Bupivacaine/Epinephrine +Dexamethasone vs. Liposomal Bupivacaine
NCT03906617
Recruiting
This study will assess analgesia after robotic lung surgery. Subjects will be randomized to receive wound infiltration and intercostal nerve block with either liposomal bupivacaine or bupivacaine/epinephrine + dexamethasone. Liposomal bupivacaine is a newer local anesthetic product and has not been compared to a combination of bupivacaine/epinephrine + dexamethasone in the context of pain control after robotic lung surgery.
Gender:
ALL
Ages:
Between 18 years and 90 years
Trial Updated:
11/11/2021
Locations: Cooper University Hospital, Camden, New Jersey
Conditions: Robotic Lung Surgery
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DEXTENZA for the Treatment of Pain and Inflammation Following Surgical Trabeculectomy and Ahmed Valve Procedures
NCT05116345
Unknown
This is a prospective, comparative, open-label, single-center, randomized, investigator-sponsored clinical study and seeks to investigate clinical outcomes with standard of care and high dose DEXTENZA treatment compared to standard of care topical dexamethasone in patients undergoing trabeculectomy, trabeculectomy Ex-PRESS, Xen Gel stent, and Ahmed Valve surgery. Patients will be followed through 6 months. After screening a given patient for inclusion and exclusion criteria, and gaining informed... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
11/09/2021
Locations: Hamilton Eye Institute, Memphis, Tennessee
Conditions: Glaucoma Following Surgery
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A Study of the Combination Vorinostat With Lenalidomide, Bortezomib and Dexamethasone for Patients With Newly Diagnosed Multiple Myeloma
NCT01038388
Completed
The purpose of the study is to evaluate the clinical effectiveness and side effects of the vorinostat, bortezomib, lenalidomide, and dexamethasone investigational combination.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
11/01/2021
Locations: Emory University Winship Cancer Institute, Atlanta, Georgia
Conditions: Multiple Myeloma
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Chemotherapy and Azidothymidine, With or Without Radiotherapy, for High Grade Lymphoma in AIDS-Risk Group Members
NCT00000703
Completed
To determine the safety and effectiveness of a combination chemotherapy-radiation-zidovudine (AZT) treatment for patients with peripheral lymphoma. Other chemotherapies have been tried in patients with AIDS related lymphomas, but the results have not been satisfactory. This study will show whether the combination of chemotherapy, radiation, and AZT is more effective and less toxic than previously used treatments.
Gender:
ALL
Ages:
Between 19 years and 69 years
Trial Updated:
10/27/2021
Locations: Los Angeles County - USC Med Ctr, Los Angeles, California +13 locations
Conditions: Lymphoma, Non-Hodgkin, HIV Infections
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The Use of Chemotherapy Plus Radiotherapy Plus Azidothymidine in Patients With AIDS-Related Lymph Node Cancer
NCT00000723
Terminated
To determine the safety and toxicity of high-dose systemic methotrexate (MTX) and dexamethasone (DEX) combined with zidovudine (AZT) and brain irradiation in patients with AIDS-related primary central nervous system (CNS) lymphoma and to determine response rates and survival of treated patients. Also to determine if the treatment inhibits HIV replication in patients who are HIV culture and/or antigen positive and to assess the incidence of opportunistic infection in these patients Results of rad... Read More
Gender:
ALL
Ages:
Between 18 years and 70 years
Trial Updated:
10/27/2021
Locations: Tulane Med. Ctr. - Charity Hosp. of New Orleans, ACTU, New Orleans, Louisiana
Conditions: Lymphoma, Non-Hodgkin, HIV Infections
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Dexamethasone in Cryptococcal Meningitis
NCT00000776
Completed
To evaluate the effect of corticosteroids on reducing elevated intracranial pressure in cryptococcal meningitis. To evaluate the safety of corticosteroids in patients with cryptococcal meningitis and intracranial hypertension. In AIDS patients with cryptococcal meningitis, a correlation has been found between early death and elevated intracranial pressure. Since dexamethasone has been found to reduce intracranial pressure resulting from other forms of meningitis, it may be of benefit in AIDS pa... Read More
Gender:
ALL
Ages:
13 years and above
Trial Updated:
10/27/2021
Locations: Univ of Alabama at Birmingham, Birmingham, Alabama +13 locations
Conditions: Meningitis, Cryptococcal, HIV Infections
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A Phase III Randomized Trial of Low-Dose Versus Standard-Dose mBACOD Chemotherapy With rGM-CSF for Treatment of AIDS-Associated Non-Hodgkin's Lymphoma
NCT00000658
Completed
