Iontophoresis With Dexamethasone and Physical Therapy to Treat Apophysitis of the Knee in Pediatrics
NCT03606980
Terminated
The goal of this clinical research study is to determine if there is a difference in time to meet return to sport criteria for Pediatric patients with apophysitis of the knee who receive iontophoresis with Dexamethasone Sodium Phosphate (DSP) and Physical Therapy (PT) as those who receive iontophoresis with placebo and PT or PT alone. Approximately 147 patients will be enrolled in this study.
Gender:
ALL
Ages:
Between 7 years and 18 years
Trial Updated:
02/07/2024
Locations: CHKD Sports Medicine Physical Therapy - Oakbrooke, Chesapeake, Virginia +4 locations
Conditions: Apophysitis; Juvenile
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Isatuximab, Velcade, and Dexamethasone in Patients With Multiple Myeloma and Severe KIDNEY Disease
NCT04912427
Terminated
This is a phase Ib study to assess the safety, tolerability, preliminary efficacy, and renal response of isatuximab, bortezomib, and dexamethasone in newly diagnosed multiple myeloma patients with severe renal impairment or dialysis-dependent end-stage renal disease. Such patients have limited therapeutic options due to renal clearance or nephrotoxicity of many myeloma therapies and are often excluded from clinical trials. Isatuximab in other regimens has shown efficacy and tolerability in patie... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
02/06/2024
Locations: Washington University School of Medicine, Saint Louis, Missouri
Conditions: Multiple Myeloma
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Ofatumumab in Combination With Cyclophosphamide, Doxorubicin Hydrochloride, Vincristine Sulfate, and Dexamethasone Alternating With Ofatumumab in Combination With Cytarabine and Methotrexate in Treating Patients With Newly Diagnosed Mantle Cell Lymphoma
NCT01527149
Completed
This phase II trial studies how well ofatumumab in combination with cyclophosphamide, doxorubicin hydrochloride, vincristine sulfate, and dexamethasone alternating with ofatumumab in combination with cytarabine and methotrexate works in treating patients with newly diagnosed mantle cell lymphoma (MCL). Monoclonal antibodies, such as ofatumumab, may interfere with the ability of cancer cells to grow and spread. Drugs used in chemotherapy, such as cyclophosphamide, doxorubicin hydrochloride, vincr... Read More
Gender:
ALL
Ages:
Between 18 years and 70 years
Trial Updated:
02/04/2024
Locations: Roswell Park Cancer Institute, Buffalo, New York +1 locations
Conditions: Stage I Mantle Cell Lymphoma, Stage II Contiguous Mantle Cell Lymphoma, Stage II Non-Contiguous Mantle Cell Lymphoma, Stage III Mantle Cell Lymphoma, Stage IV Mantle Cell Lymphoma
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Isatuximab, Bela Maf, Pom, and Dex in Relapsed/Refractory Multiple Myeloma
NCT05922501
Not Yet Recruiting
The main goal of this phase II study is to evaluate the overall response rate of isatuximab, belantamab mafodotin, pomalidomide, and dexamethasone in relapsed and refractory multiple myeloma. The study drugs provided for research purposes are isatuximab and belantamab mafodotin.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
01/31/2024
Locations: Massachusetts General Hospital, Boston, Massachusetts +1 locations
Conditions: Relapsed Cancer, Refractory Multiple Myeloma, Multiple Myeloma
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A Study of Melphalan Flufenamide (Melflufen)-Dex or Pomalidomide-dex for RRMM Patients Refractory to Lenalidomide
NCT03151811
Terminated
This was a randomized, controlled, open-label, Phase 3 multicenter study which enrolled patients with RRMM following 2-4 lines of prior therapy and who were refractory to lenalidomide in the last line of therapy as demonstrated by disease progression on or within 60 days of completion of the last dose of lenalidomide. Patients received either melflufen+dex or pomalidomide+dex.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
01/29/2024
Locations: US17, Tucson, Arizona +104 locations
Conditions: Multiple Myeloma
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Dexamethasone for Post Uterine Artery Embolization Pain
NCT04655144
Active Not Recruiting
The purpose of this research is to investigate if administration steroids (anti-inflammatory medication) via the uterine arteries during uterine fibroid embolization (A non surgical procedure for treating uterine fibroids by blocking their blood supply) can help reduce the pain, nausea, vomiting, and general feeling of weakness following the procedure.
