Study of Multiple Myeloma Patients Relapsing or Progressing After Autologous Transplantation on Total Therapy 2
NCT00573391
Terminated
This study is being done to find out if the combination of VelcadeTM with melphalan and dexamethasone (VMD) will be as effective, or even more effective as it is in combination with thalidomide and dexamethasone (VTD).
Gender:
ALL
Ages:
18 years and above
Trial Updated:
07/18/2011
Locations: University of Arkansas for Medical Sciences, Little Rock, Arkansas
Conditions: Multiple Myeloma
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Reduced Fluence Visudyne-Anti-VEGF-Dexamethasone In Combination for AMD Lesions (RADICAL)
NCT00492284
Completed
The objective of this study is to determine if combination therapy (reduced-fluence Visudyne followed by Lucentis \[within 2 hours\] or either of two regimens of reduced-fluence Visudyne followed by Lucentis-Dexamethasone triple therapy \[within 2 hours\]) reduces retreatment rates compared with Lucentis monotherapy while maintaining similar vision outcomes and an acceptable safety profile.
Gender:
ALL
Ages:
50 years and above
Trial Updated:
05/31/2011
Locations: Not set, Mobile, Alabama +25 locations
Conditions: Choroidal Neovascularization, Macular Degeneration
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A Study of the Safety and Efficacy of a New Treatment for Non-Infectious Anterior Uveitis
NCT00333996
Terminated
This study will evaluate the safety and efficacy of an intravitreal implant of dexamethasone for the treatment of non-infectious anterior uveitis.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
05/27/2011
Locations: Not set, Dallas, Texas
Conditions: Anterior Uveitis
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Cyclophosphamide, Bortezomib, and Dexamethasone in Treating Patients With Newly Diagnosed Multiple Myeloma
NCT00609167
Completed
RATIONALE: Drugs used in chemotherapy such as cyclophosphamide and dexamethasone work in different ways to stop the growth of cancer cells, either by killing the cells or by stopping them from dividing. Bortezomib may stop the growth of cancer cells by blocking some of the enzymes needed for cell growth. Giving cyclophosphamide and dexamethasone together with bortezomib may kill more cancer cells. PURPOSE: This phase II trial is studying giving cyclophosphamide and dexamethasone together with b... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
05/13/2011
Locations: Mayo Clinic in Arizona, Scottsdale, Arizona +1 locations
Conditions: Multiple Myeloma and Plasma Cell Neoplasm
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A Pilot Study of the Combination of Melphalan, Bortezomib, Thalidomide and Dexamethasone (MEL-VTD)
NCT00577668
Withdrawn
In this study, researchers want to find out if using the VTD regimen, along with higher doses melphalan, in subjects who have relapsed or progressed after previous transplant(s), can be given safely to subjects who have failed previous transplant(s).
Gender:
ALL
Ages:
18 years and above
Trial Updated:
05/02/2011
Locations: University of Arkansas for Medical Sciences, Little Rock, Arkansas
Conditions: Multiple Myeloma
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Safety and Efficacy Study of EGP-437 (Dexamethasone Phosphate Formulated for Ocular Iontophoresis) to Treat Dry Eye
NCT01129856
Completed
The purpose of this study is to assess the safety and efficacy of EGP-437 (dexamethasone phosphate formulated for ocular iontophoresis) using the EyeGate® II Iontophoresis system in patients with dry eye.
Gender:
ALL
Ages:
12 years and above
Trial Updated:
04/25/2011
Locations: The Eye Care Group, Waterbury, Connecticut +4 locations
Conditions: Dry Eye
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Total Therapy Study XIV for Newly Diagnosed Patients With Acute Lymphoblastic Leukemia
NCT00187005
Terminated
The main purpose of this study is to find out if radiation to the central nervous system (CNS) can be safely omitted with early intensification of chemotherapy and chemotherapy given directly to the CNS. Another purpose is to find out if survival of children with ALL can be improved with risk-directed therapy given on this protocol.
Gender:
ALL
Ages:
18 years and below
Trial Updated:
03/29/2011
Locations: St.Jude Children's Research Hospital, Memphis, Tennessee
Conditions: Acute Lymphoblastic Leukemia
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A Study of the Safety and Efficacy of a New Treatment for Non-Infectious Intermediate or Posterior Uveitis
NCT00333814
Completed
This study will evaluate the safety and efficacy of an intravitreal implant of dexamethasone for the treatment of non-infectious intermediate or posterior uveitis.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
03/11/2011
Locations: Not set, Dallas, Texas +17 locations
Conditions: Intermediate Uveitis, Posterior Uveitis
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Calcitriol and Dexamethasone in Treating Patients With Prostate Cancer Who Have Undergone Surgery or Radiation Therapy
NCT00054522
Completed
RATIONALE: Calcitriol may help tumor cells develop into normal cells. Dexamethasone may increase the effectiveness of calcitriol by making tumor cells more sensitive to the drug. PURPOSE: Phase II trial to study the effectiveness of combining calcitriol with dexamethasone in treating patients with prostate cancer who have undergone surgery or radiation therapy.
Gender:
MALE
Ages:
18 years and above
Trial Updated:
03/07/2011
Locations: Roswell Park Cancer Institute, Buffalo, New York +1 locations
Conditions: Prostate Cancer
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Dexamethasone Treatment of Congenital Adrenal Hyperplasia
NCT00621985
Completed
The purpose of this study is to determine if dexamethasone given at night is a more effective treatment for congenital adrenal hyperplasia in young children than standard three times per day hydrocortisone. Our hypothesis is that nocturnal dexamethasone will lead to more efficient suppression of the hypothalamic-pituitary-adrenal axis. We performed a cross-over trial comparing hormonal control during two 24-hour hospitalizations, one on hydrocortisone and one on nocturnal dexamethasone.
Gender:
ALL
Ages:
Between 2 years and 9 years
Trial Updated:
01/26/2011
Locations: Children's Hospital Boston, Boston, Massachusetts
Conditions: Adrenal Hyperplasia, Congenital
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High-Dose Chemotherapy Followed by Total-Body Irradiation and Peripheral Stem Cell Transplantation in Treating Patients With Chronic Lymphocytic Leukemia
NCT00002788
Completed
RATIONALE: Drugs used in chemotherapy use different ways to stop cancer cells from dividing so they stop growing or die. Radiation therapy uses high-energy x-rays to damage cancer cells. Combining chemotherapy and radiation therapy with peripheral stem cell transplantation may allow the doctor to give higher doses of chemotherapy drugs and kill more cancer cells. PURPOSE: Phase I trial to study the effectiveness of high-dose combination chemotherapy followed by total-body irradiation and periph... Read More
Gender:
ALL
Ages:
Between 17 years and 65 years
Trial Updated:
09/13/2010
Locations: Fred Hutchinson Cancer Research Center, Seattle, Washington
Conditions: Leukemia
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Safety and Efficacy Study of Iontophoresis and Dexamethasone Phosphate to Treat Dry Eye
NCT00765804
Completed
The purpose of this study is to assess the safety and efficacy of iontophoretic delivery of dexamethasone phosphate ophthalmic solution using the EyeGate® II Drug Delivery System in patients with dry eye.
Gender:
ALL
Ages:
12 years and above
Trial Updated:
08/27/2010
Locations: Ophthalmic Research Associates, Andover, Massachusetts +1 locations
Conditions: Dry Eye Syndrome
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