Medicine Cancer Center Delnor, Geneva, Illinois

Northwestern Medicine Glenview Outpatient Center, Glenview, Illinois

Northwestern Medicine Grayslake Outpatient Center, Grayslake, Illinois

Advocate South Suburban Hospital, Hazel Crest, Illinois

Northwestern Medicine Lake Forest Hospital, Lake Forest, Illinois

AMG Libertyville - Oncology, Libertyville, Illinois

Condell Memorial Hospital, Libertyville, Illinois

Carle Physician Group-Mattoon/Charleston, Mattoon, Illinois

Loyola University Medical Center, Maywood, Illinois

Edward Hospital/Cancer Center, Naperville, Illinois

HSHS Saint Elizabeth's Hospital, O'Fallon, Illinois

Advocate Christ Medical Center, Oak Lawn, Illinois

Advocate Children's Hospital-Oak Lawn, Oak Lawn, Illinois

Northwestern Medicine Orland Park, Orland Park, Illinois

Advocate Children's Hospital-Park Ridge, Park Ridge, Illinois

Advocate Lutheran General Hospital, Park Ridge, Illinois

Saint Jude Midwest Affiliate, Peoria, Illinois

Edward Hospital/Cancer Center?Plainfield, Plainfield, Illinois

UW Health Carbone Cancer Center Rockford, Rockford, Illinois

Memorial Hospital East, Shiloh, Illinois

Southern Illinois University School of Medicine, Springfield, Illinois

Carle Cancer Center, Urbana, Illinois

Northwestern Medicine Cancer Center Warrenville, Warrenville, Illinois

Rush-Copley Healthcare Center, Yorkville, Illinois

Riley Hospital for Children, Indianapolis, Indiana

Ascension Saint Vincent Indianapolis Hospital, Indianapolis, Indiana

UI Health Care Mission Cancer and Blood - Ankeny Clinic, Ankeny, Iowa

UI Health Care Mission Cancer and Blood - West Des Moines Clinic, Clive, Iowa

Blank Children's Hospital, Des Moines, Iowa

Iowa Methodist Medical Center, Des Moines, Iowa

UI Health Care Mission Cancer and Blood - Des Moines Clinic, Des Moines, Iowa

UI Health Care Mission Cancer and Blood - Laurel Clinic, Des Moines, Iowa

University of Iowa/Holden Comprehensive Cancer Center, Iowa City, Iowa

UI Health Care Mission Cancer and Blood - Waukee Clinic, Waukee, Iowa

Wesley Medical Center, Wichita, Kansas

University of Kentucky/Markey Cancer Center, Lexington, Kentucky

Norton Children's Hospital, Louisville, Kentucky

The James Graham Brown Cancer Center at University of Louisville, Louisville, Kentucky

UofL Health Medical Center Northeast, Louisville, Kentucky

Children's Hospital New Orleans, New Orleans, Louisiana

Ochsner Medical Center Jefferson, New Orleans, Louisiana

Eastern Maine Medical Center, Bangor, Maine

Maine Children's Cancer Program, Scarborough, Maine

University of Maryland/Greenebaum Cancer Center, Baltimore, Maryland

Sinai Hospital of Baltimore, Baltimore, Maryland

Johns Hopkins University/Sidney Kimmel Cancer Center, Baltimore, Maryland

Dana-Farber Cancer Institute, Boston, Massachusetts

UMass Memorial Medical Center - University Campus, Worcester, Massachusetts

Trinity Health Saint Joseph Mercy Hospital Ann Arbor, Ann Arbor, Michigan

C S Mott Children's Hospital, Ann Arbor, Michigan

Bronson Battle Creek, Battle Creek, Michigan

Trinity Health IHA Medical Group Hematology Oncology - Brighton, Brighton, Michigan

Trinity Health IHA Medical Group Hematology Oncology - Canton, Canton, Michigan

Trinity Health IHA Medical Group Hematology Oncology - Chelsea Hospital, Chelsea, Michigan

Corewell Health Dearborn Hospital, Dearborn, Michigan

Children's Hospital of Michigan, Detroit, Michigan

Wayne State University/Karmanos Cancer Institute, Detroit, Michigan

Henry Ford Hospital, Detroit, Michigan

Michigan State University, East Lansing, Michigan

Weisberg Cancer Treatment Center, Farmington Hills, Michigan

Corewell Health Farmington Hills Hospital, Farmington Hills, Michigan

Corewell Health Grand Rapids Hospitals - Butterworth Hospital, Grand Rapids, Michigan

Corewell Health Grand Rapids Hospitals - Helen DeVos Children's Hospital, Grand Rapids, Michigan

Trinity Health Grand Rapids Hospital, Grand Rapids, Michigan

Bronson Methodist Hospital, Kalamazoo, Michigan

West Michigan Cancer Center, Kalamazoo, Michigan

Beacon Kalamazoo Cancer Center, Kalamazoo, Michigan

Trinity Health Saint Mary Mercy Livonia Hospital, Livonia, Michigan

Trinity Health Muskegon Hospital, Muskegon, Michigan

Cancer and Hematology Centers of Western Michigan - Norton Shores, Norton Shores, Michigan

Henry Ford Medical Center-Columbus, Novi, Michigan

Corewell Health Reed City Hospital, Reed City, Michigan

Corewell Health Children's, Royal Oak, Michigan

Corewell Health William Beaumont University Hospital, Royal Oak, Michigan

Corewell Health Lakeland Hospitals - Marie Yeager Cancer Center, Saint Joseph, Michigan

Munson Medical Center, Traverse City, Michigan

Corewell Health Beaumont Troy Hospital, Troy, Michigan

University of Michigan Health - West, Wyoming, Michigan

Trinity Health IHA Medical Group Hematology Oncology Ann Arbor Campus, Ypsilanti, Michigan

Mercy Hospital, Coon Rapids, Minnesota

Fairview Southdale Hospital, Edina, Minnesota

Children's Hospitals and Clinics of Minnesota - Minneapolis, Minneapolis, Minnesota

Abbott-Northwestern Hospital, Minneapolis, Minnesota

University of Minnesota/Masonic Cancer Center, Minneapolis, Minnesota

Mayo Clinic in Rochester, Rochester, Minnesota

Park Nicollet Clinic - Saint Louis Park, Saint Louis Park, Minnesota

Regions Hospital, Saint Paul, Minnesota

United Hospital, Saint Paul, Minnesota

University of Mississippi Medical Center, Jackson, Mississippi

Saint Luke's Hospital, Chesterfield, Missouri

Siteman Cancer Center at West County Hospital, Creve Coeur, Missouri

Children's Mercy Hospitals and Clinics, Kansas City, Missouri

Cardinal Glennon Children's Medical Center, Saint Louis, Missouri

Washington University School of Medicine, Saint Louis, Missouri

Siteman Cancer Center-South County, Saint Louis, Missouri

Siteman Cancer Center at Christian Hospital, Saint Louis, Missouri

Mercy Hospital Saint Louis, Saint Louis, Missouri

Siteman Cancer Center at Saint Peters Hospital, Saint Peters, Missouri

Nebraska Medicine-Bellevue, Bellevue, Nebraska

Children's Hospital and Medical Center of Omaha, Omaha, Nebraska

Nebraska Medicine-Village Pointe, Omaha, Nebraska

University of Nebraska Medical Center, Omaha, Nebraska

Alliance for Childhood Diseases/Cure 4 the Kids Foundation, Las Vegas, Nevada

Renown Regional Medical Center, Reno, Nevada

Dartmouth Hitchcock Medical Center/Dartmouth Cancer Center, Lebanon, New Hampshire

