Irinotecan, Vincristine, and Dexamethasone In Children With Relapsed And/Or Refractory Hematologic Malignancies
NCT00718757
Completed
The purpose of this study is to estimate the maximum tolerated dose of dexamethasone given for 5 consecutive days when combined with fixed doses of irinotecan (given IV, qd x 5, 2 days off, qd x 5) and vincristine (given IV, 2 doses total on days 1 and 8 of schedule) in children with relapsed or refractory hematologic malignancies. In addition we will also study the pharmacokinetics of irinotecan when given without and then with dexamethasone in each patient, evaluate the relationship between ir... Read More
Gender:
ALL
Ages:
21 years and below
Trial Updated:
08/26/2013
Locations: Rady's Children Hospital San Diego, San Diego, California +1 locations
Conditions: Non-Hodgkins Lymphoma, Hodgkin's Disease, Acute Lymphoblastic Leukemia
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Combination Chemotherapy in Treating Children With Acute Lymphocytic Leukemia
NCT00002812
Completed
RATIONALE: Drugs used in chemotherapy use different ways to stop cancer cells from dividing so they stop growing or die. Combining more than one drug and giving the drugs in different combinations may kill more cancer cells. PURPOSE: Randomized phase III trial to compare the effectiveness of standard combination chemotherapy treatment with more intensive combination chemotherapy in treating children with acute lymphocytic leukemia.
Gender:
ALL
Ages:
Between 1 year and 21 years
Trial Updated:
08/23/2013
Locations: Long Beach Memorial Medical Center, Long Beach, California +34 locations
Conditions: Leukemia
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Combination Chemotherapy in Treating Children With Relapsed Acute Lymphoblastic Leukemia
NCT00002816
Completed
RATIONALE: Drugs used in chemotherapy use different ways to stop cancer cells from dividing so they stop growing or die. PURPOSE: Phase III trial to compare the effectiveness of combination chemotherapy in treating children who have relapsed acute lymphoblastic leukemia.
Gender:
ALL
Ages:
20 years and below
Trial Updated:
08/21/2013
Locations: Long Beach Memorial Medical Center, Long Beach, California +32 locations
Conditions: Leukemia
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Combination Chemotherapy in Treating Patients With Non-Hodgkin's Lymphoma or Acute Lymphocytic Leukemia
NCT00005977
Completed
RATIONALE: Drugs used in chemotherapy use different ways to stop cancer cells from dividing so they stop growing or die. Combining more than one drug may kill more cancer cells. PURPOSE: Phase II trial to study the effectiveness of combination chemotherapy in treating patients who have non-Hodgkin's lymphoma or acute lymphocytic leukemia.
Gender:
ALL
Ages:
22 years and below
Trial Updated:
08/19/2013
Locations: University of Alabama at Birmingham Comprehensive Cancer Center, Birmingham, Alabama +118 locations
Conditions: Leukemia, Lymphoma
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Phase 1/2 Study of VELCADE® in Combination With Other Drugs to Treat Previously Untreated Multiple Myeloma Patients
NCT00507442
Completed
The purpose of this Phase 1/2 study is to evaluate the efficacy and safety of treatment with VELCADE, dexamethasone, and Revlimid® (VDR) as well as VELCADE, dexamethasone, cyclophosphamide, and Revlimid (VDCR) in patients with multiple myeloma who have received no prior treatment. This study will evaluate whether the addition of Revlimid to VELCADE and Dexamethasone will increase the complete response (CR)/ very good partial response (VGPR) rate.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
07/18/2013
Locations: Rocky Mountain Cancer Center, Denver, Colorado +1 locations
Conditions: Multiple Myeloma
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Radiation Therapy Plus Chemotherapy in Treating Patients With Pancreatic Cancer
NCT00002689
Completed
RATIONALE: Radiation therapy uses high-energy x-rays to damage tumor cells. Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. Radiation therapy combined with chemotherapy may kill more tumor cells. PURPOSE: Phase II trial to study the effectiveness of brachytherapy followed by external-beam radiation therapy plus chemotherapy in treating patients who have pancreatic cancer that cannot be removed surgically.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
07/17/2013
Locations: Northside Hospital Cancer Center, Atlanta, Georgia +1 locations
Conditions: Pancreatic Cancer
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Hepatic Arterial Infusion Plus Chemotherapy in Treating Patients With Colorectal Cancer Metastatic to the Liver
NCT00026234
Completed
Phase II trial to study the effectiveness of hepatic arterial infusion plus chemotherapy in treating patients who have colorectal cancer metastatic to the liver. Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. Giving the drugs in different combinations and different ways may kill more tumor cells.
