Efficacy of Aprepitant (Emend®) in Children
NCT01661335
Completed
The purpose of this study is to find out whether or not adding aprepitant(Emend®) to the standard therapy will help children who receive chemotherapy to have less nausea and vomiting.
Gender:
ALL
Ages:
Between 6 months and 20 years
Trial Updated:
03/18/2021
Locations: Jimmy Everest Center for Cancer and Blood Disorders in Children, Oklahoma City, Oklahoma
Conditions: Nausea, Vomiting, Childhood Cancer
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Expanded Access Program for Melphalan Flufenamide (Melflufen) in Triple Class Refractory Multiple Myeloma
NCT04534322
Approved For Marketing
To provide early treatment access and evaluate the safety of melflufen and dexamethasone in patients with triple class refractory (TCR) multiple myeloma (MM).
Gender:
ALL
Ages:
18 years and above
Trial Updated:
03/16/2021
Locations: Highlands Oncology Group, Springdale, Arkansas +10 locations
Conditions: Relapsed and/or Refractory Multiple Myeloma
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Ozurdex for Treatment of Recalcitrant Diabetic Macular Edema
NCT01571232
Completed
The purpose of this study is to test the efficacy of an 0.7 mg intravitreal dexamethasone implant (Ozurdex®) on macular leakage and visual acuity for patients with recalcitrant diabetic macular edema.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
03/08/2021
Locations: Retina Macula Institute, Torrance, California
Conditions: Diabetic Macular Edema, Non-proliferative Diabetic Retinopathy, Proliferative Diabetic Retinopathy
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ABT-751 With Chemotherapy for Relapsed Pediatric ALL
NCT00439296
Terminated
This is a phase I/II study of an investigational drug called ABT-751, produced by Abbott Laboratories, given in combination with chemotherapy drugs used to treat acute lymphoblastic leukemia (ALL) that has come back (recurred). The phase I portion of this study is being done to find the highest dose of ABT-751 that can be given safely in combination with other chemotherapy drugs. A safe dose is one that does not result in unacceptable side effects. After a safe dose for ABT-751 given with chemot... Read More
Gender:
ALL
Ages:
21 years and below
Trial Updated:
02/22/2021
Locations: Childrens Hospital Los Angeles, Los Angeles, California +4 locations
Conditions: Recurrent Pediatric ALL, Relapsed Pediatric ALL, Acute Lymphoblastic Leukemia, Refractory Pediatric ALL
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Study Comparing Rovalpituzumab Tesirine Versus Topotecan in Subjects With Advanced or Metastatic Small Cell Lung Cancer With High Levels of Delta-like Protein 3 (DLL3) and Who Have First Disease Progression During or Following Front-line Platinum-based Chemotherapy (TAHOE)
NCT03061812
Completed
The purpose of this randomized, open-label, 2-arm, phase 3 study is to assess the efficacy, safety and tolerability of rovalpituzumab tesirine versus topotecan in participants with advanced or metastatic SCLC with high levels of DLL3, who have first disease progression during or following front-line platinum-based chemotherapy.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
02/19/2021
Locations: Clearview Cancer Institute /ID# 155873, Huntsville, Alabama +194 locations
Conditions: Small Cell Lung Cancer
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A Study of Aezea® (Cenersen) in Transfusion Dependent Anemia Associated With Myelodysplastic Syndrome (MDS)
NCT02243124
Terminated
The purpose of the study is to test the safety of six cycles of cenersen treatment and to begin to test the hypothesis that intermittent administration of cenersen may lead to a reduced dependence on transfusion.
Gender:
ALL
Ages:
Between 18 years and 95 years
Trial Updated:
02/18/2021
Locations: H. Lee Moffitt Cancer Center & Research Institute, Tampa, Florida
Conditions: Myelodysplastic Syndromes
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Carfilzomib, Lenalidomide, and Dexamethasone in New Multiple Myeloma Patients
NCT01402284
Completed
Background: - Carfilzomib is an experimental anti-cancer drug that has not yet been approved for treating multiple myeloma. Lenalidomide is a drug that may stop tumor growth and help the immune system kill cancer cells. Dexamethasone is a drug that helps stop inflammation. It is sometimes used to treat (alone or with other drugs) certain types of cancer, especially multiple myeloma. This combination of drugs has not been tested in people with multiple myeloma. Researchers want to see whether it... Read More
Gender:
ALL
Ages:
Between 18 years and 99 years
Trial Updated:
02/10/2021
Locations: National Institutes of Health Clinical Center, 9000 Rockville Pike, Bethesda, Maryland
Conditions: Multiple Myeloma
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Intraoperative TAP Block With Bupivacaine/Dexamethasone Against Liposomal Bupivacaine (Exparel®)
NCT03723447
Completed
Traditionally, opioids are heavily utilized in treating postoperative pain but they are associated with numerous side effects. The use of the transversus abdominis plane (TAP) blocks have become standard practice to extend the post-operative analgesic window and limit opioid use. A new liposomal-depo formulation of bupivacaine (Exparel) has gained popularity as a long-lasting TAP block medication, but has not been studied in a well-powered clinical trial specifically in colorectal patients nor c... Read More
Gender:
ALL
Ages:
Between 18 years and 90 years
Trial Updated:
02/08/2021
Locations: Cedars Sinai Medical Center, Los Angeles, California
Conditions: Pain, Postoperative, Crohn Disease, Inflammatory Bowel Diseases, Colorectal Cancer, Gastrointestinal Cancer, Gastrointestinal Disease, Digestive System Disease, Pain, Pain, Neuropathic, Intestinal Disease
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Liposomal Bupivacaine Plus Bupivacaine Peripheral Nerve Blockade Versus Ropivacaine Plus Dexamethasone Peripheral Nerve Blockade for Arthroscopic Rotator Cuff Repair
NCT04737980
Completed
This study is a comparison of analgesia effect from peripheral nerve blockade (PNB) with liposomal bupivacaine combined with bupivacaine compared to PNB with ropivacaine combined with dexamethasone for arthroscopic rotator cuff repair.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
02/03/2021
Locations: HSS Florida, West Palm Beach, Florida
Conditions: Rotator Cuff Tears, Shoulder Pain
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Dexamethasone Dyspnea Study
NCT01670097
Completed
The goal of this clinical research study is to learn if dexamethasone can help reduce shortness of breath in cancer patients. Researchers also want to learn if it can help to improve lung function and quality of life. In this study, dexamethasone will be compared to a placebo. Dexamethasone is commonly used for treatment of nausea, tiredness, and pain. It may help patients with shortness of breath. A placebo is not a drug. It looks like the study drug but is not designed to treat any disease o... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
01/31/2021
Locations: University of Texas MD Anderson Cancer Center, Houston, Texas
Conditions: Advanced Cancers, Hematologic Disorder, Solid Tumors
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INtravitreal and Aqueous Dexamethasone Levels After DEXtenza
NCT04529512
Unknown
A prospective, open-label, interventional study to determine intraocular concentration levels of dexamethasone following use of the DEXTENZA® implant.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
01/28/2021
Locations: California Retina Consultants, Paso Robles, California +2 locations
Conditions: Ocular Disease Requiring Surgery
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Intraoperative Dexamethasone and Its Effect on Hyperglycemia
NCT03646916
Withdrawn
To study the effect of intra-operative dexamethasone on the management of post-operative blood sugar in diabetic patients.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
01/19/2021
Locations: Genesys Regional Medical Center, Grand Blanc, Michigan
Conditions: Diabetes Mellitus
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