Arsenic Trioxide, Thalidomide, Dexamethasone, and Ascorbic Acid in Treating Patients With Relapsed or Refractory Multiple Myeloma
NCT00227682
Terminated
RATIONALE: Drugs used in chemotherapy, such as arsenic trioxide, dexamethasone, and ascorbic acid, work in different ways to stop the growth of cancer cells, either by killing the cells or by stopping them from dividing. Giving more than one drug (combination chemotherapy) may kill more cancer cells. Sometimes when chemotherapy is given, it does not stop the growth of cancer cells. The cancer is said to be resistant to chemotherapy. Giving arsenic trioxide together with chemotherapy may reduce d... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
05/24/2012
Locations: OHSU Knight Cancer Institute, Portland, Oregon
Conditions: Multiple Myeloma and Plasma Cell Neoplasm
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Focal Segmental Glomerulosclerosis Clinical Trial (FSGS-CT)
NCT00135811
Completed
The FSGS Clinical Trial is a multi-center, prospective, controlled, open label randomized trial designed to determine if treatment with mycophenolate mofetil (MMF) in conjunction with pulse steroids is superior to treatment with Cyclosporine-A (CSA) in inducing remission from proteinuria over 12 months.
Gender:
ALL
Ages:
Between 2 years and 40 years
Trial Updated:
05/21/2012
Locations: Data Coordinating Center; Cleveland Clinic Foundation; Quantitative Health Sciences; 9500 Euclid Avenue, Cleveland, Ohio
Conditions: Glomerulosclerosis, Focal
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Corticosteroid Injection for Common Upper Extremity Problems
NCT00438672
Completed
The purpose of the study is to compare the effectiveness of a steroid injection to a placebo (inactive substance) in the treatment of lateral elbow pain, deQuervain's tendonitis, or base of the thumb carpometacarpal (CMC) arthritis. We are also trying to identify which personality factors and mindsets influence perceptions of elbow, wrist and hand pain. We hope to enroll 213 subjects in this study.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
04/25/2012
Locations: Massachusetts General Hospital, Boston, Massachusetts
Conditions: Lateral Elbow Pain
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Study of KIR-Ligand Mismatched Haplo-Identical Natural Killer Cells Transfused Before Autologous Stem Cell Transplant
NCT00089453
Completed
The purpose of this study is to induce anti-myeloma responses in patients with high risk or relapsed myeloma using combination chemo- and immunotherapy comprising sequentially: 1) lymphoid and myeloid suppressive conditioning, 2) adoptive transfer of purified KIR-ligand mismatched Natural Killer cells from a haplo-identical donor, and 3) autografting two weeks after infusion of NK cells to ensure autologous reconstitution. Other objectives include establishing the response rate, disease free sur... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
04/17/2012
Locations: University of Arkansas for Medical Sciences/MIRT, Little Rock, Arkansas
Conditions: Multiple Myeloma
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Post Operative Sore Throat and Dexamethasone
NCT01052038
Completed
Sore throat is a common postoperative complaint that can lead to morbidity and patient dissatisfaction . The incidence of sore throat has been reported to be between 6% and 90% even under optimal intubating conditions. There are several factors that have been shown to contribute to postoperative sore throat such as patient related factors, type of anesthesia and type of surgery. Corticosteroids are also commonly used in the perioperative period to potentiate analgesics and as antiemetics. The p... Read More
Gender:
FEMALE
Ages:
Between 18 years and 64 years
Trial Updated:
04/05/2012
Locations: Northwesten University, Chicago, Illinois
Conditions: Sore Throat, Pain
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Alternative Schedule of Velcade/Dexamethasone Plus Doxil for Patients With Multiple Myeloma
NCT00366106
Terminated
The current study is being conducted to evaluate the possibility that a different schedule of bortezomib, doxorubicin HCl liposome, and dexamethasone might decrease the incidence of peripheral neuropathy yet maintain similar efficacy and allow maintenance of bortezomib dosing for a longer period.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
04/04/2012
Locations: Wilshire Oncology Medical Group, Inc., La Verne, California +14 locations
Conditions: Multiple Myeloma
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A Bioequivalence Study of Tobradex AF
NCT00362895
Completed
The purpose of the study is to determine the amount of study medication that moves from the front of the eye into the fluid at the front of the inside of the eye.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
03/02/2012
Locations: Contact Alcon for Trial Location(s), Fort Worth, Texas
Conditions: Cataract
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Study of Augmented Hyper-CVAD in Acute Lymphoblastic Leukemia Salvage
NCT00890656
Completed
The goal of this clinical research study is to learn if a special combination of chemotherapy drugs called "augmented hyper-CVAD chemotherapy" given over 6 to 8 months followed by monthly maintenance chemotherapy for one year can help to control acute lymphoblastic leukemia or lymphoblastic lymphoma. The safety of this therapy will also be studied.
Gender:
ALL
Ages:
All
Trial Updated:
02/17/2012
Locations: UT MD Anderson Cancer Center, Houston, Texas
Conditions: Acute Lymphoblastic Leukemia
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Velcade, Doxil, and Dexamethasone (VDd) as First Line Therapy for Multiple Myeloma
NCT00116961
Completed
This is a research study for patients with newly diagnosed multiple myeloma. Multiple myeloma remains a non-curable disease however, newer medications and their combinations appear to provide higher response rates and higher complete response rates than current treatment options. One of the new medications in multiple myeloma is Velcade. Preliminary results from a study using a combination of Velcade with Doxil have shown high response rates (disease reduction). Preliminary results also show tha... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
02/05/2012
Locations: University of Michigan, Ann Arbor, Michigan
Conditions: Multiple Myeloma
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Study of Combination Therapy With VELCADE, Doxil, and Dexamethasone (VDd) in Multiple Myeloma
NCT00135187
Completed
Patients are being asked to take part in this research study because they have multiple myeloma which has relapsed after (come back), or is refractory to (unaffected by), initial therapy. For patients who have relapsed or are refractory to therapy, there is no agreed upon standard treatment. Treatment options include chemotherapy and, for some patients, bone marrow transplants. None of the available treatments are curative and investigators are continually looking for more effective treatments.... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
02/05/2012
Locations: University of Michigan Cancer Center, Ann Arbor, Michigan
Conditions: Multiple Myeloma
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Using Dexamethasone After Uvulopalatopharyngoplasty
NCT00584168
Completed
This study looks at lessening the pain after a Uvulopalatopharyngoplasty (UPPP) surgery by using Dexamethasone (a corticosteroid).
Gender:
ALL
Ages:
18 years and above
Trial Updated:
02/01/2012
Locations: University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma +1 locations
Conditions: Pain
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Zylet vs TobraDex in Blepharokeratoconjunctivitis
NCT00447577
Completed
The objective of this study is to evaluate the safety and efficacy of Zylet vs. Tobradex in the treatment of ocular inflammation associated with blepharokeratoconjunctivitis
Gender:
ALL
Ages:
18 years and above
Trial Updated:
12/07/2011
Locations: Cornerstone Eye Care, High Point, North Carolina
Conditions: Blepharokeratoconjunctivitis
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