Iressa and Taxotere Study in Patients With Metastatic Urothelial Cancer
Terminated
Primary Objective: 1. To compare the proportion of patients free from progression 9 months from the start of consolidation therapy with the combination of docetaxel and ZD1839 (Iressa) versus docetaxel alone. For the purposes of this protocol, "consolidation" therapy refers to treatment given at the time of maximal benefit from conventional front-line multi-agent chemotherapy. Secondary Objective: 1. To compare time to progression (TTP), overall survival (OS) and cause-specific survival (CSS)... Read More
Gender:
ALL
Ages:
All
Trial Updated:
10/08/2015
Locations: University of Texas MD Anderson Cancer Center, Houston, Texas
Conditions: Bladder Cancer
A Phase I Study of Ganetespib +/- Bortezomib in Patients With Relapsed and/or Refractory Multiple Myeloma
Completed
The purpose of this study is to find out what effects, good and/or bad, that ganetespib and bortezomib has on you and your cancer. The investigators will determine the side effects of different dose levels of ganetespib when given alone and the effect it has on your cancer alone. The investigators will also determine the side effects of ganetespib at different dose levels when given in combination with bortezomib and the effect the combination has on your cancer. The study will measure levels of... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
10/08/2015
Locations: Colorado Blood Cancer Institute, Denver, Colorado +7 locations
Conditions: Multiple Myeloma
UARK 2005-01 Study of Velcade, Thalidomide, and Dexamethasone (VTD) With or Without Adriamycin® in Relapsed/Refractory Patients
Completed
The main goal of this study is to evaluate the effectiveness of the combination of these drugs, and whether they can be given safely together.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
10/02/2015
Locations: University of Arkansas for Medical sciences, Little Rock, Arkansas
Conditions: Multiple Myeloma
A Study of Combination Thalidomide Plus Dexamethasone Therapy vs. Dexamethasone Therapy Alone in Previously Untreated Subjects With Multiple Myeloma
Completed
To compare the efficacy of combination oral thalidomide plus oral dexamethasone treatment to that of oral dexamethasone-alone treatments as induction (first-line) therapy for subjects with active multiple myeloma
Gender:
ALL
Ages:
18 years and above
Trial Updated:
09/09/2015
Locations: Clinical Research Consultants, Inc., Hoover, Alabama +98 locations
Conditions: Multiple Myeloma
Study for Treatment of Cancer in Children With Ataxia-telangiectasia
Completed
This is a pilot/feasibility study designed to investigate the feasibility of treating children with Ataxia-Telangiectasia (A-T) and cancer with regimens nearly as intense as non-A-T patients with cancer would receive.
Gender:
ALL
Ages:
10 years and below
Trial Updated:
08/26/2015
Locations: St. Jude Children's Research Hospital, Memphis, Tennessee
Conditions: Ataxia-Telangiectasia
Study of Hyper-CVAD Plus Imatinib Mesylate for Philadelphia-Positive Acute Lymphocytic Leukemia
Completed
The goal of this clinical research study is to learn if intensive chemotherapy, combined with imatinib mesylate (Gleevec, STI571) given for 8 courses over 6 months, followed by maintenance imatinib mesylate plus chemotherapy for 2 years, followed by imatinib mesylate indefinitely can improve Philadelphia-positive acute lymphoblastic leukemia. The safety of this treatment will also be studied.