Gender:
ALL
Ages:
All
Trial Updated:
07/15/2013
Locations: North Central Cancer Treatment Group, Rochester, Minnesota
Conditions: Adenocarcinoma of the Colon, Adenocarcinoma of the Rectum, Liver Metastases, Recurrent Colon Cancer, Recurrent Rectal Cancer, Stage IV Colon Cancer, Stage IV Rectal Cancer
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Isotretinoin Plus Dexamethasone in Treating Patients With Multiple Myeloma
NCT00021359
Completed
RATIONALE: Drugs used in chemotherapy use different ways to stop cancer cells from dividing so they stop growing or die. Combining chemotherapy with dexamethasone may be an effective treatment for multiple myeloma. PURPOSE: Phase II trial to study the effectiveness of combining isotretinoin and dexamethasone in treating patients who have multiple myeloma.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
07/09/2013
Locations: Hunterdon Regional Cancer Center, Flemington, New Jersey +17 locations
Conditions: Multiple Myeloma and Plasma Cell Neoplasm
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Interferon Alfa Following Chemotherapy and Peripheral Stem Cell Transplantation in Treating Patients With Stage III or Stage IV Multiple Myeloma
NCT00003007
Completed
RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. Peripheral stem cell transplantation may allow the doctor to give higher doses of chemotherapy drugs and kill more tumor cells. Interferon alfa may interfere with the growth of cancer cells. PURPOSE: Phase II trial to determine the effectiveness of giving interferon alfa after chemotherapy and peripheral stem cell transplantation to patients who have stage III or stage IV mult... Read More
Gender:
ALL
Ages:
Between 19 years and 64 years
Trial Updated:
06/25/2013
Locations: William F. Bowld Hospital, Memphis, Tennessee +3 locations
Conditions: Multiple Myeloma and Plasma Cell Neoplasm
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Combination Chemotherapy in Treating Pediatric Patients With Stage III or IV Non-Hodgkin's Lymphoma
NCT00002691
Completed
RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. Combining more than one drug and using drugs in different ways may kill more tumor cells. PURPOSE: Phase II trial to study the effectiveness of combination chemotherapy in treating pediatric patients with stage III or stage IV non-Hodgkin's lymphoma.
Gender:
ALL
Ages:
21 years and below
Trial Updated:
06/24/2013
Locations: Memorial Sloan-Kettering Cancer Center, New York, New York
Conditions: Lymphoma
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GCS-100LE in Combination With Etoposide and Dexamethasone in Relapsed or Refractory Diffuse Large B-Cell Lymphoma
NCT00776802
Withdrawn
Phase 1/2, open-label, dose-escalation study to assess the safety and tolerability of GCS-100 in combination with etoposide and dexamethasone in patients with relapsed or refractory diffuse large B-cell lymphoma.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
06/21/2013
Locations: UCLA Medical Center, Los Angeles, California
Conditions: Diffuse Large B-cell Lymphoma
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Safety and Efficacy Study of GCS-100LE in the Treatment of Multiple Myeloma
NCT00609817
Terminated
A Phase 1, open-label, dose escalation, multi-center study in patients who have been diagnosed with multiple myeloma and who have relapsed or have refractory/relapsed disease after treatment with at least 2 prior therapies.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
06/21/2013
Locations: University of Florida, Gainesville, Florida +2 locations
Conditions: Multiple Myeloma
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