Study: Treatment of Relapsed Lymphoid Malignancies With an Anti-Angiogenic Approach
NCT00250718
Terminated
1.1 To determine the efficacy of a combination treatment of VP-16, chlorambucil, dexamethasone, and vincristine in patients with relapsed/refractory hematological malignancies. 1.2 To determine the toxicity profile of the above regimen in this patient population. 1.3 Evaluate the effect of low dose administration of chemotherapy on angiogenesis, and correlate this with tumor responses.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
07/06/2015
Locations: University of New Mexico Cancer Center, Albuquerque, New Mexico
Conditions: Non-Hodgkin's Lymphoma, Cancer
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Bortezomib and Dexamethasone With or Without Lenalidomide in Treating Patients With Multiple Myeloma Previously Treated With Dexamethasone
NCT00522392
Terminated
This randomized phase III trial compares bortezomib, dexamethasone, and lenalidomide with bortezomib and dexamethasone to see how well they work in treating patients with multiple myeloma previously treated with dexamethasone. Bortezomib may stop the growth of cancer cells by blocking some of the enzymes needed for cell growth. Drugs used in chemotherapy, such as dexamethasone, work in different ways to stop the growth of cancer cells, either by killing the cells or by stopping them from dividin... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
06/23/2015
Locations: Mayo Clinic in Arizona, Scottsdale, Arizona +275 locations
Conditions: Stage I Multiple Myeloma, Stage II Multiple Myeloma, Stage III Multiple Myeloma
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A Safety and Efficacy Study of a Dexamethasone Drug Delivery System for Postoperative Inflammation and Pain After Cataract Surgery
NCT01605942
Terminated
This is a safety and efficacy study of a Dexamethasone Drug Delivery System for anterior segment inflammation and pain following cataract extraction with lens implantation.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
06/11/2015
Locations: Not set, Newport Beach, California
Conditions: Cataract
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Methotrexate, Vincristine, Pegylated L-Asparaginase and Dexamethasone (MOAD) in Acute Lymphoblastic Leukemia (ALL) Salvage
NCT00905034
Completed
This goal of this clinical research study is to learn if the combination of methotrexate, pegylated-L-asparaginase, vincristine, and dexamethasone (also rituximab in some patients) can help to control ALL that has not responded to previous treatment or has come back after a response or chronic myeloid leukemia (CML).
Gender:
ALL
Ages:
1 year and above
Trial Updated:
06/09/2015
Locations: University of Texas MD Anderson Cancer Center, Houston, Texas
Conditions: Leukemia, Lymphocytic, Acute
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Minimal Breathing Support and Early Steroids to Prevent Chronic Lung Disease in Extremely Premature Infants (SAVE)
NCT00005777
Terminated
This multicenter clinical trial tested whether minimal ventilation decreases death or BPD. Infants with birth weight 501g to 1000g and mechanically ventilated before 12 hours were randomly assigned to minimal ventilation (partial pressure of carbon dioxide \[PCO(2)\] target \>52 mm Hg) or routine ventilation (PCO(2) target \<48 mm Hg) and a tapered dexamethasone course or saline placebo for 10 days, using a 2 x 2 factorial design. The primary outcome was death or BPD at 36 weeks' postmenstrual a... Read More
Gender:
ALL
Ages:
Between 5 minutes and 10 days
Trial Updated:
06/03/2015
Locations: University of Alabama at Birmingham, Birmingham, Alabama +12 locations
Conditions: Bronchopulmonary Dysplasia, Respiratory Distress Syndrome, Infant, Newborn, Infant, Low Birth Weight, Infant, Small for Gestational Age, Infant, Premature
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Lenalidomide/Bortezomib/Dexamethasone & CNTO 328 in Transplant Eligible Newly Diagnosed Multiple Myeloma (MM)
NCT01531998
Completed
The goal of this clinical research study is to find the highest tolerable dose of Siltuximab that can be given in combination with Velcade (bortezomib), Revlimid (lenalidomide), and dexamethasone to patients with MM. The safety of this drug combination will also be studied.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
06/02/2015
Locations: University of Texas MD Anderson Cancer Center, Houston, Texas
Conditions: Myeloma
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EryDex Pharmacokinetics in Healthy Volunteers
NCT01925859
Completed
To compare the pharmacokinetic properties of two different doses of EryDex (dexamethasone sodium phosphate encapsulated in erythrocytes) given as a single infusion in healthy volunteers, based on plasma concentrations of dexamethasone.