Cooper Hospital University Medical Center, Camden, New Jersey

Trinitas Hospital and Comprehensive Cancer Center - Williamson Street Campus, Elizabeth, New Jersey

Hackensack University Medical Center, Hackensack, New Jersey

Jersey City Medical Center, Jersey City, New Jersey

Saint Barnabas Medical Center, Livingston, New Jersey

Monmouth Medical Center, Long Branch, New Jersey

Morristown Medical Center, Morristown, New Jersey

Jersey Shore Medical Center, Neptune, New Jersey

Saint Peter's University Hospital, New Brunswick, New Jersey

Rutgers Cancer Institute of New Jersey-Robert Wood Johnson University Hospital, New Brunswick, New Jersey

Rutgers Cancer Institute of New Jersey, New Brunswick, New Jersey

Newark Beth Israel Medical Center, Newark, New Jersey

Saint Joseph's Regional Medical Center, Paterson, New Jersey

Community Medical Center, Toms River, New Jersey

Presbyterian Hospital, Albuquerque, New Mexico

University of New Mexico Cancer Center, Albuquerque, New Mexico

Albany Medical Center, Albany, New York

Montefiore Medical Center - Moses Campus, Bronx, New York

Roswell Park Cancer Institute, Buffalo, New York

Hematology Oncology Associates of CNY at Camillus, Camillus, New York

Hematology Oncology Associates of Central New York-East Syracuse, East Syracuse, New York

Glens Falls Hospital, Glens Falls, New York

NYU Langone Hospital - Long Island, Mineola, New York

The Steven and Alexandra Cohen Children's Medical Center of New York, New Hyde Park, New York

Laura and Isaac Perlmutter Cancer Center at NYU Langone, New York, New York

NYP/Columbia University Medical Center/Herbert Irving Comprehensive Cancer Center, New York, New York

Memorial Sloan Kettering Cancer Center, New York, New York

NYP/Weill Cornell Medical Center, New York, New York

University of Rochester, Rochester, New York

Stony Brook University Medical Center, Stony Brook, New York

State University of New York Upstate Medical University, Syracuse, New York

Wilmot Cancer Institute at Webster, Webster, New York

Mission Hospital, Asheville, North Carolina

UNC Lineberger Comprehensive Cancer Center, Chapel Hill, North Carolina

Carolinas Medical Center/Levine Cancer Institute, Charlotte, North Carolina

Duke University Medical Center, Durham, North Carolina

East Carolina University, Greenville, North Carolina

Wake Forest University Health Sciences, Winston-Salem, North Carolina

Sanford Broadway Medical Center, Fargo, North Dakota

Children's Hospital Medical Center of Akron, Akron, Ohio

Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio

Rainbow Babies and Childrens Hospital, Cleveland, Ohio

Cleveland Clinic Foundation, Cleveland, Ohio

Nationwide Children's Hospital, Columbus, Ohio

Dayton Children's Hospital, Dayton, Ohio

ProMedica Toledo Hospital/Russell J Ebeid Children's Hospital, Toledo, Ohio

University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma

Providence Willamette Falls Medical Center, Oregon City, Oregon

Providence Portland Medical Center, Portland, Oregon

Providence Saint Vincent Medical Center, Portland, Oregon

Legacy Emanuel Children's Hospital, Portland, Oregon

Oregon Health and Science University, Portland, Oregon

Lehigh Valley Hospital-Cedar Crest, Allentown, Pennsylvania

Geisinger Medical Center, Danville, Pennsylvania

Penn State Children's Hospital, Hershey, Pennsylvania

Children's Hospital of Philadelphia, Philadelphia, Pennsylvania

Saint Christopher's Hospital for Children, Philadelphia, Pennsylvania

Children's Hospital of Pittsburgh of UPMC, Pittsburgh, Pennsylvania

Rhode Island Hospital, Providence, Rhode Island

Smilow Cancer Hospital Care Center - Westerly, Westerly, Rhode Island

Prisma Health Cancer Institute - Spartanburg, Boiling Springs, South Carolina

Medical University of South Carolina, Charleston, South Carolina

Prisma Health Richland Hospital, Columbia, South Carolina

Saint Francis Hospital, Greenville, South Carolina

BI-LO Charities Children's Cancer Center, Greenville, South Carolina

Saint Francis Cancer Center, Greenville, South Carolina

Prisma Health Cancer Institute - Eastside, Greenville, South Carolina

Sanford USD Medical Center - Sioux Falls, Sioux Falls, South Dakota

T C Thompson Children's Hospital, Chattanooga, Tennessee

East Tennessee Childrens Hospital, Knoxville, Tennessee

The Children's Hospital at TriStar Centennial, Nashville, Tennessee

Vanderbilt University/Ingram Cancer Center, Nashville, Tennessee

Dell Children's Medical Center of Central Texas, Austin, Texas

Driscoll Children's Hospital, Corpus Christi, Texas

Medical City Dallas Hospital, Dallas, Texas

UT Southwestern/Simmons Cancer Center-Dallas, Dallas, Texas

El Paso Children's Hospital, El Paso, Texas

Cook Children's Medical Center, Fort Worth, Texas

Baylor College of Medicine/Dan L Duncan Comprehensive Cancer Center, Houston, Texas

M D Anderson Cancer Center, Houston, Texas

Covenant Children's Hospital, Lubbock, Texas

UMC Cancer Center / UMC Health System, Lubbock, Texas

Children's Hospital of San Antonio, San Antonio, Texas

Methodist Children's Hospital of South Texas, San Antonio, Texas

University of Texas Health Science Center at San Antonio, San Antonio, Texas

Scott and White Memorial Hospital, Temple, Texas

Huntsman Cancer Institute/University of Utah, Salt Lake City, Utah

Primary Children's Hospital, Salt Lake City, Utah

University of Vermont and State Agricultural College, Burlington, Vermont

University of Virginia Cancer Center, Charlottesville, Virginia

Inova Fairfax Hospital, Falls Church, Virginia

Children's Hospital of The King's Daughters, Norfolk, Virginia

Naval Medical Center - Portsmouth, Portsmouth, Virginia

VCU Massey Comprehensive Cancer Center, Richmond, Virginia

Carilion Children's, Roanoke, Virginia

Valley Medical Center, Renton, Washington

Seattle Children's Hospital, Seattle, Washington

Providence Sacred Heart Medical Center and Children's Hospital, Spokane, Washington

Mary Bridge Children's Hospital and Health Center, Tacoma, Washington

West Virginia University Charleston Division, Charleston, West Virginia

Edwards Comprehensive Cancer Center, Huntington, West Virginia

Aurora Cancer Care-Southern Lakes VLCC, Burlington, Wisconsin

Aurora Saint Luke's South Shore, Cudahy, Wisconsin

Aurora Health Care Germantown Health Center, Germantown, Wisconsin

Aurora Cancer Care-Grafton, Grafton, Wisconsin

Saint Vincent Hospital Cancer Center Green Bay, Green Bay, Wisconsin

Aurora BayCare Medical Center, Green Bay, Wisconsin

Aurora Cancer Care-Kenosha South, Kenosha, Wisconsin

Gundersen Lutheran Medical Center, La Crosse, Wisconsin

University of Wisconsin Carbone Cancer Center - Eastpark Medical Center, Madison, Wisconsin