Gender:
ALL
Ages:
15 years and above
Trial Updated:
08/19/2015
Locations: UT MD Anderson Cancer Center, Houston, Texas
Conditions: Leukemia
Rituximab and Dexamethasone in Treating Patients With Recurrent or Refractory Indolent Non-Hodgkin's Lymphoma
Withdrawn
RATIONALE: Monoclonal antibodies can locate tumor cells and either kill them or deliver tumor-killing substances to them without harming normal cells. Combining the monoclonal antibody rituximab with dexamethasone may kill more cancer cells. PURPOSE: Phase II trial to study the effectiveness of rituximab and dexamethasone in treating patients with recurrent or refractory indolent non-Hodgkin's lymphoma.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
08/17/2015
Locations: Hoag Memorial Hospital Presbyterian, Newport Beach, California +2 locations
Conditions: Lymphoma
Temsirolimus, Dexamethasone, Mitoxantrone Hydrochloride, Vincristine Sulfate, and Pegaspargase in Treating Young Patients With Relapsed Acute Lymphoblastic Leukemia or Non-Hodgkin Lymphoma
Completed
This phase I trial studies the side effects and the best dose of temsirolimus when given together with dexamethasone, mitoxantrone hydrochloride, vincristine sulfate, and pegaspargase in treating young patients with relapsed acute lymphoblastic leukemia or non-Hodgkin lymphoma. Temsirolimus may stop the growth of cancer cells by blocking some of the enzymes needed for cell growth. Drugs used in chemotherapy, such as dexamethasone, mitoxantrone hydrochloride, vincristine sulfate, and pegaspargase... Read More
Gender:
ALL
Ages:
Between 1 year and 21 years
Trial Updated:
07/09/2015
Locations: Children's Hospital of Alabama, Birmingham, Alabama +30 locations
Conditions: Childhood B Acute Lymphoblastic Leukemia, Childhood T Acute Lymphoblastic Leukemia, Mature T-Cell and NK-Cell Non-Hodgkin Lymphoma, Recurrent Childhood Acute Lymphoblastic Leukemia, Recurrent Childhood Lymphoblastic Lymphoma
Clinical Trial of PXD101 in Patients With Advanced Multiple Myeloma
Completed
The purpose of this open-label, non-randomized trial is to assess the safety and effectiveness of PXD101, both alone and in combination with dexamethasone, in patients with advanced multiple myeloma. PXD101 is a new, potent histone deacetylase (HDAC) inhibitor. Various members of this class of drugs have shown activity in preclinical studies and in initial clinical trials of multiple myeloma and lymphoma. Furthermore, HDAC inhibitors, including PXD101, have been shown to sensitize myeloma cells... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
07/07/2015
Locations: James Berenson, MD, Inc, West Hollywood, California +9 locations
Conditions: Multiple Myeloma
Study: Treatment of Relapsed Lymphoid Malignancies With an Anti-Angiogenic Approach
Terminated
1.1 To determine the efficacy of a combination treatment of VP-16, chlorambucil, dexamethasone, and vincristine in patients with relapsed/refractory hematological malignancies. 1.2 To determine the toxicity profile of the above regimen in this patient population. 1.3 Evaluate the effect of low dose administration of chemotherapy on angiogenesis, and correlate this with tumor responses.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
07/06/2015
Locations: University of New Mexico Cancer Center, Albuquerque, New Mexico
Conditions: Non-Hodgkin's Lymphoma, Cancer
Bortezomib and Dexamethasone With or Without Lenalidomide in Treating Patients With Multiple Myeloma Previously Treated With Dexamethasone
Terminated
This randomized phase III trial compares bortezomib, dexamethasone, and lenalidomide with bortezomib and dexamethasone to see how well they work in treating patients with multiple myeloma previously treated with dexamethasone. Bortezomib may stop the growth of cancer cells by blocking some of the enzymes needed for cell growth. Drugs used in chemotherapy, such as dexamethasone, work in different ways to stop the growth of cancer cells, either by killing the cells or by stopping them from dividin... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
06/23/2015
Locations: Mayo Clinic in Arizona, Scottsdale, Arizona +275 locations
Conditions: Stage I Multiple Myeloma, Stage II Multiple Myeloma, Stage III Multiple Myeloma
A Safety and Efficacy Study of a Dexamethasone Drug Delivery System for Postoperative Inflammation and Pain After Cataract Surgery
Terminated
This is a safety and efficacy study of a Dexamethasone Drug Delivery System for anterior segment inflammation and pain following cataract extraction with lens implantation.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
06/11/2015
Locations: Not set, Newport Beach, California
Conditions: Cataract