Gender:
ALL
Ages:
Between 18 years and 55 years
Trial Updated:
05/29/2015
Locations: SNBL Clinical Pharmacology Center, Baltimore, Maryland
Conditions: Healthy
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Ozurdex for Macular Edema Post Membrane Peeling
NCT01273727
Completed
An epiretinal membrane is scar tissue on the retina that can cause blurring and distortion of vision and lead to swelling, or macular edema. Despite surgery to remove the scar tissue(membrane peeling), residual swelling of the retina may continue to interfere with vision. In this study the investigators will inject an implantable steroid device into the back, fluid-filled portion of the eye. Steroids have been found to decrease the swelling in the retina. Ozurdex™ is an implantable steroid. Onc... Read More
Gender:
ALL
Ages:
21 years and above
Trial Updated:
05/12/2015
Locations: Retina Specialists PC, New York, New York
Conditions: Epiretinal Membrane, Cellophane Maculopathy, Macular Edema, Retinal Edema
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Dexamethasone Iontophoretic Patch for the Treatment of Pain Associated With Lateral Epicondylitis
NCT00794976
Completed
The objective of this study is to determine the safety and efficacy of a dexamethasone iontophoretic transdermal patch for the treatment of pain associated with lateral epicondylitis (tennis elbow).
Gender:
ALL
Ages:
18 years and above
Trial Updated:
05/11/2015
Locations: Not set, Birmingham, Alabama +9 locations
Conditions: Lateral Epicondylitis, (Tennis Elbow)
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Phenylbutyrate, Dexamethasone, and Sargramostim in Treating Patients With Refractory or Relapsed Acute Myeloid Leukemia
NCT00006240
Completed
RATIONALE: Drugs used in chemotherapy use different ways to stop cancer cells from dividing so they stop growing or die. Colony-stimulating factors such as sargramostim may increase the number of immune cells found in bone marrow or peripheral blood and may help a person's immune system recover from the side effects of chemotherapy. PURPOSE: Phase II trial to study the effectiveness of combining phenylbutyrate, dexamethasone, and sargramostim in treating patients who have refractory or relapsed... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
04/27/2015
Locations: Warren Grant Magnuson Clinical Center - NCI Clinical Studies Support, Bethesda, Maryland +3 locations
Conditions: Leukemia
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Randomized Phase II Trial of Doxil With or Without Dexamethasone for Metastatic Hormone Refractory Prostate Cancer
NCT00176293
Terminated
The primary objective of this study is to assess disease response to Doxil in patients with hormone refractory prostate cancer with or without dexamethasone pre-treatment. Study Design: We will perform an open labeled, parallel, randomized phase II study using a two-stage design to determine if there is sufficient anti-tumor activity in either arm to warrant further study. Assumptions made in this study: an unacceptable overall response rate is \Read More
Gender:
MALE
Ages:
18 years and above
Trial Updated:
04/20/2015
Locations: University of Kentucky, Lexington, Kentucky
Conditions: Prostate Cancer
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Safety and Effectiveness of Granulocyte Transfusions in Resolving Infection in People With Neutropenia (The RING Study)
NCT00627393
Completed
Neutropenia, a condition characterized by an abnormally low number of infection-fighting white blood cells called neutrophils, commonly develops in people who have undergone chemotherapy or hematopoietic stem cell (HSC) transplantation. The severely reduced immunity of those with neutropenia can put them at risk of entry of life-threatening infections, making the implementation of treatments that increase white blood cell numbers important. Several studies have shown that the transfusion of dono... Read More
Gender:
ALL
Ages:
All
Trial Updated:
04/16/2015
Locations: University of Iowa Hospitals and Clinics, Iowa City, Iowa +12 locations
Conditions: Neutropenia, Infection
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