University of Wisconsin Carbone Cancer Center - University Hospital, Madison, Wisconsin

Aurora Bay Area Medical Group-Marinette, Marinette, Wisconsin

Marshfield Medical Center-Marshfield, Marshfield, Wisconsin

Aurora Cancer Care-Milwaukee, Milwaukee, Wisconsin

Aurora Saint Luke's Medical Center, Milwaukee, Wisconsin

Children's Hospital of Wisconsin, Milwaukee, Wisconsin

Aurora Sinai Medical Center, Milwaukee, Wisconsin

ProHealth D N Greenwald Center, Mukwonago, Wisconsin

ProHealth Oconomowoc Memorial Hospital, Oconomowoc, Wisconsin

Vince Lombardi Cancer Clinic - Oshkosh, Oshkosh, Wisconsin

Aurora Cancer Care-Racine, Racine, Wisconsin

Saint Vincent Hospital Cancer Center at Sheboygan, Sheboygan, Wisconsin

Vince Lombardi Cancer Clinic-Sheboygan, Sheboygan, Wisconsin

Saint Vincent Hospital Cancer Center at Sturgeon Bay, Sturgeon Bay, Wisconsin

Aurora Medical Center in Summit, Summit, Wisconsin

Vince Lombardi Cancer Clinic-Two Rivers, Two Rivers, Wisconsin

UW Cancer Center at ProHealth Care, Waukesha, Wisconsin

Aurora Cancer Care-Milwaukee West, Wauwatosa, Wisconsin

Aurora West Allis Medical Center, West Allis, Wisconsin

Alberta Children's Hospital, Calgary, Alberta

University of Alberta Hospital, Edmonton, Alberta

CancerCare Manitoba, Winnipeg, Manitoba

IWK Health Centre, Halifax, Nova Scotia

McMaster Children's Hospital at Hamilton Health Sciences, Hamilton, Ontario

Children's Hospital, London, Ontario

Children's Hospital of Eastern Ontario, Ottawa, Ontario

Hospital for Sick Children, Toronto, Ontario

The Montreal Children's Hospital of the MUHC, Montreal, Quebec

Centre Hospitalier Universitaire Sainte-Justine, Montreal, Quebec

Centre Hospitalier Universitaire de Sherbrooke-Fleurimont, Sherbrooke, Quebec

Jim Pattison Children's Hospital, Saskatoon, Saskatchewan

CHU de Quebec-Centre Hospitalier de l'Universite Laval (CHUL), Quebec, Not set

University Pediatric Hospital, San Juan, Not set

Conditions: Lugano Classification Limited Stage Hodgkin Lymphoma AJCC v8

Learn More ›

Optimizing PTCy Dose and Timing

NCT03983850

Recruiting

Background: Stem cell or bone marrow transplants can cure or control blood cancers. Sometimes the donor cells see the recipient's body as foreign. This can cause complications. A high dose of the drug cyclophosphamide (PTCy) can help reduce these risks. Researchers want to see if a lower dose of PTCy can have the same benefits. Based on encouraging results from the first part of the study, researchers now are investigating whether a lower dose of PTCy can allow other immunosuppression to be decreased. Objective: To see if a lower dose of PTCy and now also shorter duration of another immunosuppressant called mycophenolate mofetil will help people with blood cancers have a more successful transplant and fewer side effects. Eligibility: People ages 15-65 with leukemia, lymphoma, or multiple myeloma that is not curable with standard therapy and is at high risk of returning without transplant, and their healthy adult relatives Design: Transplant participants will be screened with: Blood, urine, breathing, and heart tests Scans Chest x-ray Bone marrow samples: A needle inserted into the participant s pelvis will remove marrow and a bone fragment. Transplant recipients will stay at the hospital and be prepped with chemotherapy over 6 days for the transplant. They will get stem cells through a catheter in the chest or neck. They will get the cyclophosphamide chemotherapy. They will stay in the hospital about 4 more weeks. They will have blood transfusions. They will have frequent blood tests and 2 bone marrow samples within 1 year after the transplant. Donor participants will be screened with: Blood, urine, and heart tests Chest x-ray Scans Donor participants will have bone marrow taken from their pelvis or stem cells taken from their blood. For the blood donation, blood will be taken from a vein in one arm, move through a machine to remove white blood cells, and be returned through a vein in the other arm. Participation will last up to 5 years.... Read Less

Gender:

ALL

Ages:

Between 12 years and 120 years

Trial Updated:

08/16/2025

Locations: National Institutes of Health Clinical Center, Bethesda, Maryland

Conditions: Graft Versus Host Disease, Hematologic Neoplasms

Learn More ›

Phase II Study of CD5 CAR Engineered IL15-transduced Cord Blood-derived NK Cells in Conjunction With Lymphodepleting Chemotherapy for the Management of Aggressive T Cell Hematological Malignancies

NCT07137481

Not Yet Recruiting

To determine the safety and efficacy (1-year PFS) of iC9/CD5CAR/IL-15 NK cells as consolidation in patients with aggressive T-cell malignances in first remission.

Gender:

ALL

Ages:

Between 18 years and 80 years

Trial Updated:

08/15/2025

Locations: The University of Texas M. D. Anderson Cancer Center, Houston, Texas

Conditions: Hematological Malignancies

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Haplo-identical Transplantation for Severe Aplastic Anemia, Hypo-plastic MDS and PNH Using Peripheral Blood Stem Cells and Post-transplant Cyclophosphamide for GVHD Prophylaxis

NCT03520647

Recruiting

Background: Severe aplastic anemia (SAA), and myelodysplastic syndrome (MDS), and paroxysmal nocturnal hemoglobinuria (PNH) cause serious blood problems. Stem cell transplants using bone marrow or blood plus chemotherapy can help. Researchers want to see if using peripheral blood stem cells (PBSCs) rather than bone marrow cells works too. PBSCs are easier to collect and have more cells that help transplants. Objectives: To see how safely and effectively SAA, MDS and PNH are treated using per... Read More

Gender:

ALL

Ages:

Between 4 years and 75 years

Trial Updated:

08/15/2025

Locations: National Institutes of Health Clinical Center, Bethesda, Maryland

Conditions: Severe Aplastic Anemia (SAA), Hypo-Plastic Myelodysplastic Syndrome (MDS), Paroxysmal Nocturnal Hemoglobinuria (PNH)

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Nivolumab in Combination With Chemo-Immunotherapy for the Treatment of Newly Diagnosed Primary Mediastinal B-Cell Lymphoma

NCT04759586

Active Not Recruiting

This phase III trial compares the effects of nivolumab with chemo-immunotherapy versus chemo-immunotherapy alone in treating patients with newly diagnosed primary mediastinal B-cell lymphoma (PMBCL). Immunotherapy with monoclonal antibodies, such as nivolumab, may help the body's immune system attack the cancer, and may interfere with the ability of cancer cells to grow and spread. Treatment for PMBCL involves chemotherapy combined with an immunotherapy called rituximab. Chemotherapy drugs work... Read More