Gender:
FEMALE
Ages:
Between 20 years and 50 years
Trial Updated:
01/29/2024
Locations: Sylvester Comprehensive Cancer Center, Miami, Florida
Conditions: Leiomyoma
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Bendamustine + Pomalidomide + Dex in R/R Multiple Myeloma
NCT01754402
Active Not Recruiting
This study is designed as a phase I-II, open label, dose finding study. Study treatment will be as follows, in 28 day cycles: * Pomalidomide: once daily orally (PO) dosing on days 1-21, every 28 days * Bendamustine: once intravenously (IV) dosing on day 1, every 28 days * Dexamethasone: weekly PO or IV dosing on days 1, 8, 15, and 22. After completing 6 cycles of treatment, dexamethasone may be decreased to 20mg per investigator discretion. After completing 12 cycles of treatment, patients wi... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
01/25/2024
Locations: Duke University Medical Center, Durham, North Carolina
Conditions: Multiple Myeloma
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Intracanalicular Dexamethasone Insert for Post-Corneal Cross-Linking Inflammation and Pain- The LINK Study
NCT04168112
Completed
There is no standard of care medication regimen for the management of pain and inflammation post-corneal crosslinking (CXL), although most cornea specialists agree on use of an antibiotic and steroid eye drop in the immediate postoperative period. However, steroid tapering schedule and use of additional topical non-steroidal anti-inflammatory (NSAID) eyedrops vary amongst practitioners. The goal of this study is to compare postoperative pain scores between patients receiving a tapering dose of t... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
01/25/2024
Locations: SightMD, Babylon, New York
Conditions: Keratoconus, Unstable, Collagen Crosslinking, Postoperative Pain
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Distal Radius Steroid
NCT05655130
Terminated
The primary goal of this study is to compare functional outcomes (range of motion \[flexion, extension, supination, pronation\], return to work, of patients with distal radius fractures who receive intraoperative glucocorticoids to those that do not. Secondary goals include comparison of pain control (number of pain pills consumed, visual analog scale (VAS) pain scores) between patients with distal radius fractures who receive intraoperative glucocorticoids to those that do not. The primary endp... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
01/19/2024
Locations: Indiana Hand to Shoulder Center, Indianapolis, Indiana
Conditions: Fractures, Bone, Fractures, Closed, Radius Fracture Distal
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Chemotherapy With or Without Radiation, Low and Intermediate Risk Hodgkins Lymphoma, TXCH-HD-12A
NCT01858922
Completed
Subjects have a type of cancer called Hodgkin Disease (HD), a cancer of the lymph system. The lymph system is made up of tissue throughout the body that makes and stores infection-fighting cells. HD is one of the most treatable childhood cancers. The standard treatment for HD involves chemotherapy (treatment with anti-cancer drugs) and radiation therapy (the use of high-dose x-rays to get rid of cancer cells). Although they are cured from their cancer, some patients experience negative side effe... Read More
Gender:
ALL
Ages:
All
Trial Updated:
01/10/2024
Locations: Texas Children's Hospital, Houston, Texas
Conditions: Hodgkin Disease
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Stem Cell Transplant in Treating Patients With Acute Myeloid Leukemia
NCT00630565
Terminated
RATIONALE: Giving chemotherapy and colony-stimulating factors, such as G-CSF, may increase the number of stem cells in the blood. The stem cells are collected from the patient's blood and stored. Chemotherapy or radiation therapy is given to prepare the bone marrow for the stem cell transplant. The stem cells are then returned to the patient to replace the blood-forming cells that were destroyed by the chemotherapy and radiation therapy. PURPOSE: This clinical trial is studying how well an auto... Read More
Gender:
ALL
Ages:
70 years and below
Trial Updated:
01/09/2024
Locations: Masonic Cancer Center, University of Minnesota, Minneapolis, Minnesota
Conditions: Leukemia
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Intratumor Injection of Anti-Mesothelin Immunotoxin LMB-100 With Ipilimumab in Malignant Mesothelioma
NCT04840615
Terminated
Background: Mesothelioma is a type of cancer. It originates in cells that line human body cavities. Most people have advanced disease when they are diagnosed. Researchers want to see if a combination of drugs can help. Objective: To find a safe dose of LMB-100 in combination with ipilimumab when LMB-100 is injected into tumors. Eligibility: Adults ages 18 and older with malignant pleural or peritoneal mesothelioma, that cannot be cured with surgery and has not responded to standard first-li... Read More
Gender:
ALL
Ages:
Between 18 years and 120 years
Trial Updated:
01/09/2024
Locations: National Institutes of Health Clinical Center, Bethesda, Maryland
Conditions: Mesothelioma
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