Efficacy and Safety Study of bb2121 Versus Standard Regimens in Subjects With Relapsed and Refractory Multiple Myeloma (RRMM)
NCT03651128
Active Not Recruiting
This is a multicenter, randomized, open-label, Phase 3 study comparing the efficacy and safety of bb2121 versus standard regimens in subjects with relapsed and refractory multiple myeloma (RRMM). The study is anticipated to randomize approximately 381 subjects with RRMM. Approximately 254 subjects will be randomized to Treatment Arm A and approximately 127 subjects will be randomized to Treatment Arm B.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
12/13/2022
Locations: Local Institution - 109, Birmingham, Alabama +59 locations
Conditions: Multiple Myeloma
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Frailty Score-guided Dosing of Lenalidomide, Dexamethasone and Daratumumab Induction Therapy
NCT04223661
Withdrawn
The purpose of this study is to determine if using a subject's baseline frailty score to guide the dosing of lenalidomide in a combination with dexamethasone and daratumumab (DRd lite).
Gender:
ALL
Ages:
65 years and above
Trial Updated:
12/06/2022
Locations: VA Roudebush Medical Center, Indianapolis, Indiana
Conditions: Multiple Myeloma
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The Effects of Dexamethasone on the Time to Pain Resolution in Dental Periapical Abscess
NCT03005522
Completed
An individual's quality of life can be seriously affected by the severity of dental pain. The emergency department is a common place to find those seeking relief from their dental pain- often times seeking removal of the affected tooth, dental anesthetic injections or oral pain medications. There are a number of dental infections that cause this type of debilitating pain. One such dental infection is termed periapical abscess. This infection involves the tooth pulp. These infections can arise in... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
11/29/2022
Locations: Banner University Medical Center, Tucson, Arizona
Conditions: Dental Research, Pharmaceutical Preparations, Dental
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Comparative Trial Via Tranforaminal Approach Versus Epidural Catheter Via Interlaminar Approach
NCT03382821
Completed
Do cervical epidural steroid injections done by transforaminal catheter targeted approach improve pain and function in patients with cervical radicular pain?
Gender:
ALL
Ages:
Between 18 years and 80 years
Trial Updated:
11/22/2022
Locations: University of Utah Orthopaedic Center, Salt Lake City, Utah
Conditions: Cervical Radiculopathy
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A Study of Ixazomib, Given With Dexamethasone in Adults With Multiple Myeloma
NCT03170882
Completed
The main aim of this study is to learn if ixazomib, given with dexamethasone, stops the cancer from getting worse in people with relapsed or refractory multiple myeloma. It will be compared to another medicine called pomalidomide, given with dexamethasone with people with the same condition. Relapsed means the previous cancer treatment stopped working, over time. Refractory means they did not respond to previous cancer treatment. Another aim is to check for side effects from the study medicines.... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
11/21/2022
Locations: Highlands Oncology Group, Fayetteville, Arkansas +110 locations
Conditions: Relapsed and/or Refractory Multiple Myeloma
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A Study of Melphalan Flufenamide (Melflufen) Plus Dexamethasone in Patients With Relapsed or Refractory Multiple Myeloma
NCT02963493
Completed
This study will evaluate melflufen in combination with dexamethasone in adult patients with relapsed or refractory multiple myeloma in whose disease is refractory to pomalidomide and/or an anti-CD38 monoclonal antibody. All patients in the study will be treated with melflufen on Day 1 and dexamethasone on Days 1, 8, 15 and 22 of each 28-day cycle.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
11/18/2022
Locations: Innovative Clinical Research Institute (ICRI), Whittier, California +19 locations
Conditions: Multiple Myeloma
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Selinexor for Treatment of Light Chain Amyloidosis With Relapsed/Refractory Disease
NCT04984330
Withdrawn
The purpose of this study is to test the safety and efficacy of Selinexor and Dexamethasone and see what effects it has on AL amyloidosis.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
11/11/2022
Locations: Weill Cornell Medicine - Multiple Myeloma Center, New York, New York
Conditions: Amyloid, Amyloidosis, AL Amyloidosis
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Phase 3 Study With Carfilzomib and Dexamethasone Versus Bortezomib and Dexamethasone for Relapsed Multiple Myeloma Patients
NCT01568866
Completed
The primary objective of this study was to compare progression-free survival in patients with multiple myeloma who relapsed after 1 to 3 prior therapies treated with carfilzomib plus dexamethasone or bortezomib plus dexamethasone.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
11/10/2022
Locations: Providence St. Joseph Medical Center, Burbank, California +240 locations
Conditions: Multiple Myeloma
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Oprozomib and Dexamethasone,in Combination With Lenalidomide or Oral Cyclophosphamide to Treat Newly Diagnosed Multiple Myeloma
NCT01881789
Terminated
The primary objectives of this study included the following: Phase 1b: * To establish the maximum tolerated dose (MTD) of oprozomib given in combination with lenalidomide and dexamethasone (ORd) or with cyclophosphamide and dexamethasone (OCyd) * To evaluate the safety and tolerability of oprozomib and dexamethasone administered in combination with lenalidomide or oral cyclophosphamide Phase 2: * To estimate the antitumor activity of each combination regimen, as measured by overall response... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
11/10/2022
Locations: Clearview Cancer Institute, Huntsville, Alabama +13 locations
Conditions: Multiple Myeloma
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Palliative Management of Inoperable Malignant Bowel Obstruction
NCT04027348
Terminated
To identify the role of palliative medical management of inoperable malignant bowel obstruction (MBO) with Octreotide, Dexamethasone and Metoclopramide given together as triple therapy.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
11/09/2022
Locations: Roswell Park Cancer Institute, Buffalo, New York
Conditions: Malignant Bowel Obstruction
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Clinical Investigation of the Dextenza 0.4mg Intracanalicular Insert Delivery System Used in Cataract Surgery
NCT04687800
Terminated
To monitor intraocular pressure in glaucoma patients after cataract surgery preformed in conjunction with minimally invasive glaucoma surgery (MIGS)
Gender:
ALL
Ages:
Between 18 years and 90 years
Trial Updated:
11/08/2022
Locations: The Eye Associates of Manatee, Bradenton, Florida
Conditions: Cataract
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A Safety and Efficacy Study of Ibrutinib in Pediatric and Young Adult Participants With Relapsed or Refractory Mature B-cell Non-Hodgkin Lymphoma
NCT02703272
Terminated
The purpose of this study is to confirm that the pharmacokinetics of ibrutinib in pediatric participants is consistent with that in adults (part 1) and to assess efficacy (event-free survival \[EFS\]) of ibrutinib in combination with rituximab, ifosfamide, carboplatin, and etoposide (RICE) or rituximab, vincristine, ifosfamide, carboplatin, and idarubicin (RVICI) background therapy compared to RICE or RVICI background therapy alone (part 2).
Gender:
ALL
Ages:
Between 1 year and 30 years
Trial Updated:
11/07/2022
Locations: Not set, Los Angeles, California +76 locations
Conditions: Lymphoma, Non-Hodgkin
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