Gender:

ALL

Ages:

2 years and above

Trial Updated:

08/15/2025

Locations: Children's Hospital of Alabama, Birmingham, Alabama +233 locations

Children's Hospital of Alabama, Birmingham, Alabama

USA Health Strada Patient Care Center, Mobile, Alabama

Providence Alaska Medical Center, Anchorage, Alaska

Banner Children's at Desert, Mesa, Arizona

Banner University Medical Center - Tucson, Tucson, Arizona

Arkansas Children's Hospital, Little Rock, Arkansas

UC Irvine Health Cancer Center-Newport, Costa Mesa, California

Kaiser Permanente Downey Medical Center, Downey, California

City of Hope Comprehensive Cancer Center, Duarte, California

UCI Health - Chao Family Comprehensive Cancer Center and Ambulatory Care, Irvine, California

City of Hope at Irvine Lennar, Irvine, California

Loma Linda University Medical Center, Loma Linda, California

Miller Children's and Women's Hospital Long Beach, Long Beach, California

Children's Hospital Los Angeles, Los Angeles, California

Cedars Sinai Medical Center, Los Angeles, California

Mattel Children's Hospital UCLA, Los Angeles, California

Valley Children's Hospital, Madera, California

Kaiser Permanente-Oakland, Oakland, California

Children's Hospital of Orange County, Orange, California

UC Irvine Health/Chao Family Comprehensive Cancer Center, Orange, California

Lucile Packard Children's Hospital Stanford University, Palo Alto, California

University of California Davis Comprehensive Cancer Center, Sacramento, California

Rady Children's Hospital - San Diego, San Diego, California

Children's Hospital Colorado, Aurora, Colorado

Rocky Mountain Hospital for Children-Presbyterian Saint Luke's Medical Center, Denver, Colorado

Connecticut Children's Medical Center, Hartford, Connecticut

Alfred I duPont Hospital for Children, Wilmington, Delaware

MedStar Georgetown University Hospital, Washington, District of Columbia

Children's National Medical Center, Washington, District of Columbia

Broward Health Medical Center, Fort Lauderdale, Florida

Golisano Children's Hospital of Southwest Florida, Fort Myers, Florida

University of Florida Health Science Center - Gainesville, Gainesville, Florida

Memorial Regional Hospital/Joe DiMaggio Children's Hospital, Hollywood, Florida

Nemours Children's Clinic-Jacksonville, Jacksonville, Florida

University of Miami Miller School of Medicine-Sylvester Cancer Center, Miami, Florida

Arnold Palmer Hospital for Children, Orlando, Florida

Nemours Children's Hospital, Orlando, Florida

Johns Hopkins All Children's Hospital, Saint Petersburg, Florida

Tampa General Hospital, Tampa, Florida

Saint Joseph's Hospital/Children's Hospital-Tampa, Tampa, Florida

Emory Proton Therapy Center, Atlanta, Georgia

Emory University Hospital Midtown, Atlanta, Georgia

Emory University Hospital/Winship Cancer Institute, Atlanta, Georgia

Children's Healthcare of Atlanta - Arthur M Blank Hospital, Atlanta, Georgia

Emory Saint Joseph's Hospital, Atlanta, Georgia

Memorial Health University Medical Center, Savannah, Georgia

Kapiolani Medical Center for Women and Children, Honolulu, Hawaii

Saint Luke's Cancer Institute - Boise, Boise, Idaho

Rush-Copley Medical Center, Aurora, Illinois

Lurie Children's Hospital-Chicago, Chicago, Illinois

Northwestern University, Chicago, Illinois

University of Illinois, Chicago, Illinois

University of Chicago Comprehensive Cancer Center, Chicago, Illinois

Carle at The Riverfront, Danville, Illinois

Decatur Memorial Hospital, Decatur, Illinois

Northwestern Medicine Cancer Center Kishwaukee, DeKalb, Illinois

Carle Physician Group-Effingham, Effingham, Illinois

Northwestern Medicine Cancer Center Delnor, Geneva, Illinois

Northwestern Medicine Lake Forest Hospital, Lake Forest, Illinois

Carle Physician Group-Mattoon/Charleston, Mattoon, Illinois

Loyola University Medical Center, Maywood, Illinois

HSHS Saint Elizabeth's Hospital, O'Fallon, Illinois

Advocate Children's Hospital-Oak Lawn, Oak Lawn, Illinois

Advocate Children's Hospital-Park Ridge, Park Ridge, Illinois

Saint Jude Midwest Affiliate, Peoria, Illinois

Southern Illinois University School of Medicine, Springfield, Illinois

Springfield Clinic, Springfield, Illinois

Springfield Memorial Hospital, Springfield, Illinois

Carle Cancer Center, Urbana, Illinois

Northwestern Medicine Cancer Center Warrenville, Warrenville, Illinois

Riley Hospital for Children, Indianapolis, Indiana

Reid Health, Richmond, Indiana

UI Health Care Mission Cancer and Blood - Ankeny Clinic, Ankeny, Iowa

UI Health Care Mission Cancer and Blood - West Des Moines Clinic, Clive, Iowa

Blank Children's Hospital, Des Moines, Iowa

Mercy Medical Center - Des Moines, Des Moines, Iowa

UI Health Care Mission Cancer and Blood - Laurel Clinic, Des Moines, Iowa

University of Iowa/Holden Comprehensive Cancer Center, Iowa City, Iowa

Siouxland Regional Cancer Center, Sioux City, Iowa

UI Health Care Mission Cancer and Blood - Waukee Clinic, Waukee, Iowa

Wesley Medical Center, Wichita, Kansas

University of Kentucky/Markey Cancer Center, Lexington, Kentucky

Norton Children's Hospital, Louisville, Kentucky

Children's Hospital New Orleans, New Orleans, Louisiana

Ochsner Medical Center Jefferson, New Orleans, Louisiana

Eastern Maine Medical Center, Bangor, Maine

Maine Children's Cancer Program, Scarborough, Maine

University of Maryland/Greenebaum Cancer Center, Baltimore, Maryland

Greater Baltimore Medical Center, Baltimore, Maryland

Sinai Hospital of Baltimore, Baltimore, Maryland

Johns Hopkins University/Sidney Kimmel Cancer Center, Baltimore, Maryland

Walter Reed National Military Medical Center, Bethesda, Maryland

Tufts Medical Center, Boston, Massachusetts

Dana-Farber Cancer Institute, Boston, Massachusetts

C S Mott Children's Hospital, Ann Arbor, Michigan

Children's Hospital of Michigan, Detroit, Michigan

Henry Ford Hospital, Detroit, Michigan

Michigan State University, East Lansing, Michigan

Corewell Health Grand Rapids Hospitals - Helen DeVos Children's Hospital, Grand Rapids, Michigan

Bronson Methodist Hospital, Kalamazoo, Michigan

Corewell Health Lakeland Hospitals - Niles Hospital, Niles, Michigan

Corewell Health Children's, Royal Oak, Michigan

Minnesota Oncology - Burnsville, Burnsville, Minnesota

Mercy Hospital, Coon Rapids, Minnesota

Fairview Southdale Hospital, Edina, Minnesota

Unity Hospital, Fridley, Minnesota

Minnesota Oncology Hematology PA-Maplewood, Maplewood, Minnesota

Children's Hospitals and Clinics of Minnesota - Minneapolis, Minneapolis, Minnesota