To determine the impact of dose intensity on tumor response and survival in patients with HIV-associated non-Hodgkin's lymphoma (NHL). HIV-infected patients are at increased risk for developing intermediate and high-grade NHL. While combination chemotherapy for aggressive B-cell NHL in the absence of immunodeficiency is highly effective, the outcome of therapy for patients with AIDS-associated NHL has been disappointing. Treatment is frequently complicated by the occurrence of multiple opportun... Read More
Gender:
ALL
Ages:
12 years and above
Trial Updated:
10/26/2021
Locations: USC CRS, Los Angeles, California +21 locations
Conditions: Lymphoma, Non-Hodgkin, HIV Infections
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Phase I Trial of mBACOD and Granulocyte-Macrophage Colony-Stimulating Factor (GM-CSF) in AIDS-Associated Large Cell, Immunoblastic, and Small Non-cleaved Lymphoma
NCT00000689
Completed
To determine the toxicity and effectiveness of adding sargramostim (recombinant granulocyte-macrophage colony stimulating factor; GM-CSF) to a standard chemotherapy drug combination (methotrexate, bleomycin, doxorubicin, cyclophosphamide, vincristine, and dexamethasone) known as mBACOD in the treatment of non-Hodgkin's lymphoma in patients who are infected with HIV. Treatment of patients with AIDS-associated lymphoma is achieving inferior results when compared with outcomes for non-AIDS patient... Read More
Gender:
ALL
Ages:
13 years and above
Trial Updated:
10/26/2021
Locations: USC CRS, Los Angeles, California
Conditions: Lymphoma, Non-Hodgkin, HIV Infections
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Stem Cell Transplantation in Individuals With Multiple Myeloma (BMT CTN 0102)
NCT00075829
Completed
The study is designed as a Phase III, multi-center trial of tandem autologous transplants versus the strategy of autologous followed by Human Leukocyte Antigen (HLA)-matched sibling non-myeloablative allogeneic transplant. Study subjects will be biologically assigned to the appropriate arm depending on the availability of an HLA-matched sibling. There is a nested randomized phase III trial of observation versus maintenance therapy following the second autologous transplant for patients on the ta... Read More
Gender:
ALL
Ages:
70 years and below
Trial Updated:
10/19/2021
Locations: University of Alabama at Birmingham, Birmingham, Alabama +35 locations
Conditions: Multiple Myeloma
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S1106 Rituximab With Combination Chemotherapy or Bendamustine Hydrochloride Followed by Consolidation Chemotherapy and Stem Cell Transplantation in Older Patients With Previously Untreated Mantle Cell Lymphoma
NCT01412879
Completed
RATIONALE: Monoclonal antibodies, such as rituximab, can block cancer growth in different ways. Some find cancer cells and help kill them or carry cancer-killing substances to them. Others interfere with the ability of cancer cells to grow and spread. Drugs used in chemotherapy also work in different ways to kill more cancer cells or stop them from growing. It is not yet known whether rituximab is more effective with combination chemotherapy or bendamustine hydrochloride in treating patients wit... Read More
Gender:
ALL
Ages:
Between 18 years and 65 years
Trial Updated:
10/14/2021
Locations: City of Hope Comprehensive Cancer Center, Duarte, California +203 locations
Conditions: Lymphoma
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Comparison of Dexamethasone Oral Preparations to Assess Taste and Acceptance in Children With Asthma and Croup
NCT03705273
Terminated
Study of the palatability and acceptability of dexamethasone oral tablets crushed and placed in apple sauce or pudding in comparison with the IV solution mixed with sugar syrup and given orally. It is hypothesized that dexamethasone tablets crushed and administered in apple sauce or pudding will be more palatable and acceptable for pediatric patients receiving dexamethasone for an acute asthma exacerbation or croup.
Gender:
ALL
Ages:
Between 1 year and 7 years
Trial Updated:
10/11/2021
Locations: Vanderbilt University Medical Center, Nashville, Tennessee
Conditions: Asthma, Croup
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Study of Single Agent Lenalidomide in Older Adults With Newly Diagnosed Multiple Myeloma
NCT01054144
Completed
The purpose of this research is to estimate the effectiveness of a response adapted approach with the use of the drug, lenalidomide in the treatment of older adults with newly diagnosed standard risk multiple myeloma. This means that participants will be given the study drug, lenalidomide but depending on how they respond to this drug they may also be given dexamethasone and/or prednisone to help with their treatment.
Gender:
ALL
Ages:
65 years and above
Trial Updated:
10/08/2021
Locations: H. Lee Moffitt Cancer Center and Research Institute, Tampa, Florida
Conditions: Multiple Myeloma
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