Abbott-Northwestern Hospital, Minneapolis, Minnesota

Park Nicollet Clinic - Saint Louis Park, Saint Louis Park, Minnesota

United Hospital, Saint Paul, Minnesota

University of Mississippi Medical Center, Jackson, Mississippi

Saint Luke's Hospital, Chesterfield, Missouri

Siteman Cancer Center at West County Hospital, Creve Coeur, Missouri

Children's Mercy Hospitals and Clinics, Kansas City, Missouri

Washington University School of Medicine, Saint Louis, Missouri

Siteman Cancer Center-South County, Saint Louis, Missouri

Siteman Cancer Center at Christian Hospital, Saint Louis, Missouri

Mercy Hospital Saint Louis, Saint Louis, Missouri

Siteman Cancer Center at Saint Peters Hospital, Saint Peters, Missouri

Children's Hospital and Medical Center of Omaha, Omaha, Nebraska

University of Nebraska Medical Center, Omaha, Nebraska

Alliance for Childhood Diseases/Cure 4 the Kids Foundation, Las Vegas, Nevada

Renown Regional Medical Center, Reno, Nevada

Dartmouth Hitchcock Medical Center/Dartmouth Cancer Center, Lebanon, New Hampshire

Memorial Sloan Kettering Basking Ridge, Basking Ridge, New Jersey

Hackensack University Medical Center, Hackensack, New Jersey

Memorial Sloan Kettering Monmouth, Middletown, New Jersey

Memorial Sloan Kettering Bergen, Montvale, New Jersey

Morristown Medical Center, Morristown, New Jersey

Rutgers Cancer Institute of New Jersey-Robert Wood Johnson University Hospital, New Brunswick, New Jersey

Rutgers Cancer Institute of New Jersey, New Brunswick, New Jersey

Saint Joseph's Regional Medical Center, Paterson, New Jersey

Presbyterian Hospital, Albuquerque, New Mexico

Albany Medical Center, Albany, New York

Montefiore Medical Center - Moses Campus, Bronx, New York

Roswell Park Cancer Institute, Buffalo, New York

Memorial Sloan Kettering Commack, Commack, New York

Memorial Sloan Kettering Westchester, Harrison, New York

The Steven and Alexandra Cohen Children's Medical Center of New York, New Hyde Park, New York

Laura and Isaac Perlmutter Cancer Center at NYU Langone, New York, New York

NYP/Columbia University Medical Center/Herbert Irving Comprehensive Cancer Center, New York, New York

Memorial Sloan Kettering Cancer Center, New York, New York

NYP/Weill Cornell Medical Center, New York, New York

University of Rochester, Rochester, New York

Stony Brook University Medical Center, Stony Brook, New York

State University of New York Upstate Medical University, Syracuse, New York

Memorial Sloan Kettering Nassau, Uniondale, New York

New York Medical College, Valhalla, New York

Wilmot Cancer Institute at Webster, Webster, New York

Mission Hospital, Asheville, North Carolina

AdventHealth Infusion Center Asheville, Asheville, North Carolina

Carolinas Medical Center/Levine Cancer Institute, Charlotte, North Carolina

Novant Health Presbyterian Medical Center, Charlotte, North Carolina

East Carolina University, Greenville, North Carolina

AdventHealth Hendersonville, Hendersonville, North Carolina

Wake Forest University Health Sciences, Winston-Salem, North Carolina

Sanford Broadway Medical Center, Fargo, North Dakota

Children's Hospital Medical Center of Akron, Akron, Ohio

Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio

Rainbow Babies and Childrens Hospital, Cleveland, Ohio

Cleveland Clinic Foundation, Cleveland, Ohio

Nationwide Children's Hospital, Columbus, Ohio

Dayton Children's Hospital, Dayton, Ohio

Dayton Physician LLC - Englewood, Dayton, Ohio

Greater Dayton Cancer Center, Kettering, Ohio

Kettering Medical Center, Kettering, Ohio

ProMedica Toledo Hospital/Russell J Ebeid Children's Hospital, Toledo, Ohio

University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma

Legacy Emanuel Children's Hospital, Portland, Oregon

Oregon Health and Science University, Portland, Oregon

Lehigh Valley Hospital-Cedar Crest, Allentown, Pennsylvania

Geisinger Medical Center, Danville, Pennsylvania

Penn State Children's Hospital, Hershey, Pennsylvania

Children's Hospital of Philadelphia, Philadelphia, Pennsylvania

Saint Christopher's Hospital for Children, Philadelphia, Pennsylvania

Children's Hospital of Pittsburgh of UPMC, Pittsburgh, Pennsylvania

Rhode Island Hospital, Providence, Rhode Island

Prisma Health Richland Hospital, Columbia, South Carolina

Saint Francis Hospital, Greenville, South Carolina

BI-LO Charities Children's Cancer Center, Greenville, South Carolina

Saint Francis Cancer Center, Greenville, South Carolina

Prisma Health Cancer Institute - Eastside, Greenville, South Carolina

Sanford USD Medical Center - Sioux Falls, Sioux Falls, South Dakota

East Tennessee Childrens Hospital, Knoxville, Tennessee

Saint Jude Children's Research Hospital, Memphis, Tennessee

The Children's Hospital at TriStar Centennial, Nashville, Tennessee

Vanderbilt University/Ingram Cancer Center, Nashville, Tennessee

Texas Tech University Health Sciences Center-Amarillo, Amarillo, Texas

Dell Children's Medical Center of Central Texas, Austin, Texas

Driscoll Children's Hospital, Corpus Christi, Texas

Medical City Dallas Hospital, Dallas, Texas

UT Southwestern/Simmons Cancer Center-Dallas, Dallas, Texas

El Paso Children's Hospital, El Paso, Texas

Baylor College of Medicine/Dan L Duncan Comprehensive Cancer Center, Houston, Texas

Houston Methodist Hospital, Houston, Texas

M D Anderson Cancer Center, Houston, Texas

Covenant Children's Hospital, Lubbock, Texas

UMC Cancer Center / UMC Health System, Lubbock, Texas

Children's Hospital of San Antonio, San Antonio, Texas

Methodist Children's Hospital of South Texas, San Antonio, Texas

University of Texas Health Science Center at San Antonio, San Antonio, Texas

Primary Children's Hospital, Salt Lake City, Utah

University of Virginia Cancer Center, Charlottesville, Virginia

Inova Fairfax Hospital, Falls Church, Virginia

Children's Hospital of The King's Daughters, Norfolk, Virginia

VCU Massey Comprehensive Cancer Center, Richmond, Virginia

Carilion Children's, Roanoke, Virginia

Valley Medical Center, Renton, Washington

Seattle Children's Hospital, Seattle, Washington

Providence Sacred Heart Medical Center and Children's Hospital, Spokane, Washington

Mary Bridge Children's Hospital and Health Center, Tacoma, Washington

Madigan Army Medical Center, Tacoma, Washington

West Virginia University Charleston Division, Charleston, West Virginia

University of Wisconsin Carbone Cancer Center - University Hospital, Madison, Wisconsin

Marshfield Medical Center-Marshfield, Marshfield, Wisconsin

John Hunter Children's Hospital, Hunter Regional Mail Centre, New South Wales

The Children's Hospital at Westmead, Westmead, New South Wales

Queensland Children's Hospital, South Brisbane, Queensland

Royal Children's Hospital, Parkville, Victoria

Perth Children's Hospital, Perth, Western Australia

University of Alberta Hospital, Edmonton, Alberta

CancerCare Manitoba, Winnipeg, Manitoba

Janeway Child Health Centre, Saint John's, Newfoundland and Labrador

IWK Health Centre, Halifax, Nova Scotia

McMaster Children's Hospital at Hamilton Health Sciences, Hamilton, Ontario

Children's Hospital, London, Ontario

Children's Hospital of Eastern Ontario, Ottawa, Ontario

Hospital for Sick Children, Toronto, Ontario

The Montreal Children's Hospital of the MUHC, Montreal, Quebec

Centre Hospitalier Universitaire Sainte-Justine, Montreal, Quebec

Centre Hospitalier Universitaire de Sherbrooke-Fleurimont, Sherbrooke, Quebec

CHU de Quebec-Centre Hospitalier de l'Universite Laval (CHUL), Quebec, Not set

HIMA San Pablo Oncologic Hospital, Caguas, Not set

Conditions: Primary Mediastinal Large B-Cell Lymphoma

Learn More ›

Allogeneic Hematopoietic Stem Cell Transplantation With Briquilimab-Based Conditioning in Participants With GATA2 Deficiency

NCT05907746

Active Not Recruiting

Background: People with GATA2 deficiency have a mutation on the GATA2 gene. This gene affects immune function. People with this disease are prone to serious infections; in time, they may develop blood cancers. A hematopoietic stem cell (HSC) transplant can cure GATA2 deficiency, but using stem cells donated by other people can cause serious side effects. Objective: To test a new drug (Briquilimab) to see if it can make HSC transplants safer. Eligibility: People aged 6 to 70 years who have G... Read More

Gender:

ALL

Ages:

Between 6 years and 70 years

Trial Updated:

08/15/2025

Locations: National Institutes of Health Clinical Center, Bethesda, Maryland

Conditions: GATA2, Immunodeficiency

Learn More ›

A Study to Evaluate Zilovertamab Vedotin (MK-2140) Combination With Rituximab Plus Cyclophosphamide, Doxorubicin, and Prednisone (R-CHP) Versus Rituximab Plus Cyclophosphamide, Doxorubicin, Vincristine, and Prednisone (R-CHOP) in Participants With Previously Untreated DLBCL (MK-2140-010)

NCT06717347

Recruiting

The purpose of this study is to evaluate if zilovertamab vedotin with standard treatment can help people live longer without the cancer growing or spreading than people who receive standard treatment alone.

Gender:

ALL

Ages:

18 years and above

Trial Updated:

08/14/2025

Locations: The University of Arizona Cancer Center - North Campus ( Site 0124), Tucson, Arizona +198 locations

The University of Arizona Cancer Center - North Campus ( Site 0124), Tucson, Arizona

Cancer Blood and Specialty Clinic ( Site 0109), Los Alamitos, California

Cedars-Sinai Medical Center ( Site 0115), Los Angeles, California

Bioresearch Partner ( Site 0157), Hialeah, Florida

Cancer Care Specialists of Illinois ( Site 0152), O'Fallon, Illinois

Fort Wayne Medical Oncology and Hematology ( Site 0149), Fort Wayne, Indiana

Cotton O'Neil Cancer Center ( Site 0108), Topeka, Kansas

Corewell Health ( Site 0130), Grand Rapids, Michigan

Truman Medical Center ( Site 0122), Kansas City, Missouri

OptumCare Cancer Care ( Site 0121), Las Vegas, Nevada

Comprehensive Cancer Centers of Nevada ( Site 0113), Las Vegas, Nevada

New York Oncology Hematology, P.C. ( Site 0129), Albany, New York

The University of Tennessee Medical Center ( Site 0142), Knoxville, Tennessee

University of Virginia Cancer Center ( Site 0138), Charlottesville, Virginia

Virginia Cancer Institute ( Site 0148), Richmond, Virginia

Blue Ridge Cancer Care ( Site 0132), Roanoke, Virginia

SSM Health Dean Medical Group ( Site 0140), Madison, Wisconsin

Clinica Adventista Belgrano ( Site 0309), Caba., Buenos Aires

Instituto de Investigaciones Clinicas Mar del Plata ( Site 0306), Mar del Plata, Buenos Aires

Hospital Universitario Austral ( Site 0307), Pilar, Buenos Aires

Hospital Aleman ( Site 0301), Buenos Aites, Caba

Fundacion Estudios Clinicos ( Site 0311), Rosario., Santa Fe

C.I.C.E. 9 de Julio ( Site 0305), San Miguel de Tucuman, Tucuman

Hospital Italiano de Buenos Aires ( Site 0304), Caba, Not set

Clinica EL Castaño ( Site 0312), San Juan, Not set

Townsville University Hospital ( Site 3006), Douglas, Queensland

Grampians Health ( Site 3003), Ballarat, Victoria

Royal Perth Hospital-Haematology ( Site 3004), Perth, Western Australia

AZ Sint-Maarten, Campus Leopoldstraat 2 ( Site 1102), Mechelen, Antwerpen

ASBL CHU Helora - Hôpital de Mons - Site Kennedy ( Site 1103), Mons, Hainaut

CEONC ( Site 0412), Cascavel, Parana

Hospital Erasto Gaertner ( Site 0401), Curitiba, Parana

Liga Norte Riograndense Contra o Cancer ( Site 0407), Natal, Rio Grande Do Norte

CEPEN - Centro de Pesquisa e Ensino em Oncologia de Santa Catarina ( Site 0403), Florianópolis, Santa Catarina

Hope ( Site 0413), Ribeirao Preto, Sao Paulo

Clinica Advanze ( Site 0411), Sao Carlos, Sao Paulo

F. F. R. M. São Jose do Rio Preto ( Site 0404), Sjrp, Sao Paulo

Hospital Paulistano ( Site 0406), Sao Paulo, Not set

Lakeridge Health - The R.S. McLaughlin Durham Regional Cancer Centre (MDRCC) ( Site 0206), Oshawa, Ontario

Biocenter ( Site 0510), Concepcion., Biobio

IC La Serena Research ( Site 0504), La Serena, Coquimbo

Oncocentro Valdivia ( Site 0506), Valdivia, Los Rios

Centro de Estudios Clínicos SAGA ( Site 0508), Santiago., Region M. De Santiago

Bradfordhill ( Site 0502), Santiago., Region M. De Santiago

FALP ( Site 0501), Santiago, Region M. De Santiago

Clinica Inmunocel ( Site 0503), Santiago, Region M. De Santiago

Clínica RedSalud Vitacura ( Site 0512), Santiago, Region M. De Santiago

Centro de Investigaciones ( Site 0511), Vina del mar, Valparaiso

Anhui Provincial Cancer Hospital ( Site 3124), Hefei, Anhui

Peking University Third Hospital ( Site 3102), Beijing, Beijing

Beijing Cancer Hospital ( Site 3101), Beijing, Beijing

Chongqing Cancer Hospital ( Site 3113), Chongqing, Chongqing

Fujian Provincial Cancer Hospital. ( Site 3119), Fuzhou, Fujian

The First Affiliated Hospital of Xiamen University ( Site 3120), Xiamen, Fujian

Sun Yat-sen University Cancer Center ( Site 3121), Guangzhou, Guangdong

Zhujiang Hospital of Southern Medical University ( Site 3122), Guangzhou, Guangdong

Affiliated Cancer Hospital of Guangxi Medical University ( Site 3123), Nanning, Guangxi

The Affiliated Hospital of Guizhou Medical University ( Site 3112), Guiyang, Guizhou

Hubei Cancer Hospital ( Site 3125), Wuhan, Hubei

Affiliated Hospital of Nantong University ( Site 3117), Nantong, Jiangsu

Jiangxi Cancer Hospital ( Site 3118), Nanchang, Jiangxi

The First Hospital Of Jilin University ( Site 3103), Changchun, Jilin

Shandong Cancer Hospital ( Site 3108), Jinan, Shandong

LinYi Cancer Hospital ( Site 3104), Linyi, Shandong

Fudan University Shanghai Cancer Center ( Site 3115), Shanghai, Shanghai

Shanxi Cancer Hospital ( Site 3106), Taiyuan, Shanxi

1st Affil Hosp of Med College of Xi'an Jiaotong University ( Site 3107), XI An, Shanxi

Sichuan Cancer Hospital. ( Site 3111), Chengdu, Sichuan

West China Hospital, Sichuan University ( Site 3110), Chengdu, Sichuan

Institute of Hematology and Blood Diseases Hosp CAMS&PUMC ( Site 3105), Tianjin, Tianjin

Yunnan Province Cancer Hospital ( Site 3109), Kunming, Yunnan

The First Affiliated Hospital, Zhejiang Medical University ( Site 3116), Hangzhou, Zhejiang

Hospital Pablo Tobon Uribe ( Site 0604), Medellin, Antioquia

IMAT S.A.S ( Site 0603), Montería, Cordoba

Hospital Universitario San Ignacio ( Site 0607), Bogota., Distrito Capital De Bogota

Oncologos del Occidente ( Site 0601), Pereira., Risaralda

Fundación Valle del Lili ( Site 0602), Cali, Valle Del Cauca

Regionshospitalet Gødstrup ( Site 1301), Herning, Midtjylland

Aalborg University Hospital ( Site 1302), Aalborg, Nordjylland

Centre Antoine-Lacassagne ( Site 1514), Nice, Alpes-Maritimes

CHU Dijon Bourgogne ( Site 1516), Dijon, Cote-d Or

Institut Curie - site Saint-Cloud ( Site 1501), Saint-Cloud, Hauts-de-Seine

Centre Hospitalier Universitaire de Limoges - Hôpital Dupuytren ( Site 1512), Limoges, Limousin

Centre Hospitalier Régional Metz Thionville - Hôpital de Mercy ( Site 1515), Metz, Moselle

Centre Hospitalier de Dunkerque ( Site 1513), Dunkerque, Nord

Centre Hospitalier Universitaire Estaing ( Site 1508), Clermont-Ferrand, Puy-de-Dome

Centre Hospitalier de la Cote Basque ( Site 1509), Bayonne, Pyrenees-Atlantiques

HIA Sainte Anne ( Site 1506), Toulon, Var

Centre Hospitalier d'Avignon ( Site 1505), Avignon, Vaucluse

CHD Vendee ( Site 1502), La Roche-sur-Yon, Vendee

Evangelismos General Hospital of Athens ( Site 1602), Athens, Attiki

General Hospital of Athens "Laiko"-Hematology Department ( Site 1603), Athens, Attiki

Attikon University General Hospital of Athens ( Site 1604), Athens, Attiki

University General Hospital of Alexandroupoli ( Site 1601), Alexandroupolis, Evros

CELAN,S.A ( Site 0702), Guatemala., Not set

MEDI-K ( Site 0701), Guatemala, Not set

Cen Integral Onco Gastro y Hemato Onco Guatemala S.A. ( Site 0703), Guatemala, Not set

Princess Margaret Hospital ( Site 3202), Hong Kong, Not set

Queen Mary Hospital ( Site 3201), Hong Kong, Not set

Carmel Hospital ( Site 1903), Haifa, Not set

Hadassah Medical Center ( Site 1901), Jerusalem, Not set

Sourasky Medical Center ( Site 1904), Tel Aviv, Not set

Poria Medical Center ( Site 1902), Tiberias, Not set

Fondazione IRCCS San Gerardo dei Tintori ( Site 2008), Monza, Lombardia

IRCCS Crob ( Site 2002), Rionero in Vulture, Potenza

Istituto di Candiolo IRCCS - Fondazione del Piemonte per l'Oncologia ( Site 2010), Candiolo, Torino

AOU delle Marche Ospedali Riuniti di Ancona ( Site 2011), Ancona, Not set

Azienda Ospedaliera Spedali Civili di Brescia-Hemathology ( Site 2001), Brescia, Not set

IRCCS Ospedale San Raffaele ( Site 2012), Milano, Not set

IEO Istituto Europeo di Oncologia ( Site 2009), Milano, Not set

Azienda Ospedaliero Universitaria Maggiore della Carità ( Site 2004), Novara, Not set

Az. Osp. Ospedali Riuniti VILLA SOFIA-CERVELLO ( Site 2005), Palermo, Not set

Ospedale Santa Maria delle Croci ( Site 2006), Ravenna, Not set

Fondazione Policlinico Universitario Agostino Gemelli IRCCS - Università Cattolica del Sacro Cuore ( Site 2003), Roma, Not set

Nagoya University Hospital ( Site 3309), Nagoya, Aichi

National Hospital Organization Shikoku Cancer Center ( Site 3321), Matsuyama, Ehime

Kobe City Medical Center General Hospital ( Site 3318), Kobe, Hyogo

Kanazawa University Hospital ( Site 3308), Kanazawa, Ishikawa

Tokai University Hospital ( Site 3302), Isehara, Kanagawa

Tohoku University Hospital ( Site 3301), Sendai, Miyagi

Kindai University Hospital ( Site 3310), Osakasayama, Osaka

Saitama Medical University Hospital ( Site 3305), Iruma-gun, Saitama

Juntendo University Hospital ( Site 3307), Bunkyo, Tokyo

University of Yamanashi Hospital ( Site 3320), Chuo, Yamanashi

Chiba Cancer Center ( Site 3314), Chiba, Not set

Kyushu University Hospital ( Site 3313), Fukuoka, Not set

Hiroshima Red Cross Hospital & Atomic-bomb Survivors Hospital ( Site 3322), Hiroshima, Not set

University Hospital,Kyoto Prefectural University of Medicine ( Site 3315), Kyoto, Not set

University of Miyazaki Hospital ( Site 3319), Miyazaki, Not set

Okayama University Hospital ( Site 3311), Okayama, Not set

Osaka Metropolitan University Hospital ( Site 3317), Osaka, Not set

Yamagata University Hospital ( Site 3312), Yamagata, Not set

National Cancer Center- Center for Hemotologic malignancy ( Site 3806), Goyang-si, Kyonggi-do

Pusan National University Hospital ( Site 3804), Busan, Pusan-Kwangyokshi

Chungnam National University Hospital ( Site 3801), Daejeon, Taejon-Kwangyokshi

Severance Hospital, Yonsei University Health System ( Site 3802), Seoul, Not set

Asan Medical Center ( Site 3803), Seoul, Not set

Samsung Medical Center ( Site 3807), Seoul, Not set

St.Mary's H., Youido ( Site 3805), Seoul, Not set

Queen Elizabeth Hospital ( Site 3405), Kota Kinabalu, Sabah

Sarawak General Hospital ( Site 3402), Kuching, Sarawak

Hospital Miri ( Site 3403), Miri, Sarawak

Sunway Medical Centre ( Site 3406), Petaling Jaya, Selangor

Hospital Ampang ( Site 3404), Selangor Darul Ehsan, Selangor

Centro de Infusion Superare ( Site 0804), Ciudad de Mexico, Distrito Federal

Health Pharma Professional Research S.A. de C.V. ( Site 0801), Mexico City, Distrito Federal

Grupo Ollin Care ( Site 0806), Pachuca, Hidalgo

Centro de Investigacion Clinica Chapultepec ( Site 0803), Morelia, Michoacan

Hospital Universitario ""Dr. Jose Eleuterio Gonzalez"" ( Site 0802), Monterrey, Nuevo Leon

Centro de Investigacion Clinica de Oaxaca ( Site 0805), Oaxaca, Not set

Meander Medisch Centrum ( Site 2101), Amersfoort, Utrecht

Albert Schweitzer Ziekenhuis ( Site 2103), Dordrecht, Zuid-Holland

Clínicas AUNA Sede Chiclayo ( Site 0904), Chiclayo, Lambayeque

Clínica San Felipe ( Site 0906), Lima, Not set

Narodowy Instytut Onkologii im. Marii Sklodowskiej-Curie ( Site 2201), Warszawa, Mazowieckie

Wojewódzki Szpital Specjalistyczny im. J. Korczaka w Słupsku ( Site 2210), Słupsk, Pomorskie

Narodowy Instytut Onkologii - Oddzial w Gliwicach ( Site 2208), Gliwice, Slaskie

Pratia Onkologia Katowice ( Site 2204), Katowice, Slaskie

Szpital Kliniczny Ministerstwa Spraw Wewnętrznych i Administracji z Warmińsko-Mazurskim Centrum Onko ( Site 2205), Olsztyn, Warminsko-mazurskie

Unidade Local de Saude de Braga - Hospital de Braga ( Site 2306), Braga, Not set

Instituto Portugues de Oncologia Do Porto Francisco Gentil E.P.E. ( Site 2302), Porto, Not set

BRCR Global - Mayaguez ( Site 1003), Mayaguez, Not set

Auxilio Mutuo Cancer Center ( Site 1001), San Juan, Not set

Institutul Oncologic Cluj ( Site 2404), Cluj-Napoca, Cluj

Centrul de Diagnostic si Tratament Oncologic Brasov ( Site 2402), Brasov, Not set

Spital Judetean Sibiu ( Site 2405), Sibiu, Not set

National University Hospital ( Site 3702), Singapore, Central Singapore

National Cancer Centre Singapore ( Site 3701), Singapore, Central Singapore

Haemalife ( Site 2501), Cape Town, Western Cape

Hospital Universitario Virgen Macarena ( Site 2608), Sevilla, Andalucia

ICO L Hospitalet ( Site 2601), Hospitalet de Llobregat, Barcelona

H. Insular de Gran Canaria ( Site 2606), Las Palmas de Gran Canaria, Las Palmas

Hospital General Universitario Dr. Balmis ( Site 2604), Alicante, Valenciana, Comunitat

Hospital del Mar ( Site 2610), Barcelona, Not set

Hospital Universitario La Paz ( Site 2611), Madrid, Not set

Hospital Virgen de la Victoria ( Site 2609), Malaga, Not set

Hospital Universitario Miguel Servet ( Site 2607), Zaragoza, Not set

Kantonspital Baden ( Site 2703), Baden, Aargau

Cantonal Hospital St.Gallen-Oncology & Hematology ( Site 2702), St. Gallen, Sankt Gallen

Ospedale Regionale Bellinzona e Valli ( Site 2701), Bellinzona, Ticino

Chang Gung Memorial Hospital - Linkou Branch ( Site 3903), Taoyuan City, Taoyuan

Chang Gung Memorial Hospital at Kaohsiung ( Site 3905), Kaohsiung, Not set

National Cheng Kung University Hospital ( Site 3902), Tainan, Not set

National Taiwan University Hospital ( Site 3901), Taipei, Not set

Mackay Memorial Hospital ( Site 3908), Taipei, Not set

Tri-Service General Hospital ( Site 3906), Taipei, Not set

Maharaj Nakorn Chiang Mai Hospital ( Site 4002), Muang, Chiang Mai

Faculty of Medicine Siriraj Hospital ( Site 4001), Bangkoknoi, Krung Thep Maha Nakhon

Chulalongkorn University ( Site 4003), Pathumwan, Krung Thep Maha Nakhon

Hacettepe Universite Hastaneleri ( Site 2810), Ankara, Not set

Ankara University Faculty of Medicine ( Site 2801), Ankara, Not set

MNPE ClinCenter of Oncology,Hematology,Transplantology and Palliative Care of CherkasyRegCouncil ( Site 2904), Cherkasy, Cherkaska Oblast

Communal non-profit enterprise "Regional clinical hospital of Ivano-Frankivsk Regional Council" ( Site 2906), Ivano-Frankivsk, Ivano-Frankivska Oblast

Khmelnytskyi Regional Hospital ( Site 2907), Khmelnytskiy, Khmelnytska Oblast

Institute of Blood Pathology and Transfusion Medicine AMS Ukraine ( Site 2903), Lviv, Lvivska Oblast

SNPE National Cancer Institute ( Site 2902), Kyiv, Not set

Universal Clinic Oberig ( Site 2908), Kyiv, Not set

SI National Research Center of Radiation Medicine, Hematology, Oncology ( Site 2901), Kyiv, Not set

Public Non-Profit Enterprise Kyiv City Clinical Hospital #9 under the Executive Body of Kyiv City Co ( Site 2905), Kyiv, Not set

Conditions: Diffuse Large B-Cell Lymphoma

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Dose Escalation/Dose Expansion Study of PRGN-3007 UltraCAR-T Cells in Patients With Advanced Hematologic and Solid Tumor Malignancies

NCT05694364

Active Not Recruiting

The purpose of the study is to find out if an investigational drug called PRGN-3007 UltraCAR-T cells (PRGN-3007 T cells) can help people with ROR1-positive hematologic chronic lymphocytic leukemia (CLL), mantle cell lymphoma (MCL), acute lymphoblastic leukemia (ALL), diffuse large B-cell lymphoma (DLBCL) and solid tumor triple negative breast cancer (TNBC) malignancies.

Gender:

ALL

Ages:

18 years and above

Trial Updated:

08/14/2025

Locations: Moffitt Cancer Center, Tampa, Florida

Conditions: Chronic Lymphocytic Leukemia, Mantle Cell Lymphoma, Acute Lymphoblastic Leukemia, Diffuse Large B Cell Lymphoma, Triple Negative Breast Cancer Malignancies

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